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World J Exp Med. May 20, 2013; 3(2): 21-25
Published online May 20, 2013. doi: 10.5493/wjem.v3.i2.21
Steroid resistance in leukemia
Darshan S Shah, Raj Kumar
Darshan S Shah, Raj Kumar, Department of Basic Sciences, The Commonwealth Medical College, Scranton, PA 18509, United States
Author contributions: Both authors contributed to this paper.
Correspondence to: Raj Kumar, PhD, Department of Basic Sciences, The Commonwealth Medical College, Scranton, 525 Pine Street, Scranton, PA 18509, United States. rkumar@tcmedc.org
Telephone: +1-570-5049675 Fax: +1-570-5049660
Received: April 10, 2013
Revised: May 2, 2013
Accepted: May 19, 2013
Published online: May 20, 2013
Core Tip

Core tip: The exact mechanism of this resistance has yet not been completely elucidated, but a correlation between functional glucocorticoid receptor expression levels and steroid-resistance in patients has been found. In recent years, several other mechanisms of action have been reported that could play an important role in the development of such drug resistances in leukemia.