• Peyronie’s disease
• collagenase clostridium histolyticum
• erectile dysfunction
• penile curvature
• tadalafil
• vacuum therapy

• Peyronie’s disease
• erectile dysfunction
• extracorporeal shockwave
• phosphodiesterase type 5 inhibitors
• vacuum erection device

• acute phase
• andrology
• male sexual health
• penile curvature
• peyronie disease

• Humans
• Male
• Penile Induration/therapy
• Platelet-Rich Plasma
• Extracorporeal Shockwave Therapy/methods
• Retrospective Studies
• Middle Aged
• Combined Modality Therapy
• Adult
• Treatment Outcome
• Tadalafil/therapeutic use
• Tadalafil/administration & dosage
• Colchicine/administration & dosage
• Colchicine/therapeutic use
• Acute Disease
• Vitamin E/administration & dosage
• Vitamin E/therapeutic use

• Male
• Humans
• Penile Induration/therapy
• Retrospective Studies
• Tadalafil/therapeutic use
• Treatment Outcome
• Penis

• Peyronie’s disease
• curvature
• epidemiology
• induratio penis plastica
• surgery

• Male
• Humans
• Middle Aged
• Penile Induration
• Cross-Sectional Studies
• Penis/surgery
• Treatment Outcome
• Penile Implantation
• Erectile Dysfunction/surgery
• Erectile Dysfunction/complications

• sexual dysfunction
• combination drug therapy

• Male
• Humans
• Penile Induration/drug therapy
• Treatment Outcome
• Microbial Collagenase/therapeutic use
• Penis
• Pelvic Pain

• fibroblast
• fibrosis
• myofibroblast
• sildenafil
• tadalafil
• tamoxifen
• vardenafil

• humans
• male
• erectile dysfunction
• pain
• penile induration
• penile induration/therapy
• quality of life
• randomized controlled trials as topic
• verapamil

• Male
• Humans
• Penile Induration/therapy
• Erectile Dysfunction
• Quality of Life
• Pain
• Verapamil
• Randomized Controlled Trials as Topic

• intralesional cch
• penile prosthesis
• peyronie's disease
• psychological impact
• surgical treatment

• Taiwan
• erectile dysfunction
• prostate cancer
• sexual dysfunction

• Erectile dysfunction
• Extracorporeal shockwave therapy
• Patient satisfaction
• Penile erection

• Combination therapy
• Meta-analysis
• Peyronie’s disease
• Systematic review

Peyronie's disease is the disease that results in an alteration in the curvature of the penis, which can lead to a shortening of length, pain in erection, or difficulties in penetration, thus leading the patient to psychological alterations due to loss of functionality such as aesthetic alteration. That is why there are several studies to define the best form of treatment, which currently continues to be the first choice surgical treatment.

We present the most recommended therapies for Peyronie's disease and suggest an algorithm as a guide to direct therapy.

We used the PubMed platform to review the literature related to Peyronie's disease. Various editorials were reviewed as well as original articles and reviews focusing on the various treatments as well as their indications and results.

Peyronie's disease in which conservative or drug treatment does not have a response, surgical treatment with corporoplasty, penile prosthesis implantation or both may be indicated. Corporoplasty refers to both the plication of the tunica albuginea as well as the incision of the tunica with the placement of a graft. An accurate history should always be carried out to identify erectile dysfunction as well as to be able to guide you on the repercussions of the treatment. If refractory erectile dysfunction is present, placement of a penile prosthesis with or without further adjunctive straightening maneuvers is recommended. We reviewed the indications, advantages, disadvantages, and results of the available techniques, and proposed a surgical treatment algorithm.

Penile shortening procedures are usually indicated in curvatures <60°, in penises with adequate length. Partial excision/incision and grafting are indicated for curvatures >60°, hourglass or hinge deformities, and short penises, if the patient's erectile function is adequate. The presence of “borderline” erectile function and/or ventral curvature tilts the choice toward shortening procedures, and refractory erectile dysfunction is an indication for penile prosthesis placement. An accurate risk/benefit assessment of the individual patient as well as meticulous patient counseling are critically important.

