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Guo Y, Liu Y, Zhang Z, Zhang X, Jin X, Zhang R, Chen G, Zhu L, Zhu M. Biopolymer based Fibrous Aggregate Materials for Diagnosis and Treatment: Design, Manufacturing, and Applications. ADVANCED MATERIALS (DEERFIELD BEACH, FLA.) 2025:e2414877. [PMID: 40351104 DOI: 10.1002/adma.202414877] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 09/30/2024] [Revised: 04/05/2025] [Indexed: 05/14/2025]
Abstract
Biopolymer-based fibrous aggregate materials (BFAMs) have gained increasing attention in biomedicine due to their excellent biocompatibility, processability, biodegradability, and multifunctionality. Especially, the medical applications of BFAMs demand advanced structure, performance, and function, which conventional trial-and-error methods struggle to provide. This necessitates the rational selection of materials and manufacturing methods to design BFAMs with various intended functions and structures. This review summarizes the current progress in raw material selection, structural and functional design, processing technology, and application of BFAMs. Additionally, the challenges encountered during the development of BFAMs are discussed, along with perspectives for future research offered.
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Affiliation(s)
- Ying Guo
- State Key Laboratory of Advanced Fiber Materials, College of Materials Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai, 201620, China
| | - Yifan Liu
- State Key Laboratory of Advanced Fiber Materials, College of Materials Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai, 201620, China
| | - Zeqi Zhang
- State Key Laboratory of Advanced Fiber Materials, College of Materials Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai, 201620, China
| | - Xiaozhe Zhang
- State Key Laboratory of Advanced Fiber Materials, College of Materials Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai, 201620, China
| | - Xu Jin
- State Key Laboratory of Advanced Fiber Materials, College of Materials Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai, 201620, China
| | - Ruxu Zhang
- State Key Laboratory of Advanced Fiber Materials, College of Materials Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai, 201620, China
| | - Guoyin Chen
- State Key Laboratory of Advanced Fiber Materials, College of Materials Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai, 201620, China
| | - Liping Zhu
- State Key Laboratory of Advanced Fiber Materials, College of Materials Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai, 201620, China
| | - Meifang Zhu
- State Key Laboratory of Advanced Fiber Materials, College of Materials Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai, 201620, China
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Xu Z, Zhang C, Wang F, Yu J, Yang G, Surmenev RA, Li Z, Ding B. Smart Textiles for Personalized Sports and Healthcare. NANO-MICRO LETTERS 2025; 17:232. [PMID: 40278986 PMCID: PMC12031719 DOI: 10.1007/s40820-025-01749-6] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Received: 01/19/2025] [Accepted: 03/26/2025] [Indexed: 04/26/2025]
Abstract
Advances in wearable electronics and information technology drive sports data collection and analysis toward real-time visualization and precision. The growing pursuit of athleticism and healthy life makes it appealing for individuals to track their real-time health and exercise data seamlessly. While numerous devices enable sports and health monitoring, maintaining comfort over long periods remains a considerable challenge, especially in high-intensity and sweaty sports scenarios. Textiles, with their breathability, deformability, and moisture-wicking abilities, ensure exceptional comfort during prolonged wear, making them ideal for wearable platforms. This review summarized the progress of research on textile-based sports monitoring devices. First, the design principles and fabrication methods of smart textiles were introduced systematically. Textiles undergo a distinctive fiber-yarn-fabric or fiber-fabric manufacturing process that allows for the regulation of performance and the integration of functional elements at every step. Then, the performance requirements for precise sports data collection of smart textiles, including main vital signs, joint movement, and data transmission, were discussed. Lastly, the applications of smart textiles in various sports scenarios are demonstrated. Additionally, the review provides an in-depth analysis of the emerging challenges, strategies, and opportunities for the research and development of sports-oriented smart textiles. Smart textiles not only maintain comfort and accuracy in sports, but also serve as inexpensive and efficient information-gathering terminals. Therefore, developing multifunctional, cost-effective textile-based systems for personalized sports and healthcare is a pressing need for the future of intelligent sports.
