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Lapointe K, Suffren S, Lassonde M, Lepage JF, Frasnelli J. Odor localization in structural interhemispheric deficits. Chem Senses 2025; 50:bjaf010. [PMID: 40277384 PMCID: PMC12084763 DOI: 10.1093/chemse/bjaf010] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/20/2024] [Indexed: 04/26/2025] Open
Abstract
Contrary to all other sensory systems, olfactory information is processed predominantly ipsilaterally. Furthermore, odor localization, based on inter-nostril differences, is usually not possible under controlled conditions. These two observations suggest information exchange between both cerebral hemispheres in the olfactory system, although the exact anatomical substrate remains unknown. This study aimed to identify the anatomical structures necessary for odor localization, with a particular focus on the role of interhemispheric communication. We assessed the ability to localize pure olfactory and mixed olfactory/trigeminal stimuli in 6 participants with structural interhemispheric deficits (including surgical transection or agenesis of the corpus callosum (CC) and agenesis of the CC and anterior commissure (AC, one case)) and compared their performance to 46 healthy controls. Of the six participants with structural interhemispheric deficits, three were unable to localize either stimulus. Two participants performed significantly better than chance for both pure and mixed stimuli, while one participant exhibited the typical localization pattern observed in most controls-accurate localization of the mixed olfactory/trigeminal stimulus but inability to localize the pure olfactory stimulus. Our results suggest that localization of chemosensory stimuli relies, at least in part, on CC, highlighting its role in interhemispheric communication for olfactory processing. The varying odor localization performance observed in participants with agenesis of CC indicates that compensatory mechanisms may be promoted in some cases, potentially preserving normal localization functions despite the absence of major commissural pathways.
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Affiliation(s)
- Keven Lapointe
- Department of Anatomy, Université du Québec, Trois-Rivières, Canada
| | - Sabrina Suffren
- Department of Psychology, Epsylon Research Unit EA, Université Paul-Valéry Montpellier 3, Montpellier, France
| | - Maryse Lassonde
- Department of Psychology, Université de Montréal, Montreal, Canada
| | - Jean-François Lepage
- Department of Pediatrics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke University Hospital Research Center, Sherbrooke, Canada
| | - Johannes Frasnelli
- Department of Anatomy, Université du Québec, Trois-Rivières, Canada
- Research Center, Sacré-Coeur Hospital, Montréal, Canada
- Research Center, Institut Universitaire de Gériatrie de Montréal, Montreal, Canada
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Feit NZ, Kloosterman N, LaPointe KA, Pitiranggon C, Finnegan IE, Smith CD, Gregoski MJ, Rowan NR, Soler ZM, Schlosser RJ. Intranasal Trigeminal Function in Aging Adults. Am J Rhinol Allergy 2024; 38:413-420. [PMID: 39169723 DOI: 10.1177/19458924241274973] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 08/23/2024]
Abstract
BACKGROUND Intranasal trigeminal function is important in detecting environmental stimuli. The impact of age-associated chemosensory dysfunction upon taste and olfaction is well described, but an understanding of trigeminal loss (chemesthesis) is lacking. OBJECTIVE The goal of this study was to characterize trigeminal function in a cohort of older adults and explore potential impacts. METHODS Twenty-eight participants over 50 years of age were recruited from the community as part of an aging cohort study. This nested cohort completed chemosensory questionnaires, patient-reported outcome measures (PROMs), and psychophysical testing for taste (taste strips), olfaction (Sniffin' Sticks), and trigeminal function (eucalyptol lateralization). Data were analyzed for associations between trigeminal function, olfactory, and taste psychophysical performance, patient-reported metrics, and demographic risk factors. RESULTS Patient-reported trigeminal impairment is less severe than other chemosensory loss, with mean visual analog scores (VAS, rated 0-100 from least to most severe) for smell (32.9 ± 34.2), taste (20.6 ± 28.4), and trigeminal sensation (9.5 ± 12.8). Despite low VAS scores, psychophysical trigeminal dysfunction was present in 10 (35.7%) subjects. Psychophysical olfactory and taste dysfunction were present in 16 (57.1%) and eight (28.6%) participants respectively. Hypercholesterolemia was associated with psychophysical trigeminal dysfunction (mean lateralization performance in hypercholesterolemia 57.7% ± 17.1 vs. 74.1% ± 10.4, p = .008). CONCLUSION Intranasal trigeminal impairment is present in nearly one-third of aging adults when assessed by psychophysical methods but is under-recognized. Hyperlipidemia may be associated with trigeminal impairment. Future inquiries should better characterize these findings in larger and prospective cohorts.
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Affiliation(s)
- Noah Z Feit
- Department of Otolaryngology- Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina
| | - Nicole Kloosterman
- Department of Otolaryngology- Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina
| | - Kristina A LaPointe
- Department of Otolaryngology- Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina
| | - Charn Pitiranggon
- Department of Otolaryngology- Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina
| | - Isabel E Finnegan
- Department of Otolaryngology- Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina
| | - Carter D Smith
- Department of Otolaryngology- Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina
| | - Mathew J Gregoski
- Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina
| | - Nicholas R Rowan
- Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland
| | - Zachary M Soler
- Department of Otolaryngology- Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina
| | - Rodney J Schlosser
- Department of Otolaryngology- Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina
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Coşkun O, Karacabey BN, Ünal A, Paksoy S, Durak HN. Evaluation of Smell Function in Patients with Childhood Epilepsy with Centrotemporal Spikes at a Pediatric Neurology Clinic-A Case-Control Study. J Clin Med 2024; 13:6474. [PMID: 39518613 PMCID: PMC11546507 DOI: 10.3390/jcm13216474] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/10/2024] [Revised: 10/22/2024] [Accepted: 10/23/2024] [Indexed: 11/16/2024] Open
Abstract
Objective: Childhood epilepsy with centrotemporal spikes (CECTS) is associated with cognitive, behavioral, and language difficulties. These epileptic discharges predominantly occur in the temporal lobe, which is known to be involved in olfactory functions. This study aims to assess olfactory dysfunction in patients with CECTS. Methods: This study included patients diagnosed with CECTS who were attending follow-ups at the Department of Child Neurology between January 2022 and July 2023. Olfactory function was evaluated using the Sniffin' Sticks (Burghart GmbH, Wedel, Germany) 12-point screening test, which was administered to 44 patients and 35 controls. The smell test and the final control EEGs were performed simultaneously. Results: A total of 44 patients and 35 control subjects were enrolled in this study. The smell scores were significantly lower in the patient group compared to the control group (p = 0.029). The patient group had a very high prevalence of anosmia compared to the control group. The normosmia rate in the control group was significantly higher. No significant difference was observed in the smell scores based on EEG findings or antiepileptic drug type. Conclusions: Olfactory dysfunction was identified in patients with CECTS compared to healthy controls, yielding results consistent with findings for other types of epilepsy. Olfactory dysfunction was detected in a greater frequency among the patients diagnosed with CECTS than among the healthy control group, and similar results were obtained with other types of epilepsy. It was deduced that these patients may experience problems with smell sensitivity throughout their lives. The most important result of this study is that this condition should be taken into account in regard to patients' well-being and lives.
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Affiliation(s)
- Orhan Coşkun
- Department of Pediatric Neurology, Gaziosmanpaşa Training and Research Hospital, 34255 Istanbul, Turkey; (A.Ü.); (S.P.); (H.N.D.)
| | - Burçin Nazlı Karacabey
- Department of Pediatric Neurology, Istanbul Faculty of Medicine, Istanbul University, 34093 Istanbul, Turkey;
| | - Afra Ünal
- Department of Pediatric Neurology, Gaziosmanpaşa Training and Research Hospital, 34255 Istanbul, Turkey; (A.Ü.); (S.P.); (H.N.D.)
| | - Samet Paksoy
- Department of Pediatric Neurology, Gaziosmanpaşa Training and Research Hospital, 34255 Istanbul, Turkey; (A.Ü.); (S.P.); (H.N.D.)
| | - Hale Nur Durak
- Department of Pediatric Neurology, Gaziosmanpaşa Training and Research Hospital, 34255 Istanbul, Turkey; (A.Ü.); (S.P.); (H.N.D.)
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Liger-Belair G, Cilindre C, Beaumont F, Polidori G. Understanding the tasting of champagne and other sparkling wines from a scientific perspective. Food Res Int 2024; 191:114678. [PMID: 39059939 DOI: 10.1016/j.foodres.2024.114678] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/13/2023] [Revised: 06/18/2024] [Accepted: 06/26/2024] [Indexed: 07/28/2024]
Abstract
From uncorking the bottle to the bursting of bubbles in the glass, the science behind the tasting of champagne and other sparkling wine is both traditional and at the forefront of modern developments. The strong interaction between the various parameters at play in a bottle and in a glass of sparkling wine has been the subject of study for around two decades. Indeed, sparkling wine tasting is often seen as the pinnacle of glamor and frivolity for most people, but it should also be considered as a fantastic playground for chemists and physicists to explore the subtle science behind this centuries-old drink, whose prestige today goes well beyond the borders of Champagne and France. This article offers an overview of the physicochemical processes that mark a tasting of champagne or sparkling wine in the broad sense, from the cork popping out of the bottleneck to the formation and bursting of bubbles in your glass, including the choice of the glass and how to serve and drink the wine correctly.
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Affiliation(s)
| | - Clara Cilindre
- Université de Reims Champagne-Ardenne, CNRS, GSMA, Reims, France
| | - Fabien Beaumont
- Université de Reims Champagne-Ardenne, ITHEMM, Reims, France
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Karunanayaka PR, Lu J, Elyan R, Yang QX, Sathian K. Olfactory-trigeminal integration in the primary olfactory cortex. Hum Brain Mapp 2024; 45:e26772. [PMID: 38962966 PMCID: PMC11222875 DOI: 10.1002/hbm.26772] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/20/2023] [Revised: 06/07/2024] [Accepted: 06/16/2024] [Indexed: 07/05/2024] Open
Abstract
Humans naturally integrate signals from the olfactory and intranasal trigeminal systems. A tight interplay has been demonstrated between these two systems, and yet the neural circuitry mediating olfactory-trigeminal (OT) integration remains poorly understood. Using functional magnetic resonance imaging (fMRI), combined with psychophysics, this study investigated the neural mechanisms underlying OT integration. Fifteen participants with normal olfactory function performed a localization task with air-puff stimuli, phenylethyl alcohol (PEA; rose odor), or a combination thereof while being scanned. The ability to localize PEA to either nostril was at chance. Yet, its presence significantly improved the localization accuracy of weak, but not strong, air-puffs, when both stimuli were delivered concurrently to the same nostril, but not when different nostrils received the two stimuli. This enhancement in localization accuracy, exemplifying the principles of spatial coincidence and inverse effectiveness in multisensory integration, was associated with multisensory integrative activity in the primary olfactory (POC), orbitofrontal (OFC), superior temporal (STC), inferior parietal (IPC) and cingulate cortices, and in the cerebellum. Multisensory enhancement in most of these regions correlated with behavioral multisensory enhancement, as did increases in connectivity between some of these regions. We interpret these findings as indicating that the POC is part of a distributed brain network mediating integration between the olfactory and trigeminal systems. PRACTITIONER POINTS: Psychophysical and neuroimaging study of olfactory-trigeminal (OT) integration. Behavior, cortical activity, and network connectivity show OT integration. OT integration obeys principles of inverse effectiveness and spatial coincidence. Behavioral and neural measures of OT integration are correlated.
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Affiliation(s)
- Prasanna R. Karunanayaka
- Department of RadiologyPennsylvania State University College of MedicineHersheyPennsylvaniaUSA
- Department of Neural and Behavioral SciencesPennsylvania State University College of MedicineHersheyPennsylvaniaUSA
- Department of Public Health SciencesPennsylvania State University College of MedicineHersheyPennsylvaniaUSA
| | - Jiaming Lu
- Department of RadiologyPennsylvania State University College of MedicineHersheyPennsylvaniaUSA
- Drum Tower HospitalMedical School of Nanjing UniversityNanjingChina
| | - Rommy Elyan
- Department of RadiologyPennsylvania State University College of MedicineHersheyPennsylvaniaUSA
| | - Qing X. Yang
- Department of RadiologyPennsylvania State University College of MedicineHersheyPennsylvaniaUSA
- Department of NeurosurgeryPennsylvania State University College of MedicineHersheyPennsylvaniaUSA
| | - K. Sathian
- Department of Neural and Behavioral SciencesPennsylvania State University College of MedicineHersheyPennsylvaniaUSA
- Department of NeurologyPenn State Health Milton S. Hershey Medical CenterHersheyPennsylvaniaUSA
- Department of PsychologyPennsylvania State University College of Liberal ArtsState CollegePennsylvaniaUSA
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Ekanayake A, Peiris S, Kanekar S, Tobia M, Yang Q, Ahmed B, McCaslin S, Kalra D, Eslinger P, Karunanayaka P. Monorhinal and birhinal odor processing in humans: an fMRI investigation. Chem Senses 2024; 49:bjae038. [PMID: 39387136 PMCID: PMC11582365 DOI: 10.1093/chemse/bjae038] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/09/2024] [Indexed: 10/12/2024] Open
Abstract
The olfactory nerve, also known as cranial nerve I, is known to have exclusive ipsilateral projections to primary olfactory cortical structures. However, the lateralization of olfactory processes is known to depend on the task and nature of stimuli. It still remains unclear whether olfactory system projections in humans also correspond to functional pathways during olfactory tasks without any trigeminal, perceptual, or cognitive-motor components. Twenty young healthy subjects with a normal sense of smell took part in an olfactory functional magnetic resonance imaging (fMRI) study. We used 2 types of nostril-specific stimulation, passive (no sniffing), and active (with sniffing), with phenyl ethyl alcohol, a pure olfactory stimulant, to investigate fMRI activity patterns in primary and secondary olfactory-related brain structures. Irrespective of the stimulated nostril and the type of stimulation, we detected symmetrical activity in primary and secondary olfactory-related brain structures such as the primary olfactory cortex, entorhinal cortex, and orbitofrontal cortex. In the absence of perceptual or cognitive-motor task demands, the perception of monorhinally presented pure odors is processed bilaterally in the brain.
