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Smolin A, Eremina G, Martyshina I, Xie J. Biomechanics of Osseointegration of a Dental Implant in the Mandible Under Shock Wave Therapy: In Silico Study. MATERIALS (BASEL, SWITZERLAND) 2024; 17:6204. [PMID: 39769804 PMCID: PMC11677247 DOI: 10.3390/ma17246204] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Received: 11/22/2024] [Revised: 12/16/2024] [Accepted: 12/18/2024] [Indexed: 01/11/2025]
Abstract
The most time-consuming aspect of dental prosthesis installation is the osseointegration of a metal implant with bone tissue. The acceleration of this process may be achieved through the use of extracorporeal shock wave therapy. The objective of this study is to investigate the conditions for osseointegration of the second premolar implant in the mandibular segment through the use of a poroelastic model implemented in the movable cellular automaton method. The mandibular segment under consideration includes a spongy tissue layer, 600 µm in thickness, covered with a cortical layer, 400 µm in thickness, and a gum layer, 400 µm in thickness. Furthermore, the periodontal layers of the roots of the first premolar and first molar were considered, while the implant of the second premolar was situated within a shell of specific tissue that corresponded to the phase of osseointegration. The model was subjected to both physiological loading and shock wave loading across the three main phases of osseointegration. The resulting fields of hydrostatic pressure and interstitial fluid pressure were then subjected to analysis in accordance with the mechanobiological principles. The results obtained have indicated that low-intensity shock wave therapy can accelerate and promote direct osseointegration: 0.05-0.15 mJ/mm2 in the first and second phases and less than 0.05 mJ/mm2 in the third phase. In comparison to physiological loads (when bone tissue regeneration conditions are observed only around the implant distal end), shock waves offer the primary advantage of creating conditions conducive to osseointegration along the entire surface of the implant simultaneously. This can significantly influence the rate of implant integration during the initial osteoinduction phase and, most crucially, during the longest final phase of bone remodeling.
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Affiliation(s)
- Alexey Smolin
- Institute of Strength Physics and Materials Science, Siberian Branch of the Russian Academy of Sciences, Pr. Akademicheskii, 2/4, 634055 Tomsk, Russia; (G.E.); (I.M.)
| | - Galina Eremina
- Institute of Strength Physics and Materials Science, Siberian Branch of the Russian Academy of Sciences, Pr. Akademicheskii, 2/4, 634055 Tomsk, Russia; (G.E.); (I.M.)
| | - Irina Martyshina
- Institute of Strength Physics and Materials Science, Siberian Branch of the Russian Academy of Sciences, Pr. Akademicheskii, 2/4, 634055 Tomsk, Russia; (G.E.); (I.M.)
| | - Jing Xie
- State Key Laboratory of Explosion Science and Technology, Beijing Institute of Technology, Beijing 100081, China;
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Berthaume M, Elton S. Biomechanics in anthropology. Evol Anthropol 2024; 33:e22019. [PMID: 38217465 DOI: 10.1002/evan.22019] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/24/2023] [Revised: 12/15/2023] [Accepted: 12/18/2023] [Indexed: 01/15/2024]
Abstract
Biomechanics is the set of tools that explain organismal movement and mechanical behavior and links the organism to the physicality of the world. As such, biomechanics can relate behaviors and culture to the physicality of the organism. Scale is critical to biomechanical analyses, as the constitutive equations that matter differ depending on the scale of the question. Within anthropology, biomechanics has had a wide range of applications, from understanding how we and other primates evolved to understanding the effects of technologies, such as the atlatl, and the relationship between identity, society, culture, and medical interventions, such as prosthetics. Like any other model, there is great utility in biomechanical models, but models should be used primarily for hypothesis testing and not data generation except in the rare case where models can be robustly validated. The application of biomechanics within anthropology has been extensive, and holds great potential for the future.
