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Thapaliya B, Miller R, Chen J, Wang YP, Akbas E, Sapkota R, Ray B, Suresh P, Ghimire S, Calhoun VD, Liu J. DSAM: A deep learning framework for analyzing temporal and spatial dynamics in brain networks. Med Image Anal 2025; 101:103462. [PMID: 39892220 DOI: 10.1016/j.media.2025.103462] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/19/2024] [Revised: 12/14/2024] [Accepted: 01/09/2025] [Indexed: 02/03/2025]
Abstract
Resting-state functional magnetic resonance imaging (rs-fMRI) is a noninvasive technique pivotal for understanding human neural mechanisms of intricate cognitive processes. Most rs-fMRI studies compute a single static functional connectivity matrix across brain regions of interest, or dynamic functional connectivity matrices with a sliding window approach. These approaches are at risk of oversimplifying brain dynamics and lack proper consideration of the goal at hand. While deep learning has gained substantial popularity for modeling complex relational data, its application to uncovering the spatiotemporal dynamics of the brain is still limited. In this study we propose a novel interpretable deep learning framework that learns goal-specific functional connectivity matrix directly from time series and employs a specialized graph neural network for the final classification. Our model, DSAM, leverages temporal causal convolutional networks to capture the temporal dynamics in both low- and high-level feature representations, a temporal attention unit to identify important time points, a self-attention unit to construct the goal-specific connectivity matrix, and a novel variant of graph neural network to capture the spatial dynamics for downstream classification. To validate our approach, we conducted experiments on the Human Connectome Project dataset with 1075 samples to build and interpret the model for the classification of sex group, and the Adolescent Brain Cognitive Development Dataset with 8520 samples for independent testing. Compared our proposed framework with other state-of-art models, results suggested this novel approach goes beyond the assumption of a fixed connectivity matrix, and provides evidence of goal-specific brain connectivity patterns, which opens up potential to gain deeper insights into how the human brain adapts its functional connectivity specific to the task at hand. Our implementation can be found on https://github.com/bishalth01/DSAM.
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Affiliation(s)
- Bishal Thapaliya
- Tri-Institutional Center for Translational Research in NeuroImaging and Data Science (TreNDS) - Georgia State, Georgia Tech and Emory, USA; Department of Computer Science, Georgia State University, Atlanta, USA
| | | | - Jiayu Chen
- Tri-Institutional Center for Translational Research in NeuroImaging and Data Science (TreNDS) - Georgia State, Georgia Tech and Emory, USA; Department of Computer Science, Georgia State University, Atlanta, USA
| | - Yu Ping Wang
- Tulane School of Medicine, Tulane University, New Orleans, USA
| | - Esra Akbas
- Department of Computer Science, Georgia State University, Atlanta, USA
| | - Ram Sapkota
- Tri-Institutional Center for Translational Research in NeuroImaging and Data Science (TreNDS) - Georgia State, Georgia Tech and Emory, USA; Department of Computer Science, Georgia State University, Atlanta, USA
| | - Bhaskar Ray
- Tri-Institutional Center for Translational Research in NeuroImaging and Data Science (TreNDS) - Georgia State, Georgia Tech and Emory, USA; Department of Computer Science, Georgia State University, Atlanta, USA
| | - Pranav Suresh
- Tri-Institutional Center for Translational Research in NeuroImaging and Data Science (TreNDS) - Georgia State, Georgia Tech and Emory, USA; Department of Computer Science, Georgia State University, Atlanta, USA
| | - Santosh Ghimire
- Department of Applied Sciences and Chemical Engineering, Tribhuvan University, Nepal
| | - Vince D Calhoun
- Tri-Institutional Center for Translational Research in NeuroImaging and Data Science (TreNDS) - Georgia State, Georgia Tech and Emory, USA; Department of Computer Science, Georgia State University, Atlanta, USA; School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, USA
| | - Jingyu Liu
- Tri-Institutional Center for Translational Research in NeuroImaging and Data Science (TreNDS) - Georgia State, Georgia Tech and Emory, USA; Department of Computer Science, Georgia State University, Atlanta, USA.
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Choy O, Raine A. The neurobiology of antisocial personality disorder. Neuropharmacology 2024; 261:110150. [PMID: 39244014 DOI: 10.1016/j.neuropharm.2024.110150] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/31/2024] [Revised: 08/21/2024] [Accepted: 09/04/2024] [Indexed: 09/09/2024]
Abstract
Despite increasing recognition that there is a neurobiological basis of antisocial behavior in addition to its psychosocial foundation, much less is known about the specificity of the neurobiological findings to the psychiatric condition of antisocial personality disorder (APD). This article provides a review of research on genetic, brain imaging, neurocognitive, and psychophysiological factors in relation to assessments of APD. Findings show that there are significant genetic effects on APD, particularly related to the serotonergic system, as well as abnormalities in brain regions such as the frontal lobe. Associations between psychophysiological measures of autonomic nervous system functioning and APD are more mixed. Results indicating that APD has a significant genetic basis and is characterized by abnormalities in brain structure/function and neurocognitive impairments provide additional evidence that supports the conceptualization of APD as a neurodevelopmental disorder. Findings may also help inform treatment approaches that target neurobiological risks for APD symptoms. This article is part of the Special Issue on "Personality Disorders".
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Affiliation(s)
- Olivia Choy
- Department of Psychology, Nanyang Technological University, Singapore.
| | - Adrian Raine
- Departments of Criminology, Psychiatry, and Psychology, University of Pennsylvania, USA.
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Ding K, Xu M, Huang T, Song Y, Kong F, Zhen Z. Sex dimorphic cortical brain volumes associated with antisocial behavior in young adults. PSYCHORADIOLOGY 2023; 3:kkad031. [PMID: 38666132 PMCID: PMC10917369 DOI: 10.1093/psyrad/kkad031] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Received: 10/30/2023] [Revised: 12/07/2023] [Accepted: 12/16/2023] [Indexed: 04/28/2024]
Abstract
Background Although sex differences in antisocial behavior are well-documented, the extent to which neuroanatomical differences are related to sex differences in antisocial behavior is unclear. The inconsistent results from different clinical populations exhibiting antisocial behaviors are mainly due to the heterogeneity in etiologies, comorbidity inequality, and small sample size, especially in females. Objective The study aimed to find sexual dimorphic brain regions associated with individual differences in antisocial behavior while avoiding the issues of heterogeneity and sample size. Methods We collected structural neuroimaging data from 281 college students (131 males, 150 females) and analyzed the data using voxel-based morphometry. Results The gray matter volume in three brain regions correlates with self-reported antisocial behavior in males and females differently: the posterior superior temporal sulcus, middle temporal gyrus, and precuneus. The findings have controlled for the total cortical gray matter volume, age, IQ, and socioeconomic status. Additionally, we found a common neural substrate of antisocial behavior in both males and females, extending from the anterior temporal lobe to the insula. Conclusion This is the first neuroanatomical evidence from a large non-clinical sample of young adults. The study suggests that differences in males and females in reading social cues, understanding intentions and emotions, and responding to conflicts may contribute to the modulation of brain morphometry concerning antisocial behavior.
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Affiliation(s)
- Ke Ding
- School of Psychology, Shenzhen University, Shenzhen 518060, China
| | - Miao Xu
- Beijing Key Laboratory of Applied Experimental Psychology, Faculty of Psychology, Beijing Normal University, Beijing, China; State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China
| | - Taicheng Huang
- Department of Psychology and Tsinghua Laboratory of Brain and Intelligence, Tsinghua University, Beijing 100084, China
| | - Yiying Song
- Beijing Key Laboratory of Applied Experimental Psychology, Faculty of Psychology, Beijing Normal University, Beijing, China; State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China
| | - Feng Kong
- School of Psychology, Shaanxi Normal University, Xi'an 710119, China
| | - Zonglei Zhen
- Beijing Key Laboratory of Applied Experimental Psychology, Faculty of Psychology, Beijing Normal University, Beijing, China; State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China
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LaVarco A, Ahmad N, Archer Q, Pardillo M, Nunez Castaneda R, Minervini A, Keenan JP. Self-Conscious Emotions and the Right Fronto-Temporal and Right Temporal Parietal Junction. Brain Sci 2022; 12:brainsci12020138. [PMID: 35203902 PMCID: PMC8869976 DOI: 10.3390/brainsci12020138] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/20/2021] [Revised: 01/17/2022] [Accepted: 01/18/2022] [Indexed: 02/04/2023] Open
Abstract
For more than two decades, research focusing on both clinical and non-clinical populations has suggested a key role for specific regions in the regulation of self-conscious emotions. It is speculated that both the expression and the interpretation of self-conscious emotions are critical in humans for action planning and response, communication, learning, parenting, and most social encounters. Empathy, Guilt, Jealousy, Shame, and Pride are all categorized as self-conscious emotions, all of which are crucial components to one’s sense of self. There has been an abundance of evidence pointing to the right Fronto-Temporal involvement in the integration of cognitive processes underlying the expression of these emotions. Numerous regions within the right hemisphere have been identified including the right temporal parietal junction (rTPJ), the orbitofrontal cortex (OFC), and the inferior parietal lobule (IPL). In this review, we aim to investigate patient cases, in addition to clinical and non-clinical studies. We also aim to highlight these specific brain regions pivotal to the right hemispheric dominance observed in the neural correlates of such self-conscious emotions and provide the potential role that self-conscious emotions play in evolution.
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Göttlich M, Buades-Rotger M, Wiechert J, Beyer F, Krämer UM. Structural covariance of amygdala subregions is associated with trait aggression and endogenous testosterone in healthy individuals. Neuropsychologia 2021; 165:108113. [PMID: 34896406 DOI: 10.1016/j.neuropsychologia.2021.108113] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/26/2021] [Accepted: 12/06/2021] [Indexed: 12/30/2022]
Abstract
Many studies point toward volume reductions in the amygdala as a potential neurostructural marker for trait aggression. However, most of these findings stem from clinical samples, rendering unclear whether the findings generalize to non-clinical populations. Furthermore, the notion of neural networks suggests that interregional correlations in gray matter volume (i.e., structural covariance) can explain individual differences in aggressive behavior beyond local univariate associations. Here, we tested whether structural covariance between amygdala subregions and the rest of the brain is associated with self-reported aggression in a large sample of healthy young students (n = 263; 49% women). Salivary testosterone concentrations were measured for a subset of n = 40 male and n = 36 female subjects, allowing us to investigate the influence of endogenous testosterone on structural covariance. Aggressive individuals showed enhanced covariance between left superficial amygdala (SFA) and left dorsal anterior insula (dAI), but lower covariance between right laterobasal amygdala (LBA) and right dorsolateral prefrontal cortex (dlPFC). These structural patterns overlap with functional networks involved in the genesis and regulation of aggressive behavior, respectively. With increasing endogenous testosterone, we observed stronger structural covariance between right centromedial amygdala (CMA) and right medial prefrontal cortex in men and between left CMA and bilateral orbitofrontal cortex in women. These results speak for structural covariance of amygdala subregions as a robust correlate of trait aggression in healthy individuals. Moreover, regions that showed structural covariance with the amygdala modulated by either testosterone or aggression did not overlap, suggesting a complex role of testosterone in human social behavior beyond facilitating aggressiveness.
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Affiliation(s)
- Martin Göttlich
- Department of Neurology, University Clinic of Lübeck, Lübeck, Germany; Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany
| | - Macià Buades-Rotger
- Department of Neurology, University Clinic of Lübeck, Lübeck, Germany; Department of Psychology, University of Lübeck, Lübeck, Germany; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands
| | - Juliana Wiechert
- Department of Neurology, University Clinic of Lübeck, Lübeck, Germany
| | - Frederike Beyer
- Psychology Department, Queen Mary University, London, United Kingdom
| | - Ulrike M Krämer
- Department of Neurology, University Clinic of Lübeck, Lübeck, Germany; Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany; Department of Psychology, University of Lübeck, Lübeck, Germany.
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6
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Purcell JB, Goodman AM, Harnett NG, Davis ES, Wheelock MD, Mrug S, Elliott MN, Emery ST, Schuster MA, Knight DC. Stress-elicited neural activity in young adults varies with childhood sexual abuse. Cortex 2021; 137:108-123. [PMID: 33609897 PMCID: PMC8044018 DOI: 10.1016/j.cortex.2020.12.020] [Citation(s) in RCA: 8] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/10/2020] [Revised: 10/25/2020] [Accepted: 12/18/2020] [Indexed: 01/17/2023]
Abstract
OBJECTIVE Childhood physical and sexual abuse are stressful experiences that may alter the emotional response to future stressors. Stress-related emotional function is supported by brain regions that include the prefrontal cortex (PFC), hippocampus, and amygdala. The present study investigated whether childhood physical and sexual abuse are associated with stress-elicited brain activity in young adulthood. METHODS Participants (N = 300; Mage = 20.0; 151 female) completed a psychosocial stress task during functional magnetic resonance imaging (fMRI). Measures of physical and sexual abuse were included in a linear mixed effects model to estimate the unique relationship each type of childhood abuse had with stress-elicited brain activity. RESULTS Stress-elicited dorsolateral PFC, ventromedial PFC, and hippocampal activity decreased as the frequency of childhood sexual abuse increased. There were no regions in which stress-elicited activation varied with physical abuse. CONCLUSIONS The present findings suggest there is a unique relationship between childhood sexual abuse and the stress-elicited PFC and hippocampal activity of young adults that is not observed following childhood physical abuse. SIGNIFICANCE These findings may have important implications for understanding the mechanisms by which childhood sexual abuse impacts the development of future psychopathology.