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Affiliation(s)
- Ziao Xu
- College of Textiles, Donghua University, Shanghai, 201620, People's Republic of China
| | - Chentian Zhang
- College of Textiles, Donghua University, Shanghai, 201620, People's Republic of China
| | - Faqiang Wang
- College of Textiles, Donghua University, Shanghai, 201620, People's Republic of China
| | - Jianyong Yu
- Innovation Center for Textile Science and Technology, Donghua University, Shanghai, 200051, People's Republic of China
| | - Gang Yang
- Jiangsu Laboratory of Advanced Functional Materials, School of Materials Engineering, Changshu Institute of Technology, Changshu, 215500, People's Republic of China
| | - Roman A Surmenev
- Physical Materials Science and Composite Materials Center, Research School of Chemistry & Applied Biomedical Sciences, National Research Tomsk Polytechnic University, Tomsk, 634050, Russia
| | - Zhaoling Li
- College of Textiles, Donghua University, Shanghai, 201620, People's Republic of China.
- Innovation Center for Textile Science and Technology, Donghua University, Shanghai, 200051, People's Republic of China.
| | - Bin Ding
- Innovation Center for Textile Science and Technology, Donghua University, Shanghai, 200051, People's Republic of China.
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Sunstrum FN, Khan JU, Li NW, Welsh AW. Wearable textile sensors for continuous glucose monitoring. Biosens Bioelectron 2025; 273:117133. [PMID: 39808994 DOI: 10.1016/j.bios.2025.117133] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/30/2024] [Revised: 12/17/2024] [Accepted: 01/03/2025] [Indexed: 01/16/2025]
Abstract
Diabetes and cardiovascular disease are interlinked chronic conditions that necessitate continuous and precise monitoring of physiological and environmental parameters to prevent complications. Non-invasive monitoring technologies have garnered significant interest due to their potential to alleviate the current burden of diabetes and cardiovascular disease management. However, these technologies face limitations in accuracy and reliability due to interferences from physiological and environmental factors. This review investigates electronic textiles (e-textiles) that integrate biomedical sensors into wearable fabrics that can enable a multimodal platform for non-invasive continuous glucose monitoring (CGM). Current advancements in e-textiles show the potential of four key methods for glucose monitoring: optical, biochemical, biomechanical, and thermal sensing techniques. Biochemical sensing through sweat-based glucose detection has demonstrated potential for accurate and non-invasive monitoring but still faces numerous challenges. While optical, biomechanical and thermal sensing are less explored in e-textiles, they offer additional physiological and environmental insights that can improve the precision of glucose readings by providing cross-validation of data. This review proposes that integrating multiple sensing modalities into a single multimodal e-textile wearable can address the accuracy and reliability challenges by providing cross-validation of data. The development of such multimodal e-textiles has the potential to revolutionise diabetes and cardiovascular disease management by providing continuous, accurate, and holistic monitoring in real-time, which could significantly improve patient outcomes and quality of life. Further research and development are crucial to fully realise the potential of these integrated systems in clinical and everyday settings.
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Affiliation(s)
- Frédérique N Sunstrum
- School of Design, Faculty of Design, Architecture and Built Environment, University of Technology Sydney, Sydney, Australia.
| | - Jawairia Umar Khan
- Institute for Biomedical Materials and Devices, School of Mathematical and Physical Sciences, Faculty of Science, University of Technology Sydney, Sydney, Australia.
| | - Nga-Wun Li
- School of Design, Faculty of Design, Architecture and Built Environment, University of Technology Sydney, Sydney, Australia
| | - Alec W Welsh
- School of Clinical Medicine, Discipline of Women's Health, Faculty of Medicine, University of New South Wales, Royal Hospital for Women, Sydney, Australia; Department of Maternal-Fetal Medicine, Royal Hospital for Women, Sydney, Australia.
