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Braun AC, Oliveira TC, Thomazini LCD, Argenti G, Kotzian BJ, Machado V, Conte JHM, Zanfir C, Souto ACA, Ulian B, Vidart J, Wajner SM. Induced Types 2 and 3 Deiodinase in Non-Thyroidal Illness Syndrome and the Implications to Critical Illness-Induced Myopathy-A Prospective Cohort Study. Int J Mol Sci 2025; 26:2410. [PMID: 40141055 PMCID: PMC11941936 DOI: 10.3390/ijms26062410] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/10/2025] [Revised: 02/18/2025] [Accepted: 03/04/2025] [Indexed: 03/28/2025] Open
Abstract
Loss of muscle mass and strength is a common condition associated with adverse outcomes in critically ill patients. Here, we determined the correlation between non-thyroidal illness (NTIS) and molecular alterations in the muscle of critically ill individuals. We evaluated deiodinase expression, intramuscular triiodothyronine (T3) levels, and mitochondria and sarcoplasmic reticulum components. The cellular colocalization of the enzymes and its influence on myocytes and genes regulated by T3 were shown, including those of mitochondria. A prospective cohort of 96 patients. Blood and muscular samples were collected on admission to the intensive care unit (ICU), as well as clinical data and ultrasonographic measurements. Patients with NTIS showed increased oxidative stress markers associated with critical illness in muscle biopsy, such as carbonyl content and low sulfhydryl and GSH. The distribution pattern of deiodinases in muscle and its biochemical properties showed significant pathophysiological linkage between NTIS and muscle loss, as type 3-deiodinase (D3) was highly expressed in stem cells, preventing their differentiation in mature myocytes. Despite the high type 2-deiodinase (D2) expression in muscle tissue in the acute phase of critical illness, T3 was unmeasurable in the samples. In this scenario, we also demonstrated impaired expression of glucose transporters GLUT4, IRS1, and 2, which are involved in muscle illness. Here, we provide evidence that altered thyroid hormone metabolism contributes to stem cell dysfunction and further explain the mechanisms underlying critical illness-induced myopathy.
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Affiliation(s)
- André Cardoso Braun
- Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 90035-003, Rio Grande do Sul, Brazil; (A.C.B.)
| | - Thaliane Carvalho Oliveira
- Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 90035-003, Rio Grande do Sul, Brazil; (A.C.B.)
| | - Ludmilla C. D. Thomazini
- Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 90035-003, Rio Grande do Sul, Brazil; (A.C.B.)
| | - Gustavo Argenti
- Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 90035-003, Rio Grande do Sul, Brazil; (A.C.B.)
| | - Bruno Jaskulski Kotzian
- Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 90035-003, Rio Grande do Sul, Brazil; (A.C.B.)
| | - Valentina Machado
- Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 90035-003, Rio Grande do Sul, Brazil; (A.C.B.)
| | - João Henrique M. Conte
- Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 90035-003, Rio Grande do Sul, Brazil; (A.C.B.)
| | - Carolina Zanfir
- Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 90035-003, Rio Grande do Sul, Brazil; (A.C.B.)
| | - Amanda C. A. Souto
- Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 90035-003, Rio Grande do Sul, Brazil; (A.C.B.)
| | - Bruna Ulian
- Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 90035-003, Rio Grande do Sul, Brazil; (A.C.B.)
| | - Josi Vidart
- Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 90035-003, Rio Grande do Sul, Brazil; (A.C.B.)
| | - Simone Magagnin Wajner
- Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 90035-003, Rio Grande do Sul, Brazil; (A.C.B.)
- Department of Internal Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 90035-003, Rio Grande do Sul, Brazil
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Gu B, Zhou Y, Shi R, Miao S, Pei F, Yuan H, Wang L, Teboul JL, Si X, Guan X, Wu J. USE OF MUSCULAR ULTRASOUND TO DETECT INTENSIVE CARE UNIT-ACQUIRED WEAKNESS: A SYSTEMATIC REVIEW AND META-ANALYSIS. Shock 2025; 63:19-29. [PMID: 39450874 DOI: 10.1097/shk.0000000000002484] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/26/2024]
Abstract
ABSTRACT Background : This systematic review and meta-analysis aims to detecting performance of muscular ultrasound for intensive care unit (ICU)-acquired weakness (ICUAW). Methods : We searched PubMed, Web of Science, Embase, Cochrane library, CNKI, VIP, and Wanfang databases for articles published before July 2024. A random-effects model was utilized to derive the summary estimates of sensitivity, specificity, and diagnostic odds ratio (DOR) with 95% confidence interval (CI). Additionally, the sources of heterogeneity were explored by subgroup analysis and meta-regression. Results : This meta-analysis comprised 10 prospective studies involving 561 participants, of whom 241 (42.96%) were diagnosed as ICUAW. Overall, muscular ultrasound exhibited good performance for detecting ICUAW, with the area of summary receiver operating characteristic (SROC) curve of 0.85 (95%CI 0.82-0.88), sensitivity of 0.76 (95%CI 0.70-0.81), specificity of 0.80 (95%CI 0.74-0.84), and DOR of 12.43 (95%CI 7.98-19.38). Upon predefined subgroup analysis, the rectus femoris exhibited significantly superior discriminatory ability in identifying ICUAW than the non-rectus femoris, with higher SROC (0.88 [95%CI 0.85-0.91] vs. 0.76 [95%CI 0.72-0.79], P < 0.01). Moreover, cross-sectional area was more effective than thickness, with higher specificity (0.86 [95%CI 0.80-0.91] vs. 0.74 [95%CI 0.68-0.79], P = 0.02) and SROC (0.89 [95%CI 0.86-0.92] vs. 0.76 [95%CI 0.72-0.80], P < 0.01). Furthermore, integrated analysis of these two indicators revealed that the cross-sectional area of rectus femoris was statistically superior to the thickness of rectus femoris, with higher sensitivity (0.82 [95%CI 0.74-0.87] vs. 0.75 [95%CI 0.65-0.83], P < 0.05) and AUC (0.91 [95%CI 0.88-0.93] vs. 0.80 [95%CI 0.76-0.83], P < 0.01). Conclusions : Muscular ultrasound could be a reliable tool for ICUAW detection. Compared with alternative indices, the cross-sectional area of the rectus femoris exhibits superior detection efficacy and may be considered as a valuable parameter for clinical application.
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Affiliation(s)
| | | | | | | | | | | | | | - Jean-Louis Teboul
- Therapeutics and Intensive Care Medicine, Paris-Saclay University Hospitals, Paris-Saclay University, Paris, France
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Homer KA, Cross MR, Jukic I. The concurrent validity of a portable ultrasound probe for muscle thickness measurements. Clin Physiol Funct Imaging 2025; 45:e12901. [PMID: 39237476 PMCID: PMC11650541 DOI: 10.1111/cpf.12901] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/27/2024] [Revised: 07/02/2024] [Accepted: 08/19/2024] [Indexed: 09/07/2024]
Abstract
Ultrasound imaging is extensively used by both practitioners and researchers in assessing muscle thickness (MT); however, its use in the field is constrained by the transportability of stationary devices. New portable ultrasound probes pose as a cost-effective and transportable alternative for field-based assessments. This study evaluated the concurrent validity of a portable probe (Lumify) against a laboratory-based device (Vivid S5) in measuring MT. Eighteen participants (nine males and nine females) visited the laboratory and their MT measurements were collected using each device at five different sites (anterior and posterior arm, anterior and posterior thigh, and posterior lower leg). Bland-Altman plots (systematic and proportional bias, random error, and 95% limits of agreement), Pearson's product-moment correlation coefficient (r), and paired samples t-tests with Cohen's d effect sizes (ES) were used to assess the concurrent validity of the Lumify device. Systematic bias was low at all sites ( ≤ 0.11 cm) while proportional bias was detected only at the posterior lower leg (r2 = 0.217 [r = 0.466]). The difference in MT between devices was significant only at the anterior thigh (p < 0.05); however, ES for all sites were considered trivial (ES ≤ 0.131). Linear associations were found between the devices at each site of measurement (r ≥ 0.95). These results highlight that the Lumify probe can be used interchangeably with the Vivid S5 for MT measurements, providing practitioners and researchers with a more cost-effective and portable alternative for field-based assessments.
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Affiliation(s)
- Kai A. Homer
- Sport Performance Research Institute New Zealand (SPRINZ)Auckland University of TechnologyAucklandNew Zealand
| | - Matt R. Cross
- Sport Performance Research Institute New Zealand (SPRINZ)Auckland University of TechnologyAucklandNew Zealand
| | - Ivan Jukic
- Sport Performance Research Institute New Zealand (SPRINZ)Auckland University of TechnologyAucklandNew Zealand
- Department of Health, Sport and Wellbeing, Faculty of Social and Applied SciencesAbertay UniversityDundeeUK
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Venco R, Artale A, Formenti P, Deana C, Mistraletti G, Umbrello M. Methodologies and clinical applications of lower limb muscle ultrasound in critically ill patients: a systematic review and meta-analysis. Ann Intensive Care 2024; 14:163. [PMID: 39443352 PMCID: PMC11499498 DOI: 10.1186/s13613-024-01395-y] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/30/2024] [Accepted: 10/14/2024] [Indexed: 10/25/2024] Open
Abstract
BACKGROUND Reduced muscle mass upon admission and development of muscle wasting are frequent in critically ill patients, and linked to unfavorable outcomes. Muscle ultrasound is a promising instrument for evaluating muscle mass. We summarized the findings of lower limb muscle ultrasound values and investigated how the muscle ultrasound parameters of the examination or the patient characteristics influence the results. METHODS Systematic review and meta-analysis of studies of lower limb ultrasound critically ill adults. PubMed, CINAHL, Embase, PEDro and Web of Science were searched. PRISMA guidelines were followed, and studies evaluated with the appropriate NIH quality assessment tool. A meta-analysis was conducted to compare the values at admission, short and long follow-up during ICU stay, and the association between baseline values and patient characteristics or ultrasound parameters was investigated with a meta-regression. RESULTS Sixty-six studies (3839 patients) were included. The main muscles investigated were rectus femoris cross-sectional area (RF-CSA, n = 33/66), quadriceps muscle layer thickness (n = 32/66), and rectus femoris thickness (n = 19/66). Significant differences were found in the anatomical landmark and ultrasound settings. At ICU admission, RF-CSA ranged from 1.1 [0.73-1.47] to 6.36 [5.45-7.27] cm2 (pooled average 2.83 [2.29-3.37] cm2) with high heterogeneity among studies (I2 = 98.43%). Higher age, higher BMI, more distal landmark and the use of probe compression were associated with lower baseline muscle mass. CONCLUSIONS Measurements of muscle mass using ultrasound varied with reference to patient characteristics, patient position, anatomical landmarks used for measurement, and the level of compression applied by the probe; this constrains the external validity of the results and highlights the need for standardization. STUDY REGISTRATION PROSPERO CRD42023420376.
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Affiliation(s)
- Roberto Venco
- Dipartimento di fisiopatologia medico-chirurgica e dei Trapianti, Università degli Studi di Milano, Milano, Italy
| | - Alessandro Artale
- Dipartimento di fisiopatologia medico-chirurgica e dei Trapianti, Università degli Studi di Milano, Milano, Italy
| | - Paolo Formenti
- SC Anestesia, Rianimazione e Terapia Intensiva, Ospedale E. Bassini, ASST Nord Milano, Cinisello Balsamo, Italy
| | - Cristian Deana
- Department of Anesthesia and Intensive Care, Health Integrated Agency of Friuli Centrale, Udine, Italy
| | - Giovanni Mistraletti
- Dipartimento di fisiopatologia medico-chirurgica e dei Trapianti, Università degli Studi di Milano, Milano, Italy
- SC Rianimazione e Anestesia, Ospedale Civile di Legnano, ASST Ovest Milanese, Via Giovanni Paolo II, 20025, Legnano, MI, Italy
| | - Michele Umbrello
- SC Rianimazione e Anestesia, Ospedale Civile di Legnano, ASST Ovest Milanese, Via Giovanni Paolo II, 20025, Legnano, MI, Italy.
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Togninalli D, Antonarakis GS, Papadopoulou AK. Relationship between craniofacial skeletal patterns and anatomic characteristics of masticatory muscles: a systematic review and meta-analysis. Prog Orthod 2024; 25:36. [PMID: 39245691 PMCID: PMC11381490 DOI: 10.1186/s40510-024-00534-2] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/09/2024] [Accepted: 07/10/2024] [Indexed: 09/10/2024] Open
Abstract
BACKGROUND The anatomic characteristics of the masticatory muscles differ across craniofacial skeletal patterns. OBJECTIVE To identify differences in the anatomic characteristics of masticatory muscles across different sagittal and vertical craniofacial skeletal patterns. ELIGIBILITY CRITERIA Studies measuring the thickness, width, cross-sectional area (CSA), volume and orientation of masticatory muscles in healthy patients of different sagittal (Class I, Class II, and Class III) and/or vertical (normodivergent, hypodivergent, and hyperdivergent) patterns. INFORMATION SOURCES Unrestricted literature searches in 8 electronic databases/registers until December 2023. RISK OF BIAS AND SYNTHESIS OF RESULTS Study selection, data extraction, and risk of bias assessment with a customised tool were performed independently in duplicate. Random-effects meta-analysis and assessment of the certainty of clinical recommendations with the GRADE approach were conducted. RESULTS 34 studies (37 publications) were selected with a total of 2047 participants and data from 16 studies were pulled in the meta-analysis. Masseter muscle thickness in relaxation was significantly greater by 1.14 mm (95% CI 0.74-1.53 mm) in hypodivergent compared to normodivergent patients while it was significantly decreased in hyperdivergent patients by - 1.14 mm (95% CI - 1.56 to - 0.73 mm) and - 2.28 mm (95% CI - 2.71 to - 1.85 mm) compared to normodivergent and hypodivergent patients respectively. Similar significant differences were seen between these groups in masseter muscle thickness during contraction as well as masseter muscle CSA and volume. Meta-analyses could not be performed for sagittal categorizations due to insufficient number of studies. CONCLUSIONS Considerable differences in masseter muscle thickness, CSA and volume were found across vertical skeletal configurations being significantly reduced in hyperdivergent patients; however, results should be interpreted with caution due to the high risk of bias of the included studies. These variations in the anatomic characteristics of masticatory muscles among different craniofacial patterns could be part of the orthodontic diagnosis and treatment planning process. REGISTRATION PROSPERO CRD42022371187 .
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Affiliation(s)
- David Togninalli
- Division of Orthodontics, University Clinics of Dental Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland
| | - Gregory S Antonarakis
- Division of Orthodontics, University Clinics of Dental Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland
| | - Alexandra K Papadopoulou
- Division of Orthodontics, University Clinics of Dental Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
- Discipline of Orthodontics and Paediatric Dentistry, Sydney Dental School, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
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Yu H, Yeo S, Lim JY, Kim I, Hwang J, Lee W. Peri-ankle muscles architecture and performance changes in patients with chronic ankle instability: A retrospective cross-sectional study. J Foot Ankle Res 2024; 17:e12035. [PMID: 38970813 PMCID: PMC11633333 DOI: 10.1002/jfa2.12035] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/28/2023] [Accepted: 06/12/2024] [Indexed: 07/08/2024] Open
Abstract
This study aimed to identify changes in the architecture and performance of the peri-ankle muscles in patients with chronic ankle instability (CAI) and investigate the relationship between them. In total, 17 subjects were evaluated retrospectively. Each subject underwent anthropometric and isokinetic test, and peroneus longus (PL) and brevis (PB), medial gastrocnemius (MGCM), and tibialis anterior (TA) ultrasound imaging were performed at rest and maximum voluntary contraction (MVC) conditions. Regarding muscle architectural variables, the pennation angle (PA) of the MGCM at rest and the PA of the TA, MGCM, and PL in MVC were significantly reduced on the injured side compared to the intact side. There were no significant differences in muscle thickness of PL, PB, MGCM, and TA observed between intact and injured side during both rest and MVC. Regarding muscle performance parameters, significant decreased were observed in the muscle strength for both limbs in all four directions under the two different conditions. A secondary finding was that the relative PA ratio of the TA showed moderate correlation with the relative dorsiflexion ratio at 30°/s. These findings can provide opportunities to better understand how injuries in patients with CAI may be related to changes in ankle and foot function.
