Sirtuins in B lymphocytes metabolism and function

Table 1 Sirtuins localization and function

Sirtuin	Localization	Enzymatic activity	General functions	References
SIRT1	Nucleus Cytoplasm	Deacetylase Deacylase	Metabolism Mitochondrial biogenesis Cellular stress Chromatin regulation Cell differentiation	[30]
SIRT2	Cytoplasm Nucleus	Deacetylase Demyristoylase ADP-ribosylase Deacylase	Cell cycle Cell differentiation Metabolism Tumor suppression	[97]
SIRT3	Mitochondria	Deacetylase Decrotonylase Deacylase	Metabolism Mitochondrial biogenesis Antioxidant activity	[98,99]
SIRT4	Mitochondria	ADP-ribosylase Lipoamidase Deacetylase Deacylase	Tumor suppression Metabolism Tumor suppression	[100]
SIRT5	Mitochondria	Desuccinylase Deacylase Demalonylase Deglutarylase Deacetylase	Metabolism	[101]
SIRT6	Nucleus	Deacylase Deacetylase ADP-ribosylase	DNA repair Metabolism Inflammation	[102]
SIRT7	Nucleus	Deacetylase Deacylase	Ribosome biogenesis Tumor promotion Metabolism	[103]

ADP: Adenine diphosphate; SIRT: Sirtuin.