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Liu J, Xu Z, Wang H, Zhao Y, Lin T. Directional Liquid Transport in Thin Fibrous Matrices: Enhancement of Advanced Applications. ACS NANO 2025; 19:5913-5937. [PMID: 39912713 DOI: 10.1021/acsnano.4c17351] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 02/07/2025]
Abstract
Directional liquid transport fibrous matrices (DLTFMs) have the unique ability to direct liquid movement in a single direction through their thickness. Beyond their inherent liquid transport function, DLTFMs can also enhance the effectiveness of additional functionalities. This review focuses on recent advances in DLTFMs, particularly the role of DLTs in enhancing secondary functions. We begin with a brief overview of the historical development and major achievements in DLTFM research, followed by an outline of the classification, fabrication techniques, and basic functions derived from their natural liquid transport properties. The integration of DLT to enhance secondary functionalities such as responsiveness, thermal regulation, and wearable technology for innovative applications in various sectors is then discussed. The review concludes with a discussion of key challenges and prospects in the field, including the durability and reliability of DLT performance, the precise regulation of fluid transport rates, the resilience and longevity of DLTFMs in harsh environments, and the impact of DLT variations on performance enhancement. The goal of this review is to stimulate further innovative studies on DLTFMs and to promote their practical implementation in a variety of industries.
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Affiliation(s)
- Junye Liu
- College of Textile and Clothing Engineering, National Engineering Laboratory for Modern Silk, Soochow University, Suzhou 215123, China
| | - Zhiguang Xu
- College of Biological, Chemical Sciences and Engineering, China-Australia Institute for Advanced Materials and Manufacturing, Jiaxing University, Jiaxing 314001, China
| | - Hongxia Wang
- School of Textile Science and Engineering, Tiangong University, Tianjin 300387, China
| | - Yan Zhao
- College of Textile and Clothing Engineering, National Engineering Laboratory for Modern Silk, Soochow University, Suzhou 215123, China
| | - Tong Lin
- School of Textile Science and Engineering, Tiangong University, Tianjin 300387, China
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Zhou N, Ji J, Qu R, Feng X, Song X, Chen M, Chen F, Ma Z, Wei Y. Permeable and Durable Liquid-Metal Fiber Mat as Implantable Physiological Electrodes with Long-Term Biocompatibility. ADVANCED MATERIALS (DEERFIELD BEACH, FLA.) 2025; 37:e2413728. [PMID: 39801201 DOI: 10.1002/adma.202413728] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 09/12/2024] [Revised: 11/21/2024] [Indexed: 02/26/2025]
Abstract
Implantable physiological electrodes provide unprecedented opportunities for real-time and uninterrupted monitoring of biological signals. Most implantable electronics adopt thin-film substrates with low permeability that severely hampers tissue metabolism, impeding their long-term biocompatibility. Recent innovations have seen the advent of permeable electronics through the strategic modification of liquid metals (LMs) onto porous substrates. However, the durability of these electronics is limited by the inherent poor wettability of LMs, particularly within the intricate 3D skeleton of the porous substrate. Herein, the study reports a spatial wettability tuning strategy that solves the wettability issue of LMs within the porous substrates, enabling the LM physiological electrodes with high durability and long-term biocompatibility. The study demonstrates the use of the electrodes as implantable neural interface to realize in vivo acquisition of electrocardiograph and electrocorticogram signals with long-term biocompatibility and high signal-to-noise ratio. This work demonstrates a promising direction for rational design of durable implantable bioelectronics with long-term biocompatibility.