• bladder
• cryoinjury
• erectile dysfunction
• shock waves

• 109-2314-B-182A-135-MY3 MOST Taiwan
• CRRPG8J0163 Kaohsiung Chang Gung Memorial Hospital

• Peyronie’s disease
• drug therapy
• intralesional injections
• penile induration
• treatment outcome

• Combination Therapy
• Erectile Dysfunction
• Erectile Function
• Low-Intensity Shockwave Therapy
• Randomized Controlled Trial
• Tadalafil

• Erectile dysfunction (ED)
• Low-intensity extracorporeal shockwave therapy (LiESWT)
• Penile prosthesis
• Penile traction devices (PTD)
• Peyronie's disease (PD)
• Vacuum erection devices (VED)

• Combined Modality Therapy
• Erectile Dysfunction/therapy
• Extracorporeal Shockwave Therapy
• Humans
• Male
• Microbial Collagenase/therapeutic use
• Penile Implantation
• Penile Induration/therapy
• Penile Prosthesis
• Traction
• Vacuum

• diabetes mellitus
• erectile dysfunction
• low-intensity shockwave therapy
• tadalafil

Low intensity extracorporeal shock wave therapy (LIESWT) improves erectile function (EF) in men with vascular erectile dysfunction (ED) but longer-term outcomes remain unknown.

To evaluate the clinical outcomes of LIESWT at a minimum 5-year follow-up.

This is an open-label single-arm prospective study involved men with vascular ED who received LIESWT.

Changes in patient demographics, IIEF-5 and Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) scores, as well as overall satisfaction score (on a 5-point scale) were reviewed at 12, 24, 48, and 60 months after completion of LIESWT. A chi-square contingency analysis was used to examine the relationship between erectile function score and treatment satisfaction, with statistical significance set at 5%.

The mean follow-up period was 69.9 (63–82; median 76) months. The mean IIEF-5 scores for pretreatment and after treatment at 12, 24, 48, and 60 months were 14.8, 17.6, 16.8, 16.5, and 16.5 while the percentages of patients who reported an improvement in IIEF-5 score by 5 points were 60%, 45%, 40%, and 40%; and EDITS scores >50% were recorded in 70%, 55%, 50%, and 48% of patients at 12, 24, 48, and 60 months post-LIESWT. Ten patients required medical therapy and 2 patients opted for penile prosthesis implantation. The overall satisfaction rate appeared sustained subsequent follow-up (score 4 out of 5; 68% vs 50% vs 40% vs 40% at 12, 24, 48, and 60 months). There were minor time-limited, but no significant adverse event reported.

This long-term study showed the observed clinical improvement in EF continues to deteriorate but appears to plateau at 40% clinical efficacy at 48–60 months after completion of LIESWT. The absence of penile pain and deformity at 5-year follow-up supports the long-term safety data of LIESWT in men with ED.

Chung E, Cartmill R. Evaluation of Long-Term Clinical Outcomes and Patient Satisfaction Rate Following Low Intensity Shock Wave Therapy in Men With Erectile Dysfunction: A Minimum 5-Year Follow-Up on a Prospective Open-Label Single-Arm Clinical Study. Sex Med 2021;9:100384.

• Clinical Outcomes
• Erectile Dysfunction
• Erectile Function
• Long-Term Data
• Low Intensity Extracorporeal Shock Wave Therapy
• Patient Satisfaction

Atypical penile tunical lesions including isolated septal (ISS) and punctate scarring (PS) are an under recognized and difficult to treat subset of Peyronie's disease (PD) that often present with normal physical exams. Current guidelines provide little direction in the treatment of these men.

To review the results of our treatment approach in men with ISS and PS.

Data from all men undergoing duplex ultrasonography for either Peyronie's disease and/or erectile dysfunction over a 3-year period were reviewed. All men with ISS or PS and normal physical exams were included. First- and second-line treatment preferences and satisfaction with treatment in men with ISS and PS were retrospectively reviewed. Logistic regression was used to investigate associations between scar features and treatment preference

Treatment preference patterns, treatment satisfaction.