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Affiliation(s)
- Juliann B Purcell
- University of Alabama at Birmingham, Department of Psychology, Birmingham, AL, USA.
| | - Adam M Goodman
- University of Alabama at Birmingham, Department of Psychology, Birmingham, AL, USA.
| | - Nathaniel G Harnett
- University of Alabama at Birmingham, Department of Psychology, Birmingham, AL, USA.
| | - Elizabeth S Davis
- University of Alabama at Birmingham, Department of Psychology, Birmingham, AL, USA.
| | - Muriah D Wheelock
- University of Alabama at Birmingham, Department of Psychology, Birmingham, AL, USA.
| | - Sylvie Mrug
- University of Alabama at Birmingham, Department of Psychology, Birmingham, AL, USA.
| | | | - Susan Tortolero Emery
- The University of Texas Health Science Center at Houston (UTHealth) School of Public Health, Houston, TX, USA.
| | - Mark A Schuster
- Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
| | - David C Knight
- University of Alabama at Birmingham, Department of Psychology, Birmingham, AL, USA.
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Ge R, Liu X, Long D, Frangou S, Vila-Rodriguez F. Sex effects on cortical morphological networks in healthy young adults. Neuroimage 2021; 233:117945. [PMID: 33711482 DOI: 10.1016/j.neuroimage.2021.117945] [Citation(s) in RCA: 10] [Impact Index Per Article: 2.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/09/2020] [Revised: 02/17/2021] [Accepted: 03/03/2021] [Indexed: 12/30/2022] Open
Abstract
Understanding sex-related differences across the human cerebral cortex is an important step in elucidating the basis of psychological, behavioural and clinical differences between the sexes. Prior structural neuroimaging studies primarily focused on regional sex differences using univariate analyses. Here we focus on sex differences in cortical morphological networks (CMNs) derived using multivariate modelling of regional cortical measures of volume and surface from high-quality structural MRI scans from healthy participants in the Human Connectome Project (HCP) (n = 1,063) and the Southwest University Longitudinal Imaging Multimodal (SLIM) study (n = 549). The functional relevance of the CMNs was inferred using the NeuroSynth decoding function. Sex differences were widespread but not uniform. In general, females had higher volume, thickness and cortical folding in networks that involve prefrontal (both ventral and dorsal regions including the anterior cingulate) and parietal regions while males had higher volume, thickness and cortical folding in networks that primarily include temporal and posterior cortical regions. CMN loading coefficients were used as input features to linear discriminant analyses that were performed separately in the HCP and SLIM; sex was predicted with a high degree of accuracy (81%-85%) across datasets. The availability of behavioral data in the HCP enabled us to show that male-biased surface-based CMNs were associated with externalizing behaviors. These results extend previous literature on regional sex-differences by identifying CMNs that can reliably predict sex, are relevant to the expression of psychopathology and provide the foundation for the future investigation of their functional significance in clinical populations.
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Affiliation(s)
- Ruiyang Ge
- Non-Invasive Neurostimulation Therapies Laboratory, Department of Psychiatry, University of British Columbia, BC, Canada
| | - Xiang Liu
- Non-Invasive Neurostimulation Therapies Laboratory, Department of Psychiatry, University of British Columbia, BC, Canada
| | - David Long
- Non-Invasive Neurostimulation Therapies Laboratory, Department of Psychiatry, University of British Columbia, BC, Canada
| | - Sophia Frangou
- Department of Psychiatry, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, BC, Canada; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
| | - Fidel Vila-Rodriguez
- Non-Invasive Neurostimulation Therapies Laboratory, Department of Psychiatry, University of British Columbia, BC, Canada.
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Jiang W, Zhang H, Zeng L, Shen H, Qin J, Thung K, Yap P, Liu H, Hu D, Wang W, Shen D. Dynamic neural circuit disruptions associated with antisocial behaviors. Hum Brain Mapp 2021; 42:329-344. [PMID: 33064332 PMCID: PMC7776000 DOI: 10.1002/hbm.25225] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/11/2019] [Revised: 08/28/2020] [Accepted: 09/22/2020] [Indexed: 12/14/2022] Open
Abstract
Antisocial behavior (ASB) is believed to have neural substrates; however, the association between ASB and functional brain networks remains unclear. The temporal variability of the functional connectivity (or dynamic FC) derived from resting-state functional MRI has been suggested as a useful metric for studying abnormal behaviors including ASB. This is the first study using low-frequency fluctuations of the dynamic FC to unravel potential system-level neural correlates with ASB. Specifically, we individually associated the dynamic FC patterns with the ASB scores (measured by Antisocial Process Screening Device) of the male offenders (age: 23.29 ± 3.36 years) based on machine learning. Results showed that the dynamic FCs were associated with individual ASB scores. Moreover, we found that it was mainly the inter-network dynamic FCs that were negatively associated with the ASB severity. Three major high-order cognitive functional networks and the sensorimotor network were found to be more associated with ASB. We further found that impaired behavior in the ASB subjects was mainly associated with decreased FC dynamics in these networks, which may explain why ASB subjects usually have impaired executive control and emotional processing functions. Our study shows that temporal variation of the FC could be a promising tool for ASB assessment, treatment, and prevention.
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Affiliation(s)
- Weixiong Jiang
- Department of Radiology and BRICUniversity of North Carolina at Chapel HillChapel HillNorth CarolinaUSA
- Department of Information Science and EngineeringHunan First Normal UniversityChangshaHunanChina
| | - Han Zhang
- Department of Radiology and BRICUniversity of North Carolina at Chapel HillChapel HillNorth CarolinaUSA
| | - Ling‐Li Zeng
- College of Intelligence Science and TechnologyNational University of Defense TechnologyChangshaHunanChina
| | - Hui Shen
- College of Intelligence Science and TechnologyNational University of Defense TechnologyChangshaHunanChina
| | - Jian Qin
- College of Intelligence Science and TechnologyNational University of Defense TechnologyChangshaHunanChina
| | - Kim‐Han Thung
- Department of Radiology and BRICUniversity of North Carolina at Chapel HillChapel HillNorth CarolinaUSA
| | - Pew‐Thian Yap
- Department of Radiology and BRICUniversity of North Carolina at Chapel HillChapel HillNorth CarolinaUSA
| | - Huasheng Liu
- Department of Radiology, The Third Xiangya HospitalCentral South UniversityChangshaHunanChina
| | - Dewen Hu
- College of Intelligence Science and TechnologyNational University of Defense TechnologyChangshaHunanChina
| | - Wei Wang
- Department of Radiology, The Third Xiangya HospitalCentral South UniversityChangshaHunanChina
| | - Dinggang Shen
- Department of Radiology and BRICUniversity of North Carolina at Chapel HillChapel HillNorth CarolinaUSA
- Department of Artificial IntelligenceKorea UniversitySeoulSouth Korea
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Chaarani B, Kan KJ, Mackey S, Spechler PA, Potter A, Banaschewski T, Millenet S, Bokde ALW, Bromberg U, Büchel C, Cattrell A, Conrod PJ, Desrivières S, Flor H, Frouin V, Gallinat J, Gowland P, Heinz A, Ittermann B, Martinot JL, Nees F, Paus T, Poustka L, Smolka MN, Walter H, Whelan R, Stringaris A, Higgins ST, Schumann G, Garavan H, Althoff RR. Neural Correlates of Adolescent Irritability and Its Comorbidity With Psychiatric Disorders. J Am Acad Child Adolesc Psychiatry 2020; 59:1371-1379. [PMID: 32860907 DOI: 10.1016/j.jaac.2019.11.028] [Citation(s) in RCA: 26] [Impact Index Per Article: 5.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/15/2018] [Revised: 11/07/2019] [Accepted: 08/19/2020] [Indexed: 12/21/2022]
Abstract
OBJECTIVE Irritable mood, a common and impairing symptom in psychopathology, has been proposed to underlie the developmental link between oppositional problems in youth and depression in adulthood. We examined the neural correlates of adolescent irritability in IMAGEN, a sample of 2,024 14-year-old adolescents from 5 European countries. METHOD The Development and Well-Being Assessment (DAWBA) was used to assess attention-deficit/hyperactivity disorder, major depressive disorder, oppositional defiant disorder, and generalized anxiety disorder. Three items from the DAWBA, selected as close matches to the Affective Reactivity Index, were used to assess irritability. Structural magnetic resonance imaging was examined using whole-brain voxel-based morphometry analysis, and functional magnetic resonance imaging was examined during a stop signal task of inhibitory control. Imaging data were included in structural equation models to examine the direct and indirect associations between irritable mood and comorbid DSM diagnoses. RESULTS Whole-brain voxelwise analysis showed that adolescent irritable mood was associated with less gray matter volume and less neural activation underlying inhibitory control in frontal and temporal cortical areas (cluster-correction at p < .05). Structural equation models suggested that part of the observed smaller gray matter volume was exclusively driven by irritability separate from direct relationships between generalized anxiety disorder (or attention-deficit/hyperactivity disorder, major depressive disorder, or oppositional defiant disorder) and gray matter volume. CONCLUSION This study identifies adolescent irritability as an independent construct and points to a neurobiological correlate to irritability that is an important contributing feature to many psychopathological disorders.
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Affiliation(s)
- Bader Chaarani
- Vermont Center on Behavior and Health, University of Vermont, Burlington.
| | - Kees-Jan Kan
- Vermont Center on Behavior and Health, University of Vermont, Burlington
| | - Scott Mackey
- Vermont Center on Behavior and Health, University of Vermont, Burlington
| | - Philip A Spechler
- Vermont Center on Behavior and Health, University of Vermont, Burlington
| | - Alexandra Potter
- Vermont Center on Behavior and Health, University of Vermont, Burlington
| | - Tobias Banaschewski
- Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
| | - Sabina Millenet
- Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
| | - Arun L W Bokde
- Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neurosciences, Trinity College Dublin, Ireland
| | - Uli Bromberg
- University Medical Centre Hamburg-Eppendorf, Hamburg, Germany
| | | | - Anna Cattrell
- Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK
| | - Patricia J Conrod
- Université de Montreal, CHU Ste Justine Hospital, Canada; Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK
| | - Sylvane Desrivières
- Medical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK
| | - Herta Flor
- Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; School of Social Sciences, University of Mannheim, Germany
| | - Vincent Frouin
- Neurospin, Commissariat à l'Energie Atomique, CEA-Saclay Center, Paris, France
| | - Jürgen Gallinat
- University Medical Centre Hamburg-Eppendorf, Hamburg, Germany
| | - Penny Gowland
- Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK
| | - Andreas Heinz
- Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany
| | - Bernd Ittermann
- Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany
| | - Jean-Luc Martinot
- Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry," University Paris Sud, University Paris Descartes-Sorbonne Paris Cité and Maison de Solenn, Paris, France
| | - Frauke Nees
- Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; School of Social Sciences, University of Mannheim, Germany
| | - Tomáš Paus
- Rotman Research Institute, University of Toronto, Ontario, Canada
| | - Luise Poustka
- Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Medical University of Vienna, Austria
| | | | - Henrik Walter
- Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany
| | | | - Argyris Stringaris
- Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK
| | - Stephen T Higgins
- Vermont Center on Behavior and Health, University of Vermont, Burlington
| | | | - Hugh Garavan
- Vermont Center on Behavior and Health, University of Vermont, Burlington
| | - Robert R Althoff
- Vermont Center on Behavior and Health, University of Vermont, Burlington
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- Université de Montreal, CHU Ste Justine Hospital, Canada
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10
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Schoenmacker GH, Sakala K, Franke B, Buitelaar JK, Veidebaum T, Harro J, Heskes T, Claassen T, Alejandro AV. Identification and validation of risk factors for antisocial behaviour involving police. Psychiatry Res 2020; 291:113208. [PMID: 32563746 DOI: 10.1016/j.psychres.2020.113208] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/05/2020] [Revised: 06/03/2020] [Accepted: 06/05/2020] [Indexed: 01/12/2023]
Abstract
Adult antisocial behaviour has precursors in childhood and adolescence and is most successfully treated using childhood interventions. The aim of this study was to identify and validate robust risk factors for antisocial behaviour involving police contact in a data-driven, hypothesis-free framework. Antisocial behavior involving police contact (20/25% incidence) as well as 554 other behavioural and environmental measures were assessed in the longitudinal general population Estonian Children Personality Behaviour and Health Study sample (n=872). The strongest risk factors for antisocial behaviour included past substance use disorder, gender, aggressive mode of action upon provocation, and concentration difficulties and physical fighting in school at age 15 years. Prediction using the selected variables for both methods in the other, unseen cohort resulted in an area under the receiver operating characteristics curve of 0.78-0.84. Our work confirms known risk factors for antisocial behaviour as well as identifies novel specific risk factors. Together, these provide good predictive power in an unseen cohort. Our identification and validation of risk factors for antisocial behaviour can aid early intervention for at-risk individuals.