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Affiliation(s)
- Ningjing Zhou
- School of Materials Science and Engineering, Zhejiang University, Hangzhou, 310058, P. R. China
- Zhejiang Lab, Hangzhou, 311100, P. R. China
| | - Jiujiang Ji
- Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China
| | | | - Xue Feng
- Zhejiang Lab, Hangzhou, 311100, P. R. China
| | | | - Mengjia Chen
- School of Materials Science and Engineering, Zhejiang University, Hangzhou, 310058, P. R. China
- Zhejiang Lab, Hangzhou, 311100, P. R. China
| | - Fuguang Chen
- School of Materials Science and Engineering, Zhejiang University, Hangzhou, 310058, P. R. China
- Zhejiang Lab, Hangzhou, 311100, P. R. China
| | - Zhijun Ma
- School of Materials Science and Engineering, Zhejiang University, Hangzhou, 310058, P. R. China
- Zhejiang Lab, Hangzhou, 311100, P. R. China
| | - Yen Wei
- Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China
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Huang Q, Chen J, Zhao Y, Huang J, Liu H. Advancements in electrochemical glucose sensors. Talanta 2025; 281:126897. [PMID: 39293246 DOI: 10.1016/j.talanta.2024.126897] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/13/2024] [Revised: 08/26/2024] [Accepted: 09/14/2024] [Indexed: 09/20/2024]
Abstract
The development of electrochemical glucose sensors with high sensitivity, specificity, and stability, enabling real-time continuous monitoring, has posed a significant challenge. However, an opportunity exists to fabricate electrochemical glucose biosensors with optimal performance through innovative device structures and surface modification materials. This paper provides a comprehensive review of recent advances in electrochemical glucose sensors. Novel classes of nanomaterials-including metal nanoparticles, carbon-based nanomaterials, and metal-organic frameworks-with excellent electronic conductivity and high specific surface areas, have increased the availability of reactive sites to improved contact with glucose molecules. Furthermore, in line with the trend in electrochemical glucose sensor development, research progress concerning their utilisation with sweat, tears, saliva, and interstitial fluid is described. To facilitate the commercialisation of these sensors, further enhancements in biocompatibility and stability are required. Finally, the characteristics of the ideal electrochemical glucose sensor are described and the developmental trends in this field are outlines.
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Affiliation(s)
- Qing Huang
- School of Integrated Circuits, Huazhong University of Science and Technology, Wuhan National Laboratory for Optoelectronics, Optics Valley Laboratory, Wuhan, Hubei, 430074, China; Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, School of Optoelectronic Materials and Technology, Jianghan University, Wuhan, 430056, China
| | - Jingqiu Chen
- School of Integrated Circuits, Huazhong University of Science and Technology, Wuhan National Laboratory for Optoelectronics, Optics Valley Laboratory, Wuhan, Hubei, 430074, China
| | - Yunong Zhao
- School of Integrated Circuits, Huazhong University of Science and Technology, Wuhan National Laboratory for Optoelectronics, Optics Valley Laboratory, Wuhan, Hubei, 430074, China
| | - Jing Huang
- School of Integrated Circuits, Huazhong University of Science and Technology, Wuhan National Laboratory for Optoelectronics, Optics Valley Laboratory, Wuhan, Hubei, 430074, China
| | - Huan Liu
- School of Integrated Circuits, Huazhong University of Science and Technology, Wuhan National Laboratory for Optoelectronics, Optics Valley Laboratory, Wuhan, Hubei, 430074, China.
