Copyright ©The Author(s) 2015.
World J Hematol. Aug 6, 2015; 4(3): 16-53
Published online Aug 6, 2015. doi: 10.5315/wjh.v4.i3.16
Figure 11
Figure 11 The clinical features of four JAK2V617F+ essential thrombocythemia and two JAK2V617F+ polycythemia vera cases refer to the numbering of cases in Figure 10. Case 2: Clinically JAK2V617F ET 2 (low serum erythropoetin) and a normocellular ET [World Health Organization (WHO)-ET] bone marrow wit pleomorph small and large megakaryocytes and reticulin fibers (RF) grade 1; Case 3 and 4: Clinically JAK2V617F ET 2 with a trilinear hypercellular PV bone marrow and RF 0 in case 3: ET 2 with increased cellularity due to increased erythropoiesis RF grade 0 in case 4; Case 5: Clinically JAK2V617F ET with moderate splenomegaly and a hypercellular megakaryocytic granulocytic myeloproliferation (ET.MGM = ET 3), with dysmorphic megakaryocytes (not cloud-like) and RF grade 0 in case 5; Case 6: Clinically JAK2V617F ET 2 with a trilinear PV bone marrow picture1 and RF grade 0; Case 7: Clinically JAK2V617F PV with a 65% hypercellular ET/PV bone marrow picture in between “normocellular ET” (WHO-ET) and trilinear hypercellular (90%-100%) PV picture in case 7 and 8 with PV with increased RCM and erythrocytes above 6 × 1012/L. In 2007, we concluded that bone histology alone does not differentiate between JAK2 mutated ET and PV, as compared to control, morphology of pleiomorph megakaryocytes in JAK2V617F mutated ET and PV are similar Source Poster P-0025. Fourth International Congress on myeloproliferaive disease/myelodysplatic syndrome New York, 2007. ET: Essential thrombocythemia; PV: Polycythemia vera.