Copyright ©The Author(s) 2015.
World J Hematol. Nov 6, 2015; 4(4): 54-68
Published online Nov 6, 2015. doi: 10.5315/wjh.v4.i4.54
Table 1 Overview of the storage lesions
LesionsReversible or irreversible1
BiochemicalLoss of metabolic modulationReversible
Accumulation of lactate and pH dropReversible
Ion leakage (K+)Irreversible
Decrease of antioxidant defensesReversible
ATP-dependent protein functionReversible
Protein oxidation (sulfenic acid)Reversible
Protein oxidation (carbonylation)/degradationIrreversible
Membrame proteins (band 3 dimerization/accumulation of oxidized proteins)Irreversible
Lipid oxidationIrreversible
MorphologicalExposure of senescence markers (phosphatidylserine)Irreversible
Shape changeReversible or irreversible
Reduced deformabilityIrreversible