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Affiliation(s)
- Anupa Ekanayake
- Grodno State Medical University, Grodno, Belarus
- Department of Radiology, Penn State University College of Medicine, Hershey, PA, United States
| | - Senal Peiris
- Department of Radiology, Penn State University College of Medicine, Hershey, PA, United States
| | - Sangam Kanekar
- Department of Radiology, Penn State University College of Medicine, Hershey, PA, United States
| | - Michael Tobia
- Department of Radiology, Penn State University College of Medicine, Hershey, PA, United States
| | - Qing Yang
- Department of Radiology, Penn State University College of Medicine, Hershey, PA, United States
- Department of Neurosurgery, Penn State University College of Medicine, Hershey, PA, United States
| | - Biyar Ahmed
- Department of Radiology, Penn State University College of Medicine, Hershey, PA, United States
| | - Silas McCaslin
- Department of Radiology, Penn State University College of Medicine, Hershey, PA, United States
| | - Deepak Kalra
- Department of Neurology, Penn State University College of Medicine, Hershey, PA, United States
| | - Paul Eslinger
- Department of Radiology, Penn State University College of Medicine, Hershey, PA, United States
- Department of Neurology, Penn State University College of Medicine, Hershey, PA, United States
| | - Prasanna Karunanayaka
- Department of Radiology, Penn State University College of Medicine, Hershey, PA, United States
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Genovese F, Xu J, Tizzano M, Reisert J. Quantifying Peripheral Modulation of Olfaction by Trigeminal Agonists. J Neurosci 2023; 43:7958-7966. [PMID: 37813571 PMCID: PMC10669757 DOI: 10.1523/jneurosci.0489-23.2023] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/03/2023] [Revised: 08/15/2023] [Accepted: 09/06/2023] [Indexed: 10/17/2023] Open
Abstract
In the mammalian nose, two chemosensory systems, the trigeminal and the olfactory mediate the detection of volatile chemicals. Most odorants are able to activate the trigeminal system, and vice versa, most trigeminal agonists activate the olfactory system as well. Although these two systems constitute two separate sensory modalities, trigeminal activation modulates the neural representation of an odor. The mechanisms behind the modulation of olfactory response by trigeminal activation are still poorly understood. We addressed this question by looking at the olfactory epithelium (OE), where olfactory sensory neurons (OSNs) and trigeminal sensory fibers co-localize and where the olfactory signal is generated. Our study was conducted in a mouse model. Both sexes, males and females, were included. We characterize the trigeminal activation in response to five different odorants by measuring intracellular Ca2+ changes from primary cultures of trigeminal neurons (TGNs). We also measured responses from mice lacking TRPA1 and TRPV1 channels known to mediate some trigeminal responses. Next, we tested how trigeminal activation affects the olfactory response in the olfactory epithelium using electro-olfactogram (EOG) recordings from wild-type (WT) and TRPA1/V1-knock out (KO) mice. The trigeminal modulation of the olfactory response was determined by measuring responses to the odorant, 2-phenylethanol (PEA), an odorant with little trigeminal potency after stimulation with a trigeminal agonist. Trigeminal agonists induced a decrease in the EOG response to PEA, which depended on the level of TRPA1 and TRPV1 activation induced by the trigeminal agonist. This suggests that trigeminal activation can alter odorant responses even at the earliest stage of the olfactory sensory transduction.SIGNIFICANCE STATEMENT Most odorants reaching the olfactory epithelium (OE) can simultaneously activate olfactory and trigeminal systems. Although these two systems constitute two separate sensory modalities, trigeminal activation can alter odor perception. Here, we analyzed the trigeminal activity induced by different odorants proposing an objective quantification of their trigeminal potency independent from human perception. We show that trigeminal activation by odorants reduces the olfactory response in the olfactory epithelium and that such modulation correlates with the trigeminal potency of the trigeminal agonist. These results show that the trigeminal system impacts the olfactory response from its earliest stage.
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Affiliation(s)
| | - Jiang Xu
- Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104
| | - Marco Tizzano
- Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104
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Bräuer AU, Sevecke-Rave J, Gläser A, Nahrath P, Hummel T, Witt M. Optimization of mRNA extraction from human nasal mucosa biopsies for gene expression profile analysis by qRT-PCR. Clin Anat 2023; 36:1001-1006. [PMID: 37337364 DOI: 10.1002/ca.24081] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/08/2023] [Accepted: 05/28/2023] [Indexed: 06/21/2023]
Abstract
Quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR) is the gold-standard method for analyzing modifications in gene expression in cells and tissues. However, large quantities of high-quality RNA samples are needed for analyzing the expression of multiple genes from one human tissue sample. Here, we provide an optimized protocol for extracting large amounts of RNA from human nasal mucosal biopsies. The quality and quantity of samples were sufficient for qRT-PCR analyses of the expressions of various genes, in duplicate. In contrast to other protocols, we optimized RNA isolation to increase the amount from nasal biopsy samples for analyses of multiple genes. In most previous publications, expressions of only one or a few genes, including housekeeping genes, were analyzed because the amount of biological material was small. We were able to improve our protocol with respect to the yield and quality of RNA. This is likely to produce better results from molecular analyses of very small biopsy samples of human nasal mucosa.
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Affiliation(s)
- A U Bräuer
- Research Group Anatomy, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany
- Research Center Neurosensory Science, Carl von Ossietzky University Oldenburg, Oldenburg, Germany
| | - J Sevecke-Rave
- Research Group Anatomy, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany
| | - A Gläser
- Research Group Anatomy, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany
| | - P Nahrath
- Smell and Taste Clinic, Department of Otorhinolaryngology, Medical Faculty Carl-Gustav Carus, Technische Universität Dresden, Dresden, Germany
| | - T Hummel
- Smell and Taste Clinic, Department of Otorhinolaryngology, Medical Faculty Carl-Gustav Carus, Technische Universität Dresden, Dresden, Germany
| | - M Witt
- Institute of Anatomy & Centre of Transdisciplinary Neuroscience Rostock, University Medical Center Rostock, Rostock, Germany
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Ekanayake A, Yang Q, Kanekar S, Ahmed B, McCaslin S, Kalra D, Eslinger P, Karunanayaka P. Monorhinal and Birhinal Odor Processing in Humans: an fMRI investigation. BIORXIV : THE PREPRINT SERVER FOR BIOLOGY 2023:2023.08.01.551475. [PMID: 37577649 PMCID: PMC10418263 DOI: 10.1101/2023.08.01.551475] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 08/15/2023]
Abstract
The olfactory nerve, also known as cranial nerve I, is known to have exclusive ipsilateral projections to primary olfactory cortical structures. It is still unclear whether these projections also correspond to functional pathways of odor processing. In an olfactory functional magnetic resonance imaging (fMRI) study of twenty young healthy subjects with a normal sense of smell, we tested whether nostril specific stimulation with phenyl ethyl alcohol (PEA), a pure olfactory stimulant, asymmetrically activates primary or secondary olfactory-related brain structures such as primary olfactory cortex, entorhinal cortex, and orbitofrontal cortex. The results indicated that without a challenging olfactory task, passive (no sniffing) and active (with sniffing) nostril-specific PEA stimulation did not produce asymmetrical fMRI activation in olfactory cortical structures.
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Affiliation(s)
- Anupa Ekanayake
- Grodno State Medical University, Grodno, Belarus
- Department of Radiology, Penn State University College of Medicine, Hershey, PA, USA
| | - Qing Yang
- Department of Radiology, Penn State University College of Medicine, Hershey, PA, USA
- Department of Neurosurgery, Penn State University College of Medicine, Hershey, PA, USA
| | - Sangam Kanekar
- Department of Radiology, Penn State University College of Medicine, Hershey, PA, USA
| | - Biyar Ahmed
- Department of Radiology, Penn State University College of Medicine, Hershey, PA, USA
| | - Silas McCaslin
- Department of Radiology, Penn State University College of Medicine, Hershey, PA, USA
| | - Deepak Kalra
- Department of Neurology, Penn State University College of Medicine, Hershey, PA, USA
| | - Paul Eslinger
- Department of Radiology, Penn State University College of Medicine, Hershey, PA, USA
- Department of Neurology, Penn State University College of Medicine, Hershey, PA, USA
| | - Prasanna Karunanayaka
- Department of Radiology, Penn State University College of Medicine, Hershey, PA, USA
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Hernandez AK, Hummel T. Intranasal trigeminal function in chronic rhinosinusitis: a review. Expert Rev Clin Immunol 2023; 19:921-938. [PMID: 37379521 DOI: 10.1080/1744666x.2023.2231149] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/17/2023] [Revised: 06/22/2023] [Accepted: 06/26/2023] [Indexed: 06/30/2023]
Abstract
INTRODUCTION Chronic rhinosinusitis (CRS) affects 5-12% of the general population with significant effects on quality of life. Chronic inflammation also seems to affect intranasal trigeminal sensitivity. AREAS COVERED A systematic literature search was done in Scopus, Web of Science, and PubMed in February 2023. The review addressed intranasal trigeminal function in patients with CRS and summarized current knowledge on trigeminal function as it relates to the symptoms, assessment, and treatment of CRS. EXPERT OPINION Olfaction and trigeminal function are synergistic and this interaction may contribute to trigeminal dysfunction in CRS. Aside from anatomic blockage through polypoid mucosal changes, trigeminal dysfunction may affect the perception of nasal obstruction in CRS. Upregulated immune defense mechanisms leading to damage of nerve endings, changes in nerve growth factor release or other mechanisms may be responsible for trigeminal dysfunction in CRS. Since the pathophysiology of trigeminal dysfunction in CRS is poorly understood, current treatment recommendations are directed toward the therapy of CRS as an underlying cause, although the effect of surgery and corticosteroids on trigeminal function remains unclear. A standardized and validated trigeminal test that is accessible and easy to use in clinical settings would be beneficial for future studies.
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Affiliation(s)
- Anna Kristina Hernandez
- Smell and Taste Clinic, Department of Otorhinolaryngology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
- Department of Otolaryngology - Head and Neck Surgery, Philippine General Hospital, University of the Philippines, Manila, Philippines
- Department of Otolaryngology - Head and Neck Surgery, Asian Hospital and Medical Center, Muntinlupa, Philippines
| | - Thomas Hummel
- Smell and Taste Clinic, Department of Otorhinolaryngology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
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Hamed SA, Kamal-Eldeen EB, Ahmed MAAR. Evaluation of children and adults with post-COVID-19 persistent smell, taste and trigeminal chemosensory disorders: A hospital based study. World J Clin Pediatr 2023; 12:133-150. [PMID: 37342446 PMCID: PMC10278074 DOI: 10.5409/wjcp.v12.i3.133] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/27/2023] [Revised: 03/16/2023] [Accepted: 04/20/2023] [Indexed: 06/08/2023] Open
Abstract
BACKGROUND Smell disorders are the most frequent persistent coronavirus disease 2019 (COVID-19) complications. AIM To describe the patterns and characteristics of persistent smell and taste disorders in Egyptian patients. METHODS Assessment was done to 185 patients (adults = 150, age: 31.41 ± 8.63 years; children = 35; age: 15.66 ± 1.63 years). Otolaryngology and neuropsychiatric evaluations were done. Measurements included: A clinical questionnaire (for smell and taste); sniffin' odor, taste and flavor identification tests and the Questionnaire of Olfactory Disorders-Negative Statements (sQOD-NS). RESULTS Duration of disorders was 11.53 ± 3.97 ms (6-24 ms). Parosmia (n = 119; 64.32%) was developed months after anosmia (3.05 ± 1.87 ms). Objective testing showed anosmia in all, ageusia and flavor loss in 20% (n = 37) and loss of nasal and oral trigeminal sensations in 18% (n = 33) and 20% (n = 37), respectively. Patients had low scoring of sQOD-NS (11.41 ± 3.66). There were no specific differences in other demographics and clinical variables which could distinguish post-COVID-19 smell and taste disorders in children from adults. CONCLUSION The course of small and taste disorders are supportive of the nasal and oral neuronal compromises. Post-COVID-19 taste and trigeminal disorders were less frequent compared to smell disorders. Post-COVID-19 flavor disorders were solely dependent on taste and not smell disorders. There were no demographics, clinical variables at onset or specific profile of these disorders in children compared to adults.