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7
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Shi S, Abbas Z, Hu X, Zheng X, Zhao X, Ren T, Wang D. Efficient Fabrication of Bioinspired Flexible Pressure Sensors via Electrohydrodynamic Jet Printing Method. Macromol Rapid Commun 2024; 45:e2400322. [PMID: 38819032 DOI: 10.1002/marc.202400322] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/08/2024] [Indexed: 06/01/2024]
Abstract
Bioinspired microdevices have made significant strides in various applications including human motion and health detection. However, facile and highly efficient fabrication approach of flexible pressure sensors remains a great challenge. Herein, inspired by the gecko's foot structure, a flexible pressure sensor with microdomes structure is fabricated by tip-assisted on-demand electrohydrodynamic jet (EHD-jet) printing method. Ascribed to the interlocking electrodes with microdome structure, 3D deformation rates are substantially enlarged. When the microdromes structure is under pressure, the resistivity of carbon nanotubes film coated on the surface of microdomes structure will change remarkably. By using the combined effect of assisted tip and ring focusing electrode, the influence and constraints on microstructure fabrication caused by substrate material and morphology are minimized. The desired uniform structures can be adjusted rapidly by changing the printing parameters and liquid properties. High length-height ratio (0.64) of microdomes enhances sensitivity, with minimum detection limit is 2 Pa and response time is 40 ms. Finally, the bionic flexible sensor indicated excellent performance in capable of detecting pressure, sound vibrations and human motion. This work presents a new method for high-efficiency fabrication micro-nano patterns for flexible sensors inspired, which could be used in wearable tech and health monitoring.
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Affiliation(s)
- Shiwei Shi
- State Key Laboratory of High-Performance Precision Manufacturing, Key Laboratory for Micro/Nano Technology and System of Liaoning Province, Dalian University of Technology, Dalian, 116024, China
| | - Zeshan Abbas
- State Key Laboratory of High-Performance Precision Manufacturing, Key Laboratory for Micro/Nano Technology and System of Liaoning Province, Dalian University of Technology, Dalian, 116024, China
| | - Xiaoguang Hu
- State Key Laboratory of High-Performance Precision Manufacturing, Key Laboratory for Micro/Nano Technology and System of Liaoning Province, Dalian University of Technology, Dalian, 116024, China
| | - Xiaohu Zheng
- State Key Laboratory of High-Performance Precision Manufacturing, Key Laboratory for Micro/Nano Technology and System of Liaoning Province, Dalian University of Technology, Dalian, 116024, China
| | - Xiangyu Zhao
- State Key Laboratory of High-Performance Precision Manufacturing, Key Laboratory for Micro/Nano Technology and System of Liaoning Province, Dalian University of Technology, Dalian, 116024, China
| | - Tongqun Ren
- State Key Laboratory of High-Performance Precision Manufacturing, Key Laboratory for Micro/Nano Technology and System of Liaoning Province, Dalian University of Technology, Dalian, 116024, China
| | - Dazhi Wang
- State Key Laboratory of High-Performance Precision Manufacturing, Key Laboratory for Micro/Nano Technology and System of Liaoning Province, Dalian University of Technology, Dalian, 116024, China
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8
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Fu X, Cheng W, Wan G, Yang Z, Tee BCK. Toward an AI Era: Advances in Electronic Skins. Chem Rev 2024; 124:9899-9948. [PMID: 39198214 PMCID: PMC11397144 DOI: 10.1021/acs.chemrev.4c00049] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 09/01/2024]
Abstract
Electronic skins (e-skins) have seen intense research and rapid development in the past two decades. To mimic the capabilities of human skin, a multitude of flexible/stretchable sensors that detect physiological and environmental signals have been designed and integrated into functional systems. Recently, researchers have increasingly deployed machine learning and other artificial intelligence (AI) technologies to mimic the human neural system for the processing and analysis of sensory data collected by e-skins. Integrating AI has the potential to enable advanced applications in robotics, healthcare, and human-machine interfaces but also presents challenges such as data diversity and AI model robustness. In this review, we first summarize the functions and features of e-skins, followed by feature extraction of sensory data and different AI models. Next, we discuss the utilization of AI in the design of e-skin sensors and address the key topic of AI implementation in data processing and analysis of e-skins to accomplish a range of different tasks. Subsequently, we explore hardware-layer in-skin intelligence before concluding with an analysis of the challenges and opportunities in the various aspects of AI-enabled e-skins.