A total of 217 men with ISS and 197 men with PS were identified. Of these, 71 ISS and 86 PS patients had normal physical exams. Majority of men in both ISS (70.4%) and PS (81.4%) cohorts initially opted for non-invasive management through either observation, oral therapy, or traction therapy. After initial management 84.5% of ISS and 93% of PS patients were satisfied with their results. A significant trend toward inflatable prostheses as second line therapy was seen in men with PS.

There is a mounting need for clinical guidance in order to best manage men with atypical PD in the absence of societal guidelines and high-quality studies. This series provides guidance to clinicians on the management of these men, suggesting that conservative therapy and education may be sufficient. A standardized approach of increasing invasiveness showed reasonable rates of satisfaction with minimally invasive therapies playing a prominent role. Stern N, Punjani N, Brock G, Management of Patients With Normal Physical Exams and Ultrasound Evidence of Isolated Septal and Punctate Penile Scarring. Sex Med 2021;9:100346

• Doppler
• Erectile Dysfunction
• Peyronie's Disease
• Ultrasonography

Peyronie’s disease (PD) is a localized fibrotic lesion of the penis that has adverse effects on men’s health. In this review, we summarized the molecular mechanisms and pharmacotherapies of PD. A literature search was conducted using PubMed and Cochrane Library during 2001–2020. Although no oral or topical medication demonstrated efficacy in monotherapy of PD, several intralesional medications have yielded promising results. Currently, the effective strategy in management of PD should be combined modality therapy, including but not limited to pharmacotherapy, mechanical therapy, and psychotherapy. Meanwhile, basic research is still necessary to facilitate the development of novel and more reliable treatments. In future, more attention should be given simultaneously to epigenetic changes, inflammatory cytokines, the abnormal wound-healing process, and profibrotic and anti-fibrotic factors to provide more options for this refractory disease.

• mechanisms
• peyronie’s disease
• pharmacotherapy
• treatment
• wound-healing

• Chirurgie
• Evaluation
• Français
• French
• Graft
• Greffe
• Guideline
• Implant pénien
• Maladie de Lapeyronie
• Medical
• Médical
• Penile prosthesis
• Peyronie's disease
• Plication
• Plicature
• Recommandation
• Surgery
• Traitement
• Treatment
• Évaluation

• Peyronie’s disease
• intralesional
• medical management
• oral
• topical
• traction

• Conservative therapy
• Intralesional therapy
• Mechanical therapy
• Oral therapy
• Peyronie’s disease

• Peyronie's disease
• medical
• minimally invasive
• non-invasive

• Antifibrotic Therapies
• Myofibroblast Transformation
• PDE5i
• Peyronie's Disease
• SERM
• Transforming Growth Factor

Published literature shows low intensity extracorporeal shock wave therapy (LIESWT) and low intensity pulsed ultrasound (LIPUS) therapy to improve erectile function and penile hemodynamic by inducing neovascularisation and promoting tissue regeneration. Key opinion leaders across the Asia Pacific region attended the recent biennial meeting of the Asia Pacific Society for Sexual Medicine in Australia, and presented the current evidence on LIESWT and LIPUS for erectile dysfunction (ED). The clinical findings were internally discussed, and the quality of evidence was graded based on the Oxford Centre for Evidence-Based Medicine recommendations. Existing literature supports the use of LIESWT and LIPUS in men with ED, with many clinical studies reported encouraging results with improved erectile function, good safety profile and short-term durability. However, controversial exists due to sampling heterogeneity, non-standardised treatment protocol and lack of large multiinstitutional studies. There is a need to better define which subgroup of ED population is best-suited, and specific treatment protocol to optimise shock wave energy delivery. More stringent and larger multi-institutional randomised placebo-controlled trials are warranted before clinical adoption of LIESWT and LIPUS as the new standard of care for men with ED.