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Affiliation(s)
- Sherifa Ahmed Hamed
- Department of Neurology and Psychiatry, Assiut University, Faculty of Medicine, Assiut 71516, Egypt
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Hamed SA. Post-COVID-19 persistent olfactory, gustatory, and trigeminal chemosensory disorders: Definitions, mechanisms, and potential treatments. World J Otorhinolaryngol 2023; 10:4-22. [DOI: 10.5319/wjo.v10.i2.4] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/20/2023] [Revised: 03/28/2023] [Accepted: 04/18/2023] [Indexed: 05/08/2023] Open
Abstract
The nose and the oral cavities are the main sites for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry into the body. Smell and taste deficits are the most common acute viral manifestations. Persistent smell disorders are the most common and bothersome complications after SARS-CoV-2 infection, lasting for months to years. The mechanisms and treatment of persistent post-coronavirus disease 2019 (COVID-19) smell and taste disorders are still challenges. Information sources for the review are PubMed, Centers for Disease Control and Prevention, Ovid Medline, Embase, Scopus, Web of Science, International Prospective Register of Systematic Reviews, Cumulative Index to Nursing and Allied Health Literature, Elton Bryson Stephens Company, Cochrane Effective Practice and Organization of Care, Cooperation in Science and Technology, International Clinical Trials Registry Platform, World Health Organization, Randomized Controlled Trial Number Registry, and MediFind. This review summarizes the up-to-date information about the prevalence, patterns at onset, and prognoses of post-COVID-19 smell and taste disorders, evidence for the neurotropism of SARS-CoV-2 and the overlap between SARS-CoV-1, Middle East respiratory syndrome coronavirus, and SARS-CoV-2 in structure, molecular biology, mode of replication, and host pathogenicity, the suggested cellular and molecular mechanisms for these post-COVID19 chemosensory disorders, and the applied pharmacotherapies and interventions as trials to treat these disorders, and the recommendations for future research to improve understanding of predictors and mechanisms of these disorders. These are crucial for hopeful proper treatment strategies.
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Affiliation(s)
- Sherifa Ahmed Hamed
- Department of Neurology and Psychiatry, Assiut University, Faculty of Medicine, Assiut 71516, Egypt
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13
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Federica G, Jiang X, Marco T, Johannes R. Quantifying peripheral modulation of olfaction by trigeminal agonists. BIORXIV : THE PREPRINT SERVER FOR BIOLOGY 2023:2023.03.13.532477. [PMID: 36993353 PMCID: PMC10054987 DOI: 10.1101/2023.03.13.532477] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Indexed: 06/19/2023]
Abstract
In the mammalian nose, two chemosensory systems, the trigeminal and the olfactory mediate the detection of volatile chemicals. Most odorants in fact are able to activate the trigeminal system, and vice versa, most trigeminal agonists activate the olfactory system as well. Although these two systems constitute two separate sensory modalities, trigeminal activation modulates the neural representation of an odor. The mechanisms behind the modulation of olfactory response by trigeminal activation are still poorly understood. In this study, we addressed this question by looking at the olfactory epithelium, where olfactory sensory neurons and trigeminal sensory fibers co-localize and where the olfactory signal is generated. We characterize the trigeminal activation in response to five different odorants by measuring intracellular Ca2+ changes from primary cultures of trigeminal neurons (TGNs). We also measured responses from mice lacking TRPA1 and TRPV1 channels known to mediate some trigeminal responses. Next, we tested how trigeminal activation affects the olfactory response in the olfactory epithelium using electro-olfactogram (EOG) recordings from WT and TRPA1/V1-KO mice. The trigeminal modulation of the olfactory response was determined by measuring responses to the odorant, 2-phenylethanol (PEA), an odorant with little trigeminal potency after stimulation with a trigeminal agonist. Trigeminal agonists induced a decrease in the EOG response to PEA, which depended on the level of TRPA1 and TRPV1 activation induced by the trigeminal agonist. This suggests that trigeminal activation can alter odorant responses even at the earliest stage of the olfactory sensory transduction.
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Affiliation(s)
| | - Xu Jiang
- Monell Chemical Senses Center, 19104 Philadelphia, PA, USA
| | - Tizzano Marco
- Monell Chemical Senses Center, 19104 Philadelphia, PA, USA
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14
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Chao YT, Nakov A, Haehner A, Poletti S, Hummel T. Olfactory stimulation may modulate the sensation of nasal patency. Rhinology 2023; 61:24-31. [PMID: 36717267 DOI: 10.4193/rhin22.333] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/07/2022]
Abstract
BACKGROUND The sensation of nasal patency can be induced by inhaling menthol, which predominantly produces trigeminal stimulation. It remains unclear whether olfactory stimulation can also induce or modulate the sensation of nasal patency. METHODOLOGY A total of 118 participants (normosmia: n=67, olfactory dysfunction: n=51) were exposed to four odors in a randomized order: 1) phenylethanol (PEA), 2) menthol, 3) a mixture of PEA and menthol, 4) nearly odorless propylene glycol. The odors were presented by nasal clips. After the nasal clip had been removed, the participants rated relative nasal patency (RNP) from - 50 to +50, and their peak nasal inspiratory flow (PNIF) was measured. Repeated measures analysis of variance was used to examine the difference of RNP and PNIF among the four conditions and the influence of olfactory function. RESULTS The RNPs, other than PNIFs, differed between the four conditions. Menthol induced the highest RNP, followed by the mixed solution, PEA and the odorless condition. Normosmic participants, but not those with olfactory dysfunction, responded to PEA significantly higher than odorless condition with regard to RNP. The correlation analysis showed that the better the subjective or measured olfactory performance, the greater the PEA-induced sensation of nasal patency. CONCLUSIONS A specific olfactory stimulant that selectively induces olfactory perception can also evoke and modulate the sensation of nasal patency. Hence, patients might benefit from exposing themselves to odors in order to relieve the annoying nasal obstruction.
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Affiliation(s)
- Y-T Chao
- Smell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany; Division of Rhinology, Department of Otorhinolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan
| | - A Nakov
- Smell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany
| | - A Haehner
- Smell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany
| | - S Poletti
- Smell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany; Department of Otorhinolaryngology, Inselspital, Bern, Switzerland
| | - T Hummel
- Smell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany
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15
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Kryukov AI, Kunel'skaya NL, Zaoeva ZO, Bajbakova EV, Chugunova MA, Vasilchenko NO, Panasov SA, Panova TN. [Involvement of the trigeminal nerve system in the sense of smell]. Zh Nevrol Psikhiatr Im S S Korsakova 2023; 123:7-12. [PMID: 38147376 DOI: 10.17116/jnevro20231231217] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/27/2023]
Abstract
A systematic review of literature on the issue of involvement in the sense of smell, as well as the interaction between the trigeminal and olfactory nerves, was carried out. The article discusses the features of the chemical perception systems, as well as the treatment of olfactory disorders using transcranial electrical stimulation of the trigeminal nerve.
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Affiliation(s)
- A I Kryukov
- Sverzhevsky Research Clinical Institute of Otorhinolaryngology, Moscow, Russia
- Pirogov Russian National Research Medical University, Moscow, Russia
| | - N L Kunel'skaya
- Sverzhevsky Research Clinical Institute of Otorhinolaryngology, Moscow, Russia
- Pirogov Russian National Research Medical University, Moscow, Russia
| | - Z O Zaoeva
- Sverzhevsky Research Clinical Institute of Otorhinolaryngology, Moscow, Russia
| | - E V Bajbakova
- Sverzhevsky Research Clinical Institute of Otorhinolaryngology, Moscow, Russia
| | - M A Chugunova
- Sverzhevsky Research Clinical Institute of Otorhinolaryngology, Moscow, Russia
| | - N O Vasilchenko
- Sverzhevsky Research Clinical Institute of Otorhinolaryngology, Moscow, Russia
| | - S A Panasov
- Sverzhevsky Research Clinical Institute of Otorhinolaryngology, Moscow, Russia
| | - T N Panova
- Sverzhevsky Research Clinical Institute of Otorhinolaryngology, Moscow, Russia
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16
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Li H, Lee C, Kay LM. Testing effects of trigeminal stimulation on binary odor mixture quality in rats. Front Neurosci 2023; 17:1059741. [PMID: 36960175 PMCID: PMC10027748 DOI: 10.3389/fnins.2023.1059741] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/02/2022] [Accepted: 02/16/2023] [Indexed: 03/09/2023] Open
Abstract
Prior attempts at forming theoretical predictions regarding the quality of binary odor mixtures have failed to find any consistent predictor for overshadowing of one component in a binary mixture by the other. We test here the hypothesis that trigeminality contributes to overshadowing effects in binary mixture perception. Most odorants stimulate the trigeminal nerve in the nasal sensory epithelium. In the current study we test rats' ability to detect component odorants in four binary odor sets chosen for their relative trigeminality. We predicted that the difference in trigeminal intensity would predict the degree of overshadowing by boosting or suppressing perceptual intensity of these odorants during learning or during mixture perception. We used a two-alternative choice (TAC) task in which rats were trained to recognize the two components of each mixture and tested on a range of mixtures of the two without reinforcement. We found that even though odorant concentrations were adjusted to balance volatility, all odor sets produced asymmetric psychometric curves. Odor pairs with the greatest difference in trigeminality showed overshadowing by the odorant with weaker trigeminal properties. Odor sets with more evenly matched trigeminal properties also showed asymmetry that was not predicted by either small differences in volatility or trigeminality. Thus, trigeminal properties may influence overshadowing in odor mixtures, but other factors are also likely involved. These mixed results further support the need to test each odor mixture to determine its odor quality and underscore recent results at the level of olfactory receptor neurons that show massive and unpredictable inhibition among odorants in complex mixtures.
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Affiliation(s)
- Huibo Li
- Department of Psychology, The University of Chicago, Chicago, IL, United States
- Institute for Mind and Biology, The University of Chicago, Chicago, IL, United States
| | - Clara Lee
- The College, The University of Chicago, Chicago, IL, United States
| | - Leslie M. Kay
- Department of Psychology, The University of Chicago, Chicago, IL, United States
- Institute for Mind and Biology, The University of Chicago, Chicago, IL, United States
- The College, The University of Chicago, Chicago, IL, United States
- *Correspondence: Leslie M. Kay,
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17
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Ramudit AE, Feldmeyer A, Johnson A, Ennis JM. Sensory interaction effects between capsicum heat and seasoning ingredients applied to unsalted potato chips. Food Qual Prefer 2022. [DOI: 10.1016/j.foodqual.2022.104682] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/28/2022]
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Lecasse F, Vallon R, Polak F, Cilindre C, Parvitte B, Liger-Belair G, Zéninari V. An Infrared Laser Sensor for Monitoring Gas-Phase CO2 in the Headspace of Champagne Glasses under Wine Swirling Conditions. SENSORS 2022; 22:s22155764. [PMID: 35957321 PMCID: PMC9371247 DOI: 10.3390/s22155764] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 07/08/2022] [Revised: 07/28/2022] [Accepted: 07/29/2022] [Indexed: 11/16/2022]
Abstract
In wine tasting, tasters commonly swirl their glasses before inhaling the headspace above the wine. However, the consequences of wine swirling on the chemical gaseous headspace inhaled by tasters are barely known. In champagne or sparkling wine tasting, starting from the pouring step, gas-phase carbon dioxide (CO2) is the main gaseous species that progressively invades the glass headspace. We report the development of a homemade orbital shaker to replicate wine swirling and the upgrade of a diode laser sensor (DLS) dedicated to monitoring gas-phase CO2 in the headspace of champagne glasses under swirling conditions. We conduct a first overview of gas-phase CO2 monitoring in the headspace of a champagne glass, starting from the pouring step and continuing for the next 5 min, with several 5 s swirling steps to replicate the natural orbital movement of champagne tasters. The first results show a sudden drop in the CO2 concentration in the glass headspace, probably triggered by the liquid wave traveling along the glass wall following the action of swirling the glass.
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Maki P, Itharat A, Thongdeeying P, Tuy-On T, Kuropakornpong P, Pipatrattanaseree W, Mingmalairak C, Davies NM. Ethnopharmacological nexus between the traditional Thai medicine theory and biologically based cancer treatment. JOURNAL OF ETHNOPHARMACOLOGY 2022; 287:114932. [PMID: 34953977 DOI: 10.1016/j.jep.2021.114932] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 10/03/2021] [Revised: 12/14/2021] [Accepted: 12/19/2021] [Indexed: 06/14/2023]
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE The two major theories utilized for diagnosis and treatment in Traditional Thai Medicine (TTM) are the Four Element Theory and the Herbal Flavor Theory. A TTM "Poh-Pu" Remedy has been effectively utilized in Thailand for cancer therapy for centuries. AIMS OF STUDY To investigate anti-inflammatory activity and liver cancer cytotoxicity of Poh-Pu remedy. To determine relationships between the TTM Herbal Flavor theory and the Four Element theory and total flavonoid content and biological activities of Poh-Pu Remedy plant extracts. MATERIALS AND METHODS Each plant ingredient was macerated with 95% ethanol. The extracts were investigated for cytotoxic activity against liver cancer using a sulforhodamine B assay, and anti-inflammatory activity was evaluated by inhibition of nitric oxide production. The total flavonoid content was determined by an aluminum chloride colorimetric assay. The relationships between the TTM theories, total flavonoid content, and biological activities were evaluated by correlation and cluster analysis. RESULTS Mammea siamensis exerted potent cytotoxicity against hepatocellular carcinoma (HepG2) cell lines with an IC50 of 3.15 ± 0.16 μg/mL and low cytotoxicity to the non-cancerous cells (HaCat) with an IC50 33.39 ± 0.40 μg/mL (Selective index (SI) = 10.6). Tiliacora triandra was selectively cytotoxic to cholangiocarcinama (KKU-M156) cells with an IC50 of 12.65 ± 0.92 μg/mL (SI = 6.4). Curcuma comosa was the most potent anti-inflammatory inhibitor of nitric oxide production with an IC50 of 2.75 ± 0.34 μg/mL. Campomanesia aromatica exhibited the highest total flavonoid content of 259.7 ± 3.21 mg quercetin equivalent/g. Pungent plants were most prevalent in the TTM remedy. CONCLUSION Pungent, fragrant, bitter and nauseating plants utilized in TTM cancer remedy were successfully investigated and identified several lead plants and components with cytotoxic and antiinflammatory activity that require further study. The TTM wind element theory appeared to be aligned with cancer-related activity. Biological activity results of taste from herbs related with The TTM Herbal Flavor theory. The extra-oral locations of flavor receptors are a promising target for biological activity of TTM which require further scrutiny and identified several lead plants and components with cytotoxic and antiinflammatory activities that also require further study.
