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World J Hematol. May 6, 2013; 2(2): 20-43
Published online May 6, 2013. doi: 10.5315/wjh.v2.i2.20
Aspirin responsive platelet thrombophilia in essential thrombocythemia and polycythemia vera
Jan Jacques Michiels, Fibo WJ Ten Kate, Peter J Koudstaal, Perry JJ Van Genderen
Jan Jacques Michiels, Department of Medicine, Erasmus Medical Center, Erasmus University Rotterdam, 3015 GE, Rotterdam, The Netherlands
Jan Jacques Michiels, Department of Hematology University Hospital Antwerp, B-2650 Edgem, Antwerp, Belgium
Jan Jacques Michiels, European Working Group on Myeloproliferative Neoplasms, Goodheart Institute and Foundation, 3069 AT, Rotterdam, The Netherlands
Fibo WJ Ten Kate, Department of Pathology, Erasmus Medical Center, Erasmus University Rotterdam, 3015 GE, Rotterdam, The Netherlands
Peter J Koudstaal, Department of Neurology, Erasmus Medical Center, Rotterdam, Erasmus University Rotterdam, 3015 GE, Rotterdam, The Netherlands
Perry JJ Van Genderen, Department of Internal Medicine, Haven Hospital, 3011 TD, Rotterdam, The Netherlands
Perry JJ Van Genderen, Erasmus Medical Center, Rotterdam, 3015 GE, Rotterdam, The Netherlands
Author contributions: Michiels JJ wrote the manuscript, discovered the platelet-mediated microvascular disturbances in thrombocythemia and conducted the studies on the etiology of platelet thrombophilia in thrombocythemia; Ten Kate FWJ performed the pathology study on skin biopsies from erythromelalgic areas and bone marrow histology for detection of early stage essential thrombocythemia and polycythemia vera; Van Genderen PJJ performed the platelet kinetic, platelet function and coagulation studies; Koudstaal PJ analyzed and interpreted the neurological, ocular and visual manifestations as part of the broad spectrum of aspirin responsive microvascular disturbances in thrombocythemia.
Correspondence to: Jan Jacques Michiels, MD, PhD, European Working Group on Myeloproliferative Neoplasms, Goodheart Institute and Foundation, Erasmus Tower, Veenmos 13, 3069 AT, Rotterdam, The Netherlands. goodheartcenter@upcmail.nl
Telephone: +31-62-6970534 Fax: +31-10-4212054
Received: August 12, 2012
Revised: December 21, 2012
Accepted: January 5, 2013
Published online: May 6, 2013
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