Copyright ©2012 Baishideng Publishing Group Co.
World J Crit Care Med. Feb 4, 2012; 1(1): 4-9
Published online Feb 4, 2012. doi: 10.5492/wjccm.v1.i1.4
Table 1 Causes of post-cardiac arrest adrenal insufficiency
Adrenal gland ischemia and anoxia
Increased inflammatory response
Oxidative stress
Ischemia/reperfusion injury
Activation of apoptosis and programmed cell death
Malfunction of hypothalamic-pituitary-adrenal axis
Down-regulation of adrenal cell membrane receptors
Adrenomedullin secretion
Abnormalities in nitric oxide production
Drugs administered during cardiopulmonary resuscitation
Low levels of cortisol binding protein