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Affiliation(s)
- Gido H Schoenmacker
- Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Geert Grooteplein Zuid 10, Route 836, room 4.84, Nijmegen 6525, GA, the Netherlands; Faculty of Science, Radboud University, Nijmegen, the Netherlands.
| | - Katre Sakala
- Department of Chronic Diseases, National Institute for Health Development, Tallinn, Estonia; Department Family Medicine and Public Health, University of Tartu, Tartu, Estonia; School of Natural Sciences and Health, Tallinn University, Tallinn, Estonia
| | - Barbara Franke
- Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Geert Grooteplein Zuid 10, Route 836, room 4.84, Nijmegen 6525, GA, the Netherlands
| | - Jan K Buitelaar
- Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Geert Grooteplein Zuid 10, Route 836, room 4.84, Nijmegen 6525, GA, the Netherlands; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands; Karakter Child and Adolescent Psychiatry University Centre, Radboud University Medical Centre, Nijmegen, the Netherlands
| | - Toomas Veidebaum
- Department of Chronic Diseases, National Institute for Health Development, Tallinn, Estonia
| | - Jaanus Harro
- Division of Neuropsychopharmacology, Department of Psychology, University of Tartu, Tartu, Estonia
| | - Tom Heskes
- Faculty of Science, Radboud University, Nijmegen, the Netherlands
| | - Tom Claassen
- Faculty of Science, Radboud University, Nijmegen, the Netherlands
| | - Arias Vásquez Alejandro
- Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Geert Grooteplein Zuid 10, Route 836, room 4.84, Nijmegen 6525, GA, the Netherlands
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11
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Hodgins S. Sex differences in antisocial and aggressive disorders that onset in childhood and persist into adulthood. HANDBOOK OF CLINICAL NEUROLOGY 2020; 175:405-422. [PMID: 33008540 DOI: 10.1016/b978-0-444-64123-6.00027-8] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 12/14/2022]
Abstract
As many as 10.7% of males and 7.5% of females display early-onset, stable, antisocial and aggressive behavior (ESAAB). Most research has focused on males. These individuals are diagnosed with conduct disorder in childhood and antisocial personality disorder in adulthood, and a very few, almost all males, present the syndrome of psychopathy. ESAAB includes three subgroups: (1) conduct problems and callousness; (2) conduct problems, callousness, and anxiety; and (3) conduct problems. Heritability of the first two subtypes is high. This high heritability derives, at least in part, from genes involved in regulating serotonergic functioning early in life and to genotypes that confer sensitivity to trauma. The first subtype is rare and characterized by difficulty in face emotion recognition, especially fear and sadness, and hypoarousal as indexed by both autonomic and neural measures, and by structural brain abnormalities. By contrast, those with conduct problems, callousness, and anxiety are more common. They include a greater proportion of females and show hypersensitivity to threat that triggers reactive aggression and that is reflected in both autonomic and neural functioning. In sum, fewer females than males present ESAAB, but many characteristics, autonomic and neural correlates, and etiology are similar. Importantly, however, females with ESAAB play a critical role in the intergenerational transfer of antisocial behavior. Despite higher prevalence of EASSB in males than females, few sex differences in neural abnormalities have been identified.
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Affiliation(s)
- Sheilagh Hodgins
- Institut Universitaire en Santé Mentale de Montréal, and Department of Psychiatry, University of Montreal, Montréal, QC, Canada.
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12
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Huang Y, Wu T, Gao Y, Luo Y, Wu Z, Fagan S, Leung S, Li X. The Impact of Callous-Unemotional Traits and Externalizing Tendencies on Neural Responsivity to Reward and Punishment in Healthy Adolescents. Front Neurosci 2019; 13:1319. [PMID: 31920489 PMCID: PMC6923186 DOI: 10.3389/fnins.2019.01319] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/14/2019] [Accepted: 11/25/2019] [Indexed: 12/15/2022] Open
Abstract
Both externalizing behavior and callous-unemotional (CU) traits in youth are precursors to later criminal offending in adulthood. It is posited that disruptions in reward and punishment processes may engender problematic behavior, such that CU traits and externalizing behavior may be linked to a dominant reward response style (e.g., heightened responsivity to rewards) and deficient punishment-processing. However, prior research has generated mixed findings and work examining both the sole and joint contribution of CU traits and externalizing problems related to functional brain alterations is lacking. In this pilot functional magnetic resonance imaging study, we measured externalizing behavior and CU traits in a community sample of adolescents (n = 29) and examined their impacts on brain activity associated with anticipation and receipt of reward and punishment using the Modified Monetary Incentive Delay task. We found that CU traits were associated with greater activation of the ventral striatum (VST) during reward anticipation. However, this effect became non-significant after controlling for externalizing behavior, indicating substantial overlap between the CU and externalizing measures in explaining VST activation when anticipating reward. In addition, externalizing behavior (but not CU) was significantly negatively associated with amygdala activation during punishment receipt, even after controlling for CU traits. The present findings extend previous evidence of hyper-responsivity to reward and hypo-responsivity to punishment in relation to psychopathic traits and antisocial behavior to non-clinical, non-incarcerated youths.
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Affiliation(s)
- Yonglin Huang
- Department of Psychology, Brooklyn College, The City University of New York, Brooklyn, NY, United States
- Department of Psychology, Queens College, The City University of New York, Queens, NY, United States
- The Graduate Center, The City University of New York, New York, NY, United States
| | - Tingting Wu
- Department of Psychology, Brooklyn College, The City University of New York, Brooklyn, NY, United States
- Department of Psychology, Queens College, The City University of New York, Queens, NY, United States
| | - Yu Gao
- Department of Psychology, Brooklyn College, The City University of New York, Brooklyn, NY, United States
- The Graduate Center, The City University of New York, New York, NY, United States
| | - Yuyang Luo
- Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, United States
| | - Ziyan Wu
- Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, United States
| | - Shawn Fagan
- Department of Psychology, Brooklyn College, The City University of New York, Brooklyn, NY, United States
- The Graduate Center, The City University of New York, New York, NY, United States
| | - Stephanie Leung
- Department of Psychology, Pace University, New York, NY, United States
| | - Xiaobo Li
- Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, United States
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13
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Perino MT, Guassi Moreira JF, Telzer EH. Links between adolescent bullying and neural activation to viewing social exclusion. COGNITIVE, AFFECTIVE & BEHAVIORAL NEUROSCIENCE 2019; 19:1467-1478. [PMID: 31292887 PMCID: PMC6864266 DOI: 10.3758/s13415-019-00739-7] [Citation(s) in RCA: 9] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 01/10/2023]
Abstract
Neuroscientists who have studied bullying have primarily focused on the psychopathology of diagnosable offenders or the resulting symptomatology of victimization. Less attention has been given to theories that suggest that bullying may be an interpersonal strategy. In an exploratory study, we recruited a sample of adolescents (N = 24) who engaged in high rates of delinquent behavior and collected self-report ratings of bullying behaviors. During an fMRI scan, adolescents observed instances of social exclusion and social inclusion. The adolescents' self-reported bullying was associated with greater ventral striatum, amygdala, medial prefrontal cortex, and insula activation when viewing social exclusion > social inclusion. Activation in these regions is commonly associated with reward-learning, salience monitoring, and motivational processes, suggesting that bullies show altered processing of interpersonal cues and social dynamic experiences in their environment. Our findings highlight the need for developmental neuroscientists to further explore the role of social motivation in processing socio-affective information, with a particular focus on goal-directed antisocial behavior.
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Affiliation(s)
- Michael T Perino
- Department of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO, USA
| | - João F Guassi Moreira
- Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA
| | - Eva H Telzer
- Department of Psychology & Neuroscience, University of North Carolina, Chapel-Hill, 235 E Cameron Avenue, Room 213D, Chapel Hill, NC, 27599, USA.
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14
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Edwards BG, Carre JR, Kiehl KA. A review of psychopathy and Cluster B personality traits and their neural correlates in female offenders. Biol Psychol 2019; 148:107740. [PMID: 31415792 DOI: 10.1016/j.biopsycho.2019.107740] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/02/2019] [Revised: 07/02/2019] [Accepted: 08/08/2019] [Indexed: 01/24/2023]
Abstract
Although men commit more crime and are incarcerated at higher rates than women, women represent the fastest growing segment of the justice system. Empirical work suggests that psychopathy and Cluster B disorders are implicated in antisocial behavior across gender, and that neurobiological correlates of personality may inform such behavior. This review utilizes a gendered perspective to discuss psychopathy and Cluster B disorders in relation to antisocial behavior and incorporates work on neural correlates of personality disorders. Co-morbidity across these conditions may be partly explained by similar frontal deficits, reflective of disinhibition. Affective processing abnormalities appear to be characterized by distinct deficits in limbic/paralimbic regions, reflecting differential etiological underpinnings and behavioral outcomes. This review underscores the utility in examining personality pathology together with neurobiological and environmental factors. Methodological issues and clinical implications are also discussed.
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Affiliation(s)
- Bethany G Edwards
- The Mind Research Network and Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico, United States; University of New Mexico, Albuquerque, New Mexico, United States.
| | - Jessica R Carre
- The Mind Research Network and Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico, United States
| | - Kent A Kiehl
- The Mind Research Network and Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico, United States; University of New Mexico, Albuquerque, New Mexico, United States
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15
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Psychopathy and Intelligence: A Study on Male Not Guilty by Reason of Insanity (NGRI) Acquittees. JOURNAL OF PSYCHOPATHOLOGY AND BEHAVIORAL ASSESSMENT 2019. [DOI: 10.1007/s10862-019-09751-0] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/26/2022]
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16
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Stam D, Huang YA, Van den Stock J. Non-overlapping and Inverse Associations Between the Sexes in Structural Brain-Trait Associations. Front Psychol 2019; 10:904. [PMID: 31105624 PMCID: PMC6491880 DOI: 10.3389/fpsyg.2019.00904] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/30/2018] [Accepted: 04/04/2019] [Indexed: 01/03/2023] Open
Abstract
Personality reflects the set of psychological traits and mechanisms characteristic for an individual. The brain-trait association between personality and gray matter volume (GMv) has been well studied. However, a recent study has shown that brain structure-personality relationships are highly dependent on sex. In addition, the present study investigates the role of sex on the association between temperaments and regional GMv. Sixty-six participants (33 male) completed the Temperament and Character Inventory (TCI) and underwent structural magnetic resonance brain imaging. Mann-Whitney U tests showed a significant higher score on Novelty Seeking (NS) and Reward Dependence (RD) for females, but no significant group effects were found for Harm Avoidance (HA) and Persistence (P) score. Full factor model analyses were performed to investigate sex-temperament interaction effects on GMv. This revealed increased GMv for females in the superior temporal gyrus when linked to NS, middle temporal gyrus for HA, and the insula for RD. Males displayed increased GMv compared to females relating to P in the posterior cingulate gyrus, the medial superior frontal gyrus, and the middle cingulate gyrus, compared to females. Multiple regression analysis showed clear differences between the brain regions that correlate with female subjects and the brain correlates that correlate with male subjects. No overlap was observed between sex-specific brain-trait associations. These results increase the knowledge of the role of sex on the structural neurobiology of personality and indicate that sex differences reflect structural differences observed in the normal brain. Furthermore, sex hormones seem an important underlying factor for the found sex differences in brain-trait associations. The present study indicates an important role for sex in these brain structure-personality relationships, and implies that sex should not just be added as a covariate of no interest.