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Affiliation(s)
- Heeju Yu
- Department of Physical TherapySahmyook University College of Health ScienceSeoulRepublic of Korea
| | - Seungmi Yeo
- Department of Rehabilitation MedicinePusan National University Yangsan HospitalPusan National University School of MedicineYangsanRepublic of Korea
| | - Ji Young Lim
- Department of Physical and Rehabilitation MedicineMedical Research InstituteSungkyunkwan University School of MedicineSuwonRepublic of Korea
| | - Inah Kim
- Department of Physical and Rehabilitation MedicineDongtan Sacred Heart HospitalHallym University College of MedicineHwaseongRepublic of Korea
| | - Jihye Hwang
- Department of Physical and Rehabilitation MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea
| | - Wan‐hee Lee
- Department of Physical TherapySahmyook University College of Health ScienceSeoulRepublic of Korea
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Shiomi T, Miyashita S, Murakami K. Novel methods to increase core muscle activity in older adults. J Phys Ther Sci 2024; 36:530-536. [PMID: 39239416 PMCID: PMC11374162 DOI: 10.1589/jpts.36.530] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/18/2024] [Accepted: 06/12/2024] [Indexed: 09/07/2024] Open
Abstract
[Purpose] This study aimed to test whether a combination of specific postures and movements can increase trunk muscle activity in older adults. [Participants and Methods] Forty-six community-dwelling older adults (mean age: 83.9 ± 4.5 years) were living independently without the need for nursing care. The thicknesses of the external oblique, internal oblique, and transversus abdominis muscles were measured during the following three tasks: task I, natural sitting posture; task II, specific sitting posture to promote activity of the deep trunk muscles; and task III, task II plus a pushing down motion using both upper limbs. During each task, an ultrasound imaging device was used to measure the thicknesses of the external oblique, internal oblique, and transversus abdominis muscles on both the left and right sides according to the time required for expiration. [Results] Significant differences were found in the thicknesses of the internal oblique and transversus abdominis muscles between tasks II and III. Among the three muscles, the transversus abdominis showed the highest increase in thickness. [Conclusion] High activity of the trunk muscles, especially the transverse abdominis, can be achieved via specific sitting positions/tasks and further manipulations to increase the intra-abdominal pressure in both upper limbs.
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Affiliation(s)
- Taizo Shiomi
- Graduate School of Medical Sciences, Teikyo University of Science: 2-2-1 Senjyusakuragi, Adachi-ku, Tokyo 120-0045, Japan
| | - Satoshi Miyashita
- Graduate School of Medical Sciences, Teikyo University of Science: 2-2-1 Senjyusakuragi, Adachi-ku, Tokyo 120-0045, Japan
| | - Kenji Murakami
- Graduate School of Medical Sciences, Teikyo University of Science: 2-2-1 Senjyusakuragi, Adachi-ku, Tokyo 120-0045, Japan
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Soares ALC, Carvalho RF, Mogami R, Meirelles CDM, Gomes PSC. Effect of resistance training on quadriceps femoris muscle thickness obtained by ultrasound: A systematic review with meta-analysis. J Bodyw Mov Ther 2024; 39:270-278. [PMID: 38876638 DOI: 10.1016/j.jbmt.2024.02.007] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/15/2022] [Revised: 11/26/2023] [Accepted: 02/25/2024] [Indexed: 06/16/2024]
Abstract
OBJECTIVE The present study aimed to determine the magnitude and intervention time of resistance training required to generate adaptations in the muscle thickness of the quadriceps muscle obtained by ultrasound in healthy adults. METHOD A systematic review with meta-analysis was conducted on studies recovered from Pubmed, Web of Science, and Scopus databases up to March 2022. The study selection process was carried out by two independent researchers, with the presence of a third researcher in case of disagreements. The methodological quality of the studies was determined with the TESTEX scale, and the risk of bias analysis was determined using Cochrane's RoB 2.0 tool. The meta-analysis used the inverse of the variance with a fixed model, and the effect size was reported by the standardized mean difference (SMD) with a confidence interval of 95%. RESULTS Ten studies were included in a meta-analysis. The overall analysis of the studies demonstrated an SMD = 0.35 [95% CI: 0.13-0.56] (P = 0.002), with a low heterogeneity of I2 = 0% (P = 0.52). No publication bias was detected using a funnel plot followed by Egger's test (P = 0.06). The degree of certainty of the meta-analysis was high using the GRADE tool. CONCLUSION We found that resistance training can generate significant average increases of 16.6% in muscle thickness obtained by ultrasound in the quadriceps femoris muscles of healthy adults. However, the subgroup analysis showed that significant effect sizes were only observed after eight weeks of training.
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Affiliation(s)
- André Luiz Conveniente Soares
- Laboratory Crossbridges, Institute of Physical Education and Sports, Rio de Janeiro State University, Rio de Janeiro - RJ, Brazil.
| | - Ramon Franco Carvalho
- Laboratory Crossbridges, Institute of Physical Education and Sports, Rio de Janeiro State University, Rio de Janeiro - RJ, Brazil.
| | - Roberto Mogami
- Faculty of Medical Sciences, Rio de Janeiro State University, Rio de Janeiro - RJ, Brazil.
| | | | - Paulo Sergio Chagas Gomes
- Laboratory Crossbridges, Institute of Physical Education and Sports, Rio de Janeiro State University, Rio de Janeiro - RJ, Brazil.
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Sahrmann AS, Handsfield GG, Gizzi L, Gerlach J, Verl A, Besier TF, Rohrle O. A System for Reproducible 3D Ultrasound Measurements of Skeletal Muscles. IEEE Trans Biomed Eng 2024; 71:2022-2032. [PMID: 38285583 DOI: 10.1109/tbme.2024.3359854] [Citation(s) in RCA: 2] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/31/2024]
Abstract
In 3D freehand ultrasound imaging, operator dependent variations in applied forces and movements can lead to errors in the reconstructed images. In this paper, we introduce an automated 3D ultrasound system, which enables acquisitions with controlled movement trajectories by using motors, which electrically move the probe. Due to integrated encoders there is no need of position sensors. An included force control mechanism ensures a constant contact force to the skin. We conducted 8 trials with the automated 3D ultrasound system on 2 different phantoms with 3 force settings and 10 trials on a human tibialis anterior muscle with 2 force settings. For comparison, we also conducted 8 freehand 3D ultrasound scans from 2 operators (4 force settings) on one phantom and 10 with one operator on the tibialis anterior muscle. Both freehand and automated trials showed small errors in volume and length computations of the reconstructions, however the freehand trials showed larger standard deviations. We also computed the thickness of the phantom and the tibialis anterior muscle. We found significant differences in force settings for the operators and higher coefficients of variation for the freehand trials. Overall, the automated 3D ultrasound system shows a high accuracy in reconstruction. Due to the smaller coefficients of variation, the automated 3D ultrasound system enables more reproducible ultrasound examinations than the freehand scanning. Therefore, the automated 3D ultrasound system is a reliable tool for 3D investigations of skeletal muscle.
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Voskuil CC, Dudar MD, Carr JC. Exploring the Relationship between Ultrasonographic Measures of the Quadriceps and Knee Extensor Muscle Fitness in Endurance-Trained Individuals. TRANSLATIONAL SPORTS MEDICINE 2024; 2024:3415740. [PMID: 38654724 PMCID: PMC11023727 DOI: 10.1155/2024/3415740] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/19/2023] [Revised: 03/04/2024] [Accepted: 03/20/2024] [Indexed: 04/26/2024]
Abstract
Background B-mode ultrasonography is an accessible and cost-effective method to assess muscle size and quality through muscle thickness (MT) and echo intensity (EI), respectively. Muscle thickness and EI have demonstrated relationships with maximal strength and local muscle endurance, providing a noninvasive and efficient modality to examine muscle fitness. However, these relationships have not been quantified in the individual quadriceps muscles of habitually endurance-trained populations, which may provide information to practitioners regarding rehabilitation and performance. Methods Twenty-three participants (males: N = 10; females: N = 13) underwent B-mode ultrasonography to assess MT, EI, and adipose tissue thickness-corrected echo intensity (cEI) in the vastus intermedius (VI), vastus lateralis (VL), and rectus femoris (RF). Muscle fitness was evaluated through maximal strength (1RM) and local muscle endurance (4 sets to failure at 50% 1RM) during dynamic knee extension. Relationships between ultrasonography outcomes and muscle fitness were examined through stepwise multiple linear regression. Results The results indicate that VI cEI is the strongest predictor of 1RM strength (r = -0.643), while no ultrasonography-derived measures significantly predicted local muscle endurance. Conclusion The study demonstrates that ultrasonography, specifically measures of cEI in the VI, has the greatest association with maximal strength in endurance-trained individuals. These findings suggest monitoring VI muscle size and quality may benefit practitioners who aim to improve knee extension strength for performance or following injury. In addition, the findings support the use of EI examinations in trained populations.
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Affiliation(s)
- Caleb C. Voskuil
- Texas Christian University, Department of Kinesiology, Fort Worth, TX, USA
| | - Monique D. Dudar
- Texas Christian University, Department of Kinesiology, Fort Worth, TX, USA
| | - Joshua C. Carr
- Texas Christian University, Department of Kinesiology, Fort Worth, TX, USA
- Department of Medical Education, Anne Burnett Marion School of Medicine at Texas Christian University, Fort Worth, TX, USA
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Yakut H, Ayyıldız VA, Bekar Z, Kayan M, Kutluhan S. The Relationship of Gastrocnemius-Soleus Muscle Architecture with Balance and Functional Strength in Acute Stroke Patients. J Mot Behav 2024:1-10. [PMID: 38503319 DOI: 10.1080/00222895.2024.2329697] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/24/2023] [Accepted: 02/26/2024] [Indexed: 03/21/2024]
Abstract
Balance and functional impairment could occur due to the weakness of the gastrocsoleus muscles in acute stroke patients. This study was planned to determine the muscle architecture and its relationship to balance and functional strength functional ability in patients with acute stroke. A cross-sectional analysis of 22 stroke patients (68.59 ± 8.16) was performed in this study. Gastrocnemius muscle thickness and cross-sectional area were significantly greater on the non-paretic than on the paretic sides (p = 0.004, p = 0.005, respectively). Partial correlation analysis showed that soleus muscle thickness and cross-sectional area was significantly correlated with Berg Balance Scale, Single Leg Stance Test, Five Times Sit to Stand Test and Tandem test results in the paretic side (r = 0.49-0.77, p < 0.05). The gastrocnemius muscle thickness of the non-paretic side had a significant relationship with balance (r = 0.45-0.65, p < 0.05). The muscle thickness and cross-sectional area of the soleus muscle on the paretic sides was significantly related with the functional strength and balance after stroke. It may be beneficial to develop clinical assessment and intervention programs focusing on distal plantar flexor muscle groups in order to improve the functional status and balance.
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Affiliation(s)
- Hatice Yakut
- Faculty of Health Sciences, Department of Physical Therapy and Rehabilitation, Süleyman Demirel University, Isparta, Turkey
| | - Veysel Atilla Ayyıldız
- Faculty of Medicine, Department of Radiology, Süleyman Demirel University, Isparta, Turkey
| | - Zülal Bekar
- Faculty of Health Sciences, Department of Physical Therapy and Rehabilitation, Gazi University, Ankara, Turkey
| | - Mustafa Kayan
- Faculty of Medicine, Department of Radiology, Süleyman Demirel University, Isparta, Turkey
| | - Süleyman Kutluhan
- Faculty of Medicine, Department of Neurology, Süleyman Demirel University, Isparta, Turkey
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12
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Mohseni F, Rahmani N, Mohseni Bandpei MA, Abdollahi I. Reliability of ultrasonography to measure cervical multifidus, semispinalis cervicis and longus colli muscles dimensions in patients with unilateral cervical disc herniation: An observational cross-sectional test-retest study. J Bodyw Mov Ther 2024; 37:399-403. [PMID: 38432836 DOI: 10.1016/j.jbmt.2023.11.008] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/19/2022] [Revised: 10/03/2023] [Accepted: 11/06/2023] [Indexed: 03/05/2024]
Abstract
BACKGROUND Ultrasonography (US) has been suggested to assess the morphology and function of cervical muscles; but little is known about the reliability of the US measures in patients with cervical disc herniation (CDH). The purpose of this study was to evaluate within-day inter and intra-rater and between-day intra-rater reliability of US to measure dimensions of deep cervical muscles in patients with unilateral CDH. METHODS Thirty patients with unilateral CDH participated. Anterior-posterior and lateral dimension of longus colli (LC), multifidus (MF) and semispinalis cervicis (SC) were measured using B-mode ultrasound. The measurements were repeated by rater A 1 h (for within-day reliability) and one week (for between-day reliability) later. For inter-rater reliability, rater B performed all muscles measurements like rater A. RESULTS Within-day reliability measurement for all muscles was good to excellent with IntraClass Correlation Coefficients (ICC) ranging from 0.82 to 0.96, standard error of measurement (SEM) from 0.18 to 0.46 and minimal detectable changes (MDC) from 0.43 to 1.09. Between-day reliability was good for all muscle dimensions with ICC ranging from 0.75 to 0.89, SEM from 0.30 to 0.64 and MDC from 0.71 to 1.52. Inter-rater reliability was also good with ICC ranging from 0.75 to 0.89, SEM from 0.34 to 0.65 and MDC from 0.81 to 1.55. CONCLUSIONS US was demonstrated to have high within-day inter and intra-rater and between-day intra-rater reliability to measure muscles dimensions in patients with unilateral CDH. It can be used to assess deep cervical muscles or to monitor the effects of interventions.
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Affiliation(s)
- Fariba Mohseni
- Physiotherapy Department, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
| | - Nahid Rahmani
- Pediatric Neurorehabilitation Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
| | | | - Iraj Abdollahi
- Physiotherapy Department, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
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13
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Elkalawy H, Sekhar P, Abosena W. Early detection and assessment of intensive care unit-acquired weakness: a comprehensive review. Acute Crit Care 2023; 38:409-424. [PMID: 38052508 DOI: 10.4266/acc.2023.00703] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/14/2023] [Accepted: 10/17/2023] [Indexed: 12/07/2023] Open
Abstract
Intensive care unit-acquired weakness (ICU-AW) is a serious complication in critically ill patients. Therefore, timely and accurate diagnosis and monitoring of ICU-AW are crucial for effectively preventing its associated morbidity and mortality. This article provides a comprehensive review of ICU-AW, focusing on the different methods used for its diagnosis and monitoring. Additionally, it highlights the role of bedside ultrasound in muscle assessment and early detection of ICU-AW. Furthermore, the article explores potential strategies for preventing ICU-AW. Healthcare providers who manage critically ill patients utilize diagnostic approaches such as physical exams, imaging, and assessment tools to identify ICU-AW. However, each method has its own limitations. The diagnosis of ICU-AW needs improvement due to the lack of a consensus on the appropriate approach for its detection. Nevertheless, bedside ultrasound has proven to be the most reliable and cost-effective tool for muscle assessment in the ICU. Combining the Sequential Organ Failure Assessment (SOFA) score, Acute Physiology and Chronic Health Evaluation (APACHE) II score assessment, and ultrasound can be a convenient approach for the early detection of ICU-AW. This approach can facilitate timely intervention and prevent catastrophic consequences. However, further studies are needed to strengthen the evidence.
