Copyright ©2014 Baishideng Publishing Group Inc.
World J Clin Infect Dis. Nov 25, 2014; 4(4): 16-26
Published online Nov 25, 2014. doi: 10.5495/wjcid.v4.i4.16
Table 1 Outline of viral proteins that contribute to virulence as determined by reverse genetics
VirusVirulence factorsRole in pathogenesis
Influenza AMultibasic cleavage siteFacilitates viral spread to cells outside the respiratory tract
EbolaGlycoprotein Viral protein 24 and nucleoproteinTransmembrane form mediates host cell attachment and its soluble forms activate mononuclear phagocytes and endothelial cells Antagonists of IFN responses
Viral protein 35Viral polymerase cofactor that suppresses RIG-I like receptor signalling
RabiesGlycoproteinNeurotropic surface glycoprotein that facilitates spread to the brain
PhosphoproteinViral polymerase cofactor and antagonist of IFN responses
Hendra and NipahPhosphoproteinViral polymerase cofactor and antagonist of IFN responses
V and W proteinsAntagonists of IFN responses
C proteinRegulates viral transcription and affects activation of innate immune cells