Perrone AM, Pozzati F, Santini D, Rossi M, Procaccini M, Casalini L, Santi E, Tesei M, Zamagni C, Iaco PD. Gynecological malignancies and hormonal therapies: Clinical management and recommendations.
World J Obstet Gynecol 2014;
3:162-170. [DOI:
10.5317/wjog.v3.i4.162]
[Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/28/2014] [Revised: 05/15/2014] [Accepted: 09/10/2014] [Indexed: 02/05/2023] Open
Abstract
Every year in the world a large number of women receive a diagnosis of gynecological cancer and undergo a therapy such as surgery, chemotherapy and radiotherapy to the pelvic region. A large portion of these patients are already in menopause, but for younger patients therapies are responsible of early menopause. The physical and psychological symptoms due to iatrogenic menopause significantly reduce the quality of life; however hormone replacement therapy (HRT) has a high efficacy in reducing menopausal symptoms. The prescription of HRT in patients with story of gynecological cancer is debated because its safety has not been completely proven. The main criticism is based on the theory that the hormone replacement could stimulate growth of residual cancer cells increasing the risk of recurrence.
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