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Affiliation(s)
- Ponlawat Maki
- Student of Doctor of Philosophy (Applied Thai Traditional Medicine), Faculty of Medicine, Thammasat University (Rangsit Campus), Pathumthani, 12120, Thailand.
| | - Arunporn Itharat
- Faculty of Medicine, Thammasat University (Rangsit Campus), Department of Applied Thai Traditional Medicine, Pathumthani, 12120, Thailand; Center of Excellence in Applied Thai Traditional Medicine Research, Thammasat University (Rangsit Campus), Pathumthani, 12120, Thailand.
| | - Pakakrong Thongdeeying
- Faculty of Medicine, Thammasat University (Rangsit Campus), Department of Applied Thai Traditional Medicine, Pathumthani, 12120, Thailand; Center of Excellence in Applied Thai Traditional Medicine Research, Thammasat University (Rangsit Campus), Pathumthani, 12120, Thailand.
| | - Thammarat Tuy-On
- Center of Excellence in Applied Thai Traditional Medicine Research, Thammasat University (Rangsit Campus), Pathumthani, 12120, Thailand.
| | - Pranporn Kuropakornpong
- Center of Excellence in Applied Thai Traditional Medicine Research, Thammasat University (Rangsit Campus), Pathumthani, 12120, Thailand.
| | - Weerachai Pipatrattanaseree
- Regional Medical Science Center 12 Songkhla, Department of Medical Sciences, Ministry of Public Health, Songkhla, 90100, Thailand.
| | - Chatchai Mingmalairak
- Faculty of Medicine, Thammasat University (Rangsit Campus), Department of Surgery and Research Group in Thai Herbs and Traditional Remedy for Cancer Patients, Pathumthani, 12120, Thailand.
| | - Neal M Davies
- Faculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, Edmonton, Canada.
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20
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Badran BW, Gruber EM, O’Leary GH, Austelle CW, Huffman SM, Kahn AT, McTeague LM, Uhde TW, Cortese BM. Electrical stimulation of the trigeminal nerve improves olfaction in healthy individuals: A randomized, double-blind, sham-controlled trial. Brain Stimul 2022; 15:761-768. [PMID: 35561963 PMCID: PMC9976566 DOI: 10.1016/j.brs.2022.05.005] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/25/2022] [Revised: 05/03/2022] [Accepted: 05/05/2022] [Indexed: 11/02/2022] Open
Abstract
BACKGROUND Both activated by environmental odorants, there is a clear role for the intranasal trigeminal and olfactory nerves in smell function. Unfortunately, our ability to perceive odorants decreases with age or with injury, and limited interventions are available to treat smell loss. OBJECTIVE We investigated whether electrical stimulation of the trigeminal nerve via trigeminal nerve stimulation (TNS) or transcranial direct current stimulation (tDCS) modulates odor sensitivity in healthy individuals. METHODS We recruited 20 healthy adults (12 Female, mean age = 27) to participate in this three-visit, randomized, double-blind, sham-controlled trial. Participants were randomized to receive one of three stimulation modalities (TNS, tDCS, or sham) during each of their visits. Odor detection thresholds were obtained at baseline, immediately post-intervention, and 30-min post-intervention. Furthermore, participants were asked to complete a sustained attention task and mood assessments before odor detection testing. RESULTS Findings reveal a timeXcondition interaction for guaiacol (GUA) odorant detection thresholds (F (3.188, 60.57) = 3.833, P = 0.0125), but not phenyl ethyl alcohol (PEA) odorant thresholds. At 30-min post-stimulation, both active TNS and active tDCS showed significantly increased sensitivity to GUA compared to sham TNS (Sham TNS = -8.30% vs. Active TNS = 9.11%, mean difference 17.43%, 95% CI 5.674 to 29.18, p = 0.0044; Sham TNS = -8.30% vs. Active tDCS = 13.58%, mean difference 21.89%, 95% CI 10.47 to 33.32, p = 0.0004). CONCLUSION TNS is a safe, simple, noninvasive method for boosting olfaction. Future studies should investigate the use of TNS on smell function across different stimulation parameters, odorants, and patient populations.
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Affiliation(s)
| | | | | | | | | | | | | | | | - Bernadette M. Cortese
- Corresponding author. Department of Psychiatry and Behavioral Sciences, The Medical University of South Carolina, 67 President Street, BA 504F, Charleston, South Carolina, 29425, USA. (B.M. Cortese)
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21
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Tremblay C, Iravani B, Aubry Lafontaine É, Steffener J, Fischmeister FPS, Lundström JN, Frasnelli J. Parkinson's Disease Affects Functional Connectivity within the Olfactory-Trigeminal Network. JOURNAL OF PARKINSONS DISEASE 2021; 10:1587-1600. [PMID: 32597818 DOI: 10.3233/jpd-202062] [Citation(s) in RCA: 9] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 12/12/2022]
Abstract
BACKGROUND Olfactory dysfunction (OD) is a frequent symptom of Parkinson's disease (PD) that appears years prior to diagnosis. Previous studies suggest that PD-related OD is different from non-parkinsonian forms of olfactory dysfunction (NPOD) as PD patients maintain trigeminal sensitivity as opposed to patients with NPOD who typically exhibit reduced trigeminal sensitivity. We hypothesize the presence of a specific alteration of functional connectivity between trigeminal and olfactory processing areas in PD. OBJECTIVE We aimed to assess potential differences in functional connectivity within the chemosensory network in 15 PD patients and compared them to 15 NPOD patients, and to 15 controls. METHODS Functional MRI scanning session included resting-state and task-related scans where participants carried out an olfactory and a trigeminal task. We compared functional connectivity, using a seed-based correlation approach, and brain network modularity of the chemosensory network. RESULTS PD patients had impaired functional connectivity within the chemosensory network while no such changes were observed for NPOD patients. No group differences we found in modularity of the identified networks. Both patient groups exhibited impaired connectivity when executing an olfactory task, while network modularity was significantly weaker for PD patients than both other groups. When performing a trigeminal task, no changes were found for PD patients, but NPOD patients exhibited impaired connectivity. Conversely, PD patients exhibited a significantly higher network modularity than both other groups. CONCLUSION In summary, the specific pattern of functional connectivity and chemosensory network recruitment in PD-related OD may explain distinct behavioral chemosensory features in PD when compared to NPOD patients and healthy controls.
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Affiliation(s)
- Cécilia Tremblay
- Department of Anatomy, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada
| | - Behzad Iravani
- Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
| | - Émilie Aubry Lafontaine
- Department of Anatomy, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada
| | - Jason Steffener
- Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada
| | | | - Johan N Lundström
- Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
| | - Johannes Frasnelli
- Department of Anatomy, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada.,Research Center, Sacré-Coeur Hospital of Montrealéal, Québec, Canada
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22
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Liger-Belair G, Cilindre C. Recent Progress in the Analytical Chemistry of Champagne and Sparkling Wines. ANNUAL REVIEW OF ANALYTICAL CHEMISTRY (PALO ALTO, CALIF.) 2021; 14:21-46. [PMID: 34014763 DOI: 10.1146/annurev-anchem-061318-115018] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 06/12/2023]
Abstract
The strong interplay between the various parameters at play in a bottle and in a glass of champagne or sparkling wine has been the subject of study for about two decades. After a brief overview of the history of champagne and sparkling wines, this article presents the key steps involved in the traditional method leading to the production of premium modern-day sparkling wines, with a specific focus on quantification of the dissolved CO2 found in the sealed bottles and in a glass. Moreover, a review of the literature on the various chemical and instrumental approaches used in the analysis of dissolved and gaseous CO2, effervescence, foam, and volatile organic compounds is reported.
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Affiliation(s)
- Gérard Liger-Belair
- Equipe Effervescence Champagne et Applications, Groupe de Spectrométrie Moléculaire et Atmosphérique (GSMA), CNRS UMR 7331, UFR Sciences Exactes et Naturelles, BP 1039, Université de Reims Champagne-Ardenne, 51687 Reims CEDEX 2, France; ,
| | - Clara Cilindre
- Equipe Effervescence Champagne et Applications, Groupe de Spectrométrie Moléculaire et Atmosphérique (GSMA), CNRS UMR 7331, UFR Sciences Exactes et Naturelles, BP 1039, Université de Reims Champagne-Ardenne, 51687 Reims CEDEX 2, France; ,
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23
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Arias-Pérez I, Sáenz-Navajas MP, de-la-Fuente-Blanco A, Ferreira V, Escudero A. Insights on the role of acetaldehyde and other aldehydes in the odour and tactile nasal perception of red wine. Food Chem 2021; 361:130081. [PMID: 34022483 DOI: 10.1016/j.foodchem.2021.130081] [Citation(s) in RCA: 29] [Impact Index Per Article: 7.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/20/2020] [Revised: 05/05/2021] [Accepted: 05/08/2021] [Indexed: 11/27/2022]
Abstract
Wine models with or without a dearomatised and lyophilized red wine extract containing a young red aroma base (control) plus one vector with one or several aroma compounds (unsaturated-aldehydes, saturated-aldehydes, benzaldehyde, isoamyl-alcohol, methoxypyrazines and (Z)-1,5-octadien-3-one) were prepared. Models were spiked with increasing amounts of acetaldehyde whose headspace concentrations were controlled. Odour and nasal chemesthesic properties were assessed by a trained sensory panel. Results confirm the contribution of the different players, notably isoamyl-alcohol, (Z)-1,5-octadien-3-one, benzaldehyde and methoxypyrazines, to wine aroma and tactile nasal characteristics and demonstrate that acetaldehyde levels play an outstanding role in their modulation. At low levels, it can play positive roles in some specific aromatic contexts, while at higher levels, enhance the negative effects associated to the generic presence of other aldehydes (saturated, unsaturated and Strecker aldehydes) by enhancing "green vegetable" notes and "itching" character and the "burning" effects linked to high levels of isoamyl alcohol.
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Affiliation(s)
- I Arias-Pérez
- Laboratorio de análisis del aroma y enología (LAAE), Department of Analytical Chemistry, Universidad de Zaragoza, Instituto Agroalimentario de Aragón (IA2) (UNIZAR-CITA), Associate unit to Instituto de Ciencias de la Vid y del Vino (ICVV) (UR-CSIC-GR), c/ Pedro Cerbuna 12, 50009 Zaragoza, Spain
| | - M P Sáenz-Navajas
- Instituto de Ciencias de la Vid y del Vino (ICVV) (Universidad de La Rioja-CSIC-Gobierno de La Rioja), Carretera de Burgos Km. 6, Finca La Grajera, 26007 Logroño, La Rioja, Spain
| | - A de-la-Fuente-Blanco
- Laboratorio de análisis del aroma y enología (LAAE), Department of Analytical Chemistry, Universidad de Zaragoza, Instituto Agroalimentario de Aragón (IA2) (UNIZAR-CITA), Associate unit to Instituto de Ciencias de la Vid y del Vino (ICVV) (UR-CSIC-GR), c/ Pedro Cerbuna 12, 50009 Zaragoza, Spain
| | - V Ferreira
- Laboratorio de análisis del aroma y enología (LAAE), Department of Analytical Chemistry, Universidad de Zaragoza, Instituto Agroalimentario de Aragón (IA2) (UNIZAR-CITA), Associate unit to Instituto de Ciencias de la Vid y del Vino (ICVV) (UR-CSIC-GR), c/ Pedro Cerbuna 12, 50009 Zaragoza, Spain
| | - A Escudero
- Laboratorio de análisis del aroma y enología (LAAE), Department of Analytical Chemistry, Universidad de Zaragoza, Instituto Agroalimentario de Aragón (IA2) (UNIZAR-CITA), Associate unit to Instituto de Ciencias de la Vid y del Vino (ICVV) (UR-CSIC-GR), c/ Pedro Cerbuna 12, 50009 Zaragoza, Spain.