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Affiliation(s)
| | - Sarah Elton
- Department of Anthropology, Durham University, Durham, UK
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Berthaume MA, Kramer PA. Anthroengineering: an independent interdisciplinary field. Interface Focus 2021; 11:20200056. [PMID: 34938428 PMCID: PMC8361575 DOI: 10.1098/rsfs.2020.0056] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 07/07/2021] [Indexed: 12/31/2022] Open
Abstract
In recent decades, funding agencies, institutes and professional bodies have recognized the profound benefits of transdisciplinarity in tackling targeted research questions. However, once questions are answered, the previously abundant support often dissolves. As such, the long-term benefits of these transdisciplinary approaches are never fully achieved. Over the last several decades, the integration of anthropology and engineering through inter- and multidisciplinary work has led to advances in fields such as design, human evolution and medical technologies. The lack of formal recognition, however, of this transdisciplinary approach as a unique entity rather than a useful tool or a subfield makes it difficult for researchers to establish laboratories, secure permanent jobs, fund long-term research programmes and train students in this approach. To facilitate the growth and development and witness the long-term benefits of this approach, we propose the integration of anthropology and engineering be recognized as a new, independent field known as anthroengineering. We present a working definition for anthroengineering and examples of how anthroengineering has been used. We discuss the necessity of recognizing anthroengineering as a unique field and explore potential novel applications. Finally, we discuss the future of anthroengineering, highlighting avenues for moving the field forward.
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Affiliation(s)
- Michael A. Berthaume
- Division of Mechanical Engineering and Design, London South Bank University, London SE1 0AA, UK
| | - Patricia Ann Kramer
- Department of Anthropology, University of Washington, Seattle, WA 98195-3100, USA
- Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, WA 98195-3100, USA
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Murashima N, Michimoto I, Koyama D, Matsukawa M. Anisotropic Longitudinal Wave Propagation in Swine Skull. IEEE TRANSACTIONS ON ULTRASONICS, FERROELECTRICS, AND FREQUENCY CONTROL 2021; 68:65-71. [PMID: 32746210 DOI: 10.1109/tuffc.2020.3009135] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 06/11/2023]
Abstract
To understand the in-plane elastic character of ultrasonic waves in the skull, longitudinal wave velocities were studied in the MHz range using a conventional pulse technique. Taking advantage of the thickness of swine skulls, anisotropic in-plane wave velocity changes in the outer and diploe layers were experimentally investigated using structural information measured by X-ray computer tomography (CT). The velocities in the thin inner layer were difficult to measure. The main trabecular alignment (MTA) in the thick swine diploe layer was almost perpendicular to the thickness direction and changed with position inside the skull. The degree of anisotropy of in-plane longitudinal wave velocity ranged 1.07-1.33 in both outer and diploe layers, depending on position and swine sample. The angle of the fastest velocity in the outer layer was different from that in most parts of the diploe layer. Anisotropic character in the diploe layer gradually changed with position in the thickness direction.
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Gräsel M, Glüer CC, Barkmann R. Characterization of a new ultrasound device designed for measuring cortical porosity at the human tibia: A phantom study. ULTRASONICS 2017; 76:183-191. [PMID: 28107676 DOI: 10.1016/j.ultras.2017.01.001] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 09/15/2016] [Revised: 12/30/2016] [Accepted: 01/02/2017] [Indexed: 06/06/2023]
Abstract
Quantitative ultrasound (QUS) measurements of trabecular bone are a useful tool for the assessment of osteoporotic fracture risk. However, cortical bone properties (e.g. porosity) have an impact on bone strength as well and thus current research is focused on QUS assessment of cortical bone properties. Simulation studies of ultrasound propagation through cortical bone indicate that anisotropy, calculated from the ratio of the velocities in axial and tangential directions, is correlated with porosity. However, this relationship is affected by error sources, specifically bone surface curvature and variability of probe positioning. With the aim of in vivo estimation of cortical porosity a new ultrasound device was developed, which sequentially measures velocities in 3 different directions (axial=0° and ±37.5°) using the axial transmission method. Measurements on planar porosity phantoms (0-25%) were performed to confirm the results of the afore mentioned simulation studies. Additionally, measurements on cylindrical phantoms without pores (min. radius=34mm for strongest curvature) were performed to estimate the influence of surface curvature on velocity measurements (the tibia bone surface is fairly flat but may show surface curvature in some patients). The velocities in the axial and ±37.5° directions were used to calculate an anisotropy index. The velocities measured on the porosity phantoms showed a decrease by -6.3±0.2m/s and -10.1±0.2m/s per percent increase in porosity in axial and ±37.5° directions, respectively. Surface curvature had an effect on the velocities measured in ±37.5° directions which could be minimized by a correction algorithm resulting in an error of 5m/s. The anisotropy index could be used to estimate porosity with an accuracy error of 1.5%. These results indicate that an estimation of porosity using velocity measurements in different directions might be feasible, even in bones with curved surface. These results obtained on phantom material indicate that the approach tested may be suited for porosity measurements on human tibia bone.