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Affiliation(s)
- Daphne Stam
- Laboratory for Translational Neuropsychiatry, Department of Neurosciences, KU Leuven, Leuven, Belgium
| | - Yun-An Huang
- Laboratory for Translational Neuropsychiatry, Department of Neurosciences, KU Leuven, Leuven, Belgium
| | - Jan Van den Stock
- Laboratory for Translational Neuropsychiatry, Department of Neurosciences, KU Leuven, Leuven, Belgium.,Geriatric Psychiatry, University Psychiatric Center KU Leuven, Leuven, Belgium.,Brain and Emotion Laboratory, Maastricht University, Maastricht, Netherlands
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17
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Pujol J, Harrison BJ, Contreras-Rodriguez O, Cardoner N. The contribution of brain imaging to the understanding of psychopathy. Psychol Med 2019; 49:20-31. [PMID: 30207255 DOI: 10.1017/s0033291718002507] [Citation(s) in RCA: 21] [Impact Index Per Article: 3.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 12/28/2022]
Abstract
Psychopathy is a personality type characterized by both callous emotional dysfunction and deviant behavior that affects society in the form of actions that harm others. Historically, researchers have been concerned with seeking data and arguments to support a neurobiological foundation of psychopathy. In the past few years, increasing research has begun to reveal brain alterations putatively underlying the enigmatic psychopathic personality. In this review, we describe the brain anatomical and functional features that characterize psychopathy from a synthesis of available neuroimaging research and discuss how such brain anomalies may account for psychopathic behavior. The results are consistent in showing anatomical alterations involving primarily a ventral system connecting the anterior temporal lobe to anterior and ventral frontal areas, and a dorsal system connecting the medial frontal lobe to the posterior cingulate cortex/precuneus complex and, in turn, to medial structures of the temporal lobe. Functional imaging data indicate that relevant emotional flow breakdown may occur in both these brain systems and suggest specific mechanisms via which emotion is anomalously integrated into cognition in psychopathic individuals during moral challenge. Directions for future research are delineated emphasizing, for instance, the relevance of further establishing the contribution of early life stress to a learned blockage of emotional self-exposure, and the potential role of androgenic hormones in the development of cortical anomalies.
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Affiliation(s)
- Jesus Pujol
- MRI Research Unit, Department of Radiology,Hospital del Mar,CIBERSAM G21, Barcelona,Spain
| | - Ben J Harrison
- Department of Psychiatry,Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health,Melbourne,Australia
| | - Oren Contreras-Rodriguez
- Psychiatry Department,Bellvitge University Hospital, Bellvitge Biomedical Research Institute-IDIBELL,CIBERSAM G17, Barcelona,Spain
| | - Narcis Cardoner
- Department of Mental Health, Corporació Sanitaria Parc Taulí, Sabadell, and Department of Psychiatry,Autonomous University of Barcelona,Barcelona,Spain
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18
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Johanson M, Vaurio O, Tiihonen J, Lähteenvuo M. A Systematic Literature Review of Neuroimaging of Psychopathic Traits. Front Psychiatry 2019; 10:1027. [PMID: 32116828 PMCID: PMC7016047 DOI: 10.3389/fpsyt.2019.01027] [Citation(s) in RCA: 37] [Impact Index Per Article: 6.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/12/2019] [Accepted: 12/30/2019] [Indexed: 12/19/2022] Open
Abstract
INTRODUCTION Core psychopathy is characterized by grandiosity, callousness, manipulativeness, and lack of remorse, empathy, and guilt. It is often comorbid with conduct disorder and antisocial personality disorder (ASPD). Psychopathy is present in forensic as well as prison and general populations. In recent years, an increasing amount of neuroimaging studies has been conducted in order to elucidate the obscure neurobiological etiology of psychopathy. The studies have yielded heterogenous results, and no consensus has been reached. AIMS This study systematically reviewed and qualitatively summarized functional and structural neuroimaging studies conducted on individuals with psychopathic traits. Furthermore, this study aimed to evaluate whether the findings from different MRI modalities could be reconciled from a neuroanatomical perspective. MATERIALS AND METHODS After the search and auditing processes, 118 neuroimaging studies were included in this systematic literature review. The studies consisted of structural, functional, and diffusion tensor MRI studies. RESULTS Psychopathy was associated with numerous neuroanatomical abnormalities. Structurally, gray matter anomalies were seen in frontotemporal, cerebellar, limbic, and paralimbic regions. Associated gray matter volume (GMV) reductions were most pronounced particularly in most of the prefrontal cortex, and temporal gyri including the fusiform gyrus. Also decreased GMV of the amygdalae and hippocampi as well the cingulate and insular cortices were associated with psychopathy, as well as abnormal morphology of the hippocampi, amygdala, and nucleus accumbens. Functionally, psychopathy was associated with dysfunction of the default mode network, which was also linked to poor moral judgment as well as deficient metacognitive and introspective abilities. Second, reduced white matter integrity in the uncinate fasciculus and dorsal cingulum were associated with core psychopathy. Third, emotional detachment was associated with dysfunction of the posterior cerebellum, the human mirror neuron system and the Theory of Mind denoting lack of empathy and persistent failure in integrating affective information into cognition. CONCLUSIONS Structural and functional aberrancies involving the limbic and paralimbic systems including reduced integrity of the uncinate fasciculus appear to be associated with core psychopathic features. Furthermore, this review points towards the idea that ASPD and psychopathy might stem from divergent biological processes.
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Affiliation(s)
- Mika Johanson
- Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
| | - Olli Vaurio
- Department of Forensic Psychiatry, Niuvanniemi Hospital, Kuopio, Finland.,Department of Forensic Psychiatry, University of Eastern Finland, Kuopio, Finland
| | - Jari Tiihonen
- Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.,Department of Forensic Psychiatry, Niuvanniemi Hospital, Kuopio, Finland.,Department of Forensic Psychiatry, University of Eastern Finland, Kuopio, Finland
| | - Markku Lähteenvuo
- Department of Forensic Psychiatry, Niuvanniemi Hospital, Kuopio, Finland
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19
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20
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Anderson NE, Harenski KA, Harenski CL, Koenigs MR, Decety J, Calhoun VD, Kiehl KA. Machine learning of brain gray matter differentiates sex in a large forensic sample. Hum Brain Mapp 2018; 40:1496-1506. [PMID: 30430711 DOI: 10.1002/hbm.24462] [Citation(s) in RCA: 34] [Impact Index Per Article: 4.9] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/11/2018] [Revised: 09/05/2018] [Accepted: 10/27/2018] [Indexed: 12/31/2022] Open
Abstract
Differences between males and females have been extensively documented in biological, psychological, and behavioral domains. Among these, sex differences in the rate and typology of antisocial behavior remains one of the most conspicuous and enduring patterns among humans. However, the nature and extent of sexual dimorphism in the brain among antisocial populations remains mostly unexplored. Here, we seek to understand sex differences in brain structure between incarcerated males and females in a large sample (n = 1,300) using machine learning. We apply source-based morphometry, a contemporary multivariate approach for quantifying gray matter measured with magnetic resonance imaging, and carry these parcellations forward using machine learning to classify sex. Models using components of brain gray matter volume and concentration were able to differentiate between males and females with greater than 93% generalizable accuracy. Highly differentiated components include orbitofrontal and frontopolar regions, proportionally larger in females, and anterior medial temporal regions proportionally larger in males. We also provide a complimentary analysis of a nonforensic healthy control sample and replicate our 93% sex discrimination. These findings demonstrate that the brains of males and females are highly distinguishable. Understanding sex differences in the brain has implications for elucidating variability in the incidence and progression of disease, psychopathology, and differences in psychological traits and behavior. The reliability of these differences confirms the importance of sex as a moderator of individual differences in brain structure and suggests future research should consider sex specific models.
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Affiliation(s)
- Nathaniel E Anderson
- The Mind Research Network & Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico
| | - Keith A Harenski
- The Mind Research Network & Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico
| | - Carla L Harenski
- The Mind Research Network & Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico
| | | | | | - Vince D Calhoun
- The Mind Research Network & Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico.,University of New Mexico, Albuquerque, New Mexico
| | - Kent A Kiehl
- The Mind Research Network & Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico.,University of New Mexico, Albuquerque, New Mexico
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21
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Abstract
PURPOSE OF REVIEW This review aims to give an overview on the current literature on sex differences in personality disorders and to highlight the potential of dimensional approaches. RECENT FINDINGS Empirical findings on sex differences in personality disorders are inconsistent and appear to be highly dependent on study settings. Current studies have mainly focused on borderline and antisocial personality disorder and the question whether these are sex-specific representations of a common substrate. In general, sexes differ in the manifestation of personality disorders as well as in comorbidities. Criticism of the established categorical model led to an additional dimensional model of personality disorders in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. Investigations on sex differences in personality disorders are sparse and mainly limited to antisocial and borderline personality disorder. The introduction of a dimensional model offers the chance to re-think the construct of "personality disorder" and thereby also opens the possibility for a better understanding of sex differences.
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22
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Brain structure abnormalities in young women who presented conduct disorder in childhood/adolescence. COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE 2018; 17:869-885. [PMID: 28695488 PMCID: PMC5548815 DOI: 10.3758/s13415-017-0519-7] [Citation(s) in RCA: 16] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Indexed: 12/13/2022]
Abstract
The phenotype and genotype of antisocial behavior among females are different from those among males. Previous studies have documented structural brain alterations in males with antisocial behavior, yet little is known about the neural correlates of female antisocial behavior. The present study examined young women who had presented conduct disorder (CDW) prior to age 15 to determine whether brain abnormalities are present in adulthood and whether the observed abnormalities are associated with comorbid disorders or maltreatment that typically characterize this population. Using magnetic resonance imaging and voxel-based morphometry, we compared gray matter volumes (GMV) of 31 women who presented CD by midadolescence and 25 healthy women (HW), age, on average, 23 years. Participants completed structured, validated interviews to diagnose mental disorders, and validated questionnaires to document physical and sexual abuse. Relative to HW, CDW presented increased GMV in the left superior temporal gyrus that was associated with past alcohol and drug dependence, current use of alcohol and drugs, and current anxiety and depression symptoms and maltreatment. Additionally, CDW displayed reduced GMV in lingual gyrus, hippocampus, and anterior cingulate cortex that was associated with past comorbid disorders, current alcohol and drugs use, current anxiety and depression symptoms, and maltreatment. The CDW also presented reduced total GMV that was associated with past comorbid disorders and current anxiety/depression symptoms. Alterations of brain structure were observed among young adult females with prior CD, relative to HW, all of which were associated with internalizing and externalizing disorders and maltreatment that typically accompany CD.
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23
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Beckwith TJ, Dietrich KN, Wright JP, Altaye M, Cecil KM. Reduced regional volumes associated with total psychopathy scores in an adult population with childhood lead exposure. Neurotoxicology 2018; 67:1-26. [PMID: 29634994 PMCID: PMC6054826 DOI: 10.1016/j.neuro.2018.04.004] [Citation(s) in RCA: 15] [Impact Index Per Article: 2.1] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/02/2017] [Revised: 04/03/2018] [Accepted: 04/04/2018] [Indexed: 01/05/2023]
Abstract
Childhood lead exposure has been correlated to acts of delinquency and criminal behavior; however, little research has been conducted to examine its potential long term influence on behavioral factors such as personality, specifically psychopathic personality. Neuroimaging studies have demonstrated that the effects of childhood lead exposure persist into adulthood, with structural abnormalities found in gray and white matter regions involved in behavioral decision making. The current study examined whether measurements of adult psychopathy were associated with neuroanatomical differences in structural brain volumes for a longitudinal cohort with measured childhood lead exposure. We hypothesized that increased total psychopathy scores and increased blood lead concentration at 78 months of age (PbB78) would be inversely associated with volumetric measures of gray and white matter brain structures responsible for executive and emotional processing. Analyses did not display a direct effect between total psychopathy score and gray matter volume; however, reduced white matter volume in the cerebellum and brain stem in relation to increased total psychopathy scores was observed. An interaction between sex and total psychopathy score was also detected. Females displayed increased gray matter volume in the frontal, temporal, and parietal lobes associated with increased total psychopathy score, but did not display any white matter volume differences. Males primarily displayed reductions in frontal gray and white matter brain volume in relation to increased total psychopathy scores. Additionally, reduced gray and white matter volume was associated with increased blood lead levels in the frontal lobes; reduced white matter volume was also observed in the parietal and temporal lobes. Females demonstrated gray and white matter volume loss associated with increased PbB78 values in the right temporal lobe, as well as reduced gray matter volume in the frontal lobe. Males displayed reduced white matter volumes associated with increased PbB78 values in the frontal, temporal, and parietal lobes. Comparison of the two primary models revealed a volumetric decrease in the white matter of the left prefrontal cortex associated with increased total psychopathy scores and increased blood lead concentration in males. The results of this study suggested that increased psychopathy scores in this cohort may be attributable to the neuroanatomical abnormalities observed and that childhood lead exposure may be influential to these outcomes.