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24
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Kashiwadani H, Higa Y, Sugimura M, Kuwaki T. Linalool odor-induced analgesia is triggered by TRPA1-independent pathway in mice. Behav Brain Funct 2021; 17:3. [PMID: 33902628 PMCID: PMC8077846 DOI: 10.1186/s12993-021-00176-y] [Citation(s) in RCA: 9] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/06/2020] [Accepted: 04/19/2021] [Indexed: 11/10/2022] Open
Abstract
We had recently reported that linalool odor exposure induced significant analgesic effects in mice and that the effects were disappeared in olfactory-deprived mice in which the olfactory epithelium was damaged, thus indicating that the effects were triggered by chemical senses evoked by linalool odor exposure. However, the peripheral neuronal mechanisms, including linalool receptors that contribute toward triggering the linalool odor-induced analgesia, still remain unexplored. In vitro studies have shown that the transient receptor potential ankyrin 1 (TRPA1) responded to linalool, thus raising the possibility that TRPA1 expressed on the trigeminal nerve terminal detects linalool odor inhaled into the nostril and triggers the analgesic effects. To address this hypothesis, we measured the behavioral pain threshold for noxious mechanical stimulation in TRPA1-deficient mice. In contrast to our expectation, we found a significant increase in the threshold after linalool odor exposure in TRPA1-deficient mice, indicating the analgesic effects of linalool odor even in TRPA1-deficient mice. Furthermore, intranasal application of TRPA1 selective antagonist did not alter the analgesic effect of linalool odor. These results showed that the linalool odor-induced analgesia was triggered by a TRPA1-independent pathway in mice.
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Affiliation(s)
- Hideki Kashiwadani
- Department of Physiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan.
| | - Yurina Higa
- Department of Physiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan.,Department of Dental Anesthesiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan
| | - Mitsutaka Sugimura
- Department of Dental Anesthesiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan
| | - Tomoyuki Kuwaki
- Department of Physiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan
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25
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Tremblay C, Frasnelli J. Olfactory-Trigeminal Interactions in Patients with Parkinson's Disease. Chem Senses 2021; 46:6218692. [PMID: 33835144 DOI: 10.1093/chemse/bjab018] [Citation(s) in RCA: 8] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 02/07/2023] Open
Abstract
Olfactory dysfunction (OD) is a highly frequent early non-motor symptom of Parkinson's disease (PD). An important step to potentially use OD for the development of early diagnostic tools of PD is to differentiate PD-related OD from other forms of non-parkinsonian OD (NPOD: postviral, sinunasal, post-traumatic, and idiopathic OD). Measuring non-olfactory chemosensory modalities, especially the trigeminal system, may allow to characterize a PD-specific olfactory profile. We here review the literature on PD-specific chemosensory alteration patterns compared with NPOD. Specifically, we focused on the impact of PD on the trigeminal system and particularly on the interaction between olfactory and trigeminal systems. As this interaction is seemingly affected in a disease-specific manner, we propose a model of interaction between both chemosensory systems that is distinct for PD-related OD and NPOD. These patterns of chemosensory impairment still need to be confirmed in prodromal PD; nevertheless, appropriate chemosensory tests may eventually help to develop diagnostic tools to identify individuals at risks for PD.
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Affiliation(s)
- Cécilia Tremblay
- Department of Anatomy, Université du Québec à Trois-Rivières, 3351 Boulevard des Forges, Trois-Rivières, QC, G9A 5H7, Canada
| | - Johannes Frasnelli
- Department of Anatomy, Université du Québec à Trois-Rivières, 3351 Boulevard des Forges, Trois-Rivières, QC, G9A 5H7, Canada.,Research Center, Sacré-Coeur Hospital of Montreal, 5400 Boulevard Gouin Ouest, Montréal, QC, H4J 1C5, Canada
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26
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Kesserwani H. Migraine Triggers: An Overview of the Pharmacology, Biochemistry, Atmospherics, and Their Effects on Neural Networks. Cureus 2021; 13:e14243. [PMID: 33954064 PMCID: PMC8088284 DOI: 10.7759/cureus.14243] [Citation(s) in RCA: 13] [Impact Index Per Article: 3.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/07/2023] Open
Abstract
We define a migraine trigger to be an endogenous agent or agency such as the menses or an exogenous agent or agency such as red wine or a drop in barometric pressure, and their ability to reduce the threshold of a migraine attack in those predisposed to migraine. This definition excludes agents with idiosyncratic mechanisms that may trigger a migrainous (migraine-like) headache in non-migraineurs such as benign cough headaches or headaches due to altitude-sickness. We also assume as axiomatic that migraine has as its basis the activation of the trigeminovascular pathway (TVP) and the key role of serotonin and the calcitonin gene-related peptide (CGRP). The network activation of the visual/auditory association cortices and the rostrodorsal pons (locus ceruleus and raphe nucleus) are also accepted as key features of activation of the TVP. In addition, we outline the role of the superior salivatory nucleus-sphenopalatine ganglion-greater superficial petrosal nerve (SSN-SPG-GSPN) arc in migraine activation. We also explore how olfactory afferents intermingle with trigeminal nerve collaterals in the glomeruli of the olfactory bulb thus allowing volatile molecules to activate the TVP and induce a migraine. The classification of migraine triggers is complex, as there is a wide panorama of inciting agents, including atmospheric conditions, a wide-ranging variety of foods and beverages, endogenous hormonal influences, synthetic alkaloids and dyes, and volatile molecules (odorants). We will explore the high-frequency migraine-provoking agents in each category. There are exciting and intriguing hypotheses regarding the role of atmospheric chemistry when the barometric pressure drops; the role of hot, dry desert winds and lightning discharges in the generation of cations and the turnover of serotonin in the nervous system. We will explore the effects of a drop in barometric pressure on the vestibular nuclei and the modulation of sympathetically mediated pain. The role of volatile odorants and their activation of the transient receptor potential ankyrin-1 (TRPA-1) receptor will be outlined. We will streamline the highly complex role of estrogen fluctuation in the precipitation of migraine headaches, its pharmacodynamic effects, and the role of the sexually dimorphic nucleus of the preoptic area (SDN-POA) of the hypothalamus. We will also adumbrate the protean effects of alcohol and its congeners and the role of stress and sleep disturbances in the allostatic load model of salience network-pain perception.
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27
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Lötsch J, Hummel T. Data Science-Based Analysis of Patient Subgroup Structures Suggest Effects of Rhinitis on All Chemosensory Perceptions in the Upper Airways. Chem Senses 2021; 46:6075427. [PMID: 33421076 DOI: 10.1093/chemse/bjab001] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/12/2022] Open
Abstract
Viral rhinitis contributes significantly to olfactory dysfunction, but it is unclear how many patients have other chemosensory symptoms in addition to olfactory loss. This was addressed in the present reanalysis of data previously published in Pellegrino R, Walliczek-Dworschak U, Winter G, Hull D, Hummel T. 2017. Investigation of chemosensitivity during and after an acute cold. Int Forum Allergy Rhinol. 7(2):185-191, using unsupervised and supervised machine-learning methods. Fifty-eight patients with acute rhinitis and 59 healthy controls were assessed for orthonasal and retronasal olfactory function, taste, and intranasal trigeminal sensitivity. Unsupervised analysis showed that during rhinitis, clinical scores of olfactory function, expressed as threshold, discrimination, identification (TDI) values, were trimodally distributed. Two minor modes were separated from the main mode at TDI = 30.5, which corresponds to the established limit of hyposmia. This trimodal distribution was not observed after the rhinitis subsided. Olfactory function was not significantly impaired in 40% of all rhinitis patients, whereas it was transiently impaired in 59%. For this group, supervised machine-learning algorithms could be trained with information on retronasal olfactory function, gustatory function, and trigeminal sensitivity to assign patients to subgroups based on orthonasal olfactory function with a balanced classification accuracy of 64-65%. The ability to recognize patients with olfactory loss based on retronasal olfactory function as well as gustatory function and trigeminal sensitivity suggests in turn that these modalities are affected by rhinitis. However, the only modest accuracy at which this information allowed to reproduce the olfactory diagnosis indicated they are involved in the symptomatology of rhinitis to a lesser extent compared with the orthonasal olfactory function.
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Affiliation(s)
- Jörn Lötsch
- Institute of Clinical Pharmacology, Goethe University, Frankfurt am Main, Germany.,Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt am Main, Germany
| | - Thomas Hummel
- Smell & Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany
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28
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Manescu S, Chouinard-Leclaire C, Collignon O, Lepore F, Frasnelli J. Enhanced Odorant Localization Abilities in Congenitally Blind but not in Late-Blind Individuals. Chem Senses 2021; 46:bjaa073. [PMID: 33140091 PMCID: PMC7909301 DOI: 10.1093/chemse/bjaa073] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.8] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/12/2022] Open
Abstract
Although often considered a nondominant sense for spatial perception, chemosensory perception can be used to localize the source of an event and potentially help us navigate through our environment. Would blind people who lack the dominant spatial sense-vision-develop enhanced spatial chemosensation or suffer from the lack of visual calibration on spatial chemosensory perception? To investigate this question, we tested odorant localization abilities across nostrils in blind people compared to sighted controls and if the time of vision loss onset modulates those abilities. We observed that congenitally blind individuals (10 subjects) outperformed sighted (20 subjects) and late-blind subjects (10 subjects) in a birhinal localization task using mixed olfactory-trigeminal stimuli. This advantage in congenitally blind people was selective to olfactory localization but not observed for odorant detection or identification. We, therefore, showed that congenital blindness but not blindness acquired late in life is linked to enhanced localization of chemosensory stimuli across nostrils, most probably of the trigeminal component. In addition to previous studies highlighting enhanced localization abilities in auditory and tactile modalities, our current results extend such enhanced abilities to chemosensory localization.
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Affiliation(s)
- Simona Manescu
- Centre de Recherche en Neuropsychologie et Cognition, Département de psychologie, Université de Montréal, Pavillon Marie-Victorin, CP, succursale Centre-Ville, Montréal, Québec, Canada
| | - Christine Chouinard-Leclaire
- Centre de Recherche en Neuropsychologie et Cognition, Département de psychologie, Université de Montréal, Pavillon Marie-Victorin, CP, succursale Centre-Ville, Montréal, Québec, Canada
| | - Olivier Collignon
- Center of Mind/Brain Sciences of University of Trento, Via Delle Regole, Mattarello, Trentino, Italy
- Institutes for Research in Psychology and Neurosciences, University of Louvain, IPSY - Place du Cardinal Mercier, Louvain-la-Neuve, Belgium
| | - Franco Lepore
- Centre de Recherche en Neuropsychologie et Cognition, Département de psychologie, Université de Montréal, Pavillon Marie-Victorin, CP, succursale Centre-Ville, Montréal, Québec, Canada
| | - Johannes Frasnelli
- Centre de Recherche en Neuropsychologie et Cognition, Département de psychologie, Université de Montréal, Pavillon Marie-Victorin, CP, succursale Centre-Ville, Montréal, Québec, Canada
- Centre d’études avancées en médecine du sommeil, Centre de Recherche de l’Hôpital du Sacré-Coeur de Montréal, Centre intégré universitaire de santé et de services sociaux du Nord-de-l’Île-de-Montréal, Montréal, Québec, Canada
- Department of Anatomy, Université du Québec à Trois-Rivières, boulevard des Forges, Trois-Rivières, Québec, Canada
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29
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Pullicin AJ, Kim H, Brinkman MC, Buehler SS, Clark PI, Lim J. Impacts of Nicotine and Flavoring on the Sensory Perception of E-Cigarette Aerosol. Nicotine Tob Res 2020; 22:806-813. [PMID: 30997500 DOI: 10.1093/ntr/ntz058] [Citation(s) in RCA: 30] [Impact Index Per Article: 6.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/02/2019] [Accepted: 04/12/2019] [Indexed: 12/29/2022]
Abstract
INTRODUCTION To examine the interaction between an added flavoring (cherry) and nicotine on the perception of electronic cigarette (e-cigarette) aerosol and how this impacts the appeal of flavored liquids for e-cigarette (e-liquids). METHODS A total of 19 subjects (13 male, 6 female) vaped six commercially available e-liquids with varying contents of nicotine (0, 6, 12 mg/mL) and cherry flavor (4.7% or 9.3% vol/vol). For each e-liquid, subjects first rated overall liking/disliking of the aerosol using the Labeled Hedonic Scale, followed by perceived intensities of sweetness, bitterness, harshness (irritation), and cherry flavor of the aerosol using the general version of Labeled Magnitude Scale. RESULTS The main findings were that (1) added nicotine increased perceived irritation and bitterness, and decreased the perceived sweetness of the e-cigarette aerosol; (2) cherry flavoring added a characteristic "cherry flavor" and an increase in the flavoring concentration from 4.7% to 9.3% tended to increase perceived intensities of sweetness, harshness, and bitterness; and (3) hedonic ratings of the e-cigarette aerosol decreased as nicotine level increased, but were not affected by flavor level. CONCLUSIONS Our findings indicate that the appeal of the e-cigarette aerosol decreases as nicotine concentration increases. Conversely, perceived sweetness improved liking. An increase in the concentration of cherry flavoring did not appear to impact any of the measured attributes to a significant degree. IMPLICATIONS This work demonstrates that the perception of specific sensory attributes of e-cigarettes and their overall appeal are affected by the e-liquid constituents. Most significantly, the results suggest that nicotine decreases the sensory appeal of e-cigarettes by contributing to the perceived irritation and bitterness of the aerosol. These data have implications for the role that nicotine plays in the sensory perception and appeal of e-cigarettes aerosol and further how these sensory factors can be modulated by sweet flavoring.
