Review
Copyright ©2014 Baishideng Publishing Group Inc.
World J Immunol. Nov 27, 2014; 4(3): 141-148
Published online Nov 27, 2014. doi: 10.5411/wji.v4.i3.141
Table 1 Characteristics of transgenic rices for oral immunotherapy against allergic rhinitis and bronchial asthma
Tg rice nameTarget diseaseTarget allergenExpression plasmid construction
Allergen accumulation
Pharmacological effectRef.
PromoterCoding proteinKDEL sequenceLocalizationYield
Cry jAllergic rhinitisCryptomeria Japonica pollen (Japanese cedar pollen)GluB-1Fusion protein of mouse T-cel epitopes in Cry j 1 and Cry j 2, and glycinin A1aB1babsencepresumaply PB-II7 μg/grainIgE and IgG CD4+ T-cell proliferation Th2 cytokine Histamine Sneezing↓↓↓↓↓[74]
7CrpAllergic rhinitisCryptomeria Japonica pollen (Japanese cedar pollen)GluB-1Fusion protein of seven human T-cell epitopes in Cry j 1 and Cry j 2presencePB-I and PB-II62 μg/grainCD4+ T-cell proliferation IgE↓↓[79]
Shuffled Cry jAllergic rhinitisCryptomeria Japonica pollen (Japanese cedar pollen)Prolamin (16-kDa) GluB Prolamin (10-kDa) GluB-1Fusion protein of deconstructed full-length Cry j 1, Cry j 2, and glutelinspresencePB-I10-25 μg/grainIgE and IgG CD4+ T-cell proliferation Th2 cytokine Histamine Sneezing Eosinophilia↓↓↓↓↓↓[84]
Der p 1Bronchial asthmaDermatophagoides Pteronyssinus (House dust mite)GluB-1Human and mouse T-cell epitopes in Der p 1absencePB-I90 μg/grainIgE and IgG CD4+ T-cell proliferation Th2 cytokine Eosinophilia Bronchial hyperreactivity↓↓↓↓↓[89-91]
Der f 2Bronchial asthmaDermatophagoides Farinae (House dust mite)GluB-1Cysteine residue-mutated full-length Der f 2presenceDer f 2 body15-30 μg/grainIgE and IgG[99]