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Affiliation(s)
- Hanan Elkalawy
- Department of Anesthesiology and Perioperative Medicine, Tufts Medical Center, Boston, MA, USA
| | - Pavan Sekhar
- Department of Anesthesiology and Perioperative Medicine, Tufts Medical Center, Boston, MA, USA
| | - Wael Abosena
- Department of Surgery, Faculty of Medicine, Tanta University, Gharbeya, Egypt
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14
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Homma H, Aoki M, Okino K, Hayashi T, Yamane M, Sasaki Y. Reproducibility of subscapularis muscle thickness measurement using ultrasound imaging. -Relationship between subscapularis muscle thickness and internal rotation torque of the shoulder joint. J Bodyw Mov Ther 2023; 36:349-356. [PMID: 37949583 DOI: 10.1016/j.jbmt.2023.09.003] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/05/2022] [Revised: 07/06/2023] [Accepted: 09/04/2023] [Indexed: 11/12/2023]
Abstract
BACKGROUND Few studies have reported on the morphometry of the subscapularis muscle using ultrasound imaging (USI); and their reproducibility has not been verified. OBJECTIVES This study aimed to clarify the relative and absolute reproducibility of USI measurements of subscapularis muscle thickness at rest and during isometric contraction as well as the degree of change in muscle thickness caused by the amount of internal rotational torque in the shoulder joint. DESIGN Two-group repeated-measures study. METHODS The subjects were the inferior fibers of the subscapularis muscle of 40 healthy adult males. Muscle thickness was measured at rest and at 10%-30% of the maximum isometric internal rotation torque. Intraclass correlation coefficients (ICC) and Brand Altman analysis were used for reproducibility measurement. The degree of change in muscle thickness at each torque was also calculated. RESULTS Intra- and inter-rater ICCs (ranged from 0.69 to 0.91) were good. A proportional error was observed in intra-rater measurements. Both minimal detectable change 95 (ranged from 2.33 to 6.47) were high. The subscapularis muscle thickness was significantly increased at 10% torque (25.49 ± 3.80 mm), 20% torque (26.07 ± 3.90 mm), and 30% torque (25.96 ± 3.82 mm) as compared to that in resting conditions (24.53 ± 4.46 mm) (p < 0.05). CONCLUSION The reproducibility and error of the subscapularis muscle thickness measurement using USI used in this study were clarified when repeated measurements were made in the same limb position and under the same probe installation conditions, suggesting that the contraction of the subscapularis muscle can be estimated by muscle thickness measurement.
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Affiliation(s)
- Hisashi Homma
- Graduate School of Rehabilitation Sciences, Health Sciences University of Hokkaido, 1757 Kanazawa, Tobetsu-cho, Ishikari-gun, 061-0293, Hokkaido, Japan; Department of Rehabilitation, Sapporo Hachiken Orthopedic Clinic, Hokkaido, Japan.
| | - Mitsuhiro Aoki
- Graduate School of Rehabilitation Sciences, Health Sciences University of Hokkaido, 1757 Kanazawa, Tobetsu-cho, Ishikari-gun, 061-0293, Hokkaido, Japan.
| | - Kumiko Okino
- Graduate School of Rehabilitation Sciences, Health Sciences University of Hokkaido, 1757 Kanazawa, Tobetsu-cho, Ishikari-gun, 061-0293, Hokkaido, Japan.
| | - Tomoya Hayashi
- Graduate School of Rehabilitation Sciences, Health Sciences University of Hokkaido, 1757 Kanazawa, Tobetsu-cho, Ishikari-gun, 061-0293, Hokkaido, Japan.
| | - Masahiro Yamane
- Graduate School of Rehabilitation Sciences, Health Sciences University of Hokkaido, 1757 Kanazawa, Tobetsu-cho, Ishikari-gun, 061-0293, Hokkaido, Japan.
| | - Yuji Sasaki
- Graduate School of Rehabilitation Sciences, Health Sciences University of Hokkaido, 1757 Kanazawa, Tobetsu-cho, Ishikari-gun, 061-0293, Hokkaido, Japan.
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Koh YG, Shin SH, Kim KR, Yeoum SH, Choi WW, Park KY. A Double-Blinded, Randomized, Dose-Comparison Pilot Study to Comparatively Evaluate Efficacy and Safety of Two Doses of Botulinum Toxin Type A Injection for Deltoid Muscle Hypertrophy. Ann Dermatol 2023; 35:355-359. [PMID: 37830417 PMCID: PMC10579568 DOI: 10.5021/ad.22.155] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/28/2022] [Revised: 04/25/2023] [Accepted: 05/10/2023] [Indexed: 10/14/2023] Open
Abstract
BACKGROUND Botulinum toxin type A (BTX-A) injection is being widely used off-label for muscular hypertrophy, including deltoid muscle hypertrophy. However, very few studies have evaluated the optimal dosage and its clinical response. OBJECTIVE This study aimed to assess the efficacy and safety of different doses of Prabotulinum toxin A (PBoNT) for treating deltoid muscle hypertrophy. METHODS Twelve particiapants with bilateral deltoid muscle hypertrophy were enrolled and randomly received either 16 U or 32 U of PBoNT. In each participant, the same dose was administered to both deltoid muscles. Both participants and evaluators were blinded. Deltoid muscle thickness and upper arm circumference were measured on day 0, and weeks 2, 4, and 12 after the PBoNT injection. RESULTS Upper arm circumference significantly decreased in both groups; however, deltoid muscle thickness was reduced in the 16 U group only. No major complications were reported in both groups. However, a few minor complications were reported in the 16 U injection group. CONCLUSION Both 16 U and 32 U of PBoNT intramuscular injections are safe and effective in treating deltoid hypertrophy.
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Affiliation(s)
- Young Gue Koh
- Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea
| | - Sun Hye Shin
- Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea
| | - Ka Ram Kim
- Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea
| | | | | | - Kui Young Park
- Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.
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Saeteros M, Virto N, Oyarzábal I, de Frutos XR, García R, Avendaño A, Cortés EB, Gómez E, Abizanda P, Rodríguez-Mañas L, Matheu A, Lazcano U, Vergara I, Arjona L, Coca A, Sanabria SJ. Ultrasound quantitative monitoring of muscle quality changes in sarcopenia patients after supervised exercise intervention. 2023 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IUS) 2023:1-4. [DOI: 10.1109/ius51837.2023.10307573] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 01/04/2025]
Affiliation(s)
- Morelva Saeteros
- University of Deusto,Deusto Institute of Technology,Bilbao,Spain
| | - Naiara Virto
- University of Deusto,Deusto Institute of Technology,Bilbao,Spain
| | | | | | | | | | | | - Elena Gómez
- Albacete University Hospital,Department of Geriatrics,Albacete,Spain
| | | | | | - Ander Matheu
- Biodonostia Health Research Institute,San Sebastian,Spain
| | - Uxue Lazcano
- Biodonostia Health Research Institute,San Sebastian,Spain
| | - Itziar Vergara
- Biodonostia Health Research Institute,San Sebastian,Spain
| | - Laura Arjona
- University of Deusto,Deusto Institute of Technology,Bilbao,Spain
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17
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Özgül B, Starbuck C, Polat MG, Abdeen R, Nester C. Inter and intra-examiner reliability of musculoskeletal ultrasound scanning of Anterior Talofibular Ligament and ankle muscles. J Ultrasound 2023; 26:137-146. [PMID: 36048331 PMCID: PMC10063751 DOI: 10.1007/s40477-022-00699-8] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/17/2022] [Accepted: 06/13/2022] [Indexed: 10/14/2022] Open
Abstract
PURPOSE Although the function of subjects with chronic ankle instability (CAI) has been examined, structural analysis by ultrasound scanning of the structures surrounding the ankle is limited. Before such structural comparisons between injured and uninjured people can be made it is important to investigate a reliable measurement protocol of structures possibly related to CAI. The aim of this study was to investigate the inter-intra examiner reliability of ultrasonic characteristics of selected structures in healthy subjects. METHODS Eleven healthy participants were assessed by an experienced sonographer and inexperienced certificated examiner. Ultrasound images were collected of the ATFL length and ankle muscles of gastrocnemius medialis (GM), tibialis anterior (TA) and peroneals. Thickness was measured for the muscles, whilst cross-sectional area (CSA) was measured for the peroneals. Inexperienced examiner repeated the measurements a week later. RESULTS Inter-examiner reliability was excellent for all structures (ICC3,1 = 0.91-0.98). Intra-examiner reliability shows excellent agreement for all structures (ICC3,1 = 0.92-0.98) except GM (good agreement) (ICC3,1 = 0.82). LoA, relative to structure size, ranged from 1.38 to 6.88% for inter-reliability and from 0.07 to 5.79% for intra-reliability. CONCLUSION This study shows a high level of inter-intra examiner reliability in measuring the structures possibly related to CAI. Future research has been planned to investigate the structural analysis in CAI by using applied MSUS protocol.
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Affiliation(s)
- Bahar Özgül
- Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Marmara University, Istanbul, Turkey.
| | - Chelsea Starbuck
- Applied Sports, Technology, Exercise, and Medicine Research Centre, Faculty of Science and Engineering, Swansea University, Swansea, UK
| | - Mine Gülden Polat
- Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Marmara University, Istanbul, Turkey
| | - Rawan Abdeen
- Faculty of Applied Medical Sciences, Diagnostic Radiology Technology Department, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia
| | - Christopher Nester
- School of Health Sciences and Society, University of Salford, Manchester, UK
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18
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Reliability and feasibility of skeletal muscle ultrasound in the acute burn setting. Burns 2023; 49:68-79. [PMID: 35361498 DOI: 10.1016/j.burns.2022.03.003] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/16/2021] [Revised: 02/11/2022] [Accepted: 03/12/2022] [Indexed: 01/06/2023]
Abstract
OBJECTIVES Despite the impact of muscle wasting after burn, tools to quantify muscle wasting are lacking. This multi-centre study examined the utility of ultrasound to measure muscle mass in acute burn patients comparing different methodologies. METHODS B-mode ultrasound was used by two raters to determine feasibility and inter-rater reliability in twenty burned adults following admission. Quadriceps muscle layer thickness (QMLT) and rectus femoris cross-sectional area (RF-CSA) were measured, comparing the use of i) a single versus average measurements, ii) a proximal versus distal location for QMLT, and iii) a maximum- versus no-compression technique for QMLT. RESULTS Analysis of twenty burned adults (50 years [95%CI 42-57], 32%TBSA [95%CI 23-40]) yielded ICCs of> 0.97 for QMLT (for either location and compression technique) and> 0.95 for RF-CSA, using average measurements. Relative minimal detectable changes were smaller using no-compression than maximum-compression (6.5% vs. 15%). Using no-compression to measure QMLT was deemed feasible for both proximal and distal locations (94% and 96% of attempted measurements). In 9.5% of cases maximum-compression was not feasible. 95% of RF-CSA measurements were successfully completed. CONCLUSION Ultrasound provides feasible and reliable values of quadriceps muscle architecture that can be adapted to clinical scenarios commonly encountered in acute burn settings.
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Isaka M, Sugimoto K, Akasaka H, Yasunobe Y, Takahashi T, Xie K, Onishi Y, Yoshida S, Minami T, Yamamoto K, Kamide K, Rakugi H. The Muscle Thickness Assessment Using Ultrasonography is a Useful Alternative to Skeletal Muscle Mass by Bioelectrical Impedance Analysis. Clin Interv Aging 2022; 17:1851-1861. [PMID: 36545348 PMCID: PMC9762259 DOI: 10.2147/cia.s385469] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/08/2022] [Accepted: 11/24/2022] [Indexed: 12/23/2022] Open
Abstract
Purpose Muscle mass, a key index for the diagnosis of sarcopenia, is currently assessed using the appendicular skeletal muscle mass index (ASMI) by bioelectrical impedance analysis (BIA). Muscle thickness (MT) assessed by ultrasonography (US) may be a better determinant and/or predictor of muscle condition than ASMI. Thus, we compared it to the ASMI determined by the BIA. Patients and Methods Our study included 165 ambulatory older adults (84 males, 81 females, mean age: 76.82 years). The ASMI by the BIA method, MT by US, and the distribution of body mass index (BMI) and body fat percentage (BFP) were examined using defined values for men and women. These were used as the basis for examining the association of MT and ASMI with handgrip strength (HGS), leg muscle strength (LMS), gait speed (GS), and echo intensity (EI). We compared HGS, LMS, GS, and EI for high and low ASMI among lower BMI or BFP. The same was also done for MT assessed by US. Results MT, as well as ASMI, was strongly associated with HGS and LMS. There was a correlation between MT and GS and EI but not between ASMI and GS and EI. There were significant differences in the prevalence between high ASMI and high MT or low ASMI and low MT in those with lower BMI or BFP. In non-overweight participants, HGS, LMS, GS, and EI were significantly higher in those with high MT than in those with low MT; however, there were no significant differences in them between those with high and low ASMI. Conclusion In the non-overweight group, the MT assessment by US showed a stronger relationship to muscle strength and muscle quality than the ASMI assessment by BIA. The MT assessment using US is a useful alternative to BIA-assessed ASMI, especially in non-overweight participants.
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Affiliation(s)
- Masaaki Isaka
- Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan,Department of Health Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan,Physical Therapy, Osaka Yukioka College of Health Science, Ibaraki, Osaka, Japan
| | - Ken Sugimoto
- Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan,Department of General Geriatric Medicine, Kawasaki Medical School, Okayama, Okayama, Japan,Correspondence: Ken Sugimoto, Department of General Geriatric Medicine, Kawasaki Medical School, 2-6-1, Nakasange, Kita-ku, Okayama, Okayama, 700-8505, Japan, Tel +81 86 225 2111, Fax +81 86 232 8343, Email
| | - Hiroshi Akasaka
- Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
| | - Yukiko Yasunobe
- Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
| | - Toshimasa Takahashi
- Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
| | - Keyu Xie
- Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
| | - Yuri Onishi
- Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
| | - Shino Yoshida
- Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
| | - Tomohiro Minami
- Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
| | - Koichi Yamamoto
- Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
| | - Kei Kamide
- Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan,Department of Health Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
| | - Hiromi Rakugi
- Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
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Ispir NG, Toraman M. The relationship of masseter muscle thickness with face morphology and parafunctional habits: an ultrasound study. Dentomaxillofac Radiol 2022; 51:20220166. [PMID: 35926082 PMCID: PMC9717398 DOI: 10.1259/dmfr.20220166] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/10/2022] [Revised: 07/28/2022] [Accepted: 07/29/2022] [Indexed: 12/15/2022] Open
Abstract
OBJECTIVE The aim of this study was to determine the normal range of masseter muscle thickness by ultrasonographic measurement in individuals over 15 years of age, and to evaluate its relationship with age, gender, facial morphology, body mass index and parafunctional habits. METHODS The study was conducted on 115 volunteers whose lateral cephalometric radiography was performed within the indication in Gazi University Faculty of Dentistry, Department of Dentomaxillofacial Radiology. The participants in the study were asked questions about their parafunctional habits, age, height and weight. Individuals were grouped as hypodivergent (n = 28), normdivergent (n = 55), or hyperdivergent (n = 32) according to vertical face morphology by making measurements on lateral cephalometric films. Right and left masseter muscle thicknesses of individuals were measured by ultrasonography while at rest and in contraction. RESULTS The mean value of masseter muscle thickness was found to be 13.57 ± 2.57 mm. The rest and contracted muscle thicknesses were significantly higher in males than in females for the right and left masseter muscles (p < 0.05). When the masseter muscle was at rest and contracted, its thickness was higher in individuals with hypodivergent facial morphology, than in the other groups. No statistically significant difference was found in terms of masseter muscle thickness between individuals having parafunctional habits and those who did not have parafunctional habits (p > 0.05). CONCLUSION Although masseter muscle thickness varied according to vertical facial morphology, this was not the case for parafunctional habits.
