Alendronate disturbs femoral growth due to changes during immunolocalization of transforming growth factor-β1 and bone morphogenetic protein-2 in epiphyseal plate

doi:10.5493/wjem.v10.i1.1

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World Journal of Experimental Medicine

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2220-315x

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Exp Med. Jan 8, 2020; 10(1): 1-9
Published online Jan 8, 2020. doi: 10.5493/wjem.v10.i1.1

Table 1 Median, minimum and maximum values of linear value found between the apex of the greater trochanter until to the lower intercondylar midlle face

Day	Linear Size of Femur (cm)		P value
Day	Control	Alendronate	P value
3	5.93 (5.67 – 6.04)	6.85 (5.99 – 7.21)	P = 0.062
12	12.72 (11.67-13.52)	8.84 (8.43 – 9.08)	P = 0.027

For each same time period values P > 0.05 are statistically similar.

Table 2 Median, minimum and maximum values of area in mm2 of each chondroid zone

Cartilage zone	Area accounted (mm²)
	3^rd day			12^th day
	Control	Alendronate	P value	Control	Alendronate	P value
Reserve	6.12 (5.52-6.51)	5.63 (5.07-5.71)	P = 0.061	3.33 (3.22-3.51)	2.26 (2.11-2.29)	P = 0.056
Proliferative	4.02 (3.82-4.44)	4.12 (3.98-4.58)	P = 0.071	3.38 (3.35-3.43)	3.11 (3.05-3.26)	P = 0.061
Maturation	0.4 (0.32-0.46)	0.36 (0.29-0.40)	P = 0.073	0.27 (0.16-0.29)	0.04 (0.01-0.06)	P = 0.002
Hipertrophic	4.12 (3.66-4.31)	7.59 (7.31-7.77)	P = 0.032	4.02 (3.96-4.26)	2.17 (2.11-2.32)	P < 0.0001

For each same time period values P < 0.05 were considered statistically different.

Table 3 Percentage in median, minimum and maximum for transforming growth factor-β1 and bone morphogenetic protein-2 values in cells for chondroid zone

Chondroid layer	Day	TGF-b1		P value	BMP-2		P value
Chondroid layer	Day	Control	Alendronate	P value	Control	Alendronate	P value
Reserve	3	-	-	-	-	12 (10-14)	P < 0.001
Reserve	12	-	-	-	-	34 (30-36)	P < 0.001
Proliferative	3	23.01 (19-26)	16.27 (14-19)	P = 0.047	-	72.21 (70-75)	P < 0.001
Proliferative	12	19.12 (17-23)	2.33 (0-3)	P < 0.001	-	67.43 (66-69)	P < 0.001
Maturation	3	89.64 (85-93)	93.07 (91-94)	P = 0.673	-	88.61 (86-81)	P < 0.001
Maturation	12	83 (80-84)	1.06 (0-1)	P < 0.001	13 (12-15)	94.05 (92-98)	P < 0.001
Hipertrophic	3	96.35 (94-99)	97.66 (95-98)	P = 0.772	2 (2-3)	82.17 (80-85)	P < 0.001
Hipertrophic	12	93.52 (92-95)	92.31 (90-93)	P = 0.694	42 (41-44)	93.00 (90-95)	P = 0.027

For each same time period values P < 0.05 were considered statistically different.

Citation: Vieira JS, Cunha EJ, de Souza JF, Chaves LHK, de Souza JL, Giovanini AF. Alendronate disturbs femoral growth due to changes during immunolocalization of transforming growth factor-β1 and bone morphogenetic protein-2 in epiphyseal plate. World J Exp Med 2020; 10(1): 1-9
URL: https://www.wjgnet.com/2220-315x/full/v10/i1/1.htm
DOI: https://dx.doi.org/10.5493/wjem.v10.i1.1