Probiotics and allergic diseases

Table 1 Clinical studies evaluating the effects of probiotics in allergic diseases

Disease	Ref.	Number of participants	Strains	Age	Results
Atopic dermatitis	Kalliomäki et al[54], 2007	159	Lactobacillus GG	Prenatal and postnatal	Decreased incidence of eczema
	Taylor et al[55], 2007	178	L. acidophilus LAVRI- Al	Postnatal	No change in eczema rates
	Kopp et al[56], 2008	94	Lactobacillus GG	Prenatal and postnatal	No difference
	Griskevicius et al[57], 2008	446	Group 1: L. Rhamnosus HN001 Group 2: B. animalis ssp. lactis HN019	Prenatal and postnatal	Decreased incidence of eczema by the intake of L. rhamnosus
	Enomoto et al[27], 2014	130	Bifidobacterium breve M-16V, Bifidobacterium longum BB536	Prenatal and postnatal	Decreased incidence of eczema
	Rautava et al[28], 2012	241	Lactobacillus rhamnosus LPR and Bifidobacterium longum BL999, Lactobacillus paracasei ST11 and Bifidobacterium longum BL999	Prenatal and postnatal	Decreased incidence of eczema
Atopic sensitization	Huurre et al[58], 2008	171	Lactobacillus GG, B. lactis	Prenatal and postnatal	Decreased incidence of sensitization
Allergic airway diseases	Abrahamsson et al[59], 2007	232	L. reuteri	Prenatal and postnatal	No difference in wheeze
	Wickens et al[60], 2012	425	B. lactis, Lactobacillus HN001	Prenatal and postnatal	Decreased incidence of rinoconjunctivitis
	Chen et al[40], 2010	105	L. gasseri A5	School children	Decrease in asthmatic symptoms
	Wassenberg et al[41], 2011	31	Lactobacillus paracasei ST11	Adults	Decreased cytokine release
Food allergy	Dupont et al[47], 2015	119	Probiotic supplemented formula	Infants with cows' milk protein allergy	Decreased incidence in food related symptoms
	Tang et al[48], 2015	62	Lactobacillus rhamnosus CGMCC 1.3724	Children with peanut allergy	Increased incidence of desensitization
Urticaria	Arslanoğlu et al[5], 2008	134	Prebiotic-supplemented hypoallergenic formula	Postnatal	Decreased cumulative incidence of allergic urticaria
Systemic nickel allergy syndrome	Randazzo et al[43], 2015	22	Lactobacillus reuteri DSM 17938	Adults	Decrease in symptoms