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Affiliation(s)
- Nebiha Gozde Ispir
- Department of Dentomaxillofacial Radiology, Gazi University, Ankara, Turkey
| | - Meryem Toraman
- Department of Dentomaxillofacial Radiology, Gazi University, Ankara, Turkey
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Kim AY, Elam LH, Lambrechts NE, Salman MD, Duerr FM. Appendicular skeletal muscle mass assessment in dogs: a scoping literature review. BMC Vet Res 2022; 18:280. [PMID: 35842654 PMCID: PMC9288046 DOI: 10.1186/s12917-022-03367-5] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/30/2022] [Accepted: 06/30/2022] [Indexed: 11/10/2022] Open
Abstract
BACKGROUND Monitoring changes in appendicular skeletal muscle mass is frequently used as a surrogate marker for limb function. The primary objective of this study was to review scientific information related to the assessment of appendicular skeletal muscle mass in dogs. The secondary objective was to develop practical recommendations for serial evaluation of muscle mass. METHODS A scoping review was conducted with a systematic search of PubMed, Web of Science, CAB abstract, and Cochrane from inception to June 2021. The following modalities were included in the search: limb circumference, diagnostic ultrasound, computed tomography, magnetic resonance imaging, and dual-energy x-ray absorptiometry. RESULTS A total of 62 articles that measured appendicular skeletal muscle mass in dogs were identified. Limb circumference (55 articles) was the most commonly used modality. Its reliability was investigated in five studies. Several factors, including measuring tape type, body position, joint angles, and the presence of hair coat, were reported as variables that can affect measurements. Diagnostic ultrasound (five articles) was validated in three articles, but there is scarce information about observer reliability and variables affecting the measurement. Computed tomography (four articles) and magnetic resonance imaging (one article) have been used to validate other modalities at a single time point rather than as a clinical tool for serial muscle mass monitoring. Dual-energy x-ray absorptiometry (two articles) has been used to quantify specific skeletal muscle mass but was mainly used to evaluate body composition in dogs. CONCLUSION Limb circumference and ultrasound are likely the main modalities that will continue to be used for serial muscle mass measurement in the clinical setting unless a new technology is developed. The reliability of limb circumference is questionable. Several key factors, including measuring tape type, body position, joint angles, and coat clipping, need to be controlled to improve the reliability of limb circumference measurements. Ultrasound may provide a reasonable alternative, but further studies are required to evaluate the reliability of this modality and identify factors that influence ultrasound measurements.
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Affiliation(s)
- Ah Young Kim
- Colorado State University College of Veterinary Medicine and Biomedical Sciences, 300 W Drake Road, Fort Collins, CO 80523 USA
| | - Lindsay Hochman Elam
- Colorado State University College of Veterinary Medicine and Biomedical Sciences, 300 W Drake Road, Fort Collins, CO 80523 USA
| | - Nicolaas Everhardus Lambrechts
- Colorado State University College of Veterinary Medicine and Biomedical Sciences, 300 W Drake Road, Fort Collins, CO 80523 USA
| | - Mo D. Salman
- Colorado State University College of Veterinary Medicine and Biomedical Sciences, 300 W Drake Road, Fort Collins, CO 80523 USA
| | - Felix Michael Duerr
- Colorado State University College of Veterinary Medicine and Biomedical Sciences, 300 W Drake Road, Fort Collins, CO 80523 USA
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Lee JH, Chun YM, Kim DS, Lee DH, Shin SJ. Effects of neuromuscular electrical muscle stimulation on the deltoid for shoulder function restoration after reverse total shoulder arthroplasty in the early recovery period: a prospective randomized study. Arch Orthop Trauma Surg 2022; 143:3037-3046. [PMID: 35804165 DOI: 10.1007/s00402-022-04515-0] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/06/2021] [Accepted: 06/09/2022] [Indexed: 11/30/2022]
Abstract
INTRODUCTION Neuromuscular electrical stimulation (NMES) is a treatment modality that has been used to accelerate the rehabilitation of patients with neurological damage. However, it is unclear whether NMES of the deltoid can lead to the early restoration of shoulder function after reverse total shoulder arthroplasty (RSA). MATERIALS AND METHODS In this prospective and randomized study, 88 patients who underwent RSA with the same prosthesis design for cuff tear arthropathy or irreparable rotator cuff tear were assessed. The patients were divided into two groups (NMES group and non-NMES group, 44 patients each). For the NMES group, two pads of the NMES device were placed over the middle and posterior deltoid area, and NMES was maintained for 1 month after surgery. Shoulder functional outcomes and deltoid thickness were compared at 3, 6, and 12 months postoperatively. Shoulder functional outcomes were assessed based on the visual analog scale (VAS) for pain, American Shoulder and Elbow Surgeons (ASES), and Constant scores and the range of motion (ROM) and power of the affected shoulder. The thickness of the anterior, middle, and posterior deltoid was measured by ultrasonography. RESULTS A total of 76 patients (NMES group, 33 patients; non-NMES group, 43 patients) were enrolled in the final analysis. The preoperative demographics and status of the remaining rotator cuff of both groups were not significantly different. At postoperative 3 months, the ROM and power of external rotation of the NMES group were significantly greater than those of the non-NMES group (ROM, 36° ± 14° vs. 29° ± 12°; P = .003; power, 4.8 kg ± 1.8 kg vs. 3.8 kg ± 1.0 kg; P < .002). The ROM of external rotation of the NMES group at postoperative 6 months was also greater than that of the non-NMES group (41° ± 12° vs. 34° ± 11°; P = .013). However, there was no significant difference in the VAS, ASES, and Constant scores at all follow-up points despite gradual improvements until 1 year postoperatively. Serial measurements of the thickness of the anterior, middle, and posterior deltoid of both groups did not show significant differences. CONCLUSIONS Postoperative NMES of the deltoid after RSA contributed to significantly faster ROM restoration and considerable improvement in the power of external rotation. Therefore, NMES following RSA could lead to the early restoration of external rotation and recovery of deltoid function.
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Affiliation(s)
- Jae-Hoo Lee
- Department of Orthopaedic Surgery, Inje University, Ilsan Paik Hospital, Goyang-si, Republic of Korea
| | - Yong-Min Chun
- Department of Orthopaedic Surgery, College of Medicine, Arthroscopy and Joint Research Institute, Severance Hospital, Yonsei University, Seoul, Republic of Korea
| | - Doo-Sup Kim
- Department of Orthopaedic Surgery, Wonju College of Medicine, Wonju Severance Christian Hospital, Yonsei University, Wonju, Republic of Korea
| | - Doo-Hyung Lee
- Department of Orthopaedic Surgery, School of Medicine, Ajou University, Suwon, Republic of Korea
| | - Sang-Jin Shin
- Department of Orthopaedic Surgery, Ewha Shoulder Disease Center, Seoul Hospital, Ewha Womans University School of Medicine, Seoul, Republic of Korea.
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Wong V, Song JS, Abe T, Spitz RW, Yamada Y, Bell ZW, Kataoka R, Kang M, Loenneke JP. Muscle thickness assessment of the forearm via ultrasonography: is experience level important? Biomed Phys Eng Express 2022; 8. [PMID: 35051910 DOI: 10.1088/2057-1976/ac4d42] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/24/2021] [Accepted: 01/20/2022] [Indexed: 11/11/2022]
Abstract
It is suggested that experience is needed in order to capture valid estimates of muscle size with ultrasound. However, it is unknown whether there is a large degree of skill needed to analyze the images once they are captured.Objective:To determine if less experienced raters could accurately analyze ultrasound images of the forearm by comparing their estimates with those of a very experienced ultrasonographer (criterion).Approach:50 muscle thickness images were captured by one experienced ultrasonographer (also Rater 1). Those images were saved and were then measured by four raters with different levels of experience. The rater who captured the images was very experienced (criterion), the second rater was also experienced and provided 5 minutes of instruction for Rater 3 (minimal experience) and Rater 4 (no experience). Test-retest reliability was also determined for Rater 3 and 4.Main Results:The average muscle thickness value for the criterion was 3.73 cm. The constant error for Rater 2, 3, and 4 was -0.003 (0.02) cm (p=0.362), -0.07 (0.04) cm (p<0.001), and 0.02 (0.09) cm (p=0.132), respectively. The SD for Rater 4 was greater, resulting in wider limits of agreement compared to Rater 2 and 3. Absolute error was 0.01 cm for Rater 2, whilst it was 0.07 cm and 0.03 cm for the two inexperienced raters (Rater 3 and 4). The error for Rater 3 was systematic and post-hoc assessment found that this rater was using a different border than the other three raters (but consistent across time). For the test-retest reliability, the minimal difference for Rater 3 was 0.08 cm (relative minimal difference of 2%) and 0.17 cm (relative minimal difference of 4%) for Rater 4.Significance:Less experienced raters were able to accurately and reliably analyze already captured muscle thickness images of the forearm with low absolute errors.
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Affiliation(s)
- Vickie Wong
- Department of Health, Exercise Science, and Recreation Management, University of Mississippi, PO Box 1848, University Park, Mississippi, 38677, UNITED STATES
| | - Jun Seob Song
- Department of Health, Exercise Science, and Recreation Management, University of Mississippi, PO Box 1848, University Park, Mississippi, 38677, UNITED STATES
| | - Takashi Abe
- Juntendo University, Japan, Bunkyo-ku, Tokyo, NA, JAPAN
| | - Robert W Spitz
- Department of Health, Exercise Science, and Recreation Management, University of Mississippi, PO Box 1848, University Park, Mississippi, 38677, UNITED STATES
| | - Yujiro Yamada
- Department of Health, Exercise Science, and Recreation Management, University of Mississippi, PO Box 1848, University Park, Mississippi, 38677, UNITED STATES
| | - Zachary W Bell
- Department of Health, Exercise Science, and Recreation Management, University of Mississippi, PO Box 1848, University Park, Mississippi, 38677, UNITED STATES
| | - Ryo Kataoka
- Department of Health, Exercise Science, and Recreation Management, University of Mississippi, PO Box 1848, University Park, Mississippi, 38677, UNITED STATES
| | - Minsoo Kang
- Department of Health, Exercise Science, and Recreation Management, University of Mississippi, PO Box 1848, University Park, Mississippi, 38677, UNITED STATES
| | - Jeremy P Loenneke
- Department of Health, Exercise Science, and Recreation Management, University of Mississippi, PO Box 1848, University Park, Mississippi, 38677, UNITED STATES
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Liu S, Chen J, Xie H, Huang Q, Ge M, Yin L, Zhang M, Huo M, Onoda K, Maruyama H. The reliability and effectiveness of shoulder joint evaluation by ultrasonography in stroke patients: deltoid muscle thickness, acromion-humeral distance, acromion-lesser tuberosity distance. J Phys Ther Sci 2022; 34:31-35. [PMID: 35035076 PMCID: PMC8752282 DOI: 10.1589/jpts.34.31] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/07/2021] [Accepted: 10/05/2021] [Indexed: 12/02/2022] Open
Abstract
[Purpose] This study aimed to evaluate the reliability of the intraclass correlation
coefficient (ICC) in measuring deltoid muscle thickness (DMT) at different angles,
acromion-humeral distance (AHD), and acromion nodule tuberosity (ALT) distance in a
resting position in stroke patients using ultrasonography. [Participants and Methods] We
included 40 stroke patients. During the measurement of parameters by ultrasonography, we
measured the deltoid muscle thickness on both sides at three test angles (0°, 30°, and 60°
abduction) and AHD and ALT on both sides at 0° angle. The ICC was used to assess intra-
and interrater reliability. The relationship between the hemiplegic and non-hemiplegic
sides and each angle were analyzed using a two-way repeated-measure analysis of variance
(ANOVA). [Results] When the shoulders were at three testing angles (0°, 30°, and 60°
abduction), the deltoid muscle thickness of the hemiplegic and non-hemiplegic sides showed
good reliability; the AHD and ALT of the shoulder joint at 0° angle equally showed good
reliability. There was a significant difference in each abduction angle of the shoulder
joint between the thickness of the hemiplegic and non-hemiplegic deltoid. [Conclusion]
Measuring deltoid muscle thickness by ultrasonography showed excellent reliability and can
be used in stroke patients.
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Affiliation(s)
- Shan Liu
- Department of Physical Therapy, International University of Health and Welfare: 2600-1 Kitakanemaru, Otawara city, Tochigi 324-0021, Japan
| | - Jing Chen
- The Affiliated Hospital of Inner Mongolia Medical University, China
| | - Hualong Xie
- Wangjing Hospital of China Academy of Chinese Medical Sciences, China
| | | | - Meng Ge
- Department of Physical Therapy, International University of Health and Welfare: 2600-1 Kitakanemaru, Otawara city, Tochigi 324-0021, Japan
| | - Lu Yin
- Department of Physical Therapy, International University of Health and Welfare: 2600-1 Kitakanemaru, Otawara city, Tochigi 324-0021, Japan
| | | | - Ming Huo
- Department of Physical Therapy, Faculty of Medical Health, Himeji Dokkyo University, Japan
| | - Ko Onoda
- Department of Physical Therapy, International University of Health and Welfare: 2600-1 Kitakanemaru, Otawara city, Tochigi 324-0021, Japan
| | - Hitoshi Maruyama
- Department of Physical Therapy, International University of Health and Welfare: 2600-1 Kitakanemaru, Otawara city, Tochigi 324-0021, Japan
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González-Fernández M, Perez-Nogueras J, Serrano-Oliver A, Torres-Anoro E, Sanz-Arque A, Arbones-Mainar JM, Sanz-Paris A. Masseter Muscle Thickness Measured by Ultrasound as a Possible Link with Sarcopenia, Malnutrition and Dependence in Nursing Homes. Diagnostics (Basel) 2021; 11:1587. [PMID: 34573928 PMCID: PMC8469670 DOI: 10.3390/diagnostics11091587] [Citation(s) in RCA: 13] [Impact Index Per Article: 3.3] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/16/2021] [Revised: 08/06/2021] [Accepted: 08/30/2021] [Indexed: 01/13/2023] Open
Abstract
Sarcopenia is a progressive and generalized loss of skeletal muscle mass and strength. It is frequently associated with malnutrition and dependence in nursing homes. Masticatory muscle strength could be the link between sarcopenia, malnutrition and dependence. We aimed to study the relation between sarcopenia, malnutrition and dependence with masseter muscle thickness measured by ultrasound. A cross-sectional study was realized, with 464 patients from 3 public nursing homes in Zaragoza (Spain). The diagnosis of sarcopenia was assessed according to the European Working Group on Sarcopenia in Older People 2 criteria, malnutrition by the Mini Nutritional Assessment (MNA) and the Global Leadership Initiative on Malnutrition (GLIM) criteria and functional capacity by the Barhel Index and the texture diet. Masseter muscle thickness (MMT) was measured by ultrasound. The median age was 84.7 years, and 70% of the participants were women. Sarcopenia was confirmed in 39.2% of patients, malnutrition in 26.5% (risk 47.8%), total dependence in 37.9% and diet texture was modified in 44.6%. By logistic regression, once the model was adjusted for age, sex, Barthel index and texture diet, our analyses indicated that each 1 mm decrease in MMT increased the risk of sarcopenia by ~57% (OR: 0.43), the risk of malnutrition by MNA by ~63% (OR: 0.37) and the risk of malnutrition by GLIM by ~34% (OR: 0.66). We found that MMT was reduced in sarcopenic, malnourished and dependent patients, and it could be the common point of a vicious cycle between sarcopenia and malnutrition. Further studies are needed to establish causality.