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Affiliation(s)
- Alexa J Pullicin
- Department of Food Science and Technology, Oregon State University, Corvallis, OR
| | - Hyoshin Kim
- Battelle Public Health Center for Tobacco Research, Battelle Memorial Institute, Seattle, WA
| | | | - Stephanie S Buehler
- Battelle Public Health Center for Tobacco Research, Battelle Memorial Institute, Columbus, OH
| | - Pamela I Clark
- School of Public Health, University of Maryland, College Park, MD
| | - Juyun Lim
- Department of Food Science and Technology, Oregon State University, Corvallis, OR
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30
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Karunanayaka PR, Lu J, Yang QX, Sathian K. Olfactory Costimulation Influences Intranasal Somatosensory Perception. Multisens Res 2020; 33:723-736. [PMID: 33706271 DOI: 10.1163/22134808-bja10008] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/20/2019] [Accepted: 02/17/2020] [Indexed: 11/19/2022]
Abstract
Olfactory sensitivity is influenced by intranasal trigeminal sensation. For instance, sniffing is central to how humans and animals perceive odorants. Here, we investigated the influence of olfactory costimulation on the perception of intranasal somatosensory stimulation. In this study, 22 healthy human subjects, with normal olfactory function, performed a localization task for stimulation using weak air puffs, a pure odorant, phenyl ethyl alcohol (PEA; rose odor), or their combination. Visual cues were used to inform participants to briefly hold their breath while weak, poorly localizable, air puffs and/or PEA were delivered to either nostril. Although PEA alone could not be localized to the correct nostril, when it accompanied a weak air puff in the ipsilateral nostril, localization accuracy significantly improved, relative to presentation of the air puff without the odorant. The enhancement of localization was absent when the air puff and PEA were presented to opposite nostrils. Since ipsilateral but not contralateral costimulation with PEA increased the accuracy of weak air puff localization, the results argue against a non-specific alerting effect of PEA. These findings suggest an interaction between olfactory and intranasal somatosensory stimuli leading to their integration.
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Affiliation(s)
- Prasanna R Karunanayaka
- 1Department of Radiology, The Pennsylvania State University College of Medicine, Hershey, PA, USA.,2Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, USA.,3Department of Public Health Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, USA
| | - Jiaming Lu
- 1Department of Radiology, The Pennsylvania State University College of Medicine, Hershey, PA, USA.,4Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China
| | - Qing X Yang
- 1Department of Radiology, The Pennsylvania State University College of Medicine, Hershey, PA, USA.,5Department of Neurosurgery, The Pennsylvania State University College of Medicine, Hershey, PA, USA
| | - K Sathian
- 2Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, USA.,6Department of Psychology, The Pennsylvania State University College of Medicine, Hershey, PA, USA.,7Department of Neurology, The Pennsylvania State University College of Medicine, Hershey, PA, USA
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31
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Panneton WM, Gan Q. The Mammalian Diving Response: Inroads to Its Neural Control. Front Neurosci 2020; 14:524. [PMID: 32581683 PMCID: PMC7290049 DOI: 10.3389/fnins.2020.00524] [Citation(s) in RCA: 34] [Impact Index Per Article: 6.8] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/07/2020] [Accepted: 04/27/2020] [Indexed: 01/03/2023] Open
Abstract
The mammalian diving response (DR) is a remarkable behavior that was first formally studied by Laurence Irving and Per Scholander in the late 1930s. The DR is called such because it is most prominent in marine mammals such as seals, whales, and dolphins, but nevertheless is found in all mammals studied. It consists generally of breathing cessation (apnea), a dramatic slowing of heart rate (bradycardia), and an increase in peripheral vasoconstriction. The DR is thought to conserve vital oxygen stores and thus maintain life by directing perfusion to the two organs most essential for life-the heart and the brain. The DR is important, not only for its dramatic power over autonomic function, but also because it alters normal homeostatic reflexes such as the baroreceptor reflex and respiratory chemoreceptor reflex. The neurons driving the reflex circuits for the DR are contained within the medulla and spinal cord since the response remains after the brainstem transection at the pontomedullary junction. Neuroanatomical and physiological data suggesting brainstem areas important for the apnea, bradycardia, and peripheral vasoconstriction induced by underwater submersion are reviewed. Defining the brainstem circuit for the DR may open broad avenues for understanding the mechanisms of suprabulbar control of autonomic function in general, as well as implicate its role in some clinical states. Knowledge of the proposed diving circuit should facilitate studies on elite human divers performing breath-holding dives as well as investigations on sudden infant death syndrome (SIDS), stroke, migraine headache, and arrhythmias. We have speculated that the DR is the most powerful autonomic reflex known.
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Affiliation(s)
- W. Michael Panneton
- Department of Pharmacological and Physiological Science, School of Medicine, Saint Louis University, St. Louis, MO, United States
| | - Qi Gan
- Department of Pharmacological and Physiological Science, School of Medicine, Saint Louis University, St. Louis, MO, United States
- Department of Pediatrics, School of Medicine, Saint Louis University, St. Louis, MO, United States
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32
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RIFM fragrance ingredient safety assessment, amyl butyrate, CAS Registry Number 540-18-1. Food Chem Toxicol 2020; 141 Suppl 1:111343. [PMID: 32304809 DOI: 10.1016/j.fct.2020.111343] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/07/2019] [Revised: 01/14/2020] [Accepted: 04/08/2020] [Indexed: 11/20/2022]
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Müschenich FS, Sijben R, Gallenmüller F, Singer M, Rodriguez-Raecke R, Di Francesco ME, Wiesmann M, Freiherr J. Eucalyptol Masks the Olfactory But Not the Trigeminal Sensation of Ammonia. Chem Senses 2019; 44:733-741. [PMID: 31541234 DOI: 10.1093/chemse/bjz065] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/12/2022] Open
Abstract
Eucalyptol is a substance with rather pleasant olfactory and trigeminal characteristics and is thus suggested as an efficient tool for malodor coverage. In this study ammonia would be the malodor substance such as is found in cat litter or hair coloration. We investigated the potential of eucalyptol to inhibit both the olfactory as well as the trigeminal sensation of ammonia. For this purpose, we mixed eucalyptol and ammonia and compared odor component intensities. After being presented with either the pure odors or a binary mixture thereof, 21 young and healthy participants had to lateralize the odors and rate component (eucalyptol and ammonia) and total intensity. Analysis of intensity ratings revealed hypoadditivity (total mixture intensity was less than the sum of the total intensity of the single components). Significant interaction effects verified that mixing eucalyptol and ammonia only affected the perceived intensity of ammonia. Comparing the odor components within the pure and mixed stimuli, the ammonia component was rated as significantly less intense in the mixture compared to pure ammonia whereas the eucalyptol component was rated equal in the pure and mixed condition. On the basis of lateralization scores, we observed trigeminal mixture enhancement. We conclude that eucalyptol is a suitable masking agent to cover the unpleasant smell of ammonia; however, it fails to serve as an ammonia counterirritant because it lacks the ability to mask the trigeminal sensation of ammonia.
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Affiliation(s)
| | - Rik Sijben
- Diagnostic and Interventional Neuroradiology, RWTH Aachen University, Aachen, Germany
| | - Felix Gallenmüller
- Diagnostic and Interventional Neuroradiology, RWTH Aachen University, Aachen, Germany
| | - Marco Singer
- Symrise AG, Division Scent and Care, Holzminden, Germany
| | - Rea Rodriguez-Raecke
- Diagnostic and Interventional Neuroradiology, RWTH Aachen University, Aachen, Germany
| | | | - Martin Wiesmann
- Diagnostic and Interventional Neuroradiology, RWTH Aachen University, Aachen, Germany
| | - Jessica Freiherr
- Diagnostic and Interventional Neuroradiology, RWTH Aachen University, Aachen, Germany.,Fraunhofer Institute for Process Engineering and Packaging IVV, Freising, Germany.,Friedrich-Alexander University Erlangen-Nürnberg, Department of Psychiatry and Psychotherapy, Erlangen, Germany
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Migneault-Bouchard C, Hsieh JW, Hugentobler M, Frasnelli J, Landis BN. Chemosensory decrease in different forms of olfactory dysfunction. J Neurol 2019; 267:138-143. [PMID: 31586261 DOI: 10.1007/s00415-019-09564-x] [Citation(s) in RCA: 35] [Impact Index Per Article: 5.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/15/2019] [Revised: 09/28/2019] [Accepted: 09/28/2019] [Indexed: 11/25/2022]
Abstract
The aim of this study is to investigate the effect of olfactory dysfunction (OD) on the two other chemical senses, namely gustation and the intranasal trigeminal system. Taste and trigeminal function were analyzed in a retrospective cross-sectional study of 178 participants with OD (n = 78 posttraumatic, n = 42 idiopathic, n = 27 post-infectious and n = 31 chronic rhinosinusitis (CRS) OD). All patients had been investigated for OD at our smell and taste outpatient clinic. Evaluation of olfaction was performed by means of the Sniffin' Sticks test (odor threshold, odor discrimination and odor identification), whereas gustatory function was assessed with the Taste Strips test and the intranasal trigeminal sensitivity by means of the lateralization task. The degree of olfactory impairment was found to depend on the cause of OD, but not on patients' age. Patients with posttraumatic OD showed lower olfactory function than patients with idiopathic, post-infectious and CRS OD (p = 0.01). Gustatory and trigeminal sensitivity in turn depended on age rather than the cause of olfactory dysfunction. Partial correlations between olfactory, gustatory, and trigeminal scores, with age as covariate, were significant, showing a decrease of taste and trigeminal function proportional to the OD (p < 0.05). The present data suggest that the three chemical senses are closely connected for humans underlining that in case of OD the remaining chemical senses (taste, trigeminal function) tend to decrease rather than compensate as this is seen for sensory loss in other modalities. This finding has direct clinical implications and importance when dealing with smell and taste disorders.
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Affiliation(s)
- Chloé Migneault-Bouchard
- Research Chair in Chemosensory Neuroanatomy, Department of Anatomy, Université du Québec à Trois-Rivières (UQTR), Trois-Rivières, QC, Canada
| | - Julien Wen Hsieh
- Department of Clinical Neuroscience, Geneva University Hospitals (HUG), Geneva, Switzerland.,Rhinology-Olfactology Unit, Department of Otorhinolaryngology, Head and Neck Surgery, Geneva University Hospitals (HUG), Geneva, Switzerland
| | - Marianne Hugentobler
- Rhinology-Olfactology Unit, Department of Otorhinolaryngology, Head and Neck Surgery, Geneva University Hospitals (HUG), Geneva, Switzerland
| | - Johannes Frasnelli
- Research Chair in Chemosensory Neuroanatomy, Department of Anatomy, Université du Québec à Trois-Rivières (UQTR), Trois-Rivières, QC, Canada.,Research Center of the Sacré-Coeur Hospital, Montreal, QC, Canada
| | - Basile Nicolas Landis
- Rhinology-Olfactology Unit, Department of Otorhinolaryngology, Head and Neck Surgery, Geneva University Hospitals (HUG), Geneva, Switzerland.
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35
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Coenen A, Smit A, Zhonghua L, Van Luijtelaar G. Gas mixtures for anaesthesia and euthanasia in broiler chickens. WORLD POULTRY SCI J 2019. [DOI: 10.1079/wps20000017] [Citation(s) in RCA: 26] [Impact Index Per Article: 4.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/11/2022]
Affiliation(s)
- Anton Coenen
- NICI, Department of Psychology, University of Nijmegen, P.O. Box 9104, 6500 HE Nijmegen, The Netherlands
| | - Annika Smit
- NICI, Department of Psychology, University of Nijmegen, P.O. Box 9104, 6500 HE Nijmegen, The Netherlands
| | - Li Zhonghua
- Department of Pharmacology, School of Basic Medical Sciences, Beijing Medical University, Beijing 100083, P.R. China
| | - Gilles Van Luijtelaar
- NICI, Department of Psychology, University of Nijmegen, P.O. Box 9104, 6500 HE Nijmegen, The Netherlands
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36
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Tremblay C, Emrich R, Cavazzana A, Klingelhoefer L, Brandt MD, Hummel T, Haehner A, Frasnelli J. Specific intranasal and central trigeminal electrophysiological responses in Parkinson's disease. J Neurol 2019; 266:2942-2951. [PMID: 31451911 DOI: 10.1007/s00415-019-09517-4] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/19/2019] [Revised: 08/13/2019] [Accepted: 08/16/2019] [Indexed: 01/20/2023]
Abstract
Olfactory dysfunction is a frequent early non-motor symptom of Parkinson's disease (PD). There is evidence that with regard to trigeminal perception, PD-related olfactory dysfunction is different from other olfactory disorders. More specifically, trigeminal sensitivity, when measured behaviorally, was unimpaired in PD patients as opposed to patients with non-Parkinsonian olfactory dysfunction (NPOD). We sought to investigate the trigeminal pathway by measuring electrophysiological recordings from the nasal epithelium and EEG-derived event-related potentials in response to a specific trigeminal stimulus in 21 PD patients and compare them to 23 patients with NPOD and 25 controls (C). The peripheral trigeminal response, as measured by the negative-mucosa potential, showed no difference between patients with PD and controls whereas PD patients showed faster responses than patients with NPOD, the latter having shown slower and larger responses than controls (18 PD, 14 NPOD, 20 C). The central trigeminal response, as measured by event-related potentials, revealed larger early component response in PD patients compared to patients with NPOD (15 PD, 21 NPOD, 23 C). As expected, psychophysical olfactory testing showed impaired olfactory function in both groups of patients as opposed to controls. Discriminant analysis revealed a model that could predict group membership for 80% of participants based on the negative-mucosa potential latency, olfactory threshold and discrimination tests. These results provide novel insights into the pattern of trigeminal activation in PD which will help to differentiate PD-related olfactory loss from NPOD, a crucial step towards establishing early screening batteries for PD including smell tests.