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Affiliation(s)
- M Gräsel
- Sektion Biomedizinische Bildgebung, Klinik für Radiologie und Neuroradiologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Am Botanischen Garten 14, 24118 Kiel, Germany.
| | - C-C Glüer
- Sektion Biomedizinische Bildgebung, Klinik für Radiologie und Neuroradiologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Am Botanischen Garten 14, 24118 Kiel, Germany.
| | - R Barkmann
- Sektion Biomedizinische Bildgebung, Klinik für Radiologie und Neuroradiologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Am Botanischen Garten 14, 24118 Kiel, Germany.
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Berthaume MA. Food mechanical properties and dietary ecology. AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY 2016; 159:S79-104. [DOI: 10.1002/ajpa.22903] [Citation(s) in RCA: 51] [Impact Index Per Article: 5.7] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Received: 05/18/2015] [Revised: 08/28/2015] [Accepted: 10/21/2015] [Indexed: 11/12/2022]
Affiliation(s)
- Michael A. Berthaume
- Max Planck Weizmann Center for Integrative Archaeology and Anthropology, Max Planck Institute for Evolutionary Anthropology; Deutscher Platz 6 Leipzig 04103 Germany
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Brosh T, Rozitsky D, Geron S, Pilo R. Tensile mechanical properties of swine cortical mandibular bone. PLoS One 2014; 9:e113229. [PMID: 25463971 PMCID: PMC4251974 DOI: 10.1371/journal.pone.0113229] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/04/2014] [Accepted: 10/22/2014] [Indexed: 11/19/2022] Open
Abstract
Temporary orthodontic mini implants serve as anchorage devices in orthodontic treatments. Often, they are inserted in the jaw bones, between the roots of the teeth. The stability of the mini implants within the bone is one of the major factors affecting their success and, consequently, that of the orthodontic treatment. Bone mechanical properties are important for implant stability. The aim of this study was to determine the tensile properties of the alveolar and basal mandible bones in a swine model. The diametral compression test was employed to study the properties in two orthogonal directions: mesio-distal and occluso-gingival. Small cylindrical cortical bone specimens (2.6 mm diameter, 1.5 mm thickness) were obtained from 7 mandibles using a trephine drill. The sites included different locations (anterior and posterior) and aspects (buccal and lingual) for a total of 16 specimens from each mandible. The load-displacement curves were continuously monitored while loading half of the specimens in the oclluso-gingival direction and half in the mesio-distal direction. The stiffness was calculated from the linear portion of the curve. The mesio-distal direction was 31% stiffer than the occluso-gingival direction. The basal bone was 40% stiffer than the alveolar bone. The posterior zone was 46% stiffer than the anterior zone. The lingual aspect was stiffer than the buccal aspect. Although bone specimens do not behave as brittle materials, the diametral compression test can be adequately used for determining tensile behavior when only small bone specimens can be obtained. In conclusion, to obtain maximal orthodontic mini implant stability, the force components on the implants should be oriented mostly in the mesio-distal direction.