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Affiliation(s)
| | | | | | | | | | - Jose M. Arbones-Mainar
- Instituto de Investigación Sanitaria Aragon (IIS-Aragon), 50007 Zaragoza, Spain;
- Adipocyte and Fat Biology Laboratory (AdipoFat), Translational Research Unit, Instituto Aragones de Ciencias de la Salud (IACS), University Hospital Miguel Servet, 50007 Zaragoza, Spain
- Centro de Investigación Biomédica en Red Fisiopatología Obesidad y Nutrición (CIBERObn), Instituto Salud Carlos III, 28029 Madrid, Spain
| | - Alejandro Sanz-Paris
- Nutrition Department, University Hospital Miguel Servet, 50007 Zaragoza, Spain;
- Instituto de Investigación Sanitaria Aragon (IIS-Aragon), 50007 Zaragoza, Spain;
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26
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Pinto SM, Boghra SB, Macedo LG, Zheng YP, Pang MYC, Cheung JPY, Karppinen J, Samartzis D, Wong AYL. Does Motor Control Exercise Restore Normal Morphology of Lumbar Multifidus Muscle in People with Low Back Pain? - A Systematic Review. J Pain Res 2021; 14:2543-2562. [PMID: 34447268 PMCID: PMC8384346 DOI: 10.2147/jpr.s314971] [Citation(s) in RCA: 17] [Impact Index Per Article: 4.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/09/2021] [Accepted: 07/27/2021] [Indexed: 11/23/2022] Open
Abstract
Aberrant morphological changes in lumbar multifidus muscle (LMM) are prevalent among patients with low back pain (LBP). Motor control exercise (MCE) aims to improve the activation and coordination of deep trunk muscles (eg, LMM), which may restore normal LMM morphology and reduce LBP. However, its effects on LMM morphology have not been summarized. This review aimed to summarize evidence regarding the (1) effectiveness of MCE in altering LMM morphometry and decreasing LBP; and (2) relations between post-MCE changes in LMM morphometry and LBP/LBP-related disability. Cumulative Index to Nursing and Allied Health Literature, MEDLINE, Cochrane Central Register of Controlled Trials, the Physiotherapy Evidence Database, EMBASE and SPORTDiscus were searched from inception to 30 September 2020 to identify relevant randomized controlled trials. Two reviewers independently screened articles, extracted data, and evaluated risk of bias and quality of evidence. Four hundred and fifty-one participants across 9 trials were included in the review. Very low-quality evidence supported that 36 sessions of MCE were better than general physiotherapy in causing minimal detectable increases in LMM cross-sectional areas of patients with chronic LBP. Very low- to low-quality evidence suggested that MCE was similar to other interventions in increasing resting LMM thickness in patients with chronic LBP. Low-quality evidence substantiated that MCE was significantly better than McKenzie exercise or analgesics in increasing contracted LMM thickness in patients with chronic LBP. Low-quality evidence corroborated that MCE was not significantly better than other exercises in treating people with acute/chronic LBP. Low-quality evidence suggested no relation between post-MCE changes in LMM morphometry and LBP/LBP-related disability. Collectively, while MCE may increase LMM dimensions in patients with chronic LBP, such changes may be unrelated to clinical outcomes. This raises the question regarding the role of LMM in LBP development/progression.
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Affiliation(s)
- Sabina M Pinto
- Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China
| | - Sweta B Boghra
- Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China
| | - Luciana G Macedo
- School of Rehabilitation Science, McMaster University, Hamilton, ON, Canada
| | - Yong-Ping Zheng
- Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, China
| | - Marco Y C Pang
- Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China
| | - Jason P Y Cheung
- Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong SAR, China
| | - Jaro Karppinen
- Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.,Finnish Institute of Occupational Health, Helsinki, Finland
| | - Dino Samartzis
- Department of Orthopaedics Surgery, Rush University Medical Center, Chicago, IL, USA
| | - Arnold Y L Wong
- Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China
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Yamaguchi K, Nakagawa K, Yoshimi K, Ariya C, Nakane A, Furuya J, Tohara H. Age-related changes in swallowing muscle intramuscular adipose tissue deposition and related factors. Exp Gerontol 2021; 153:111505. [PMID: 34343633 DOI: 10.1016/j.exger.2021.111505] [Citation(s) in RCA: 13] [Impact Index Per Article: 3.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/14/2021] [Revised: 07/24/2021] [Accepted: 07/27/2021] [Indexed: 01/22/2023]
Abstract
OBJECTIVES To investigate age-related changes in the intramuscular adipose tissue (IAT) of the tongue and geniohyoid muscle (GHM) and associated factors. DESIGN Exploratory cross-sectional study. SETTING AND PARTICIPANTS This study included 89 participants recruited from a health survey, which included 38 younger adults (age range, 20-63 years) and 51 older adults (age range, 65-87 years). MEASUREMENTS Age, body mass index, body fat, lean body mass, skeletal muscle mass index, trunk muscle mass index, tongue pressure, jaw opening force, and oral diadochokinesis were assessed. The cross-sectional area (CSA) and echo intensity (EI) of the tongue and GHM were measured using ultrasonography. IAT was assessed according to EI values. The factors related to the IAT of each muscle were examined using multiple regression analysis. We also investigated the correlation of IAT with factors related to oral function and systemic and morphological factors. RESULTS Neither the EI of the tongue nor that of the GHM had a significant correlation with factors related to oral function and systemic factors. In the multiple regression analysis, significant explanatory variables for EI of the tongue and GHM were age (β = 0.14, P = 0.019; tongue and β = 0.13, P = 0.017; GHM) and the CSA of each muscle (β = -0.01, P = 0.042; tongue and β = -0.04, P = 0.003; GHM). EI was positively associated with age and negatively associated with muscle CSA. CONCLUSION Age-related changes in the IAT show the same trend for both the tongue and GHM, unlike age-related changes in muscle mass. The IATs of the tongue and GHM were not significantly correlated with oral function and systemic factors. Therefore, EI may not be a useful index for the functional evaluation of the tongue and GHM.
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Affiliation(s)
- Kohei Yamaguchi
- Department of Dysphagia Rehabilitation, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
| | - Kazuharu Nakagawa
- Department of Dysphagia Rehabilitation, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
| | - Kanako Yoshimi
- Department of Dysphagia Rehabilitation, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
| | - Chantaramanee Ariya
- Department of Preventive Dentistry, Naresuan University, 99 Moo 9, Phitsanulok-Nakhon Sawan Road, Tha Pho, Mueang Phitsanulok 65000, Thailand
| | - Ayako Nakane
- Department of Dysphagia Rehabilitation, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
| | - Junichi Furuya
- Department of Dysphagia Rehabilitation, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan; Department of Geriatric Dentistry, Showa University School of Dentistry, 2-1-1 Kitasenzoku, Ohta-ku, Tokyo 145-8515, Japan
| | - Haruka Tohara
- Department of Dysphagia Rehabilitation, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
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Busatto GF, de Araújo AL, Duarte AJDS, Levin AS, Guedes BF, Kallas EG, Pinna FR, de Souza HP, da Silva KR, Sawamura MVY, Seelaender M, Imamura M, Garcia ML, Forlenza OV, Nitrini R, Damiano RF, Rocha VG, Batisttella LR, Carvalho CRRD. Post-acute sequelae of SARS-CoV-2 infection (PASC): a protocol for a multidisciplinary prospective observational evaluation of a cohort of patients surviving hospitalisation in Sao Paulo, Brazil. BMJ Open 2021; 11:e051706. [PMID: 34193506 PMCID: PMC8249176 DOI: 10.1136/bmjopen-2021-051706] [Citation(s) in RCA: 25] [Impact Index Per Article: 6.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 12/15/2022] Open
Abstract
INTRODUCTION COVID-19 may lead to persistent and potentially incapacitating clinical manifestations (post-acute sequelae of SARS-CoV-2 infection (PASC)). Using easy-to-apply questionnaires and scales (often by telephone interviewing), several studies evaluated samples of COVID-19 inpatients from 4 weeks to several months after discharge. However, studies conducting systematic multidisciplinary assessments of PASC manifestations are scarce, with thorough in-person objective evaluations restricted to modestly sized subsamples presenting greatest disease severity. METHODS AND ANALYSES We will conduct a prospective observational study of surviving individuals (above 18 years of age) from a cohort of over 3000 subjects with laboratory-confirmed COVID-19 who were treated as inpatients at the largest academic health centre in Sao Paulo, Brazil (Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo). All eligible subjects will be consecutively invited to undergo a 1-2-day series of multidisciplinary assessments at 2 time-points, respectively, at 6-9 months and 12-15 months after discharge. Assessment schedules will include detailed multidomain questionnaires applied by medical research staff, self-report scales, objective evaluations of cardiopulmonary functioning, physical functionality and olfactory status, standardised neurological, psychiatric and cognitive examinations, as well as diagnostic laboratory, muscle ultrasound and chest imaging exams. Remaining material from blood tests will be incorporated by a local biobank for use in future investigations on inflammatory markers, genomics, transcriptomics, peptidomics and metabolomics. ETHICS AND DISSEMINATION All components of this programme have been approved by local research ethics committees. We aim to provide insights into the frequency and severity of chronic/post-COVID multiorgan symptoms, as well as their interrelationships and associations with acute disease features, sociodemographic variables and environmental exposures. Findings will be disseminated in peer-reviewed journals and at scientific meetings. Additionally, we aim to provide a data repository to allow future pathophysiological investigations relating clinical PASC features to biomarker data extracted from blood samples. TRIAL REGISTRATION NUMBER RBR-8z7v5wc; Pre-results.
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Affiliation(s)
- Geraldo Filho Busatto
- Departamento e Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil
- Diretoria Executiva dos LIMs, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil
| | | | - Alberto José da Silva Duarte
- Departamento de Dermatologia, Laboratório de Dermatologia e Imunodeficiências, Faculdade de Medicina e Instituto de Medicina Tropical de São Paulo, Sao Paulo, Brazil
| | - Anna Sara Levin
- Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil
| | - Bruno Fukelmann Guedes
- Instituto Central, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo HCFMUSP, Sao Paulo, Brazil
| | - Esper Georges Kallas
- Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil
- Departamento de Clínica Médica, Laboratório de Imunologia Clínica e Alergia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil
| | - Fabio Rezende Pinna
- Instituto Central, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo HCFMUSP, Sao Paulo, Brazil
- Departamento de Oftalmologia e Otorrinolaringologia, Laboratório de Otorrinolaringologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil
| | - Heraldo Possolo de Souza
- Departamento de Clínica Médica, Laboratório de Emergências Clínicas, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil
| | - Katia Regina da Silva
- Instituto do Coração (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil
| | | | - Marilia Seelaender
- Departamento de Cirurgia, Laboratório de Pesquisa em Cirurgia Experimental, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil
| | - Marta Imamura
- Instituto de Medicina Física e de Reabilitação, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil
| | - Michelle Louvaes Garcia
- Departamento de Cardio-Pneumologia, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil
| | - Orestes Vicente Forlenza
- Departamento e Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil
| | - Ricardo Nitrini
- Departamento de Neurologia, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil
| | - Rodolfo Furlan Damiano
- Departamento e Instituto de Psiquiatria, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil
| | - Vanderson Geraldo Rocha
- Departamento de Clínica Médica, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil
- Laboratório de Genética e Hematologia Molecular, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil
| | - Linamara Rizzo Batisttella
- Instituto de Medicina Física e de Reabilitação, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil
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Association of baseline diaphragm, rectus femoris and vastus intermedius muscle thickness with weaning from mechanical ventilation. Respir Med 2021; 185:106503. [PMID: 34166958 DOI: 10.1016/j.rmed.2021.106503] [Citation(s) in RCA: 14] [Impact Index Per Article: 3.5] [Reference Citation Analysis] [Abstract] [Key Words] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/01/2021] [Revised: 05/27/2021] [Accepted: 06/03/2021] [Indexed: 12/16/2022]
Abstract
BACKGROUND To determine whether baseline diaphragm (Tdi), rectus femoris (RF) and vastus intermedius (VI) muscle thickness (TRF and TRF + VI) are associated with weaning success. MATERIAL AND METHODS Right Tdi, TRF and TRF + VI were measured by ultrasonography within 36 h of intubation and diaphragmatic excursion (DE) was evaluated at the first spontaneous breathing trial in adult critically-ill patients. Reintubation or death within 7 days after extubation was defined as weaning failure. Weaning failure and success groups were compared in terms of ultrasonographic measurements and clinical features. RESULTS Thirty-eight patients were assessed for weaning, 15 (39.4%) being in the weaning failure group. The median body mass index (BMI) was lower while the median clinical frailty scale (CFS), vasopressor use, duration of mechanical ventilation, intensive care and hospital mortality rate were higher in the weaning failure group, and the median TRF + VI (14.0 [12.3-26.2] vs 23.6 [21.3-27.1] mm, p = 0.03) and median DE (19.4 [14.6-24.0] vs 25.9 [19.3-38.5] mm, p = 0.045) were lower. The median Tdi was similar in two groups (1.9 [1.5-2.3] vs 2.0 [1.7-2.4] mm, p = 0.26). In ROC analysis, area under the curve for TRF + VI was 0.71 (95% CI: 0.51-0.90; p = 0.035), with 21 mm cut-off having sensitivity of 82% and specificity of 57%. Binary logistic regression analysis revealed TRF + VI < 21 mm as the only predictor of weaning failure with an odds ratio of 10.5 (95% CI: 1.1-97.8, p = 0.038) after adjusting for age, sex, BMI and CFS. CONCLUSIONS TRF + VI lower than 21 mm, measured by ultrasonography within 36 h of intubation, was associated with weaning failure among critically-ill patients.
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Kang KW, Kwon YH, Son SM. Ultrasound Measurement of the Transverse Abdominis, Internal Oblique, and External Oblique Muscles Associated with Forward Head Posture and Reduced Cranio-Vertebral Angle. Med Sci Monit 2021; 27:e928987. [PMID: 34097670 PMCID: PMC8194289 DOI: 10.12659/msm.928987] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/16/2022] Open
Abstract
Background Abnormal posture can affect the alignment of the cervical spine, which can lead to various physical problems. There are many ways to solve the problem by limiting the area around the neck to restore abnormal neck condition. However, there is a need to look at these problems from an enlarged perspective through the relationship between the cervical spine and trunk. This study aimed to investigate the significance of the thickness of the transverse abdominis, internal oblique, and external oblique muscles in patients with forward head posture and reduced cranio-vertebral angle. Material/Methods We included 24 healthy adult males in their 20s without lower back pain. The cranio-vertebral angle (CVA) in all the subjects was measured with the help of pictures taken in the sagittal plane using a digital camera. The thickness of muscles, including transverse abdominis (TrA), internal oblique (IO), and external oblique (EO), was measured using a diagnostic ultrasound device. Pearson’s correlation analysis was used to identify the correlation between the variables measured. Results CVA showed a statistically significant correlation with TrA thickness (r=0.506/p=0.012), and among the abdominal muscles, there was a significant correlation between IO and EO thickness (r=0.663/p=0.000). Conclusions A reduced CVA due to FHP was significantly associated with reduced TrA thickness. Therefore, increasing the bulk of the abdominal muscles with restoration of the abnormal CVA is a potential treatment approach and requires further study.