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Affiliation(s)
- Cécilia Tremblay
- Research Chair in Chemosensory Neuroanatomy, Department of Anatomy, Université du Québec à Trois-Rivières (UQTR), Trois-Rivières, QC, Canada.
| | - Rosa Emrich
- Department of Otorhinolaryngology, Smell and Taste Clinic, Technical University of Dresden, Dresden, Germany
| | - Annachiara Cavazzana
- Department of Otorhinolaryngology, Smell and Taste Clinic, Technical University of Dresden, Dresden, Germany
| | | | - Moritz D Brandt
- Department of Neurology, TU Dresden, Dresden, Germany.,German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany
| | - Thomas Hummel
- Department of Otorhinolaryngology, Smell and Taste Clinic, Technical University of Dresden, Dresden, Germany
| | - Antje Haehner
- Department of Otorhinolaryngology, Smell and Taste Clinic, Technical University of Dresden, Dresden, Germany
| | - Johannes Frasnelli
- Research Chair in Chemosensory Neuroanatomy, Department of Anatomy, Université du Québec à Trois-Rivières (UQTR), Trois-Rivières, QC, Canada.,Research Center of the Sacré-Cœur Hospital, Montréal, QC, Canada
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Maurer M, Papotto N, Sertel-Nakajima J, Schueler M, De Col R, Möhrlen F, Messlinger K, Frings S, Carr RW. Photoactivation of olfactory sensory neurons does not affect action potential conduction in individual trigeminal sensory axons innervating the rodent nasal cavity. PLoS One 2019; 14:e0211175. [PMID: 31412038 PMCID: PMC6693769 DOI: 10.1371/journal.pone.0211175] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/02/2019] [Accepted: 07/25/2019] [Indexed: 12/28/2022] Open
Abstract
Olfactory and trigeminal chemosensory systems reside in parallel within the mammalian nose. Psychophysical studies in people indicate that these two systems interact at a perceptual level. Trigeminal sensations of pungency mask odour perception, while olfactory stimuli can influence trigeminal signal processing tasks such as odour localization. While imaging studies indicate overlap in limbic and cortical somatosensory areas activated by nasal trigeminal and olfactory stimuli, there is also potential cross-talk at the level of the olfactory epithelium, the olfactory bulb and trigeminal brainstem. Here we explored the influence of olfactory and trigeminal signaling in the nasal cavity. A forced choice water consumption paradigm was used to ascertain whether trigeminal and olfactory stimuli could influence behaviour in mice. Mice avoided water sources surrounded by both volatile TRPV1 (cyclohexanone) and TRPA1 (allyl isothiocyanate) irritants and the aversion to cyclohexanone was mitigated when combined with a pure odorant (rose fragrance, phenylethyl alcohol, PEA). To determine whether olfactory-trigeminal interactions within the nose could potentially account for this behavioural effect we recorded from single trigeminal sensory axons innervating the nasal respiratory and olfactory epithelium using an isolated in vitro preparation. To circumvent non-specific effects of chemical stimuli, optical stimulation was used to excite olfactory sensory neurons in mice expressing channel-rhodopsin (ChR2) under the olfactory marker protein (OMP) promoter. Photoactivation of olfactory sensory neurons produced no modulation of axonal action potential conduction in individual trigeminal axons. Similarly, no evidence was found for collateral branching of trigeminal axon that might serve as a conduit for cross-talk between the olfactory and respiratory epithelium and olfactory dura mater. Using direct assessment of action potential activity in trigeminal axons we observed neither paracrine nor axon reflex mediated cross-talk between olfactory and trigeminal sensory systems in the rodent nasal cavity. Our current results suggest that olfactory sensory neurons exert minimal influence on trigeminal signals within the nasal cavity.
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Affiliation(s)
- Margot Maurer
- Experimental Pain Research, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany
| | - Nunzia Papotto
- Centre for Organismal Studies, University Heidelberg, Heidelberg, Germany
| | - Julika Sertel-Nakajima
- Institute for Physiology and Pathophysiology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
| | - Markus Schueler
- Department of Nephrology and Hypertension, Friedrich-Alexander University Erlangen-Nürnberg, Germany
| | - Roberto De Col
- Institute for Physiology and Pathophysiology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
| | - Frank Möhrlen
- Centre for Organismal Studies, University Heidelberg, Heidelberg, Germany
| | - Karl Messlinger
- Institute for Physiology and Pathophysiology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
| | - Stephan Frings
- Centre for Organismal Studies, University Heidelberg, Heidelberg, Germany
| | - Richard W. Carr
- Experimental Pain Research, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany
- * E-mail:
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38
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Koide T, Yabuki Y, Yoshihara Y. Terminal Nerve GnRH3 Neurons Mediate Slow Avoidance of Carbon Dioxide in Larval Zebrafish. Cell Rep 2019; 22:1115-1123. [PMID: 29386100 DOI: 10.1016/j.celrep.2018.01.019] [Citation(s) in RCA: 16] [Impact Index Per Article: 2.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/08/2017] [Revised: 12/01/2017] [Accepted: 01/05/2018] [Indexed: 12/13/2022] Open
Abstract
Escape responses to threatening stimuli are vital for survival in all animal species. Larval zebrafish display fast escape responses when exposed to tactile, acoustic, and visual stimuli. However, their behavioral responses to chemosensory stimuli remain unknown. In this study, we found that carbon dioxide (CO2) induced a slow avoidance response, which was distinct from the touch-evoked fast escape response. We identified the gonadotropin-releasing hormone 3-expressing terminal nerve as the CO2 sensor in the nose. Wide-field calcium imaging revealed downstream CO2-activated ensembles of neurons along three distinct neural pathways, olfactory, trigeminal, and habenulo-interpeduncular, further reaching the reticulospinal neurons in the hindbrain. Ablation of the nose, terminal nerve, or trigeminal ganglion resulted in a dramatic decrease in CO2-evoked avoidance responses. These findings demonstrate that the terminal nerve-trigeminal system plays a pivotal role in triggering a slow chemosensory avoidance behavior in the larval zebrafish.
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Affiliation(s)
- Tetsuya Koide
- Laboratory for Neurobiology of Synapse, RIKEN Brain Science Institute, Saitama 351-0198, Japan.
| | - Yoichi Yabuki
- Laboratory for Neurobiology of Synapse, RIKEN Brain Science Institute, Saitama 351-0198, Japan
| | - Yoshihiro Yoshihara
- Laboratory for Neurobiology of Synapse, RIKEN Brain Science Institute, Saitama 351-0198, Japan; RIKEN BSI-KAO Collaboration Center, RIKEN Brain Science Institute, Saitama 351-0198, Japan; ERATO Touhara Chemosensory Signal Project, JST, The University of Tokyo, Tokyo 113-8657, Japan.
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39
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Abstract
Many odors activate the intranasal chemosensory trigeminal system where they produce cooling and other somatic sensations such as tingling, burning, or stinging. Specific trigeminal receptors are involved in the mediation of these sensations. Importantly, the trigeminal system also mediates sensitivity to airflow. The intranasal trigeminal and the olfactory system are closely connected. With regard to central nervous processing, it is most interesting that trigeminal stimuli can activate the piriform cortex, which is typically viewed as the primary olfactory cortex. This suggests that interactions between the two systems may form at a relatively early stage of processing. For example, there is evidence showing that acquired olfactory loss leads to reduced trigeminal sensitivity, probably on account of the lack of interaction in the central nervous system. Decreased trigeminal sensitivity may also be responsible for changes in airflow perception, leading to the impression of congested nasal airways.
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Affiliation(s)
- Thomas Hummel
- Department of Otorhinolaryngology, Smell and Taste Clinic, Technische Universität Dresden, Dresden, Germany.
| | - Johannes Frasnelli
- Université du Québec à Trois-Rivières, Department of Anatomy, Trois-Rivières, QC, Canada
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40
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Bozkurt G, Elhassan HA, Sözen E, Soytaş P, Erol ZN, Güvenç MG, Coşkun BU. Assessment of taste functions in allergic rhinitis patients undergoing allergen-specific immunotherapy. Eur Arch Otorhinolaryngol 2018; 276:439-445. [PMID: 30515608 DOI: 10.1007/s00405-018-5236-5] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/29/2018] [Accepted: 12/01/2018] [Indexed: 11/29/2022]
Abstract
BACKGROUND We evaluated taste functions of patients with perennial allergic rhinitis (AR) before and after allergen-specific immunotherapy (AIT). METHODS The study was designed as a prospective clinical study in our tertiary care hospital. Patients (n = 21) who were diagnosed with perennial AR on the basis of physical examination, skin prick test of at least 3* for HDM allergen and treated with AIT were enrolled in this study. A control group (n = 21) was selected from patients who were given intranasal steroids (INS) for perennial AR. Both groups had self-reported hyposmia and subjective loss of the sense of taste before treatment. Taste strips (Burghart, Wedel, Germany) were used for the taste identification scores before and after 6 months treatment. RESULTS A total of 42 subjects were included, with a mean age of 24.1 ± 7.9 years (range 15-43 years). Overall, the AIT group showed more of an improvement of taste function, observed in the total average test scores, compared to the INS group (p < 0.05), but no change was detected between the groups before treatment. No difference was found for the bitter taste scores between the study groups (p = 0.053). CONCLUSION Subcutaneous allergen immunotherapy resulted in more of an improvement in taste function than intranasal steroids. Further studies are needed.
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Affiliation(s)
- Gülpembe Bozkurt
- Department of Otorhinolaryngology, Acıbadem University Hospital, Istanbul, Turkey.
| | | | - Esra Sözen
- Department of Otorhinolaryngology, School of Medicine, Aydın University, Istanbul, Turkey
| | - Pınar Soytaş
- Department of Otorhinolaryngology, Sisli Hamidiye Etfal Education and Research Hospital, Istanbul, Turkey
| | - Zeynep Nur Erol
- Department of Otolaryngology, Hopa State Hospital, Artvin, Turkey
| | - Melih Güven Güvenç
- Department of Otorhinolaryngology, School of Medicine, Acibadem University, Istanbul, Turkey
| | - Berna Uslu Coşkun
- Department of Otorhinolaryngology, Sisli Hamidiye Etfal Education and Research Hospital, Istanbul, Turkey
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41
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Carr R, Frings S. Neuropeptides in sensory signal processing. Cell Tissue Res 2018; 375:217-225. [PMID: 30377783 DOI: 10.1007/s00441-018-2946-3] [Citation(s) in RCA: 14] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/09/2018] [Accepted: 10/09/2018] [Indexed: 12/21/2022]
Abstract
Peptides released from trigeminal fibers fulfill well-understood functions in neuroinflammatory processes and in the modulation of nociceptive signal processing. In particular, calcitonin gene-related peptide (CGRP) and substance P (SP), released from afferent nerve terminals, exert paracrine effects on the surrounding tissue and this has been recently highlighted by the prominent parcrine role of CGRP in the development of headache and migraine. Some recent communications suggest that these sensory neuropeptides may also modulate the workings of sensory organs and influence afferent signals from nose, tongue, eyes and ears. Here, we briefly review the evidence for modulatory effects of CGRP and SP in the sensory periphery.
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Affiliation(s)
- Richard Carr
- Department of Experimental Pain Research, Medical Faculty Mannheim, University of Heidelberg, Ludolf-Krehl-Str. 13-17, 68167, Mannheim, Germany.
