Review
Copyright ©2013 Baishideng Publishing Group Co.
World J Surg Proced. Nov 28, 2013; 3(3): 18-24
Published online Nov 28, 2013. doi: 10.5412/wjsp.v3.i3.18
Table 1 Comparative studies analyzing the effects of drainage vs non drainage in open appendicectomies conducted for perforated and gangrenous appendix
Ref.YearCountryType of studyType of appendixTreatmentPatients (n)Antibiotic regimenAbdominal abscessPostoperative ileusSurgical site infectionsWound dehiscenceAdhesionsFecal fistulaBurst abdomenMortality
Everson et al[20]1977United KingdomRCTPR/GAD14Cephaloridine 1gr QDS - 3 d coverage--3 (21)-----
ND16Cephaloridine 1gr QDS - 3 d coverage--6 (38)-----
Greenall et al[11]1978United KingdomRCTPRD48(various antibiotics)7 (15)18 (38)34 (71)--2 (4)3 (6)3 (6)
ND55(various antibiotics)12 (22)12 (22)38 (69)--0 (0)0 (0)1 (2)
MacKellar et al[12]1986AustraliaRetros.PR/GAD19Metronidazole ± Gentamycin and Ampicillin (if suspected peritonitis)1 (5)-3 (16)-----
ND139Metronidazole ± Gentamycin and Ampicillin (if suspected peritonitis)2 (1)-2 (1)-----
Samelson et al[13]1987United StatesRetros.PRD24Ampicillin, Gentamycin and Clindamycin if suspected perforation for 7-10 d3 (13)-------
ND170Ampicillin, Gentamycin and Clindamycin if suspected perforation for 7-10 d3 (2)-------
Dandapat et al[14]1992IndiaRCTPRD40-8 (20)17 (43)22 (55)--2 (5)2 (5)4 (10)
ND46-10 (22)13 (28)23 (50)--0 (0)0 (0)1 (2)
Johnson et al[3]1993United StatesRetros.PRD32-0 (0)5 (16)1 (3)-----
ND34-3 (9)3 (9)2 (5.9)-----
Toki et al[15]1995JapanRCTPRD24Aminoglycoside and Cephem2 (8)-6 (25)-0 (0)---
ND29Aminoglycoside and Cephem0 (0)-2 (7)-0 (0)---
Perović et al[19]2000CroatiaRetros.PRD20--4 (20)13 (65)2 (10)----
ND36--1 (3)7 (19)2 (6)----
Narci et al[16]2007TurkeyRetros.PRD109-14 (13)-31 (28)-3 (3)---
ND117-4 (3)-19 (16)-4 (3)---
Jani et al[17]2011KenyaRCTPRD45Cefuroxime and Metronidazole or Penicillin, Gentamicin and Metronidazole or Amoxicillin-Clavulanate and Metronidazole3 (7)1 (2)15 (33)--2 (4)--
ND45Cefuroxime and Metronidazole or Penicillin, Gentamicin and Metronidazole or Amoxicillin-Clavulanate and Metronidazole0 (0)0 (0)3 (7)--0 (0)--
Akkoyun et al[18]2012TurkeyRetros.PRD61-3 (5)5 (8)3 (5)1 (2)1 (2)---
ND173-3 (2)4 (2)3 (2)0 (0)1 (1)---
Al-Shahwany et al[21]2012IraqRCTPRD46Ceftriaxone and Metronidazole--18 (39)--0 (0)-0 (0)
ND38Ceftriaxone and Metronidazole--14 (37)--0 (0)-0 (0)
TotalD48239/378 (10.3)50/246 (20.3)149/458 (32.5)3/81 (3.7)4/194 (2)6/179 (3.4)5/88 (5.7)7/134 (5.2)
ND86237/779 (4.7)33/389 (8.5)112/692 (16.2)2/209 (0.95)5/319 (1.6)0/184 (0)0/101 (0)2/139 (1.4)
Power calculation80%95%99%1%0.02%99%99%99%
odds ratio2.22.423.91.3-1-13.7
P value (D vs ND)< 0.0001< 0.0001< 0.00010.11 (NS)0.68 (NS)0.010.010.08 (NS)