Advances and perspectives on cellular therapy in acquired bone marrow failure diseases

Table 1 Advantages and disadvantages of hematopoietic stem cell transplantantion

Sources of stem cells for transplantation	Peripheral blood	Bone marrow	Cord blood
Advantages	Abundant supply	Abundant supply	Rapid procedure
	Easy to collect and differentiate	Easy to storage	Less GVHD
	No surgical procedure	Relatively fast engraftment	Tolerance of HLA-mismatching
	Short recovery period	Autologous cells are immune compatible
	Fastest engraftment
	Low rates of morbidity and mortality
Disadvantages	High risk of GVHD	Surgical procedure	Limited number of stem cells
	Requirement of close HLA-matching	Long recovery period	Difficult to grow and differentiate
		High risk of GVHD	Slow engraftment
		Requirement of close HLA-matching	Tissue rejection

GVHD: Graft-vs-host disease; HLA: Human leukocyte antigens.