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World J Obstet Gynecol. May 10, 2013; 2(2): 8-15
Published online May 10, 2013. doi: 10.5317/wjog.v2.i2.8
Published online May 10, 2013. doi: 10.5317/wjog.v2.i2.8
New developments of the effect of melatonin on reproduction
Fanuel Lampiao, Division of Physiology, Department of Basic Medical Sciences, College of Medicine, Blantyre 3, Malawi
Stefan S Du Plessis, Division of Medical Physiology, Stellenbosch University, Tygerberg Campus, Tygerberg 19063, South Africa
Author contributions: Lampiao F and Du Plessis SS were involved in conception and designing, drafting, revising and final approval of the article.
Correspondence to: Fanuel Lampiao, PhD, Division of Physiology, Department of Basic Medical Sciences, College of Medicine, PO Box 360, Blantyre 3, Malawi. flampiao@medcol.mw
Telephone: +265-1878058 Fax: +265-111872644
Received: January 5, 2013
Revised: April 18, 2013
Accepted: May 8, 2013
Published online: May 10, 2013
Revised: April 18, 2013
Accepted: May 8, 2013
Published online: May 10, 2013
Core Tip
Core tip: In recent years, many studies have been focusing on the role melatonin plays in the process of reproduction. The low success rate in assisted reproductive technologies due to the detrimental effects of oxidative stress has led to studies investigating the potency of melatonin as an antioxidant. Studies have shown that melatonin reduces oxidative stress and contributes to oocyte maturation, embryo development, and luteinization of granulosa cells. Clinical studies have demonstrated that melatonin treatment for infertile women increases intra-follicular melatonin concentrations, reduces intra-follicular oxidative damage, and increases the chances of pregnancy. This review highlights the effects of melatonin in reproduction.