Universal screening for hemoglobinopathies in today's multi-ethnic societies: How and when

doi:10.5317/wjog.v4.i4.86

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Nov 10, 2015 (publication date) through Apr 26, 2024

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World Journal of Obstetrics and Gynecology

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2218-6220

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Obstet Gynecol. Nov 10, 2015; 4(4): 86-94
Published online Nov 10, 2015. doi: 10.5317/wjog.v4.i4.86

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Figure 1 Examples of putative diagnostic results identifying carriers of the common β globin gene defects associated with sickle cell disease and β-thalassemia major on different high performance liquid chromatography or capillary electrophoresis devices. From left to right separations on Sebia CE and Bio-Rad, Menarini, Tosoh and Ultra2 HPLC devices. HPLC: High performance liquid chromatography; CE: Capillary electrophoresis; Hb: Hemoglobin.

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Figure 2 Typical hemoglobin H inclusion bodies found sporadically in carriers of alpha zero thalassemia (--/αα) and abundantly in patients with hemoglobin H disease (--/-α).

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Figure 3 Genetic risk for hemoglobinopathies and practical prevention flow chart after carrier screening early in pregnancy. HPLC: High performance liquid chromatography; CE: Capillary electrophoresis; HBP: Hemoglobinopathy; CBC: Complete blood count.

Citation: Giordano PC. Universal screening for hemoglobinopathies in today's multi-ethnic societies: How and when. World J Obstet Gynecol 2015; 4(4): 86-94
URL: https://www.wjgnet.com/2218-6220/full/v4/i4/86.htm
DOI: https://dx.doi.org/10.5317/wjog.v4.i4.86