Copyright ©The Author(s) 2015.
World J Ophthalmol. Feb 12, 2015; 5(1): 1-15
Published online Feb 12, 2015. doi: 10.5318/wjo.v5.i1.1
Table 3 Diagnostic criteria for paraneoplastic pemphigus
Diagnostic criteria for paraneoplastic pemphigus
Anhalt et al[94]
Camisa et al[95]
Painful mucosal and polymorphous skin erosions that involves the trunk, extremities, palms, and soles of a patient with a neoplasm Histological changes including intraepidermal acantholysis, keratinocyte necrosis, and vacuolar interface dermatitis) Direct immunofluorescence findings of IgG and complement localized to the intercellular regions of the epithelium in a linear or granular fashion at the basement membrane zone Circulating autoantibodies that bind to stratified squamous epithelium as well as simple, columnar, and transitional epithelium Immunoprecipitation studies that demonstrate the presence of autoantibodies directed against a complex of five proteins of 250, 230, 210, 190, and 170 kDaMajor criteria Polymorphous mucocutaneous eruption Concurrent internal neoplasia Specific serum immunoprecipitation pattern Minor criteria Histology demonstrating acantholysis Direct immunofluorescence demonstrating intercellular and basement membrane staining Indirect immunofluorescence staining with rat murine epithelium Diagnosis: All three major or two major and two minor required to diagnosis paraneoplastic pemphigus