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Affiliation(s)
- Tamar Brosh
- Department of Oral Biology, The Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
- * E-mail:
| | - Doron Rozitsky
- The Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
| | - Silvia Geron
- Department of Orthodontics, The Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
| | - Raphael Pilo
- Department of Oral Rehabilitation, The Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
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Daugschies M, Rohde K, Glüer CC, Barkmann R. The preliminary evaluation of a 1 MHz ultrasound probe for measuring the elastic anisotropy of human cortical bone. ULTRASONICS 2014; 54:4-10. [PMID: 23896622 DOI: 10.1016/j.ultras.2013.07.004] [Citation(s) in RCA: 10] [Impact Index Per Article: 0.9] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 12/30/2012] [Revised: 07/04/2013] [Accepted: 07/04/2013] [Indexed: 06/02/2023]
Abstract
Our objective is to evaluate an ultrasound probe for measurements of velocity and anisotropy in human cortical bone (tibia). The anisotropy of cortical bone is a known and mechanically relevant property in the context of osteoporotic fracture risk. Current in vivo quantitative ultrasound devices measuring the velocity of ultrasound in long bones can only be applied in the axial direction. For anisotropy measurements a second direction for velocity measurements preferably perpendicular to the axial direction is necessary. We developed a new ultrasound probe which permits axial transmission measurements with a simultaneous second perpendicular direction (tangential). Anisotropy measurements were performed on isotropic and anisotropic phantoms and two excised human female tibiae (age 63 and 82). Anisotropy ratios (AI; ratio of squared ultrasound velocities in the two directions) were for the isotropic phantom 1.06 ± 0.01 and for the anisotropic phantom 1.14 ± 0.03 (mean ± standard deviation). AI was 1.83 ± 0.29 in the tibia from the older donor and 1.37 ± 0.18 in the tibia from the younger donor. The AIs were in the expected range and differed significantly (p<0.05, t-test) between the tibiae. Measured sound velocities were reproducible (mean standard deviation of short time precision of both channels for phantom measurements 31 m/s) and in agreement with reported velocities of the phantom material. Our results document the feasibility of anisotropy measurements at long bones using a single probe. Further improvements in the design of the probe and tests in vivo are warranted. If this approach can be evaluated in vivo an additional tool for assessing the bone status is available for clinical use.
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Affiliation(s)
- M Daugschies
- Sektion Biomedizinische Bildgebung, Klinik für Radiologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Am Botanischen Garten 14, 24118 Kiel, Germany.
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Bright JA, Rayfield EJ. Sensitivity and ex vivo validation of finite element models of the domestic pig cranium. J Anat 2011; 219:456-71. [PMID: 21718316 DOI: 10.1111/j.1469-7580.2011.01408.x] [Citation(s) in RCA: 62] [Impact Index Per Article: 4.4] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/30/2022] Open
Abstract
A finite element (FE) validation and sensitivity study was undertaken on a modern domestic pig cranium. Bone strain data were collected ex vivo from strain gauges, and compared with results from specimen-specific FE models. An isotropic, homogeneous model was created, then input parameters were altered to investigate model sensitivity. Heterogeneous, isotropic models investigated the effects of a constant-thickness, stiffer outer layer (representing cortical bone) atop a more compliant interior (representing cancellous bone). Loading direction and placement of strain gauges were also varied, and the use of 2D membrane elements at strain gauge locations as a method of projecting 3D model strains into the plane of the gauge was investigated. The models correctly estimate the loading conditions of the experiment, yet at some locations fail to reproduce correct principal strain magnitudes, and hence strain ratios. Principal strain orientations are predicted well. The initial model was too stiff by approximately an order of magnitude. Introducing a compliant interior reported strain magnitudes more similar to the ex vivo results without notably affecting strain orientations, ratios or contour patterns, suggesting that this simple heterogeneity was the equivalent of reducing the overall stiffness of the model. Models were generally insensitive to moderate changes in loading direction or strain gauge placement, except in the squamosal portion of the zygomatic arch. The use of membrane elements made negligible differences to the reported strains. The models therefore seem most sensitive to changes in material properties, and suggest that failure to model local heterogeneity in material properties and structure of the bone may be responsible for discrepancies between the experimental and model results. This is partially attributable to a lack of resolution in the CT scans from which the model was built, and partially due to an absence of detailed material properties data for pig cranial bone. Thus, caution is advised when using FE models to estimate absolute numerical values of breaking stress and bite force unless detailed input parameters are available. However, if the objective is to compare relative differences between models, the fact that the strain environment is replicated well means that such investigations can be robust.
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Affiliation(s)
- Jen A Bright
- Department of Earth Sciences, University of Bristol, UK.
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