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Affiliation(s)
- Travis J Beckwith
- Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
| | - Kim N Dietrich
- Department of Environmental Health, Division of Epidemiology and Biostatistics, University of Cincinnati College of Medicine, Cincinnati, OH, United States
| | - John P Wright
- School of Criminal Justice, University of Cincinnati, Cincinnati, OH, United States
| | - Mekibib Altaye
- Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States
| | - Kim M Cecil
- Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States; Department of Environmental Health, Division of Epidemiology and Biostatistics, University of Cincinnati College of Medicine, Cincinnati, OH, United States; Department of Radiology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, United States
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24
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Ling S, Raine A, Gao Y, Schug R. The mediating role of emotional intelligence on the autonomic functioning - Psychopathy relationship. Biol Psychol 2018; 136:136-143. [PMID: 29879434 DOI: 10.1016/j.biopsycho.2018.05.012] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/18/2017] [Revised: 03/23/2018] [Accepted: 05/17/2018] [Indexed: 12/24/2022]
Abstract
Reduced autonomic activity is a risk factor for psychopathy, but the mechanisms underlying this association are under-researched. We hypothesize that emotional intelligence mediates this relationship. Emotional intelligence, cognitive intelligence, scores on the Psychopathy Checklist- Revised (PCL-R), skin conductance, and heart rate were assessed in 156 men from communities in Los Angeles. Emotional intelligence fully mediated the relationship between autonomic functioning and total psychopathy after controlling for cognitive intelligence for both autonomic measures. Full mediation was also found when using PCL-R factors and facets as outcome variables, with the exception of a partial mediation of the heart rate - Antisocial facet relationship. These findings are the first to document emotional intelligence as a mediator of the blunted physiological stress activity - psychopathy relationship, and are interpreted within the framework of the somatic marker and somatic aphasia theories of psychopathy. Possible implications for treatment interventions are also discussed.
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Affiliation(s)
- Shichun Ling
- Department of Criminology, 3718 Locust Walk, Suite 483, Philadelphia, PA, 19104, USA.
| | - Adrian Raine
- Departments of Criminology, Psychiatry, and Psychology, University of Pennsylvania, 3809 Walnut Street, Suite 204, Philadelphia, PA, 19104, USA.
| | - Yu Gao
- Department of Psychology, City University of New York - Brooklyn College, 5602C James Hall, Brooklyn, NY, 11210, USA.
| | - Robert Schug
- School of Criminology, Criminal Justice, and Emergency Management, California State University - Long Beach, 1250 Bellflower Blvd, Engineering Technology 250, Long Beach, CA, USA.
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25
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Affiliation(s)
- Adrian Raine
- Departments of Criminology, Psychiatry, and Psychology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
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26
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Ogundele MO. Behavioural and emotional disorders in childhood: A brief overview for paediatricians. World J Clin Pediatr 2018; 7:9-26. [PMID: 29456928 PMCID: PMC5803568 DOI: 10.5409/wjcp.v7.i1.9] [Citation(s) in RCA: 171] [Impact Index Per Article: 24.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/27/2017] [Revised: 11/30/2017] [Accepted: 12/05/2017] [Indexed: 02/06/2023] Open
Abstract
Mental health problems in children and adolescents include several types of emotional and behavioural disorders, including disruptive, depression, anxiety and pervasive developmental (autism) disorders, characterized as either internalizing or externalizing problems. Disruptive behavioural problems such as temper tantrums, attention deficit hyperactivity disorder, oppositional, defiant or conduct disorders are the commonest behavioural problems in preschool and school age children. The routine Paediatric clinic or Family Medicine/General Practitioner surgery presents with several desirable characteristics that make them ideal for providing effective mental health services to children and adolescents. DSM-5 and ICD-10 are the universally accepted standard criteria for the classification of mental and behaviour disorders in childhood and adults. The age and gender prevalence estimation of various childhood behavioural disorders are variable and difficult to compare worldwide. A review of relevant published literature was conducted, including published meta-analyses and national guidelines. We searched for articles indexed by Ovid, PubMed, PubMed Medical Central, CINAHL, EMBASE, Database of Abstracts and Reviews, and the Cochrane Database of Systematic reviews and other online sources. The searches were conducted using a combination of search expressions including "childhood", "behaviour", "disorders" or "problems". Childhood behaviour and emotional problems with their related disorders have significant negative impacts on the individual, the family and the society. They are commonly associated with poor academic, occupational, and psychosocial functioning. It is important for all healthcare professionals, especially the Paediatricians to be aware of the range of presentation, prevention and management of the common mental health problems in children and adolescents.
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Affiliation(s)
- Michael O Ogundele
- Department of Community Paediatrics, NHS Fife, Glenwood Health Centre, Glenrothes KY6 1HK, United Kingdom
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27
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Lam BYH, Yang Y, Schug RA, Han C, Liu J, Lee TMC. Psychopathy Moderates the Relationship between Orbitofrontal and Striatal Alterations and Violence: The Investigation of Individuals Accused of Homicide. Front Hum Neurosci 2017; 11:579. [PMID: 29249948 PMCID: PMC5717542 DOI: 10.3389/fnhum.2017.00579] [Citation(s) in RCA: 9] [Impact Index Per Article: 1.1] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/05/2017] [Accepted: 11/16/2017] [Indexed: 11/29/2022] Open
Abstract
Brain structural abnormalities in the orbitofrontal cortex (OFC) and striatum (caudate and putamen) have been observed in violent individuals. However, a uni-modal neuroimaging perspective has been used and prior findings have been mixed. The present study takes the multimodal structural brain imaging approaches to investigate the differential gray matter volumes (GMV) and cortical thickness (CTh) in the OFC and striatum between violent (accused of homicide) and non-violent (not accused of any violent crimes) individuals with different levels of psychopathic traits (interpersonal and unemotional qualities, factor 1 psychopathy and the expressions of antisocial disposition and impulsivity, factor 2 psychopathy). Structural Magnetic Resonance Imaging data, psychopathy and demographic information were assessed in sixty seven non-violent or violent adults. The results showed that the relationship between violence and the GMV in the right lateral OFC varied across different levels of the factor 1 psychopathy. At the subcortical level, the psychopathy level (the factor 1 psychopathy) moderated the positive relationship of violence with both left and right putamen GMV as well as left caudate GMV. Although the CTh findings were not significant, overall findings suggested that psychopathic traits moderated the relationship between violence and the brain structural morphology in the OFC and striatum. In conclusion, psychopathy takes upon a significant role in moderating violent behavior which gives insight to design and implement prevention measures targeting violent acts, thereby possibly mitigating their occurrence within the society.
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Affiliation(s)
- Bess Y H Lam
- Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong
| | - Yaling Yang
- Department of Pediatrics, University of Southern California, Los Angeles, CA, United States
| | - Robert A Schug
- School of Criminology and Criminal Justice, California State University, Long Beach, Long Beach, CA, United States
| | - Chenbo Han
- Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China
| | - Jianghong Liu
- School of Nursing, University of Pennsylvania, Philadelphia, PA, United States
| | - Tatia M C Lee
- Laboratory of Neuropsychology, The University of Hong Kong, Pok Fu Lam, Hong Kong.,Laboratory of Cognitive Affective Neuroscience, The University of Hong Kong, Pok Fu Lam, Hong Kong.,The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Pok Fu Lam, Hong Kong
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28
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Association of monoamine oxidase-A genetic variants and amygdala morphology in violent offenders with antisocial personality disorder and high psychopathic traits. Sci Rep 2017; 7:9607. [PMID: 28851912 PMCID: PMC5575239 DOI: 10.1038/s41598-017-08351-w] [Citation(s) in RCA: 16] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/03/2017] [Accepted: 07/11/2017] [Indexed: 01/18/2023] Open
Abstract
Violent offending is elevated among individuals with antisocial personality disorder (ASPD) and high psychopathic traits (PP). Morphological abnormalities of the amygdala and orbitofrontal cortex (OFC) are present in violent offenders, which may relate to the violence enacted by ASPD + PP. Among healthy males, monoamine oxidase-A (MAO-A) genetic variants linked to low in vitro transcription (MAOA-L) are associated with structural abnormalities of the amygdala and OFC. However, it is currently unknown whether amygdala and OFC morphology in ASPD relate to MAO-A genetic polymorphisms. We studied 18 ASPD males with a history of violent offending and 20 healthy male controls. Genomic DNA was extracted from peripheral leukocytes to determine MAO-A genetic polymorphisms. Subjects underwent a T1-weighted MRI anatomical brain scan that provided vertex-wise measures of amygdala shape and surface area and OFC cortical thickness. We found that ASPD + PP subjects with MAOA-L exhibited decreased surface area in the right basolateral amygdala nucleus and increased surface area in the right anterior cortical amygdaloid nucleus versus healthy MAOA-L carriers. This study is the first to describe genotype-related morphological differences of the amygdala in a population marked by high aggression. Deficits in emotional regulation that contribute to the violence of ASPD + PP may relate to morphological changes of the amygdala under genetic control.
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29
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Jiang W, Li G, Liu H, Shi F, Wang T, Shen C, Shen H, Lee SW, Hu D, Wang W, Shen D. Reduced cortical thickness and increased surface area in antisocial personality disorder. Neuroscience 2016; 337:143-152. [PMID: 27600947 PMCID: PMC5152675 DOI: 10.1016/j.neuroscience.2016.08.052] [Citation(s) in RCA: 15] [Impact Index Per Article: 1.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/18/2016] [Revised: 08/05/2016] [Accepted: 08/29/2016] [Indexed: 10/21/2022]
Abstract
Antisocial personality disorder (ASPD), one of whose characteristics is high impulsivity, is of great interest in the field of brain structure and function. However, little is known about possible impairments in the cortical anatomy in ASPD, in terms of cortical thickness (CTh) and surface area (SA), as well as their possible relationship with impulsivity. In this neuroimaging study, we first investigated the changes of CTh and SA in ASPD patients, in comparison to those of healthy controls, and then performed correlation analyses between these measures and the ability of impulse control. We found that ASPD patients showed thinner cortex while larger SA in several specific brain regions, i.e., bilateral superior frontal gyrus (SFG), orbitofrontal and triangularis, insula cortex, precuneus, middle frontal gyrus (MFG), middle temporal gyrus (MTG), and left bank of superior temporal sulcus (STS). In addition, we also found that the ability of impulse control was positively correlated with CTh in the SFG, MFG, orbitofrontal cortex (OFC), pars triangularis, superior temporal gyrus (STG), and insula cortex. To our knowledge, this study is the first to reveal simultaneous changes in CTh and SA in ASPD, as well as their relationship with impulsivity. These cortical structural changes may introduce uncontrolled and callous behavioral characteristic in ASPD patients, and these potential biomarkers may be very helpful in understanding the pathomechanism of ASPD.
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Affiliation(s)
- Weixiong Jiang
- Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China; Department of Information Science and Engineering, Hunan First Normal University, Changsha, Hunan 410205, China; Department of Radiology and BRIC, University of North Carolina at Chapel Hill, NC, USA; College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan 410073, China
| | - Gang Li
- Department of Radiology and BRIC, University of North Carolina at Chapel Hill, NC, USA
| | - Huasheng Liu
- Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China
| | - Feng Shi
- Department of Radiology and BRIC, University of North Carolina at Chapel Hill, NC, USA
| | - Tao Wang
- Department of Radiology and BRIC, University of North Carolina at Chapel Hill, NC, USA
| | - Celina Shen
- Department of Radiology and BRIC, University of North Carolina at Chapel Hill, NC, USA
| | - Hui Shen
- College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan 410073, China
| | - Seong-Whan Lee
- Department of Brain and Cognitive Engineering, Korea University, Seoul, Republic of Korea
| | - Dewen Hu
- College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan 410073, China
| | - Wei Wang
- Department of Radiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
| | - Dinggang Shen
- Department of Radiology and BRIC, University of North Carolina at Chapel Hill, NC, USA; Department of Brain and Cognitive Engineering, Korea University, Seoul, Republic of Korea.
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30
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Ma G, Fan H, Shen C, Wang W. Genetic and Neuroimaging Features of Personality Disorders: State of the Art. Neurosci Bull 2016; 32:286-306. [PMID: 27037690 PMCID: PMC5563771 DOI: 10.1007/s12264-016-0027-8] [Citation(s) in RCA: 14] [Impact Index Per Article: 1.6] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/15/2016] [Accepted: 03/03/2016] [Indexed: 12/11/2022] Open
Abstract
Personality disorders often act as a common denominator for many psychiatric problems, and studies on personality disorders contribute to the etiopathology, diagnosis, and treatment of many mental disorders. In recent years, increasing evidence from various studies has shown distinctive features of personality disorders, and that from genetic and neuroimaging studies has been especially valuable. Genetic studies primarily target the genes encoding neurotransmitters and enzymes in the serotoninergic and dopaminergic systems, and neuroimaging studies mainly focus on the frontal and temporal lobes as well as the limbic-paralimbic system in patients with personality disorders. Although some studies have suffered due to unclear diagnoses of personality disorders and some have included few patients for a given personality disorder, great opportunities remain for investigators to launch new ideas and technologies in the field.
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Affiliation(s)
- Guorong Ma
- Department of Clinical Psychology and Psychiatry, Zhejiang University School of Medicine, Hangzhou, 310058, China
- Department of Psychology and Behavioral Sciences, Zhejiang University College of Science, Hangzhou, 310007, China
| | - Hongying Fan
- Department of Clinical Psychology and Psychiatry, Zhejiang University School of Medicine, Hangzhou, 310058, China
| | - Chanchan Shen
- Department of Psychology and Behavioral Sciences, Zhejiang University College of Science, Hangzhou, 310007, China
| | - Wei Wang
- Department of Clinical Psychology and Psychiatry, Zhejiang University School of Medicine, Hangzhou, 310058, China.