• Clinical outcome
• Erectile dysfunction
• Low intensity pulsed ultrasound
• Low intensity shock wave therapy
• Safety
• Shock wave machine

• Collagenase
• grafting
• intralesional
• penile curvature
• plication

Erectile dysfunction (ED) is a common condition which reduces quality of life of both patients and their partners, and is a significant health care expense every year. Although phosphodiesterase type-5 inhibitors are the current first-line treatment for men with ED, they are limited by their on-demand dosing, intolerance, and variable efficacy in complex patient populations such as men with multiple medical comorbidities or ED after pelvic surgery. Regenerative medicine has been introduced and investigated in andrology as an encouraging strategy to restore diseased erectile tissue structure and function. Novel regenerative therapies for ED are controversial but are perceived to offer a durable and safe tissue restorative approach to act as a long-term solution to this cumbersome disease process. Here, we review platelet-rich plasma, amniotic fluid membranes, low-intensity extracorporeal shockwave therapy, and stem cell therapy as regenerative strategies to treat ED. Most of these approaches have preclinical and occasionally clinical data to support their ongoing investigation; however, none of these treatments are currently supported for use in ED patients outside of clinical trials.

• Erectile dysfunction (ED)
• amniotic fluid
• chorion grafts
• low-intensity extracorporeal shockwave treatment
• platelet-rich plasma
• stem cell therapy

Peyronie’s disease is a condition that causes abnormal healing of the tunica albuginea, causing penile curvature. It is difficult to treat and its management is continuing to evolve. Proposed non-surgical treatments have included oral, topical, intralesional, extracorporeal shockwave, and traction therapy. The study of Peyronie’s disease is made difficult by heterogeneity in the timing of presentation, severity and characteristics of deformity, and associated complaints. Moreover, meta-analyses of studies are difficult due to inconsistencies across study endpoints and the duration of treatments. This article reviews the current clinical evidence and guideline recommendations, with a focus on an improvement in penile curvature.

• Peyronie’s disease
• intralesional therapy
• medical management
• non-surgical management
• oral therapy
• penile traction therapy

• Chronic Prostatitis
• Erectile Dysfunction
• Peyronie's Disease
• Shockwave

• Chronic Disease
• Chronic Pain/complications
• Erectile Dysfunction/therapy
• Extracorporeal Shockwave Therapy/methods
• Humans
• Male
• Meta-Analysis as Topic
• Pelvic Pain/prevention & control
• Penile Erection/physiology
• Penile Induration/therapy
• Prospective Studies
• Prostatitis/therapy
• Randomized Controlled Trials as Topic
• Retrospective Studies
• Sexual Behavior
• Societies, Medical
• Syndrome
• Treatment Outcome

• Erectile Dysfunction
• Penile Curvature
• Penile Pain
• Peyronie’s Disease
• Plaque
• Shockwave Therapy

• Extracorporeal Shockwave Therapy/methods
• High-Energy Shock Waves/therapeutic use
• Humans
• Male
• Penile Erection/physiology
• Penile Induration/physiopathology
• Penile Induration/therapy

• Low intensity shock wave therapy
• electrohydraulic
• electromagnetic
• erectile dysfunction
• neovascularization
• piezoelectric
• regeneration technology
• shock wave machine

• efficacy
• erectile dysfunction
• extracorporeal shock wave therapy
• vacuum erectile device

• Adult
• China
• Erectile Dysfunction/physiopathology
• Erectile Dysfunction/therapy
• High-Energy Shock Waves/therapeutic use
• Humans
• Male
• Middle Aged
• Penile Erection
• Prospective Studies
• Severity of Illness Index
• Treatment Outcome
• Vacuum
• Young Adult

• Cuestionario IIEF
• Disfunción eréctil
• Erectile dysfunction
• Extracorporeal lithotripsy
• IIEF questionnaire
• Litotricia extracorpórea
• Pene
• Penis

• Erectile Dysfunction/therapy
• Extracorporeal Shockwave Therapy/methods
• Humans
• Male
• Randomized Controlled Trials as Topic
• Severity of Illness Index
• Treatment Outcome