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Affiliation(s)
- Kyung Woo Kang
- Department of Physical Therapy, Yeungnam University College, Daegu, South Korea
| | - Yong Hyun Kwon
- Department of Physical Therapy, Yeungnam University College, Daegu, South Korea
| | - Sung Min Son
- Department of Physical Therapy, College of Health Science, Cheongju University, Chungbuk, South Korea
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Sai A, Tanaka K, Ohashi Y, Kushiyama A, Tanaka Y, Motonishi S, Sakai K, Hara S, Ozawa T. Quantitative sonographic assessment of quadriceps muscle thickness for fall injury prediction in patients undergoing maintenance hemodialysis: an observational cohort study. BMC Nephrol 2021; 22:191. [PMID: 34022848 PMCID: PMC8140437 DOI: 10.1186/s12882-021-02347-5] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/02/2020] [Accepted: 04/11/2021] [Indexed: 11/10/2022] Open
Abstract
Background Accidental fall risk is high in patients undergoing maintenance hemodialysis. Falls are associated with fatal injury, comorbidities, and mortality. Risk assessment should be a primary component of fall prevention. This study investigated whether quadriceps muscle thickness measured using ultrasonography can predict fall injury among dialysis patients. Methods Using an observational cohort study design, 180 ambulatory hemodialysis patients were recruited from 2015 to 2016 from four dialysis clinics. The sum of the maximum quadriceps muscle thickness on both sides and the average of the maximum thigh circumference and handgrip strength after hemodialysis were calculated. Patients were stratified according to tertiles of quadriceps muscle thickness. Fall injury was surveyed according to the patient’s self-report during the one-year period. Results Among the 180 hemodialysis patients, 44 (24.4%) had fall injuries during the 12-month follow-up period. When the quadriceps muscle thickness levels were stratified into sex-specific tertiles, patients in the lowest tertile were more likely to have a higher incidence of fall injury than those in the higher two tertiles (0.52 vs. 0.19 and 0.17 fall injuries/person-year). After adjusting for covariates, lower quadriceps muscle thickness was found to be an independent predictor of fall injury (hazard ratio [95% confidence interval], 2.33 [1.22–4.52], P < 0.05). Receiver operating characteristic curves were constructed to determine the optimal cutoffs of quadriceps muscle thickness, thigh circumference, and handgrip strength that best predicted fall injury (quadriceps muscle thickness, 3.37 cm and 3.54 cm in men and women; thigh circumference, 44.6 cm and 37.2 cm in men and women; and handgrip strength, 23.3 kg and 16.5 kg in men and women). Using these cutoff values, the areas under the curve were 0.662 (95% CI, 0.576–0.738), 0.625 (95% CI, 0.545–0.699), and 0.701 (95% CI, 0.617–0.774), for quadriceps muscle thickness, thigh circumference, and handgrip strength, respectively. Quadriceps muscle thickness was a more precise predictor of fall injury than thigh circumference and had similar diagnostic performance as handgrip strength tests in dialysis patients. Conclusions Quadriceps muscle thickness can be measured easily at the bedside using ultrasonography and is a precise predictor of fall injury in patients undergoing maintenance hemodialysis. Supplementary Information The online version contains supplementary material available at 10.1186/s12882-021-02347-5.
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Affiliation(s)
- Asuka Sai
- Kodaira Kitaguchi Clinic, Tokyo, Japan
| | - Kentaro Tanaka
- Higashikurume Ekimae Clinic, Tokyo, Japan.,Department of Nephrology, Sakura Medical Center, Toho University, 564-1, Shimoshizu, Sakura, Chiba, 285-8741, Japan.,The Division of Diabetes and Metabolism, The Institute for Adult Diseases, Asahi Life Foundation, Tokyo, Japan
| | - Yasushi Ohashi
- Department of Nephrology, Sakura Medical Center, Toho University, 564-1, Shimoshizu, Sakura, Chiba, 285-8741, Japan.
| | - Akifumi Kushiyama
- The Division of Diabetes and Metabolism, The Institute for Adult Diseases, Asahi Life Foundation, Tokyo, Japan.,Department of Pharmacotherapy, Meiji Pharmaceutical University, Tokyo, Japan
| | | | | | - Ken Sakai
- Department of Nephrology, Faculty of Medicine, Toho University, Tokyo, Japan
| | - Shigeko Hara
- Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Tokyo, Japan
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Association between trunk core muscle thickness and functional ability in subacute hemiplegic stroke patients: an exploratory cross-sectional study. Top Stroke Rehabil 2021; 29:163-172. [PMID: 33899701 DOI: 10.1080/10749357.2021.1918840] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/21/2022]
Abstract
BACK GROUND Balance impairment could occur due to weakness of the core muscles in stroke patients. OBJECTIVE To investigate the association between functional ability, including trunk balance and core muscle thickness using ultrasonography in subacute hemiplegic stroke patients. METHODS The muscle thickness of the anterior and posterior trunk muscles was measured using ultrasonography. For the evaluation of trunk balance, trunk impairment scale and Berg balance scale (BBS) were used. The functional ambulatory scale (FAS), timed up-and-go test, 10 m gait velocity, functional reach (FR), and functional independence measure were also assessed for functional ability. RESULTS Overall, 41 patients with subacute hemiplegic stroke were included. Partial correlation analysis showed that posterior trunk muscle thickness was significantly correlated with BBS, FAS, and FR. As for the paralytic side, the posterior trunk muscle thickness of both paretic and nonparetic sides presented a significant relationship with BBS, FAS, and FR. The quadratus lumborum (QL) thickness of both sides showed a significant relationship with BBS, FAS, and FR. CONCLUSIONS The thickness of the posterior trunk muscles, especially the QL, on both the paretic and nonparetic sides, was significantly related with the functional ability after stroke. The exercise program of core posterior trunk muscles closely related with functional ability would be helpful to improve trunk balance and ambulatory function in subacute stroke patients.
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Takahashi Y, Fujino Y, Miura K, Toida A, Matsuda T, Makita S. Intra- and inter-rater reliability of rectus femoris muscle thickness measured using ultrasonography in healthy individuals. Ultrasound J 2021; 13:21. [PMID: 33856566 PMCID: PMC8050162 DOI: 10.1186/s13089-021-00224-8] [Citation(s) in RCA: 11] [Impact Index Per Article: 2.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/01/2020] [Accepted: 01/19/2021] [Indexed: 11/10/2022] Open
Abstract
BACKGROUND Ultrasonography (US) is a feasible and accessible method for the measurement of skeletal muscle mass. This technique presents acceptable intra-rater reliability; however, there are a few reports on its inter-rater reliability. Additionally, relative reliability should equally be inspected to determine the presence of systematic errors. Therefore, this study aimed to investigate the intra- and inter-rater reliabilities and absolute reliability of rectus femoris muscle thickness as measured using US. METHODS The participants included in our study comprised 12 healthy young men (26.5 ± 3.9 years. Rectus femoris muscle thickness was measured from the right side of the thigh using US by two trained physical therapists. Inter- and intra-rater reliabilities were determined using the intraclass correlation coefficient (ICC) (1, 1) and ICC (2, 1) methods, respectively. Absolute reliability was evaluated using Bland - Altman analysis. Additionally, we calculated the minimal detectable change at the 95% level of confidence (MDC95). RESULT According to the results of the Bland - Altman analysis, no fixed or proportional errors were present. The ICC (1, 1) was 0.95, and the ICC (2, 1) was 0.70. The MDC95 values of rectus femoris thickness for the intra- and inter-rater reliabilities were 2.0 mm and 4.3 mm, respectively. CONCLUSIONS In our study, intra- and inter-rater reliabilities were measured at "excellent" and "moderate" levels in the healthy individuals based on a previously defined scale. Moreover, we determined the measurement error for quantifying rectus femoris thickness. Therefore, the measurement of rectus femoris thickness using US could be considered applicable in clinical research.
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Affiliation(s)
- Yosuke Takahashi
- Department of Rehabilitation Center, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama, 350-1298, Japan
| | - Yuji Fujino
- Department of Physical Therapy, Faculty of Health Science, Juntendo University, 3-2-12, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
| | - Kohei Miura
- Department of Rehabilitation Center, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama, 350-1298, Japan
| | - Ayumi Toida
- Department of Central Examination, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama, 350-1298, Japan
| | - Tadamitsu Matsuda
- Department of Physical Therapy, Faculty of Health Science, Juntendo University, 3-2-12, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan
| | - Shigeru Makita
- Department of Cardiac Rehabilitation, Saitama Medical University International Medical Center, Hidaka, Saitama, 1397-1 Yamane350-1298, Japan
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Akazawa N, Harada K, Okawa N, Kishi M, Tamura K, Moriyama H. Changes in Quadriceps Thickness and Echo Intensity in Chronic Stroke Survivors: A 3-Year Longitudinal Study. J Stroke Cerebrovasc Dis 2021; 30:105543. [DOI: 10.1016/j.jstrokecerebrovasdis.2020.105543] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/26/2020] [Revised: 11/24/2020] [Accepted: 12/05/2020] [Indexed: 01/23/2023] Open
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Use of Reflective Tape to Detect Ultrasound Transducer Movement: A Validation Study. Life (Basel) 2021; 11:life11020104. [PMID: 33573159 PMCID: PMC7912270 DOI: 10.3390/life11020104] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/11/2020] [Revised: 01/19/2021] [Accepted: 01/27/2021] [Indexed: 01/02/2023] Open
Abstract
During dynamic ultrasound assessments, unintended transducer movement over the skin needs to be prevented as it may bias the results. The present study investigated the validity of two methods quantifying transducer motion. An ultrasound transducer was moved on a pre-specified 3 cm distance over the semitendinosus muscle of eleven adults (35.8 ± 9.8 years), stopping briefly at intervals of 0.5 cm. Transducer motion was quantified (1) measuring the 2-D displacement of the shadow produced by reflective tape (RT) attached to the skin and (2) using a marker-based, three-dimensional movement analysis system (MAS). Differences between methods were detected with Wilcoxon tests; associations were checked by means of intraclass correlation coefficients (ICC 3.1) and Bland–Altman plots. Values for RT (r = 0.57, p < 0.001) and MAS (r = 0.19, p = 0.002) were significantly higher than true distances (TD). Strong correlations were found between RT and TD (ICC: 0.98, p < 0.001), MAS and TD (ICC: 0.95, p < 0.001), and MAS and RT (ICC: 0.97, p < 0.001). Bland–Altman plots showed narrow limits of agreement for both RT (−0.49 to 0.13 cm) and MAS (−0.49 to 0.34 cm) versus TD. RT and MAS are valid methods to quantify US transducer movement. In view of its low costs and complexity, RT can particularly be recommended for application in research and clinical practice.
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Ikezoe T. Age-Related Change in Muscle Characteristics and Resistance Training for Older Adults. Phys Ther Res 2021; 23:99-105. [PMID: 33489646 DOI: 10.1298/ptr.r0009] [Citation(s) in RCA: 13] [Impact Index Per Article: 3.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/27/2020] [Accepted: 09/13/2020] [Indexed: 11/23/2022]
Abstract
In older adults, muscle weakness contributes greatly to functional restrictions on daily living activities, increased risk of falls, and adverse physiological changes. It has been suggested that not only muscle mass but also muscular infiltration of noncontractile elements may influence muscular performance such as strength and rapid force production. It is proved that resistance training may provoke substantial increases in muscle size even if it is performed at low intensities in older individuals. Also, recent studies have demonstrated the effectiveness of resistance training on muscle quality such as muscular infiltration of noncontractile elements for older people. This review shows the age-related changes in muscle mass and muscle quality, which were measured by muscle echo intensity on ultrasound images, and low-intensity resistance training effects on muscle volume and muscle quality.
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Affiliation(s)
- Tome Ikezoe
- Human Health Sciences, Graduate School of Medicine, Kyoto University
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37
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Coclici A, Roman RA, Bran S, Crasnean E, Baciut M, Dinu C, Hedesiu M. Ultrasound dimensional changes of the anterior belly of the digastric muscle induced by orthognathic surgery and botulinum toxin A injection in Class II malocclusion. Oral Radiol 2021; 37:625-630. [PMID: 33420944 DOI: 10.1007/s11282-020-00502-6] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/04/2020] [Accepted: 12/10/2020] [Indexed: 11/29/2022]
Abstract
OBJECTIVES The aim of the study is to evaluate the ultrasonographic dimensional changes of the anterior belly of the digastric muscle (ABDM), occurring after intramuscular botulinum toxin A (BTX-A) injection during orthognathic surgery, in a series of five Class II malocclusion patients. METHODS All the patients received 20 units of BTX-A, into both ABDM, intraoperatively. The length, width and cross-sectional area (CSA) of the ABDM were ultrasonographically measured at three different time points: T0 (preoperatively), T1 (postoperatively at 2 weeks after the surgical intervention), and T2 (postoperatively at 6-9 months). RESULTS A statistically significant higher length of the ABDM was noted postoperatively, at T1 and T2 compared to T0. The patients showed an increased length by 12.2% at 2 weeks postoperatively and continued to increase, reaching 24.6% at 6 months. A decreased width of ABDM by 6.5% at T1 compared with T0 was also found. CONCLUSIONS Postoperative ultrasound (US) follow-up measurements in patients with Class II malocclusion, orthognathic surgery and intraoperative BTX-A injection in the ABDM, showed dimensional changes of the muscle, with elongation and thinning. The muscular modifications were more pronounced at 6 months postoperatively, indicating consistency and potential benefit of using BTX-A in reducing the risk of surgical relapse. Further data on longer-term follow-up and larger number of cases are necessary.
