Copyright ©The Author(s) 2015.
World J Hematol. Aug 6, 2015; 4(3): 16-53
Published online Aug 6, 2015. doi: 10.5315/wjh.v4.i3.16
Table 6 The 2000 European Clinical and Pathological criteria for the diagnosis of polycythemia vera defined by Michiels[73] in 1997[9,74], and in 2000[93]
Clinical ECP criteria of PVPathological ECP criteria of PV
A1 Increased erythrocytes > 6 × 1012/L. Raised RCM: RCM (optional) male > 36 mL/kg, female > 3.2 mL/kg or increased red cell counts above 6 × 1012/LB1 Thrombocytheia: platelet count > 400 × 109/L
A2 Absence of any cause of primary or secondary erythrocytosis by clinical and laboratory investigationsB2 Granulocytes > 10 × 109/L and raised LAP score in the absence of fever or infection
A3 Histopathology of bone marrow biopsyB3 Splenomgaly on palpation or on echogram > 11 cm
(1) Increase and clusters of pleomorph large megakaryocytes with hyperploid nuceiB4 Spontaneous erythroid colony formation in the absence of EPO and low plasma or serum EPO level
(2) Increased cellulartity due to increased erythropoiesis or erythropoiesis and granulopoiesis (panmyelosis)Staging of MF related to reticulin fibrosis
(3) No or slight increase of reticulin fibersMF 0 No reticulin fibrosis RF 0/1
MF 1 Slight reticulin fibrosis RF 2
MF 2 Marked increase RF grade 3 and slight to moderate collagen fibrosis
MF 3 Advanced collagen fibrosis-osteosclerosis