Outcomes of critically ill cancer patients with Acinetobacter baumannii infection

Table 1 Demographic and clinical characteristics of the study population

Characteristics	Values
No. of patients	23
Age (years), mean ± SD	44.09 ± 17.10
Gender (women), n (%)	11 (47.8)
Length of ICU stay (d), mean ± SD	21.9 ± 28.9
Length of hospital stay (d), mean ± SD	23.9 ± 12.3
Need for vasopressors, n (%)	23 (100)
Need for invasive mechanical ventilation, n (%)	23 (100)
Length of mechanical ventilation (d), mean ± SD	21.4 ± 11.8
In hospital ward time before ICU admission, n (%)	20 (86.9)
Length of stay in hospital wards before ICU admission (d), mean ± SD	8.8 ± 10.6
Use of antibiotics 30 days before ICU admission, n (%)	17 (73.9)
Infection site, n (%)
Respiratory	21 (91.3)
Blood culture	3 (13)
Surgical site	1 (4.3)
Pansensitive, n (%)	2 (8.7)
Pandrug-resistant, n (%)	5 (21.7)
Multidrug-resistant, n (%)	16 (69.6)
APACHE II score, mean ± SD	13.3 ± 5.8
SOFA score, mean ± SD	8.7 ± 2.4
Performance status 0-2, n (%)	22 (95.7)
ICU mortality, n (%)	6 (26.1)
Hospital mortality, n (%)	10 (43.5)

ICU: Intensive care unit; APACHE: Acute Physiology and Chronic Health Evaluation; SOFA: Sequential Organ Failure Assessment; IQR: Interquartile range; PEEP: Positive end expiratory pressure.

Table 2 Demographic and clinical characteristics of the critically ill cancer patients with Acinetobacter baumannii infection on the day of admission to the intensive care unit (initial) according to outcome

Characteristics	Survivors	Nonsurvivors	P
Age, years, mean ± SD	42.6 ± 16.6	48.1 ± 19.3	0.510
Women, n (%)	8 (47)	3 (50)	0.901
APCAHE II score, mean ± SD	12.7 ± 5.0	15.3 ± 7.9	0.357
SOFA score, mean ± SD	8.4 ± 2.4	9.6 ± 2.6	0.318
PEEP, cmH2O	8.4 ± 2.8	7.3 ± 2.3	0.422
Durations of vasopressors	7.59 ± 4.2	11 ± 4.9	0.122
Leukocytes, × 109/L	8.6 ± 6.9	11.6 ± 13.1	0.487
Absolute neutrophil count, cells/mm3	7.5 ± 6.2	10.2 ± 11.2	0.472
Lymphocytes, cells/mm3	682 ± 542	666 ± 871	0.959
Platelets, × 109/L	184.4 ± 149.2	112.8 ± 105.0	0.291
Sodium, mmol/L	138 ± 5.85	135.3 ± 6.4	0.330
Potassium, mmol/L	3.9 ± 0.51	4.0 ± 0.71	0.800
Chloride, mmol/L	109.1 ± 8.74	109.3 ± 4.2	0.967
Lactate, mmo/L	2.01 ± 1.29	5.2 ± 3.2	0.002
Magnesium, mmol/L	0.93 ± 0.24	0.97 ± 0.13	0.722
Phosphorus, mmol/L	1.33 ± 0.46	1.28 ± 0.66	0.816
Hemoglobin, g/L	91.3 ± 19.2	94.5 ± 18.8	0.739
Creatinine, μmol/L	75.8 ± 39.01	133.2 ± 34.4	0.004
Glucose, mmol/L	8.34 ± 3.5	8.09 ± 2.2	0.877
Bilirubin, total, μmol/L	17.8 ± 12.5	22.5 ± 15.5	0.465
Uric acid, μmol/L	219.0 ± 94.0	189.3 ± 149.0	0.576
ARDS, n (%)	13 (76.4)	4 (66.6)	0.632
Number of organ dysfunction (≥ 4)	2 (11.7)	4 (66.6)	0.021
Malignancies
Hematological malignancy, n (%)	8 (47)	6 (100)	0.030
Solid tumor, n (%)	9 (52.9)	0 (0)

APACHE: Acute Physiology and Chronic Health Evaluation; SOFA: Sequential Organ Failure Assessment; IQR: Interquartile range; PEEP: Positive end expiratory pressure; ARDS: Acute respiratory syndrome distress.

Table 3 Univariate and multivariate logistic regression analysis for identifying independent risk factors for mortality in the intensive care unit

Variables	Univariate		P	Multivariate		P
	OR	95%CI		OR	95%CI
Age (yr)	1.02	0.96-1.08	0.491
Gender (male)	1.12	0.17-7.24	0.901
APACHE II score	1.07	0.92-1.25	0.345
SOFA score	1.23	0.82-1.84	0.308
Length of stay in hospital wards before ICU admission (d)	0.76	0.51-1.12	0.171
Duration of vasopressors (d)	1.18	0.95-1.48	0.129
Blood lactate level (mmol/L)	2.59	1.04-6.43	0.04	2.59	1.04-6.43	0.04
Number of organ dysfunction (≥ 4)	15.00	1.58-142.1	0.018
Creatinine (μmol/L)	1.03	1.004-1.064	0.024
Total bilirubin (μmol/L)	1.02	0.95-1.10	0.449
Albumin g/L	1.06	0.89-1.27	0.494
Platelets (× 109/L)	0.99	0.98-1.00	0.295
Absolute neutrophil count/μL	1.04	0.92-1.17	0.459
Absolute lymphocytes count/μL	1.03	0.93-1.15	0.479

Goodness-of-fit (Hosmer-Lemeshow) χ² = 4.42, P = 0.817, AUC = 0.88 (0.74-0.99), P = 0.006. APACHE: Acute Physiology and Chronic Health Evaluation, ICU: Intensive care unit; OR: Odds ratio; CI: Confidence interval; AUC: Area under receiver operator characteristic curve.