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Affiliation(s)
- Alina Coclici
- Department of Maxillofacial Surgery and Radiology, Faculty of Dentistry, Iuliu Hatieganu University of Medicine and Pharmacy, 37 Cardinal Iuliu Hossu Street, Cluj Napoca, Romania
| | - Raluca Ancuta Roman
- Department of Maxillofacial Surgery and Radiology, Faculty of Dentistry, Iuliu Hatieganu University of Medicine and Pharmacy, 37 Cardinal Iuliu Hossu Street, Cluj Napoca, Romania.
| | - Simion Bran
- Department of Maxillofacial Surgery and Radiology, Faculty of Dentistry, Iuliu Hatieganu University of Medicine and Pharmacy, 37 Cardinal Iuliu Hossu Street, Cluj Napoca, Romania
| | - Emil Crasnean
- Department of Maxillofacial Surgery and Radiology, Faculty of Dentistry, Iuliu Hatieganu University of Medicine and Pharmacy, 37 Cardinal Iuliu Hossu Street, Cluj Napoca, Romania
| | - Mihaela Baciut
- Department of Maxillofacial Surgery and Radiology, Faculty of Dentistry, Iuliu Hatieganu University of Medicine and Pharmacy, 37 Cardinal Iuliu Hossu Street, Cluj Napoca, Romania
| | - Cristian Dinu
- Department of Maxillofacial Surgery and Radiology, Faculty of Dentistry, Iuliu Hatieganu University of Medicine and Pharmacy, 37 Cardinal Iuliu Hossu Street, Cluj Napoca, Romania
| | - Mihaela Hedesiu
- Department of Maxillofacial Surgery and Radiology, Faculty of Dentistry, Iuliu Hatieganu University of Medicine and Pharmacy, 37 Cardinal Iuliu Hossu Street, Cluj Napoca, Romania
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Soares ALC, Nogueira FDS, Gomes PSC. Assessment methods of vastus lateralis muscle architecture using panoramic ultrasound: a new approach, test-retest reliability and measurement error. REVISTA BRASILEIRA DE CINEANTROPOMETRIA E DESEMPENHO HUMANO 2021. [DOI: 10.1590/1980-0037.2021v23e76402] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/21/2022] Open
Abstract
Abstract Extended-field-of-view ultrasonography is a valid alternative to determine the dimensions of the skeletal striated muscle; however, some factors may influence the final measurement. The aim of this study was to determine the test-retest reliability and measurement error of vastus lateralis muscle architecture variables through internal anatomical landmarks and to compare three fixed determined points using extended-field-of-view ultrasonography. Twelve young (24 ± 6 years) adult university male students participated in the study. Images were obtained through extended-field-of-view ultrasonography of the vastus lateralis muscle. Measurements were made for muscle thickness (MT), fascicle length (FL), and fascicle pennation angle (FA) using a method that identifies internal anatomical landmarks. MT was also measured at predetermined distances of 2 cm proximal, 6 cm proximal, and 2 cm distal. One-way ANOVA with repeated measures did not identify any test-retest significant differences for all variables measured. Typical measurement error in centimeters (cm) or degrees (º), coefficient of variation in percentage (%) and intraclass correlation coefficient were MT = 0.07 cm, 2.93%, 0.964; FL = 0.31 cm, 2.89%, 0.947; FA = 0.92°, 4.08%, 0.942; MT 2 cm proximal = 0.10 cm, 3.77%, 0.910; MT 6 cm proximal = 0.27 cm, 9.66%, 0.576; MT 2 cm distal = 0.35 cm, 19.76%, 0.564. MT, FL and FA showed high reliability and low measurement error. Internal anatomical landmarks proved to be more reliable and presented smaller measurement errors when compared to the predetermined distances method.
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Wong V, Yamada Y, Bell ZW, Spitz RW, Viana RB, Chatakondi RN, Abe T, Loenneke JP. Postactivation performance enhancement: Does conditioning one arm augment performance in the other? Clin Physiol Funct Imaging 2020; 40:407-414. [PMID: 32869937 DOI: 10.1111/cpf.12659] [Citation(s) in RCA: 10] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/23/2020] [Revised: 08/12/2020] [Accepted: 08/20/2020] [Indexed: 01/30/2023]
Abstract
The purpose was to determine whether postactivation performance enhancement is specific to the muscle being conditioned or if it is also observed within the homologous muscles of the contralateral limb (after accounting for the warm-up and random error). We also investigated whether this differed based on training status or muscle size. One hundred seven participants (75 untrained; 32 trained) participated in four sessions. Visit 1 included baseline measurements and familiarization. Visits 2-4 included the completion of one of the three experimental conditions: (a) control, (b) same side and (c) crossover completed in a randomized order. The control condition completed all testing except for the conditioning contraction. The same side condition completed the conditioning contraction on the same side as the strength test. The crossover condition completed the conditioning on the arm opposite to the strength test. The variable of interest was the change from baseline in isokinetic strength. Our analysis indicated that of the hypotheses compared, the posterior probabilities (posterior probability of 0.506) favoured the hypothesis that the effect was local and greatest in those who were resistance trained [mean (SD) of 1.4 (2.2) Nm over the control in those resistance trained]. We found no relationship between muscle size and postactivation performance enhancement. In conclusion, there is an influence of training status pertaining to the postactivation performance enhancement effect but no influence from baseline muscle size. It appears unlikely that the effect is due to a systemic mechanism.
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Affiliation(s)
- Vickie Wong
- Department of Health, Exercise Science, & Recreation Management, Kevser Ermin Applied Physiology Laboratory, The University of Mississippi, University, MS, USA
| | - Yujiro Yamada
- Department of Health, Exercise Science, & Recreation Management, Kevser Ermin Applied Physiology Laboratory, The University of Mississippi, University, MS, USA
| | - Zachary W Bell
- Department of Health, Exercise Science, & Recreation Management, Kevser Ermin Applied Physiology Laboratory, The University of Mississippi, University, MS, USA
| | - Robert W Spitz
- Department of Health, Exercise Science, & Recreation Management, Kevser Ermin Applied Physiology Laboratory, The University of Mississippi, University, MS, USA
| | - Ricardo B Viana
- Department of Health, Exercise Science, & Recreation Management, Kevser Ermin Applied Physiology Laboratory, The University of Mississippi, University, MS, USA.,Faculty of Physical Education and Dance, Federal University of Goiás, Goiânia, Brazil
| | - Raksha N Chatakondi
- Department of Health, Exercise Science, & Recreation Management, Kevser Ermin Applied Physiology Laboratory, The University of Mississippi, University, MS, USA
| | - Takashi Abe
- Department of Health, Exercise Science, & Recreation Management, Kevser Ermin Applied Physiology Laboratory, The University of Mississippi, University, MS, USA
| | - Jeremy P Loenneke
- Department of Health, Exercise Science, & Recreation Management, Kevser Ermin Applied Physiology Laboratory, The University of Mississippi, University, MS, USA
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Comparison of Ultrasonic Thickness of Masseter Muscle Between Individuals With and Without Severe Forward Head Posture: A Cross-Sectional Study. J Manipulative Physiol Ther 2020; 43:627-634. [PMID: 32839021 DOI: 10.1016/j.jmpt.2019.12.004] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/15/2019] [Revised: 10/26/2019] [Accepted: 12/06/2019] [Indexed: 11/22/2022]
Abstract
OBJECTIVE In this cross-sectional descriptive-analytical study, we sought to compare the ultrasonic thickness of the masseter muscle in people with severe forward head posture vs people without forward head posture, and to determine sex differences in muscle thickness. METHODS Thirty-eight volunteers (19 with normal head postures and 19 with severe forward head postures), aged 18 to 35 years, entered the study. The severity of the forward head posture was measured by a plumb line and the craniovertebral angle drawn on the recorded images. Based on the recorded images, the masseter muscle thickness was also measured by a 7.5-MHz linear transducer using an ultrasound device in the seated position with 3 mouth positions (closed, half open, and fully open). RESULTS The results showed that the head posture affects masseter thickness significantly (P = .01), with masseter thickness significantly lower in the participants without severe forward head postures compared to those with severe forward head postures in the closed, half-open, and fully open mouth positions (P < .05). Comparing the mean masseter thickness across sexes showed that the masseter muscle is significantly thicker in men compared to women (P = .01). CONCLUSION Head posture and thickness of the masseter muscle are linked, as the masseter muscle was thicker in all 3 positions in the participants with severe forward head postures.
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Talebi RZ, Rezasoltani A, Khalkhalizavieh M, Manshadi FD, Baghban AA. Evaluation of cervical spine muscles thickness in patients with cervical vertigo and healthy controls through ultrasonography. J Phys Ther Sci 2020; 32:439-443. [PMID: 32753783 PMCID: PMC7344283 DOI: 10.1589/jpts.32.439] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/11/2020] [Accepted: 04/14/2020] [Indexed: 11/30/2022] Open
Abstract
[Purpose] Cervical vertigo as a common complaint is associated with some
musculoskeletal disorders. However, to date, ultrasonographical parameters of cervical
muscles in patients with cervical vertigo have not been investigated. This study was
conducted to investigate size of cervical muscles in patients with cervical vertigo
compared to healthy controls. [Participants and Methods] Thicknesses of cervical flexor
and extensor muscles were evaluated through ultrasonography and results were compared
between the patients and healthy controls by Independent Samples t-test or Mann-Whitney U
nonparametric test. [Results] Results showed that, thickness of Longus Colli muscle was
significantly different between the patients and healthy controls. [Conclusion] According
to findings of the study, size of Longus Colli muscle is likely to be associated with
etiology of cervical vertigo.
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Affiliation(s)
- Ronak Zargar Talebi
- Department of Physical Therapy, School of Rehabilitation, Shahid Beheshti University of Medical Sciences: Tehran 161679, Iran
| | - Asghar Rezasoltani
- Department of Physical Therapy, School of Rehabilitation, Shahid Beheshti University of Medical Sciences: Tehran 161679, Iran
| | - Minoo Khalkhalizavieh
- Department of Physical Therapy, School of Rehabilitation, Shahid Beheshti University of Medical Sciences: Tehran 161679, Iran
| | - Farideh Dehghan Manshadi
- Department of Physical Therapy, School of Rehabilitation, Shahid Beheshti University of Medical Sciences: Tehran 161679, Iran
| | - Alireza Akbarzadeh Baghban
- Department of Physical Therapy, School of Rehabilitation, Shahid Beheshti University of Medical Sciences: Tehran 161679, Iran
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Torii Y, Kusunose K, Zheng R, Yamada H, Amano R, Matsumoto R, Hirata Y, Nishio S, Yamada N, Ise T, Yamaguchi K, Tobiume T, Fukuda D, Yagi S, Soeki T, Wakatsuki T, Okayama Y, Sata M. Association between Sarcopenia/Lower Muscle Mass and Short-Term Regression of Deep Vein Thrombosis Using Direct Oral Anticoagulants. Int Heart J 2020; 61:787-794. [PMID: 32684602 DOI: 10.1536/ihj.20-032] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 11/18/2022]
Abstract
Advanced age, obesity, and muscle weakness are independent factors in the onset of deep vein thrombosis (DVT). Recently, an association between sarcopenia and DVT has been reported. We hypothesized that sarcopenia related factors, observed by ultrasonography, are associated with the regression effect on the thrombus following anticoagulation therapy. The present study focused on gastrocnemius muscle (GCM) thickness and the GCM's internal echogenic brightness. We examined the association with DVT regression following direct oral anticoagulants (DOACs) treatment.The prospective cohort study period was between October 2017 and August 2018. We enrolled 46 patients diagnosed with DVT by ultrasonography, who were aged >60 years old and treated with DOACs. Sarcopenia was evaluated using the Asian Working Group for Sarcopenia flowchart. The average DOACs treatment period was 94 days, and 29 patients exhibited thrombus regression. On univariate logistic regression analysis, sarcopenia, average GCM diameter index, and gastrocnemius integrated backscatter index were significantly associated with thrombus regression. In a multivariate model, only the average GCM diameter index correlated with thrombus regression.The average GCM diameter index is associated with DVT regression treated with DOACs. Considering the GCM diameter during DVT treatment can be a marker to make a decision for the treatment of DVT.
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Affiliation(s)
- Yuta Torii
- Ultrasound Examination Center, Tokushima University Hospital
| | - Kenya Kusunose
- Department of Cardiovascular Medicine, Tokushima University Hospital
| | - Robert Zheng
- Department of Cardiovascular Medicine, Tokushima University Hospital
| | - Hirotsugu Yamada
- Department of Community Medicine for Cardiology, Tokushima University Graduate School of Biomedical Sciences
| | - Rie Amano
- Ultrasound Examination Center, Tokushima University Hospital
| | | | - Yukina Hirata
- Ultrasound Examination Center, Tokushima University Hospital
| | - Susumu Nishio
- Ultrasound Examination Center, Tokushima University Hospital
| | - Nao Yamada
- Department of Cardiovascular Medicine, Tokushima University Hospital
| | - Takayuki Ise
- Department of Cardiovascular Medicine, Tokushima University Hospital
| | - Koji Yamaguchi
- Department of Cardiovascular Medicine, Tokushima University Hospital
| | - Takeshi Tobiume
- Department of Cardiovascular Medicine, Tokushima University Hospital
| | - Daiju Fukuda
- Department of Cardiovascular Medicine, Tokushima University Hospital
| | - Shusuke Yagi
- Department of Cardiovascular Medicine, Tokushima University Hospital
| | - Takeshi Soeki
- Department of Cardiovascular Medicine, Tokushima University Hospital
| | - Tetsuzo Wakatsuki
- Department of Cardiovascular Medicine, Tokushima University Hospital
| | - Yoshihiro Okayama
- Clinical Research Center for Developmental Therapeutics, Tokushima University Hospital
| | - Masataka Sata
- Department of Cardiovascular Medicine, Tokushima University Hospital
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Boutry-Regard C, Vinyes-Parés G, Breuillé D, Moritani T. Supplementation with Whey Protein, Omega-3 Fatty Acids and Polyphenols Combined with Electrical Muscle Stimulation Increases Muscle Strength in Elderly Adults with Limited Mobility: A Randomized Controlled Trial. Nutrients 2020; 12:E1866. [PMID: 32585837 PMCID: PMC7353259 DOI: 10.3390/nu12061866] [Citation(s) in RCA: 16] [Impact Index Per Article: 3.2] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/14/2020] [Revised: 06/11/2020] [Accepted: 06/15/2020] [Indexed: 01/06/2023] Open
Abstract
Age-related sarcopenia is a progressive and generalized skeletal muscle disorder associated with adverse outcomes. Herein, we evaluate the effects of a combination of electrical muscle stimulation (EMS) and a whey-based nutritional supplement (with or without polyphenols and fish oil-derived omega-3 fatty acids) on muscle function and size. Free-living elderly participants with mobility limitations were included in this study. They received 2 sessions of EMS per week and were randomly assigned to ingest an isocaloric beverage and capsules for 12 weeks: (1) carbohydrate + placebo capsules (CHO, n = 12), (2) whey protein isolate + placebo capsules (WPI, n = 15) and (3) whey protein isolate + bioactives (BIO) capsules containing omega-3 fatty acids, rutin, and curcumin (WPI + BIO, n = 10). The change in knee extension strength was significantly improved by 13% in the WPI + BIO group versus CHO on top of EMS, while WPI alone did not provide a significant benefit over CHO. On top of this, there was the largest improvement in gait speed (8%). The combination of EMS and this specific nutritional intervention could be considered as a new approach for the prevention of sarcopenia but more work is needed before this approach should be recommended. This trial was registered at the Japanese University Hospital Medical Information Network (UMIN) clinical trial registry (UMIN000008382).
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Affiliation(s)
| | | | | | - Toshio Moritani
- Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto 606-8501, Japan;
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Ota M, Ikezoe T, Kato T, Tateuchi H, Ichihashi N. Age-related changes in muscle thickness and echo intensity of trunk muscles in healthy women: comparison of 20–60s age groups. Eur J Appl Physiol 2020; 120:1805-1814. [DOI: 10.1007/s00421-020-04412-7] [Citation(s) in RCA: 11] [Impact Index Per Article: 2.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/25/2019] [Accepted: 05/27/2020] [Indexed: 12/22/2022]
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Johnson AW, Stoneman P, McClung MS, Van Wagoner N, Corey TE, Bruening DA, Hunter TD, Myrer JW, Ridge ST. Use of Cine Loops and Structural Landmarks in Ultrasound Image Processing Improves Reliability and Reduces Error in the Assessment of Foot and Leg Muscles. JOURNAL OF ULTRASOUND IN MEDICINE : OFFICIAL JOURNAL OF THE AMERICAN INSTITUTE OF ULTRASOUND IN MEDICINE 2020; 39:1107-1116. [PMID: 31837060 DOI: 10.1002/jum.15192] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 07/31/2019] [Revised: 11/14/2019] [Accepted: 11/15/2019] [Indexed: 06/10/2023]
Abstract
OBJECTIVES Foot and leg muscle strength and size are crucial to proper function. It is important to assess these characteristics reliably. Our primary objective was to compare the measurement of still images to cine loops. The secondary purpose was to determine interoperator and intraoperator reliability between operators of different experience levels using video clips and internal and external landmarks. METHODS Twelve healthy volunteers participated in our study. Internal (navicular tuberosity) and external (lateral leg length at 30% and 50% from the knee joint line) landmarks were used. Two operators each captured and later measured still and cine loop images of selected foot and leg muscles. RESULTS The 12 participants included 8 male and 4 female volunteers (mean age ± SD, 23.5 ± 1.9 years). Good to excellent intraoperator and interoperator reliability was seen (intraclass correlation coefficient range of 0.946-0.998). The use of cine loops improved the intraclass correlation coefficients for both intraoperator and interoperator reliability (0.5%-4% increases). The use of cine loops decreased the intraoperator standard error of the measurement and limits of agreement of the novice operator (decreases of 45%-73% and 24%-51%, respectively), and these became comparable to those of experienced operators using still images. The interoperator standard errors of the measurement dropped by 42% to 53%, whereas the limits of agreement dropped by 27% to 40%. No substantial changes were noted in the tibialis anterior across reliability metrics. CONCLUSIONS Improved protocols that take advantage of using internal bony landmarks and cine loops during both the image-gathering and measurement processes improve the reliability of research examining muscle size changes in the lower leg or foot associated with muscle changes due to exercise, injury, disuse, or disease.