- Department of Psychology and Behavioral Sciences, Zhejiang University College of Science, Hangzhou, 310007, China.
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31
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Lam BYH, Yang Y, Raine A, Lee TMC. Neural mediator of the schizotypy-antisocial behavior relationship. Transl Psychiatry 2015; 5:e669. [PMID: 26529422 PMCID: PMC5068757 DOI: 10.1038/tp.2015.162] [Citation(s) in RCA: 8] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/28/2015] [Revised: 08/08/2015] [Accepted: 08/12/2015] [Indexed: 11/09/2022] Open
Abstract
Prior studies have established that schizotypal personality traits (schizotypy) were associated with antisocial behavior (crime), but it is unclear what neural factors mediate this relationship. This study assessed the mediating effect that sub-regional prefrontal gray, specifically the orbitofrontal gray matter volume, has on the schizotypy-antisocial behavior relationship. Five prefrontal sub-regional (superior, middle, inferior, orbitofrontal and rectal gyral) gray matter volumes were assessed using structural magnetic resonance imaging in 90 adults from the community, together with schizotypy and antisocial behavior. Among all five prefrontal sub-regions, the orbitofrontal cortex (OFC) was the major region-of-interest in the present study. Mediation analyses showed that orbitofrontal gray fully mediated the association between schizotypy and antisocial behavior. After having controlled the sex, age, socio-economic statuses, whole brain volumes and substance abuse/dependence of test subjects, the orbitofrontal gray still significantly mediated the effect of schizotypy on antisocial behavior by 53.5%. These findings are the first that document a neural mediator of the schizotypy-antisocial behavior relationship. Findings also suggest that functions subserved by the OFC, including impulse control and inhibition, emotion processing and decision-making, may contribute to the above comorbidity.
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Affiliation(s)
- B Y H Lam
- Laboratory of Neuropsychology, The University of Hong Kong, Hong Kong, China
| | - Y Yang
- Department of Pediatrics, Children's Hospitals Los Angeles, Keck School of Medicine, The University of Southern California, Los Angeles, CA, USA
| | - A Raine
- Department of Criminology, University of Pennsylvania, Philadelphia, PA, USA
- Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
- Department of Psychology, University of Pennsylvania, Philadelphia, PA, USA
| | - T M C Lee
- Laboratory of Neuropsychology, The University of Hong Kong, Hong Kong, China
- The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, China
- Institute of Clinical Neuropsychology, The University of Hong Kong, Hong Kong, China
- Laboratory of Cognitive Affective Neuroscience, The University of Hong Kong, Hong Kong, China
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32
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Bandelow B, Wedekind D. Possible role of a dysregulation of the endogenous opioid system in antisocial personality disorder. Hum Psychopharmacol 2015; 30:393-415. [PMID: 26250442 DOI: 10.1002/hup.2497] [Citation(s) in RCA: 21] [Impact Index Per Article: 2.1] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/02/2015] [Revised: 04/29/2015] [Accepted: 06/23/2015] [Indexed: 11/09/2022]
Abstract
Around half the inmates in prison institutions have antisocial personality disorder (ASPD). A recent theory has proposed that a dysfunction of the endogenous opioid system (EOS) underlies the neurobiology of borderline personality disorder (BPD). In the present theoretical paper, based on a comprehensive database and hand search of the relevant literature, this hypothesis is extended to ASPD, which may be the predominant expression of EOS dysfunction in men, while the same pathology underlies BPD in women. According to evidence from human and animal studies, the problematic behaviours of persons with antisocial, callous, or psychopathic traits may be seen as desperate, unconscious attempts to stimulate their deficient EOS, which plays a key role in brain reward circuits. If the needs of this system are not being met, the affected persons experience dysphoric mood, discomfort, or irritability, and strive to increase binding of endogenous opioids to receptors by using the rewarding effects of aggression by exertion of physical or manipulative power on others, by abusing alcohol or substances that have the reward system as target, by creating an "endorphin rush" by self-harm, by increasing the frequency of their sexual contacts, or by impulsive actions and sensation seeking. Symptoms associated with ASPD can be treated with opioid antagonists like naltrexone, naloxone, or nalmefene.
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Affiliation(s)
- Borwin Bandelow
- Department of Psychiatry and Psychotherapy, University of Göttingen, Germany
| | - Dirk Wedekind
- Department of Psychiatry and Psychotherapy, University of Göttingen, Germany
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33
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Shniderman AB, Solberg LB. Cosmetic Psychopharmacology for Prisoners: Reducing Crime and Recidivism Through Cognitive Intervention. NEUROETHICS-NETH 2015. [DOI: 10.1007/s12152-015-9242-7] [Citation(s) in RCA: 6] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/24/2022]
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34
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Liu J, Zhao SR, Reyes T. Neurological and Epigenetic Implications of Nutritional Deficiencies on Psychopathology: Conceptualization and Review of Evidence. Int J Mol Sci 2015; 16:18129-48. [PMID: 26251900 PMCID: PMC4581239 DOI: 10.3390/ijms160818129] [Citation(s) in RCA: 11] [Impact Index Per Article: 1.1] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/05/2015] [Revised: 07/22/2015] [Accepted: 07/28/2015] [Indexed: 12/19/2022] Open
Abstract
In recent years, a role for epigenetic modifications in the pathophysiology of disease has received significant attention. Many studies are now beginning to explore the gene-environment interactions, which may mediate early-life exposure to risk factors, such as nutritional deficiencies and later development of behavioral problems in children and adults. In this paper, we review the current literature on the role of epigenetics in the development of psychopathology, with a specific focus on the potential for epigenetic modifications to link nutrition and brain development. We propose a conceptual framework whereby epigenetic modifications (e.g., DNA methylation) mediate the link between micro- and macro-nutrient deficiency early in life and brain dysfunction (e.g., structural aberration, neurotransmitter perturbation), which has been linked to development of behavior problems later on in life.
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Affiliation(s)
- Jianghong Liu
- School of Nursing, University of Pennsylvania, 418 Curie Blvd., Philadelphia, PA 19104, USA.
| | - Sophie R Zhao
- School of Nursing, University of Pennsylvania, 418 Curie Blvd., Philadelphia, PA 19104, USA.
| | - Teresa Reyes
- School of Nursing, University of Pennsylvania, 418 Curie Blvd., Philadelphia, PA 19104, USA.
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35
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Yang Y, Wang P, Baker LA, Narr KL, Joshi SH, Hafzalla G, Raine A, Thompson PM. Thicker temporal cortex associates with a developmental trajectory for psychopathic traits in adolescents. PLoS One 2015; 10:e0127025. [PMID: 26017779 PMCID: PMC4446360 DOI: 10.1371/journal.pone.0127025] [Citation(s) in RCA: 11] [Impact Index Per Article: 1.1] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/30/2014] [Accepted: 04/10/2015] [Indexed: 11/18/2022] Open
Abstract
Psychopathy is a clinical condition characterized by a failure in normal social interaction and morality. Recent studies have begun to reveal brain structural abnormalities associated with psychopathic tendencies in children. However, little is known about whether variations in brain morphology are linked to the developmental trajectory of psychopathic traits over time. In this study, structural magnetic resonance imaging (sMRI) data from 108 14-year-old adolescents with no history of substance abuse (54 males and 54 females) were examined to detect cortical thickness variations associated with psychopathic traits and individual rates of change in psychopathic traits from ages 9 to 18. We found cortical thickness abnormalities to correlate with psychopathic traits both cross-sectionally and longitudinally. Specifically, at age 14, higher psychopathic scores were correlated with thinner cortex in the middle frontal gyrus, particularly in females, and thicker cortex in the superior temporal gyrus, middle temporal gyrus, and parahippocampal gyrus, particularly in males. Longitudinally, individual rates of change in psychopathic tendency over time were correlated with thicker cortex in the superior temporal gyrus, middle temporal gyrus, inferior temporal gyrus, parahippocampal gyrus, and posterior cingulate gyrus, particularly in males. Findings suggest that abnormal cortical thickness may reflect a delay in brain maturation, resulting in disturbances in frontal and temporal functioning such as impulsivity, sensation-seeking, and emotional dysregulation in adolescents. Thus, findings provide initial evidence supporting that abnormal cortical thickness may serve as a biomarker for the development of psychopathic propensity in adolescents.
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Affiliation(s)
- Yaling Yang
- Department of Pediatrics, Children’s Hospital Los Angeles, University of Southern California, Los Angeles, California, United States of America
- * E-mail:
| | - Pan Wang
- Department of Psychology, University of Southern California, Los Angeles, California, United States of America
| | - Laura A. Baker
- Department of Psychology, University of Southern California, Los Angeles, California, United States of America
| | - Katherine L. Narr
- Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
| | - Shantanu H. Joshi
- Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
| | - George Hafzalla
- Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
| | - Adrian Raine
- Departments of Criminology, Psychiatry, and Psychology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
| | - Paul M. Thompson
- Departments of Neurology, Psychiatry, Radiology, Engineering, Pediatrics, and Ophthalmology, University of Southern California, Los Angeles, California, United States of America
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36
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Malchow B, Hasan A, Meyer K, Schneider-Axmann T, Radenbach KE, Gruber O, Reith W, McIntosh AM, Schmitt A, Falkai P, Wobrock T. Family load impacts orbitofrontal volume in first-episode schizophrenia. Psychiatry Res 2015; 232:130-3. [PMID: 25800218 DOI: 10.1016/j.pscychresns.2015.02.006] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/26/2014] [Revised: 11/24/2014] [Accepted: 02/18/2015] [Indexed: 11/19/2022]
Abstract
In schizophrenia, reduced orbitofrontal cortex (OFC) volume is inconsistently reported. To investigate the impact of genetic load on OFC volume, manual MRI-tracing in 23 first-episode schizophrenia patients (FE-SZ) and 23 controls was performed. FE-SZ with genetic load showed a decrease in OFC volume compared to FE-SZ without load and controls.
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Affiliation(s)
- Berend Malchow
- Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Nußbaumstraße 7, 80336 Munich, Germany.
| | - Alkomiet Hasan
- Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Nußbaumstraße 7, 80336 Munich, Germany
| | - Kristina Meyer
- Department of Psychiatry and Psychotherapy, Georg-August-University Goettingen, von-Siebold-Straße 5, 37075 Göttingen, Germany
| | - Thomas Schneider-Axmann
- Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Nußbaumstraße 7, 80336 Munich, Germany
| | - Katrin E Radenbach
- Department of Psychiatry and Psychotherapy, Georg-August-University Goettingen, von-Siebold-Straße 5, 37075 Göttingen, Germany
| | - Oliver Gruber
- Department of Psychiatry and Psychotherapy, Georg-August-University Goettingen, von-Siebold-Straße 5, 37075 Göttingen, Germany
| | - Wolfgang Reith
- Department of Neuroradiology, Saarland University Hospital, Kirrberger Straße, 66421 Homburg, Germany
| | - Andrew M McIntosh
- Division of Psychiatry, The University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH10 5HF, United Kingdom
| | - Andrea Schmitt
- Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Nußbaumstraße 7, 80336 Munich, Germany; Laboratory of Neuroscience (LIM27), Institute of Psychiatry, University of Sao Paulo, Rua Dr. Ovidio Pires de Campos 785, 05453-010 São Paulo, SP, Brazil
| | - Peter Falkai
- Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Nußbaumstraße 7, 80336 Munich, Germany
| | - Thomas Wobrock
- Department of Psychiatry and Psychotherapy, Georg-August-University Goettingen, von-Siebold-Straße 5, 37075 Göttingen, Germany; Centre of Mental Health, County Hospitals Darmstadt-Dieburg, Krankenhausstraße 7, 64823 Groß-Umstadt, Germany
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Frontal and striatal alterations associated with psychopathic traits in adolescents. Psychiatry Res 2015; 231:333-40. [PMID: 25676553 PMCID: PMC4871259 DOI: 10.1016/j.pscychresns.2015.01.017] [Citation(s) in RCA: 24] [Impact Index Per Article: 2.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/07/2014] [Revised: 05/15/2014] [Accepted: 01/16/2015] [Indexed: 11/21/2022]
Abstract
Neuroimaging research has demonstrated a range of structural deficits in adults with psychopathy, but little is known about structural correlates of psychopathic tendencies in adolescents. Here we examined structural magnetic resonance imaging (sMRI) data obtained from 14-year-old adolescents (n=108) using tensor-based morphometry (TBM) to isolate global and localized differences in brain tissue volumes associated with psychopathic traits in this otherwise healthy developmental population. We found that greater levels of psychopathic traits were correlated with increased brain tissue volumes in the left putamen, left ansa peduncularis, right superiomedial prefrontal cortex, left inferior frontal cortex, right orbitofrontal cortex, and right medial temporal regions and reduced brain tissues volumes in the right middle frontal cortex, left superior parietal lobule, and left inferior parietal lobule. Post hoc analyses of parcellated regional volumes also showed putamen enlargements to correlate with increased psychopathic traits. Consistent with earlier studies, findings suggest poor decision-making and emotional dysregulation associated with psychopathy may be due, in part, to structural anomalies in frontal and temporal regions whereas striatal structural variations may contribute to sensation-seeking and reward-driven behavior in psychopathic individuals. Future studies will help clarify how disturbances in brain maturational processes might lead to the developmental trajectory from psychopathic tendencies in adolescents to adult psychopathy.
