Analysis of the therapeutic evolution in the management of airway infantile hemangioma

Table 1 Patient characteristics

	Age (mo)	Gender	Symptoms at diagnosis	Lesion location	Degree of SGE (Cotton scale)	Treatment	Outcomes
1	2	F	Stridor	Subglottic	II	Corticosteroids	Asymptomatic
2	3	F	Stridor	Glottis and subglottic		Interferon, corticosteroids	Asymptomatic
3	1	M	Stridor	Subglottic	II	Corticosteroids	Asymptomatic
4	1	F	Stridor	Subglottis and trachea	I	Resection and cricothyroidotomy	Asymptomatic
5	1	M	Stridor, dyspnea	Supraglottis and subglottis	III	Laryngotracheoplasty	Dysphonia
6	14	M	Stridor, dyspnea	Subglottic	III	Corticosteroids, laser, resection and cricothyroidotomy	Asymptomatic
7	27	F	Stridor	Subglottic	II	Laser, laryngotracheoplasty	Exitus
8	2	F	Stridor, dyspnea	Subglottic	III	Laryngotracheoplasty	Dysphonia
9	4	F	stridor, dyspnea	Subglottic	III	Corticosteroids, laryngotracheoplasty	Dysphonia
10	3	F	Stridor, dyspnea	Subglottic	III	Laryngotracheoplasty	Transitory stridor
11	5	F	Stridor, dyspnea	Subglottic	III	Laryngotracheoplasty	Asymptomatic
12	16	M	Stridor, dyspnea	Glottis and subglottic	I	Corticosteroids	Asymptomatic
13	5	F	Stridor, dyspnea	Subglottic	III	Corticosteroids, resection and cricothyroidotomy	Transitory stridor
14	3	F	Stridor	Subglottis and trachea	I	Corticosteroids, laryngotracheoplasty	Asymptomatic
14	19	M	Stridor	Subglottic	I	Propranolol	Exitus
16	5	F	Stridor	Supraglottis	-	Propranolol	Asymptomatic
17	26	M	Stridor	Subglottic	I	Propranolol	Asymptomatic
18	5	F	Stridor, dyspnea	Subglottic	III	Corticosteroids, propranolol	Asymptomatic
19	3	F	Stridor	Subglottic	II	Propranolol	Asymptomatic
20	3	M	Stridor	Subglottic	I	Propranolol	Asymptomatic
21	2	F	Stridor	Subglottic	I	Propranolol	Asymptomatic
22	2	F	Stridor	Subglottic	I	Propranolol	Asymptomatic
23	3	F	Stridor	Subglottic	I	Propranolol	Asymptomatic

F: Female; M: Male; SGE: Subglottic stenosis.

Table 2 Patient evolutions after treatment n (%)

Evolution after treatment	Group A n = 14					Group B Oral propranolol n = 9
	Oral corticosteroids		INF	Open surgical resection and endoscopic therapy
	Single treatment n = 3	Combined treatment n = 6	Combined treatment n = 11	Single treatment n = 5	Combined treatment n = 6	Single treatment n = 8	Combined treatment n = 1
Asymptomatic	3 (100)	0 (0)	0 (0)	2 (40)	4 (66.6)	8 (100)	1 (100)
Symptomatic	0 (0)	6 (100)	1(100)	3 (60)	2 (33.3)	0 (0)	0 (0)
Dysphonia	0 (0)	0 (0)	0 (0)	2 (40)	1 (16.6)	0 (0)	0 (0)
Stridor	0 (0)	5 (83.3)	1 (100)	1 (20)	1 (16.6)	0 (0)	0 (0)
Complications	0 (0)	3 (50)	0 (0)	1 (20)	1 (16.6)	0 (0)	0 (0)
Exitus	0 (0)	1 (16.6)	0 (0)	0 (0)	1 (16.6)	1 (12.5)2	0 (0)

¹Only one patient was treated with interferon, but the same patient was also treated with corticosteroids and surgery, which is included in the 6 patients with combined treatment;

²Not related to propranolol therapy. INF: Interferon.