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Affiliation(s)
- A Wayne Johnson
- Departments of Exercise Sciences, Brigham Young University, Provo, Utah, USA
| | - Paul Stoneman
- Department of Physical Therapy, Rocky Mountain University of Health Professions, Provo, Utah, USA
| | - Matthew S McClung
- Departments of Exercise Sciences, Brigham Young University, Provo, Utah, USA
| | | | - Taryn E Corey
- Departments of Exercise Sciences, Brigham Young University, Provo, Utah, USA
| | - Dustin A Bruening
- Departments of Exercise Sciences, Brigham Young University, Provo, Utah, USA
| | | | - J William Myrer
- Departments of Exercise Sciences, Brigham Young University, Provo, Utah, USA
| | - Sarah T Ridge
- Departments of Exercise Sciences, Brigham Young University, Provo, Utah, USA
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Dallaway A, Kite C, Griffen C, Duncan M, Tallis J, Renshaw D, Hattersley J. Age-related degeneration of the lumbar paravertebral muscles: Systematic review and three-level meta-regression. Exp Gerontol 2020; 133:110856. [PMID: 32006635 DOI: 10.1016/j.exger.2020.110856] [Citation(s) in RCA: 29] [Impact Index Per Article: 5.8] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/10/2019] [Revised: 01/24/2020] [Accepted: 01/28/2020] [Indexed: 02/08/2023]
Abstract
BACKGROUND Morphological changes of the lumbar spine muscles are not well characterised with ageing. To further the understanding of age-related degeneration of the lumbar spine musculature, normative morphological changes that occur within the paravertebral muscles must first be established. METHODS A systematic review and meta-regressions were conducted adhering to PRISMA guidelines. Searches for published and unpublished data were completed in June 2019. RESULTS Searches returned 4781 articles. 34 articles were included in the quantitative analysis. Three-level meta-analyses showed age-related atrophy (r = -0.26; 95% CI: -0.33, -0.17) and fat infiltration (r = 0.39; 95% CI: 0.28, 0.50) in the lumbar paravertebral muscles. Degenerative changes were muscle-specific and men (r = -0.32; 95% CI: -0.61, 0.01) exhibited significantly greater muscle atrophy than women (r = -0.24; 95% CI: -0.47, 0.03). Imaging modality, specifically ultrasound, also influenced age-related muscle atrophy. Measurements taken across all lumbar levels revealed the greatest fat infiltration with ageing (r = 0.58, 95% CI: 0.35, 0.74). Moderators explained a large proportion of between-study variance in true effects for muscle atrophy (72.6%) and fat infiltration (79.8%) models. CONCLUSIONS Lumbar paravertebral muscles undergo age-related degeneration in healthy adults with muscle, lumbar level and sex-specific responses. Future studies should use high-resolution imaging modalities to quantify muscle atrophy and fat infiltration.
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Affiliation(s)
- A Dallaway
- Centre for Sport, Exercise and Life Sciences, Faculty of Health and Life Sciences, Science and Health Building, Whitefriars Street, Coventry University, Coventry CV1 2DS, United Kingdom; Human Metabolic Research Unit, University Hospitals Coventry and Warwickshire, Clifford Bridge Rd, Coventry CV2 2DX, United Kingdom.
| | - C Kite
- School of Life and Health Sciences, Cell and Tissue Biomedical Research Group, Aston University, Aston Triangle, Birmingham B4 7ET, United Kingdom; Centre for Active Living, University Centre Shrewsbury, University of Chester, Guildhall, Frankwell Quay, Shrewsbury SY3 8HQ, United Kingdom
| | - C Griffen
- Centre for Sport, Exercise and Life Sciences, Faculty of Health and Life Sciences, Science and Health Building, Whitefriars Street, Coventry University, Coventry CV1 2DS, United Kingdom; Human Metabolic Research Unit, University Hospitals Coventry and Warwickshire, Clifford Bridge Rd, Coventry CV2 2DX, United Kingdom
| | - M Duncan
- Centre for Sport, Exercise and Life Sciences, Faculty of Health and Life Sciences, Science and Health Building, Whitefriars Street, Coventry University, Coventry CV1 2DS, United Kingdom; School of Life Sciences, Faculty of Health and Life Sciences, Science and Health Building, Whitefriars Street, Coventry University, Coventry CV1 2DS, United Kingdom
| | - J Tallis
- Centre for Sport, Exercise and Life Sciences, Faculty of Health and Life Sciences, Science and Health Building, Whitefriars Street, Coventry University, Coventry CV1 2DS, United Kingdom; School of Life Sciences, Faculty of Health and Life Sciences, Science and Health Building, Whitefriars Street, Coventry University, Coventry CV1 2DS, United Kingdom
| | - D Renshaw
- Centre for Sport, Exercise and Life Sciences, Faculty of Health and Life Sciences, Science and Health Building, Whitefriars Street, Coventry University, Coventry CV1 2DS, United Kingdom
| | - J Hattersley
- Centre for Sport, Exercise and Life Sciences, Faculty of Health and Life Sciences, Science and Health Building, Whitefriars Street, Coventry University, Coventry CV1 2DS, United Kingdom; Human Metabolic Research Unit, University Hospitals Coventry and Warwickshire, Clifford Bridge Rd, Coventry CV2 2DX, United Kingdom
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47
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Navicular drop is negatively associated with flexor hallucis brevis thickness in community-dwelling older adults. Gait Posture 2020; 78:30-34. [PMID: 32199231 DOI: 10.1016/j.gaitpost.2020.03.009] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/05/2019] [Revised: 02/04/2020] [Accepted: 03/09/2020] [Indexed: 02/02/2023]
Abstract
BACKGROUND Flatfoot is characterized as a lower longitudinal arch and is a common foot deformity in older adults. Foot intrinsic muscle dysfunction has been considered as one of the factors for a lower medial longitudinal arch. The objective of this study was to investigate the association of the navicular drop with the thickness of foot intrinsic muscles in older adults. RESEARCH QUESTION Which intrinsic muscle contributes most to support the medial longitudinal arch in older adults? METHODS We studied 88 community-dwelling older adults (mean age 74.2 ± 6.2 years). We measured the navicular height, the calcaneus inclination, and hallux valgus angle on the right foot in the sitting and standing positions using a 3D foot scanner. Then, we calculated the navicular drop and changes in the calcaneus inclination from the sitting to the standing position. The muscle thickness of the flexor hallucis brevis (FHB), flexor digitorum brevis (FDB), and abductor hallucis (AbH) was measured on the right foot using Bmode ultrasonography. RESULTS Multiple regression analysis demonstrated that FHB thickness was significantly associated with navicular height in the standing positions (β = 8.568, P = 0.016) as well as navicular drop (β = -9.495, P = 0.037) after adjusting for age, sex, height, weight, and hallux valgus angle. There was no association with FDB or AbH. The thickness of any intrinsic muscle was not associated with the calcaneus inclination or changes in the calcaneus inclination. SIGNIFICANCE Our data suggest that FHB plays an important role in preventing navicular drop and that intrinsic muscles likely do not contribute to the rearfoot angle in older adults.
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Kuehne TE, Yitzchaki N, Jessee MB, Graves BS, Buckner SL. A comparison of acute changes in muscle thickness between A-mode and B-mode ultrasound. Physiol Meas 2019; 40:115004. [PMID: 31631884 DOI: 10.1088/1361-6579/ab4f14] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/23/2022]
Abstract
OBJECTIVE The purpose of this study was to compare acute changes in muscle thickness (MT) between A-mode and B-mode ultrasound before and after four sets of biceps curls. APPROACH Participants visited the laboratory on two separate occasions. The first visit consisted of paperwork and one repetition maximum (1RM) strength assessment. During the second visit, participants performed four sets of biceps curls to volitional failure using an exercise load equal to 70% of 1RM or a time-matched non-exercise control. MT measurements were taken before and immediately after exercise. MT measures were taken using both A-mode and B-mode ultrasound. MAIN RESULTS Results are displayed as mean (SD). A total of 49 resistance-trained men (n = 24) and women (n = 25) completed the study. There was no group (experimental versus control) by mode (A-mode versus B-mode) by time interaction (p = 0.442). However, there was a group (experimental versus control) × time (pre versus post) interaction (p < 0.001). Muscle thickness increased from pre (3.61 (0.86) cm) to post exercise (4.06 (0.92) cm) in the experimental group (p < 0.001). However, there was no change from pre (3.46 (0.78) cm) to post (3.48 (0.78) cm) in the time-matched control group (p = 0.237). There was a main effect for ultrasound mode (A-mode versus B-mode) (p < 0.001). Muscle thickness values as measured by A-mode ultrasound were lower than those measured by B-mode ultrasound pre (A-mode = 3.43 (0.79) cm versus B-mode = 3.63 (0.84) cm) and post (A-mode = 3.67 (0.87) cm versus B-mode = 3.83 (0.91) cm) intervention. SIGNIFICANCE MT measurements taken using A-mode ultrasound are lower than those of B-mode ultrasound. Despite this difference, it appears A-mode can detect similar acute changes in MT following resistance exercise when compared to B-mode ultrasound. These results suggest that A-mode ultrasound can serve as a useful tool when examining acute changes in MT.
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Affiliation(s)
- Tayla E Kuehne
- USF Muscle Lab, Exercise Science Program, University of South Florida, Tampa, FL, United States of America
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Kumar R, Shah TH, Hadda V, Tiwari P, Mittal S, Madan K, Khan MA, Mohan A. Assessment of quadriceps muscle thickness using bedside ultrasonography by nurses and physicians in the intensive care unit: Intra- and inter-operator agreement. World J Crit Care Med 2019; 8:127-134. [PMID: 31853448 PMCID: PMC6918044 DOI: 10.5492/wjccm.v8.i7.127] [Citation(s) in RCA: 6] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/28/2018] [Revised: 08/29/2019] [Accepted: 10/27/2019] [Indexed: 02/06/2023] Open
Abstract
BACKGROUND Data regarding the agreement among multiple operators for measurement of quadriceps muscle thickness by bedside ultrasonography (USG) are sparse. AIM To statistically assess the agreement among 5 operators for measurement of quadriceps muscle thickness on bedside USG. METHODS This was a cross-sectional observational study. The 5 operators of varied experience (comprised of 1 critical care consultant, 2 fellows, and 2 nurses) independently measured quadriceps muscle thickness in triplicate for 45 critically ill patients each, using USG. Intra- and interrater agreement rates among the 5 operators were assessed using intraclass correlation coefficient (ICC) and expressed with 95% confidence interval (CI). RESULTS The 5 operators produced a total of 135 readings and 675 observations for ICC calculations to determine the intraoperator and interoperator variations respectively. For intraoperator agreement, the overall ICC (95%CI) was 0.998 (0.997, 0.999) for operator 1, 0.998 (0.997, 0.999) for operator 2, 0.997 (0.995, 0.999) for operator 3, 0.999 (0.998, 0.999) for operator 4, and 0.998 (0.997, 0.999) for operator 5. For interoperator agreement, the overall ICC (95%CI) was 0.977 (0.965, 0.986; P < 0.001) for reading 1, 0.974 (0.960, 0.984; P < 0.001) for reading 2, and 0.975 (0.961, 0.985; P < 0.001) for reading 3. CONCLUSION USG measurement of quadriceps muscle thickness was not dependent on clinical experience, supporting training for nurses in it.
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Affiliation(s)
- Rohit Kumar
- Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi 110029, India
| | - Tajamul Hussain Shah
- Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi 110029, India
| | - Vijay Hadda
- Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi 110029, India
| | - Pawan Tiwari
- Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi 110029, India
| | - Saurabh Mittal
- Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi 110029, India
| | - Karan Madan
- Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi 110029, India
| | - Maroof Ahmad Khan
- Department of Biostatistics, All India Institute of Medical Sciences, New Delhi 110029, India
| | - Anant Mohan
- Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi 110029, India
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50
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Nakano I, Hori H, Fukushima A, Yokota T, Kinugawa S, Takada S, Yamanashi K, Obata Y, Kitaura Y, Kakutani N, Abe T, Anzai T. Enhanced Echo Intensity of Skeletal Muscle Is Associated With Exercise Intolerance in Patients With Heart Failure. J Card Fail 2019; 26:685-693. [PMID: 31533068 DOI: 10.1016/j.cardfail.2019.09.001] [Citation(s) in RCA: 18] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/19/2019] [Revised: 08/27/2019] [Accepted: 09/03/2019] [Indexed: 12/22/2022]
Abstract
BACKGROUND Skeletal muscle is quantitatively and qualitatively impaired in patients with heart failure (HF), which is closely linked to lowered exercise capacity. Ultrasonography (US) for skeletal muscle has emerged as a useful, noninvasive tool to evaluate muscle quality and quantity. Here we investigated whether muscle quality based on US-derived echo intensity (EI) is associated with exercise capacity in patients with HF. METHODS AND RESULTS Fifty-eight patients with HF (61 ± 12 years) and 28 control subjects (58 ± 14 years) were studied. The quadriceps femoris echo intensity (QEI) was significantly higher and the quadriceps femoris muscle thickness (QMT) was significantly lower in the patients with HF than the controls (88.3 ± 13.4 vs 81.1 ± 7.5, P= .010; 5.21 ± 1.10 vs 6.54 ±1.34 cm, P< .001, respectively). By univariate analysis, QEI was significantly correlated with age, peak oxygen uptake (VO2), and New York Heart Association class in the HF group. A multivariable analysis revealed that the QEI was independently associated with peak VO2 after adjustment for age, gender, body mass index, and QMT: β-coefficient = -11.80, 95%CI (-20.73, -2.86), P= .011. CONCLUSION Enhanced EI in skeletal muscle was independently associated with lowered exercise capacity in HF. The measurement of EI is low-cost, easily accessible, and suitable for assessment of HF-related alterations in skeletal muscle quality.
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Affiliation(s)
- Ippei Nakano
- Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan
| | - Hiroaki Hori
- Department of Rehabilitation, Hokkaido University Hospital, Sapporo, Japan
| | - Arata Fukushima
- Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
| | - Takashi Yokota
- Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan
| | - Shintaro Kinugawa
- Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan
| | - Shingo Takada
- Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan
| | - Katsuma Yamanashi
- Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan
| | - Yoshikuni Obata
- Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan
| | - Yasuyuki Kitaura
- Laboratory of Nutritional Biochemistry, Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan
| | - Naoya Kakutani
- Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan
| | - Takahiro Abe
- Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan
| | - Toshihisa Anzai
- Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan
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