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Michalska KJ, Decety J, Zeffiro TA, Lahey BB. Association of regional gray matter volumes in the brain with disruptive behavior disorders in male and female children. Neuroimage Clin 2014; 7:252-7. [PMID: 25610787 PMCID: PMC4300012 DOI: 10.1016/j.nicl.2014.12.012] [Citation(s) in RCA: 24] [Impact Index Per Article: 2.2] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/14/2014] [Revised: 12/16/2014] [Accepted: 12/18/2014] [Indexed: 02/07/2023]
Abstract
Because the disruptive behavior disorders are highly impairing conditions, it is important to determine if structural variations in brain are associated early in life with these problems among children. Structural MRI data were acquired from 111 9-11 year olds (58 girls and 53 boys), 43 who met diagnostic criteria for oppositional defiant disorder and/or conduct disorder and 68 healthy controls. Voxel-based morphometry was used to examine associations of behavioral measures with gray matter volumes in whole-brain analyses. Unlike previous studies, variation in gray matter volume was not found to be associated with a disruptive behavior disorder diagnosis in any brain region at p < .05 with FWE correction. Nonetheless, an inverse nonlinear association of the number of conduct disorder (CD) symptoms with gray matter volume along the left superior temporal sulcus was significant in the full sample (p < .05 with FWE correction), with a trend in the right hemisphere (p < 0.001 uncorrected). There also was a trend toward a stronger association of the number of CD symptoms with gray matter volume along the left superior temporal sulcus in girls than boys. The present findings did not replicate previous findings of reduced gray matter volumes in the anterior insula, amygdala, and frontal cortex in youth with CD, but are consistent with previous findings of reduced gray matter volumes in temporal regions, particularly in girls.
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Affiliation(s)
| | - Jean Decety
- Department of Psychology, University of Chicago, Chicago, IL, USA
- Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA
| | - Thomas A. Zeffiro
- Neural Systems Group, Massachusetts General Hospital, Charlestown, MA, USA
| | - Benjamin B. Lahey
- Department of Public Health Sciences, University of Chicago, Chicago, IL, USA
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39
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Kyeong S, Kim E, Park HJ, Hwang DU. Functional network organizations of two contrasting temperament groups in dimensions of novelty seeking and harm avoidance. Brain Res 2014; 1575:33-44. [DOI: 10.1016/j.brainres.2014.05.037] [Citation(s) in RCA: 22] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/17/2014] [Accepted: 05/23/2014] [Indexed: 01/21/2023]
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Zhang J, Gao J, Shi H, Huang B, Wang X, Situ W, Cai W, Yi J, Zhu X, Yao S. Sex differences of uncinate fasciculus structural connectivity in individuals with conduct disorder. BIOMED RESEARCH INTERNATIONAL 2014; 2014:673165. [PMID: 24829912 PMCID: PMC4009134 DOI: 10.1155/2014/673165] [Citation(s) in RCA: 29] [Impact Index Per Article: 2.6] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 11/27/2013] [Revised: 02/17/2014] [Accepted: 03/24/2014] [Indexed: 11/29/2022]
Abstract
Conduct disorder (CD) is one of the most common behavior disorders in adolescents, such as impulsivity, aggression, and running from school. Males are more likely to develop CD than females, and two previous diffusion tensor imaging (DTI) studies have demonstrated abnormal microstructural integrity in the uncinate fasciculus (UF) in boys with CD compared to a healthy control group. However, little is known about changes in the UF in females with CD. In this study, the UF was illustrated by tractography; then, the fractional anisotropy (FA), axial diffusivity, mean diffusion, radial diffusivity (RD), and the length and number of the UF fiber bundles were compared between male and female patients with CD and between female patients with CD and female healthy controls, as well as between males with CD and healthy males. We found that males with CD showed significantly higher FA of the bilateral UF and significantly lower RD of the left UF when comparing with females with CD. Meanwhile, significantly higher FA and lower RD of the bilateral UF were also found in boys with CD relative to the male healthy controls. Our results replicated previous reports that the microstructural integrity of the UF was abnormal in boys with CD. Additionally, our results demonstrated significant gender effects on the UF of patients with CD, which may indicate why boys have higher rates of conduct problems than girls.
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Affiliation(s)
- Jibiao Zhang
- Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science, Ministry of Justice, No. 1347 West Guangfu Road, Shanghai 200063, China
- Medical Psychological Institute, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Road, Changsha, Hunan 410011, China
| | - Junling Gao
- Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, No. 102 Pokfulam Road, Hong Kong
- Centre of Buddhists Studies, The University of Hong Kong, No. 102 Pokfulam Road, Hong Kong
| | - Huqing Shi
- Medical Psychological Institute, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Road, Changsha, Hunan 410011, China
| | - Bingsheng Huang
- Department of Biomedical Engineering, School of Medicine, Shenzhen University, No. 3688, Nanhai Ave, Shenzhen, Guangdong 518060, China
| | - Xiang Wang
- Medical Psychological Institute, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Road, Changsha, Hunan 410011, China
| | - Weijun Situ
- Medical Psychological Institute, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Road, Changsha, Hunan 410011, China
| | - Weixiong Cai
- Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science, Ministry of Justice, No. 1347 West Guangfu Road, Shanghai 200063, China
| | - Jinyao Yi
- Medical Psychological Institute, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Road, Changsha, Hunan 410011, China
| | - Xiongzhao Zhu
- Medical Psychological Institute, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Road, Changsha, Hunan 410011, China
| | - Shuqiao Yao
- Medical Psychological Institute, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Road, Changsha, Hunan 410011, China
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Cerny C, Friedman SH, Smith D. Television's "crazy lady" trope: female psychopathic traits, teaching, and influence of popular culture. ACADEMIC PSYCHIATRY : THE JOURNAL OF THE AMERICAN ASSOCIATION OF DIRECTORS OF PSYCHIATRIC RESIDENCY TRAINING AND THE ASSOCIATION FOR ACADEMIC PSYCHIATRY 2014; 38:233-241. [PMID: 24574097 DOI: 10.1007/s40596-014-0035-9] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 08/28/2013] [Accepted: 01/09/2014] [Indexed: 06/03/2023]
Abstract
OBJECTIVE This article describes notable illustrations of female psychopathy on modern television to review various characters that will have utility in teaching students about female psychopathy in distinction to male psychopathy and to encourage consideration of the potential effects that viewing these countless examples may have on a generation of young women. METHODS The authors use examples from soap operas, crime procedurals, reality television, fantasy, comedies, and young adult programs to illustrate gender differences in psychopathy and make specific teaching points. They also review the research literature related to popular culture's impact on behavior and gender roles. RESULTS Gender differences in real-world psychopathy are mirrored in television portrayals. For example, female psychopaths, on TV and in reality, use sexual manipulation, demonstrate unstable emotions, and employ social aggression to achieve their ambitions. The examples of female psychopathic traits are prevalent on TV and easily accessible for teaching purposes. Research does give some support for a popular culture impact on behavior and gender roles. CONCLUSIONS As compared to male psychopathy, female psychopathy is less recognized, and there are some notable differences in how the psychopathic traits manifest. Television provides myriad teaching examples that can highlight the gender distinctions such as use of sexual manipulation, emotional instability, and social aggression. Research suggests that the prevalence of "crazy ladies" on television may be negatively impacting gender stereotypes and normalizing bad behavior in young women.
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Liu H, Liao J, Jiang W, Wang W. Changes in low-frequency fluctuations in patients with antisocial personality disorder revealed by resting-state functional MRI. PLoS One 2014; 9:e89790. [PMID: 24598769 PMCID: PMC3943846 DOI: 10.1371/journal.pone.0089790] [Citation(s) in RCA: 22] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/09/2013] [Accepted: 01/27/2014] [Indexed: 11/20/2022] Open
Abstract
Antisocial Personality Disorder (APD) is a personality disorder that is most commonly associated with the legal and criminal justice systems. The study of the brain in APD has important implications in legal contexts and in helping ensure social stability. However, the neural contribution to the high prevalence of APD is still unclear. In this study, we used resting-state functional magnetic resonance imaging (fMRI) to investigate the underlying neural mechanisms of APD. Thirty-two healthy individuals and thirty-five patients with APD were recruited. The amplitude of low-frequency fluctuations (ALFF) was analyzed for the whole brain of all subjects. Our results showed that APD patients had a significant reduction in the ALFF in the right orbitofrontal cortex, the left temporal pole, the right inferior temporal gyrus, and the left cerebellum posterior lobe compared to normal controls. We observed that the right orbitofrontal cortex had a negative correlation between ALFF values and MMPI psychopathic deviate scores. Alterations in ALFF in these specific brain regions suggest that APD patients may be associated with abnormal activities in the fronto-temporal network. We propose that our results may contribute in a clinical and forensic context to a better understanding of APD.
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Affiliation(s)
- Huasheng Liu
- Department of Radiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, P.R.China
- Biomedical Engineering Laboratory, School of Geosciences and Info-Physics, Central South University, Changsha, Hunan, P.R.China
| | - Jian Liao
- Department of Radiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, P.R.China
| | - Weixiong Jiang
- Department of Radiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, P.R.China
- Biomedical Engineering Laboratory, School of Geosciences and Info-Physics, Central South University, Changsha, Hunan, P.R.China
- Department of Information Science and Engineering, Hunan First Normal University, Changsha, Hunan, P.R.China
| | - Wei Wang
- Department of Radiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, P.R.China
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Eisenbarth H. [Psychopathic personality in women. Diagnostics and experimental findings in the forensic setting and the business world]. DER NERVENARZT 2014; 85:290, 292-4, 296-7. [PMID: 24549689 DOI: 10.1007/s00115-013-3902-9] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 10/25/2022]
Abstract
Highly psychopathic women are rare in the context of forensic psychiatry; however, the concept of psychopathy plays an important role in diagnostics, for court expertises as well as for treatment. Another so far neglected yet relevant field is the business world. The so-called successful female psychopaths are characterized by highly psychopathic traits but low antisocial behavior, at least with reference to criminal behavior. The basis for investigating and interpreting gender differences is the assessment of psychopathy. Gender differences have been repeatedly demonstrated, especially in the assessment of antisocial behavior and the differentiation of borderline personality disorder and psychopathy which have to be addressed. Group comparisons based on these diagnostic methods found lower inhibitory deficits but less aggressive behavior in female participants with respect to the first main symptom category. For the second symptom category, emotional detachment, so far there are almost no findings reporting gender differences but only few direct gender comparisons have been carried out. However, highly psychopathic women from the general population demonstrate a stronger correlation between psychopathic traits and self-perception as negotiation partner compared to men: they make more use of manipulation and perceive themselves as more powerful in negotiation situations. Future studies should address the diagnostic variability, direct gender comparisons in experimental tasks and the relationship between psychopathic traits, the core symptom categories and career-related success.
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Affiliation(s)
- H Eisenbarth
- Department of Psychology and Neuroscience, University of Colorado Boulder, 344 UCB, 80309, Boulder, USA,
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Abstract
The Diagnostic and Statistical Manual of Mental Disorders (DSM 5) classification of antisocial personality disorder (ASPD) describes individuals who engage in repetitive irresponsible, delinquent, and criminal behavior. The diagnosis is highly controversial, with many researchers and clinicians arguing that the category is too heterogeneous, overinclusive, and demonstrates considerable overlap with other disorders. This review focuses on recent studies that have improved our understanding of the characteristics of individuals who fit the ASPD definition by exploring how subtypes differ and how comorbid conditions influence the presentation of ASPD. In addition, we discuss research on the etiology of ASPD that has identified genetic and environmental factors that may contribute to the development and persistence of antisocial behavior, and brain imaging research that has improved our understanding of the relationships between ASPD and other psychopathology. Finally, we discuss promising preliminary research on treatment for this disorder.
