Case Control Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Obstet Gynecol. Aug 10, 2017; 6(3): 16-20
Published online Aug 10, 2017. doi: 10.5317/wjog.v6.i3.16
Is nitric oxide level affected in postmenopausal women with hypothyroidism?
Kiran Dahiya, Deepika Dalal, Vani Malhotra, Sameer Aggarwal, Ashish Kumar Malik, Veena Singh Ghalaut, Priya Dahiya
Kiran Dahiya, Deepika Dalal, Veena Singh Ghalaut, Department of Biochemistry, Pt. BD Sharma PGIMS, Rohtak, Haryana 124001, India
Vani Malhotra, Department of Obstetrics and Gynecology, Pt. BD Sharma PGIMS, Rohtak, Haryana 124001, India
Sameer Aggarwal, Department of Medicine, Pt. BD Sharma PGIMS, Rohtak, Haryana 124001, India
Ashish Kumar Malik, Department of Psychiatry, Pt. BD Sharma PGIMS, Rohtak, Haryana 124001, India
Priya Dahiya, Department of Obstetrics and Gynecology, Rajshree Medical Research Institute, Bareilly, UP 243501, India
Author contributions: Dahiya K and Dalal D contributed equally to the work; Dahiya K, Dalal D, Malhotra V and Aggarwal S designed the research work; Malhotra V and Aggarwal S treated the patients; Dahiya K and Dalal D collected material and clinical data from patients; Dahiya K, Dalal D and Ghalaut VS performed the assays; Dalal D, Malik AK and Dahiya P analyzed data; Dahiya K, Dahiya P and Dalal D wrote the paper. Malhotra V, Aggarwal S, Malik AK and Ghalaut VS approved the final version of the manuscript.
Institutional review board statement: This work was part of MD thesis project of Dr. Deepika Dalal under supervision of Dr. Kiran Dahiya and co-supervision of Dr. Vani Malhotra and Dr. Sameer Aggarwal. It was duly reviewed and approved by Institutional PG Board of Studies.
Informed consent statement: Informed consent was obtained from all the subjects of the study.
Conflict-of-interest statement: None.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Kiran Dahiya, MD, Professor, Department of Biochemistry, Pt. BD Sharma PGIMS, Rohtak, Haryana 124001, India.
Telephone: +91-98-96111985
Received: May 2, 2017
Peer-review started: May 10, 2017
First decision: May 25, 2017
Revised: June 25, 2017
Accepted: July 10, 2017
Article in press: July 11, 2017
Published online: August 10, 2017
Research background

Hypothyroidism and menopause, both pose a risk to the cardiac health of women.

Research objectives

As suggested by literature that estrogen induced cardio protection might be mediated by release of nitric oxide (NO), this study was conducted to estimate and compare serum NO levels in postmenopausal women with and without hypothyroidism.

Research methods

NO was analyzed as nitrite colorimetrically in 30 postmenopausal hypothyroid and euthyroid females each.

Research results

A statistically significant decrease was observed in NO levels in postmenopausal hypothyroid females as compared to their euthyroid counterparts (P < 0.05).

Research conclusions

It may be concluded that cardiovascular health is compromised in postmenopausal women because of low estrogen, which is further deteriorated by hypothyroidism, indicated by lower NO.

Research perspectives

This research directs towards future perspectives in analyzing other endothelial function markers along with actual estimation of NO and its association with reproductive hormone levels in larger study groups.