Potential for a pluripotent adult stem cell treatment for acute radiation sickness

Figure 1 Resistance of very small embryonic-like stem cells to γ-radiation. The content of very small embryonic-like stem cells (VSELs) and HSCs was evaluated in murine BM following whole-body irradiation with different doses of g-radiation (250, 500, 1000 and 1500 cGy) when compared to control (no irradiation). A: Absolute numbers of VSELs (Sca-1+/Lin-/CD45-) and HSCs (Sca1+/Lin-/CD45+) in BM after 4 d post-irradiation. The table presents mean numbers of VSELs and HSCs per mouse (mean ± SE). ^aP < 0.05 vs control (VSELs); ^cP < 0.05 vs control (HSCs); B: Absolute numbers of VSELs and HSCs incorporating BrdU following whole-body irradiation. Data are presented as mean absolute numbers of VSELs and HSCs per mouse (mean ± SE) (From Ref.[43], with permission). ^aP < 0.05 vs Control.