Storage lesion: History and perspectives

doi:10.5315/wjh.v4.i4.54

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 4, Issue 4

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (13349)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-1) series, Tables (1-1) series.

Item

Count

PDF

787

WORD

332

HTML

7142

Figures (1-1)

293

Tables (1-1)

219

Sum=8773

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

690

Download

1371

Sum=2061

Publishing Process of This Article

Item

Count

Browse

1005

Download

1510

Sum=2515

Nov 6, 2015 (publication date) through Apr 18, 2024

Times Cited of This Article

Times Cited (2)

Journal Information of This Article

Publication Name

World Journal of Hematology

ISSN

2218-6204

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Review

World J Hematol. Nov 6, 2015; 4(4): 54-68
Published online Nov 6, 2015. doi: 10.5315/wjh.v4.i4.54

Table 1 Overview of the storage lesions

	Lesions	Reversible or irreversible¹
Biochemical	Loss of metabolic modulation	Reversible
	Accumulation of lactate and pH drop	Reversible
	Ion leakage (K⁺)	Irreversible
	Decrease of antioxidant defenses	Reversible
	ATP-dependent protein function	Reversible
	Protein oxidation (sulfenic acid)	Reversible
	Protein oxidation (carbonylation)/degradation	Irreversible
	Membrame proteins (band 3 dimerization/accumulation of oxidized proteins)	Irreversible
	Hemolysis	Irreversible
	Lipid oxidation	Irreversible
Morphological	Exposure of senescence markers (phosphatidylserine)	Irreversible
	Shape change	Reversible or irreversible
	Reduced deformability	Irreversible
	Microvesiculation	Irreversible

¹Either in vivo or in vitro.

Citation: Delobel J, Garraud O, Barelli S, Lefrère JJ, Prudent M, Lion N, Tissot JD. Storage lesion: History and perspectives. World J Hematol 2015; 4(4): 54-68
URL: https://www.wjgnet.com/2218-6204/full/v4/i4/54.htm
DOI: https://dx.doi.org/10.5315/wjh.v4.i4.54