| | - Stephan Frings
- Department of Animal Physiology, Centre for Organismal Studies, University of Heidelberg, Heidelberg, Germany
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42
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Abdel-Moemin AR, Regenstein JM, Abdel-Rahman MK. New Food Products for Sensory-Compromised Situations. Compr Rev Food Sci Food Saf 2018; 17:1625-1639. [DOI: 10.1111/1541-4337.12399] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/03/2018] [Revised: 09/09/2018] [Accepted: 09/10/2018] [Indexed: 01/19/2023]
Affiliation(s)
- Aly R. Abdel-Moemin
- Dept. of Nutrition and Food Science, Faculty of Home Economics; Helwan Univ.; Cairo Egypt
| | | | - Manal K. Abdel-Rahman
- Dept. of Nutrition and Food Science, Faculty of Home Economics; Helwan Univ.; Cairo Egypt
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43
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Temporal Encoding During Unimodal and Bimodal Odor Processing in the Human Brain. CHEMOSENS PERCEPT 2018. [DOI: 10.1007/s12078-018-9251-0] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/28/2022]
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Tremblay C, Frasnelli J. Olfactory and Trigeminal Systems Interact in the Periphery. Chem Senses 2018; 43:611-616. [DOI: 10.1093/chemse/bjy049] [Citation(s) in RCA: 28] [Impact Index Per Article: 4.0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/16/2022] Open
Affiliation(s)
- Cécilia Tremblay
- Department of Anatomy, Université du Québec à Trois-Rivières, 3351 Boul. des Forges, Trois-Rivières, Québec, Canada
| | - Johannes Frasnelli
- Department of Anatomy, Université du Québec à Trois-Rivières, 3351 Boul. des Forges, Trois-Rivières, Québec, Canada
- Research Center, Sacré-Coeur Hospital of Montreal, 5400 boul. Gouin Ouest, Montréal, Québec, Canada
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45
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Haehner A, Hummel T, Heinritz W, Krueger S, Meinhardt M, Whitcroft KL, Sabatowski R, Gossrau G. Mutation in Nav
1.7 causes high olfactory sensitivity. Eur J Pain 2018; 22:1767-1773. [DOI: 10.1002/ejp.1272] [Citation(s) in RCA: 9] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 06/20/2018] [Indexed: 12/11/2022]
Affiliation(s)
- A. Haehner
- Smell & Taste Clinic; Department of Otorhinolaryngology; TU Dresden; Germany
| | - T. Hummel
- Smell & Taste Clinic; Department of Otorhinolaryngology; TU Dresden; Germany
| | - W. Heinritz
- ÜBAG for Human Genetics Oberelbe/Spree; Cottbus/Dresden Germany
| | - S. Krueger
- ÜBAG for Human Genetics Oberelbe/Spree; Cottbus/Dresden Germany
| | | | - K. L. Whitcroft
- Smell & Taste Clinic; Department of Otorhinolaryngology; TU Dresden; Germany
- UCL Ear Institute; University College London; UK
- Centre for the Study of the Senses; School of Advanced Study; London UK
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Oleszkiewicz A, Schultheiss T, Schriever VA, Linke J, Cuevas M, Hähner A, Hummel T. Effects of "trigeminal training" on trigeminal sensitivity and self-rated nasal patency. Eur Arch Otorhinolaryngol 2018; 275:1783-1788. [PMID: 29744638 PMCID: PMC5992236 DOI: 10.1007/s00405-018-4993-5] [Citation(s) in RCA: 17] [Impact Index Per Article: 2.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/08/2018] [Accepted: 05/02/2018] [Indexed: 01/02/2023]
Abstract
Purpose Patients with the feeling of a congested nose not always suffer from an anatomical obstruction but might just have a low trigeminal sensibility, which prevents them from perceiving the nasal airstream. We examined whether intermittent trigeminal stimulation increases sensitivity of the nasal trigeminal nerve and whether this effect is accompanied by subjective improvement of nasal breathing. Method Thirty-five patients (Mage = 58.4 years; SD = 14.8; Minage = 21 years; Maxage = 79 years; 43% females) and 30 healthy controls (Mage = 36.7 years, SD = 14.5; Minage = 20 years; Maxage = 73 years; 60% females) participated in a study comprised of two sessions separated by “trigeminal training”. During each session, trigeminal sensitivity towards CO2, trigeminal lateralization abilities and ratings of nasal patency were assessed. Age and training compliance were controlled. Results “Trigeminal training” had a positive effect on trigeminal sensitivity in both groups, (p = .027) and this effect depended on the training compliance (p < .001). “Trigeminal training” had no effect on lateralization abilities of the subjects (p > .05). Ratings of nasal patency increased in patients (p = .03), but not in controls. Conclusions “Trigeminal training” consisting of intermittent presentation of diverse stimulants leads to an increase of trigeminal sensitivity, but this effect depended on the training compliance. Importantly, in patients, this training is also associated with an increase in self-rated nasal patency.
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Affiliation(s)
- Anna Oleszkiewicz
- Smell and Taste Center, Department of Otorhinolaryngology, TU Dresden, Fetscherstrasse 74, 01307, Dresden, Germany. .,Institute of Psychology, University of Wroclaw, Wroclaw, Poland.
| | - Timo Schultheiss
- Smell and Taste Center, Department of Otorhinolaryngology, TU Dresden, Fetscherstrasse 74, 01307, Dresden, Germany
| | - Valentin A Schriever
- Smell and Taste Center, Department of Otorhinolaryngology, TU Dresden, Fetscherstrasse 74, 01307, Dresden, Germany
| | - Jana Linke
- Smell and Taste Center, Department of Otorhinolaryngology, TU Dresden, Fetscherstrasse 74, 01307, Dresden, Germany
| | - Mandy Cuevas
- Smell and Taste Center, Department of Otorhinolaryngology, TU Dresden, Fetscherstrasse 74, 01307, Dresden, Germany
| | - Antje Hähner
- Smell and Taste Center, Department of Otorhinolaryngology, TU Dresden, Fetscherstrasse 74, 01307, Dresden, Germany
| | - Thomas Hummel
- Smell and Taste Center, Department of Otorhinolaryngology, TU Dresden, Fetscherstrasse 74, 01307, Dresden, Germany
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47
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Moriaux AL, Vallon R, Parvitte B, Zeninari V, Liger-Belair G, Cilindre C. Monitoring gas-phase CO 2 in the headspace of champagne glasses through combined diode laser spectrometry and micro-gas chromatography analysis. Food Chem 2018; 264:255-262. [PMID: 29853374 DOI: 10.1016/j.foodchem.2018.04.094] [Citation(s) in RCA: 20] [Impact Index Per Article: 2.9] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/30/2018] [Revised: 04/18/2018] [Accepted: 04/22/2018] [Indexed: 11/25/2022]
Abstract
During Champagne or sparkling wine tasting, gas-phase CO2 and volatile organic compounds invade the headspace above glasses, thus progressively modifying the chemical space perceived by the consumer. Gas-phase CO2 in excess can even cause a very unpleasant tingling sensation perturbing both ortho- and retronasal olfactory perception. Monitoring as accurately as possible the level of gas-phase CO2 above glasses is therefore a challenge of importance aimed at better understanding the close relationship between the release of CO2 and a collection of various tasting parameters. Here, the concentration of CO2 found in the headspace of champagne glasses served under multivariate conditions was accurately monitored, all along the 10 min following pouring, through a new combined approach by a CO2-Diode Laser Sensor and micro-gas chromatography. Our results show the strong impact of various tasting conditions (volume dispensed, intensity of effervescence, and glass shape) on the release of gas-phase CO2 above the champagne surface.
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Affiliation(s)
- Anne-Laure Moriaux
- Equipe Effervescence, Champagne et Applications, Groupe de Spectrométrie Moléculaire et Applications (GSMA), UMR CNRS 7331, Université de Reims Champagne-Ardenne, B.P.1039, 51687 Reims Cedex 2, France
| | - Raphaël Vallon
- Equipe Effervescence, Champagne et Applications, Groupe de Spectrométrie Moléculaire et Applications (GSMA), UMR CNRS 7331, Université de Reims Champagne-Ardenne, B.P.1039, 51687 Reims Cedex 2, France
| | - Bertrand Parvitte
- Equipe Effervescence, Champagne et Applications, Groupe de Spectrométrie Moléculaire et Applications (GSMA), UMR CNRS 7331, Université de Reims Champagne-Ardenne, B.P.1039, 51687 Reims Cedex 2, France
| | - Virginie Zeninari
- Equipe Effervescence, Champagne et Applications, Groupe de Spectrométrie Moléculaire et Applications (GSMA), UMR CNRS 7331, Université de Reims Champagne-Ardenne, B.P.1039, 51687 Reims Cedex 2, France
| | - Gérard Liger-Belair
- Equipe Effervescence, Champagne et Applications, Groupe de Spectrométrie Moléculaire et Applications (GSMA), UMR CNRS 7331, Université de Reims Champagne-Ardenne, B.P.1039, 51687 Reims Cedex 2, France
| | - Clara Cilindre
- Equipe Effervescence, Champagne et Applications, Groupe de Spectrométrie Moléculaire et Applications (GSMA), UMR CNRS 7331, Université de Reims Champagne-Ardenne, B.P.1039, 51687 Reims Cedex 2, France.
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48
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Abstract
An objective for the assessment of smell based upon olfactory cortical responses is introduced and illustrated with clinical examples.
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49
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Inui K, Chen C, Pauli JL, Kuroki C, Tashiro S, Kanmura Y, Kashiwadani H, Kuwaki T. Nasal TRPA1 mediates irritant-induced bradypnea in mice. Physiol Rep 2017; 4:4/24/e13098. [PMID: 28039411 PMCID: PMC5210382 DOI: 10.14814/phy2.13098] [Citation(s) in RCA: 10] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/24/2016] [Revised: 12/01/2016] [Accepted: 12/03/2016] [Indexed: 12/17/2022] Open
Abstract
Transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily, exists in sensory neurons such as trigeminal neurons innervating the nasal cavity and vagal neurons innervating the trachea and the lung. Although TRPA1 has been proposed as an irritant receptor that, when stimulated, triggers bradypnea, precise locations of the receptors responsible have not been elucidated. Here, we examined the relative importance of TRPA1 located in the upper airway (nasal) and the lower airway (trachea/lungs) in urethane-anesthetized mice. To stimulate the upper and lower airways separately, two cannulas were inserted through a hole made in the trachea just caudal to the thyroid cartilage, one into the nasal cavity and the second into the lower trachea. A vapor of one of the TRPA1-agonists, allyl isothiocyanate (AITC), was introduced by placing a piece of cotton paper soaked with AITC solution into the airline. AITC decreased the respiratory frequency when applied to the upper airway (ca -30%) but not to the lower airway (ca -5%). No response was observed in TRPA1 knockout mice. Contribution of the olfactory nerve seemed minimal because olfactory bulbectomized wild-type mice showed a similar response to that of the intact mice. AITC-induced bradypnea seemed to be mediated, at least in part, by the trigeminal nerve because trigeminal ganglion neurons were activated by AITC as revealed by an increase in the phosphorylated form of extracellular signal-regulated kinase in the neurons. These data clearly show that trigeminal TRPA1 in the nasal cavity play an essential role in irritant-induced bradypnea.
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Affiliation(s)
- Keiichi Inui
- Department of Physiology, Kagoshima University Graduate School of Medical & Dental Sciences, Kagoshima, Japan
| | - ChangPing Chen
- Department of Physiology, Kagoshima University Graduate School of Medical & Dental Sciences, Kagoshima, Japan
| | - Jordan L Pauli
- Department of Physiology, Kagoshima University Graduate School of Medical & Dental Sciences, Kagoshima, Japan
| | - Chiharu Kuroki
- Department of Physiology, Kagoshima University Graduate School of Medical & Dental Sciences, Kagoshima, Japan.,Anesthesiology & Critical Care Medicine, Kagoshima University Graduate School of Medical & Dental Sciences, Kagoshima, Japan
| | - Shogo Tashiro
- Department of Physiology, Kagoshima University Graduate School of Medical & Dental Sciences, Kagoshima, Japan.,Anesthesiology & Critical Care Medicine, Kagoshima University Graduate School of Medical & Dental Sciences, Kagoshima, Japan
| | - Yuichi Kanmura
- Anesthesiology & Critical Care Medicine, Kagoshima University Graduate School of Medical & Dental Sciences, Kagoshima, Japan
| | - Hideki Kashiwadani
- Department of Physiology, Kagoshima University Graduate School of Medical & Dental Sciences, Kagoshima, Japan
| | - Tomoyuki Kuwaki
- Department of Physiology, Kagoshima University Graduate School of Medical & Dental Sciences, Kagoshima, Japan
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50
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Oleszkiewicz A, Meusel T, Güpfert M, Westermann B, Hummel T, Welge-Lüssen A. Olfactory deficits decrease the time resolution for trigeminal lateralization. Int J Psychophysiol 2017; 121:18-21. [PMID: 28918916 DOI: 10.1016/j.ijpsycho.2017.09.004] [Citation(s) in RCA: 6] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/11/2017] [Revised: 04/27/2017] [Accepted: 09/07/2017] [Indexed: 11/19/2022]
Abstract
OBJECTIVES To date the temporal resolution of the detection of almost simultaneously applied intranasal trigeminal stimuli is unknown. The aim of our study was to examine this temporal resolution in an/hyposmic subjects, who are known to have reduced trigeminal sensitivity and compare it with healthy controls. METHODS Participants were 20 posttraumatic an/hyposmic patients, and 23 healthy controls (matched with regard to sex and age). Olfactory function was tested psychophysically using the Sniffin´ Sticks test battery. Bilateral trigeminal stimulation was carried out using a birhinal high-precision olfactometer. The trigeminal stimulus used was CO₂ 60% v/v, the interstimulus interval ranged from 28 to 32s, stimulus duration was 200ms. Time-lags tested between right and left side of stimulation were at 40, 80, 120, 160 and 200ms. Subjects raised their left or right hand to indicate the side on which the stimulus had been perceived first. RESULTS In both groups the accuracy in the trigeminal lateralization task increased with the time-lag but normosmic subjects significantly outperformed an/hyposmics in the 200ms time-lag condition. Normosmics significantly exceeded 50% chance level at the time-lag of 80ms, whereas an/hyposmics were only able to score above chance starting from 120ms time-lag. Lateralization scores significantly decreased with age. CONCLUSIONS At a time lag of 200ms intranasal trigeminal stimuli can be lateralized. The reduced trigeminal sensitivity in patients with anosmia or hyposmia leads to an increased time lag required for correct perception of intranasal, almost simultaneously, applied stimuli.
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Affiliation(s)
- A Oleszkiewicz
- Smell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany; Institute of Psychology, University of Wroclaw, Wroclaw, Poland.
| | - T Meusel
- Department of Otorhinolaryngology, Head and Neck Surgery, University of Erlangen Medical School, Erlangen, Germany
| | - M Güpfert
- Department of Otorhinolaryngology, Head and Neck Surgery, University of Basel, Basel, Switzerland
| | - B Westermann
- Department of Neurosurgery, University of Basel, Basel, Switzerland
| | - T Hummel
- Smell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany
| | - A Welge-Lüssen
- Department of Otorhinolaryngology, Head and Neck Surgery, University of Basel, Basel, Switzerland
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