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Bertsch K, Grothe M, Prehn K, Vohs K, Berger C, Hauenstein K, Keiper P, Domes G, Teipel S, Herpertz SC. Brain volumes differ between diagnostic groups of violent criminal offenders. Eur Arch Psychiatry Clin Neurosci 2013; 263:593-606. [PMID: 23381548 DOI: 10.1007/s00406-013-0391-6] [Citation(s) in RCA: 56] [Impact Index Per Article: 4.7] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/02/2012] [Accepted: 01/15/2013] [Indexed: 12/19/2022]
Abstract
Studies on structural abnormalities in antisocial individuals have reported inconsistent results, possibly due to inhomogeneous samples, calling for an investigation of brain alterations in psychopathologically stratified subgroups. We explored structural differences between antisocial offenders with either borderline personality disorder (ASPD-BPD) or high psychopathic traits (ASPD-PP) and healthy controls (CON) using region-of-interest-based and voxel-based morphometry approaches. Besides common distinct clusters of reduced gray matter volumes within the frontal pole and occipital cortex, there was remarkably little overlap in the regional distribution of brain abnormalities in ASPD-BPD and ASPD-PP, when compared to CON. Specific alterations of ASPD-BPD were detected in orbitofrontal and ventromedial prefrontal cortex regions subserving emotion regulation and reactive aggression and the temporal pole, which is involved in the interpretation of other peoples' motives. Volumetric reductions in ASPD-PP were most significant in midline cortical areas involved in the processing of self-referential information and self-reflection (i.e., dorsomedial prefrontal cortex, posterior cingulate/precuneus) and recognizing emotions of others (postcentral gyrus) and could reflect neural correlates of the psychopathic core features of callousness and poor moral judgment. The findings of this first exploratory study therefore may reflect correlates of prominent psychopathological differences between the two criminal offender groups, which have to be replicated in larger samples.
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Affiliation(s)
- Katja Bertsch
- Department of General Psychiatry, Center for Psychosocial Medicine, University of Heidelberg, Vosstrase 4, 69115, Heidelberg, Germany,
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Lei X, Chen C, Xue F, He Q, Chen C, Liu Q, Moyzis RK, Xue G, Cao Z, Li J, Li H, Zhu B, Liu Y, Hsu ASC, Li J, Dong Q. Fiber connectivity between the striatum and cortical and subcortical regions is associated with temperaments in Chinese males. Neuroimage 2013; 89:226-34. [PMID: 23618602 DOI: 10.1016/j.neuroimage.2013.04.043] [Citation(s) in RCA: 32] [Impact Index Per Article: 2.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/02/2013] [Revised: 03/16/2013] [Accepted: 04/11/2013] [Indexed: 11/29/2022] Open
Abstract
The seven-factor biopsychosocial model of personality distinguished four biologically based temperaments and three psychosocially based characters. Previous studies have suggested that the four temperaments-novelty seeking (NS), reward dependence (RD), harm avoidance (HA), and persistence (P)-have their respective neurobiological correlates, especially in the striatum-connected subcortical and cortical networks. However, few studies have investigated their neurobiological basis in the form of fiber connectivity between brain regions. This study correlated temperaments with fiber connectivity between the striatum and subcortical and cortical hub regions in a sample of 50 Chinese adult males. Generally consistent with our hypotheses, results showed that: (1) NS was positively correlated with fiber connectivity from the medial and lateral orbitofrontal cortex (mOFC, lOFC) and amygdala to the striatum; (2) RD was positively correlated with fiber connectivity from the mOFC, posterior cingulate cortex/retrosplenial cortex (PCC), hippocampus, and amygdala to the striatum; (3) HA was positively linked to fiber connectivity from the dorsolateral prefrontal cortex (dlPFC) and PCC to the striatum; and (4) P was positively linked to fiber connectivity from the mOFC to the striatum. These results extended the research on the neurobiological basis of temperaments by identifying their anatomical fiber connectivity correlates within the subcortical-cortical neural networks.
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Affiliation(s)
- Xuemei Lei
- State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China; Department of Psychology and Social Behavior, University of California, Irvine, CA, USA
| | - Chuansheng Chen
- Department of Psychology and Social Behavior, University of California, Irvine, CA, USA.
| | - Feng Xue
- State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
| | - Qinghua He
- Institute of Genomics and Bioinformatics, University of California, Irvine, CA, USA
| | - Chunhui Chen
- State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
| | - Qi Liu
- State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
| | - Robert K Moyzis
- Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, USA; Institute of Genomics and Bioinformatics, University of California, Irvine, CA, USA
| | - Gui Xue
- State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China; Department of Psychology, University of Southern California, Los Angeles, CA 90089, USA
| | - Zhongyu Cao
- State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
| | - Jin Li
- State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
| | - He Li
- State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
| | - Bi Zhu
- State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
| | - Yuyun Liu
- State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
| | - Anna Shan Chun Hsu
- Department of Psychology and Social Behavior, University of California, Irvine, CA, USA
| | - Jun Li
- State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
| | - Qi Dong
- State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
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Alegria AA, Blanco C, Petry NM, Skodol AE, Liu SM, Grant B, Hasin D. Sex differences in antisocial personality disorder: results from the National Epidemiological Survey on Alcohol and Related Conditions. Personal Disord 2013; 4:214-22. [PMID: 23544428 DOI: 10.1037/a0031681] [Citation(s) in RCA: 42] [Impact Index Per Article: 3.5] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 11/08/2022]
Abstract
Despite the 3:1 prevalence ratio of men versus women with Antisocial Personality Disorder (ASPD), research on sex differences on correlates of ASPD in the general population is scarce. The purpose of this study was to examine sex differences in childhood and adult adverse events, lifetime psychiatric comorbidity, and clinical correlates of DSM-IV ASPD. The sample included 819 men and 407 women with DSM-IV ASPD diagnosis. Data were derived from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) (N = 43,093). Compared to men, women with ASPD reported more frequent childhood emotional neglect (AOR = 2.25; 95% CI: 1.52-3.34) and sexual abuse (AOR = 4.20; 95% CI: 2.78-6.35), any parent-related adverse event during childhood (e.g., parental substance use disorder) (AOR = 2.47; 95% CI: 1.60-3.82), and adverse events during adulthood (AOR = 4.20; 95% CI: 2.78-6.35). Although women with ASPD present less violent antisocial behaviors and higher rates of aggressiveness and irritability (OR = 0.46; 95% CI: 0.31-0.67), they have higher rates of victimization, greater impairment, and lower social support. Our findings suggest increased mental health needs in women with ASPD, meriting development of different treatment programs for women and men.
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48
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Fairchild G, Hagan CC, Walsh ND, Passamonti L, Calder AJ, Goodyer IM. Brain structure abnormalities in adolescent girls with conduct disorder. J Child Psychol Psychiatry 2013; 54:86-95. [PMID: 23082797 PMCID: PMC3562487 DOI: 10.1111/j.1469-7610.2012.02617.x] [Citation(s) in RCA: 119] [Impact Index Per Article: 9.9] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 11/26/2022]
Abstract
BACKGROUND Conduct disorder (CD) in female adolescents is associated with a range of negative outcomes, including teenage pregnancy and antisocial personality disorder. Although recent studies have documented changes in brain structure and function in male adolescents with CD, there have been no neuroimaging studies of female adolescents with CD. Our primary objective was to investigate whether female adolescents with CD show changes in grey matter volume. Our secondary aim was to assess for sex differences in the relationship between CD and brain structure. METHODS Female adolescents with CD (n = 22) and healthy control participants matched in age, performance IQ and handedness (n = 20) underwent structural magnetic resonance imaging. Group comparisons of grey matter volume were performed using voxel-based morphometry. We also tested for sex differences using archive data obtained from male CD and control participants. RESULTS Female adolescents with CD showed reduced bilateral anterior insula and right striatal grey matter volumes compared with healthy controls. Aggressive CD symptoms were negatively correlated with right dorsolateral prefrontal cortex volume, whereas callous-unemotional traits were positively correlated with bilateral orbitofrontal cortex volume. The sex differences analyses revealed a main effect of diagnosis on right amygdala volume (reflecting reduced amygdala volume in the combined CD group relative to controls) and sex-by-diagnosis interactions in bilateral anterior insula. CONCLUSIONS We observed structural abnormalities in brain regions involved in emotion processing, reward and empathy in female adolescents with CD, which broadly overlap with those reported in previous studies of CD in male adolescents.
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Affiliation(s)
- Graeme Fairchild
- Department of Psychiatry, University of Cambridge, Cambridge, UK.
| | - Cindy C Hagan
- Department of Psychiatry, University of CambridgeCambridge, UK
| | | | - Luca Passamonti
- Consiglio Nazionale delle Ricerche, Unità di Ricerca NeuroimmaginiCatanzaro, Italy
| | - Andrew J Calder
- Medical Research Council Cognition and Brain Sciences UnitCambridge, UK
| | - Ian M Goodyer
- Department of Psychiatry, University of CambridgeCambridge, UK
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A review on the relationship between testosterone and life-course persistent antisocial behavior. Psychiatry Res 2012; 200:984-1010. [PMID: 22925371 DOI: 10.1016/j.psychres.2012.07.044] [Citation(s) in RCA: 48] [Impact Index Per Article: 3.7] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/16/2011] [Revised: 07/18/2012] [Accepted: 07/28/2012] [Indexed: 12/11/2022]
Abstract
Life-course persistent antisocial behavior is 10 to 14 times more prevalent in males and it has been suggested that testosterone levels could account for this gender bias. Preliminary studies with measures of fetal testosterone find inconsistent associations with antisocial behavior, especially studies that use the 2D:4D ratio as a proxy for fetal testosterone. However, circulating testosterone consistently shows positive associations with antisocial behaviors throughout childhood, adolescence, and adulthood, particularly in males. It is suggested that high fetal/circulating testosterone interactively influence the maturation and functionality of mesolimbic dopaminergic circuitry, right orbitofrontal cortex, and cortico-subcortical connectivity, resulting in a strong reward motivation, low social sensitivity, and dampened regulation of strong motivational/emotional processes. The link between these testosterone induced endophenotypes and actual display of antisocial behavior is strongly modulated by different social (e.g., social rejection, low SES) and genetic (e.g., MAOA, 5HTT) risk factors that can disturb socio-, psycho-, and biological development and interact with testosterone in shaping behavior. When these additional risk factors are present, the testosterone induced endophenotypes may increase the risk for a chronic antisocial lifestyle. However, behavioral endophenotypes induced by testosterone can also predispose towards socially adaptive traits such as a strong achievement motivation, leadership, fair bargaining behaviors, and social assertiveness. These adaptive traits are more likely to emerge when the high testosterone individual has positive social experiences that promote prosocial behaviors such as strong and secure attachments with his caregivers, affiliation with prosocial peers, and sufficient socioeconomic resources. A theoretical model is presented, various hypotheses are examined, and future venues for research are discussed.
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50
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Seelan RS, Pisano MM, Greene RM, Casanova MF, Parthasarathy RN. Differential methylation of the gene encoding myo-inositol 3-phosphate synthase (Isyna1) in rat tissues. Epigenomics 2012; 3:111-24. [PMID: 21841945 DOI: 10.2217/epi.10.73] [Citation(s) in RCA: 14] [Impact Index Per Article: 1.1] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/21/2022] Open
Abstract
AIMS Myo-inositol levels are frequently altered in several brain disorders. Myo-inositol 3-phosphate synthase, encoded by the Isyna1 gene, catalyzes the synthesis of myo-inositol in cells. Very little is known about the mechanisms regulating Isyna1 expression in brain and other tissues. In this study, we have examined the role of DNA methylation in regulating Isyna1 expression in rat tissues. MATERIALS & METHODS Transfection analysis using in vitro methylated promoter constructs, Southern blot analysis of genomic DNA from various tissues digested with a methylation-sensitive enzyme and CpG methylation profiling of genomic DNA from different tissues were used to determine differential methylation of Isyna1 in tissues. Transfection analysis using plasmids harboring mutated CpG residues in the 5'-upstream region of Isyna1 was used to identify critical residues mediating promoter activity. RESULTS The -700 bp to -500 bp region (region 1) of Isyna1 exhibited increased methylation in brain cortex compared with other tissues; it also exhibited sex-specific methylation differences between matched male and female brain cortices. Mutation analysis identified one CpG residue in region 1 necessary for promoter activity in neuronal cells. A tissue-specific differentially methylated region (T-DMR) was found to be localized between +450 bp and +650 bp (region 3). This DMR was comparatively highly methylated in spleen, moderately methylated in brain cortex and poorly methylated in testis, consistent with mRNA levels observed in these tissues. CONCLUSION Rat Isyna1 exhibits tissue-specific DNA methylation. Brain DNA was uniquely methylated in the 5'-upstream region and displayed gender specificity. A T-DMR was identified within the gene body of Isyna1. These findings suggest that Isyna1 is regulated, in part, by DNA methylation and that significant alterations in methylation patterns during development could have a major impact on inositol phosphate synthase expression in later life.
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Affiliation(s)
- Ratnam S Seelan
- Molecular, Cellular & Craniofacial Biology, Birth Defects Center, University of Louisville, 501 S. Preston St, KY 40292, USA.
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