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Affiliation(s)
- Xuemei Fu
- Department of Materials Science and Engineering, National University of Singapore, Singapore 117575, Singapore
- Institute for Health Innovation & Technology, National University of Singapore, Singapore 119276, Singapore
| | - Wen Cheng
- Department of Materials Science and Engineering, National University of Singapore, Singapore 117575, Singapore
- Institute for Health Innovation & Technology, National University of Singapore, Singapore 119276, Singapore
- The N.1 Institute for Health, National University of Singapore, Singapore 117456, Singapore
| | - Guanxiang Wan
- Department of Materials Science and Engineering, National University of Singapore, Singapore 117575, Singapore
- Institute for Health Innovation & Technology, National University of Singapore, Singapore 119276, Singapore
| | - Zijie Yang
- Department of Materials Science and Engineering, National University of Singapore, Singapore 117575, Singapore
- Institute for Health Innovation & Technology, National University of Singapore, Singapore 119276, Singapore
| | - Benjamin C K Tee
- Department of Materials Science and Engineering, National University of Singapore, Singapore 117575, Singapore
- Institute for Health Innovation & Technology, National University of Singapore, Singapore 119276, Singapore
- Department of Electrical and Computer Engineering, National University of Singapore, Singapore 117583, Singapore
- The N.1 Institute for Health, National University of Singapore, Singapore 117456, Singapore
- Institute of Materials Research and Engineering, Agency for Science Technology and Research, Singapore 138634, Singapore
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Zhang J, Ma J, Zhang W, Zhang H, Geng X, Yang K, Zhang J, Mo H, Li W, Lu B, Liu X, Zhu N. Breathable Wearable Smartsensors Deriving from Interface Self-Assembled Film for Tracking l-Cysteine. Anal Chem 2024; 96:13070-13077. [PMID: 39088735 DOI: 10.1021/acs.analchem.4c01511] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 08/03/2024]
Abstract
The advent of wearable sensors heralds a transformation in the continuous, noninvasive analysis of biomarkers critical for disease diagnosis and fitness management. Yet, their advancement is hindered by the functional challenges affiliated with their active sensing analysis layer. Predominantly due to suboptimal intrinsic material properties and inconsistent dispersion leading to aggregation, thus compromising sensor repeatability and performance. Herein, an innovative approach to the functionalization of wearable electrochemical sensors was introduced, specifically addressing these limitations. The method involves a proton-induced self-assembly technique at the organic-water (O/W) interface, facilitating the generation of biomarker-responsive films. This research offers flexible, breathable sensor capable of real-time precision tracking l-cysteine (l-Cys) precision tracking. Utilizing an activation mechanism for Prussian blue nanoparticles by hydrogen peroxide, the catalytic core exhibits a specific response to l-Cys. The implications of this study refine the fabrication of film-based analysis electrodes for wearable sensing applications and the broader utilization of two-dimensional materials in functional-specific response films. Findings illuminate the feasibility of this novel strategy for precise biomarker tracking and extend to pave the way for constructing high-performance electrocatalytic analytical interfaces.
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Affiliation(s)
- Jianxin Zhang
- Central Hospital of Dalian University of Technology, School of Chemistry, Dalian University of Technology, Dalian, Liaoning 116024, China
| | - Junlin Ma
- Central Hospital of Dalian University of Technology, School of Chemistry, Dalian University of Technology, Dalian, Liaoning 116024, China
| | - Wenrui Zhang
- Central Hospital of Dalian University of Technology, School of Chemistry, Dalian University of Technology, Dalian, Liaoning 116024, China
| | - Hanwen Zhang
- Central Hospital of Dalian University of Technology, School of Chemistry, Dalian University of Technology, Dalian, Liaoning 116024, China
| | - Xiaodong Geng
- Central Hospital of Dalian University of Technology, School of Chemistry, Dalian University of Technology, Dalian, Liaoning 116024, China
| | - Kai Yang
- Central Hospital of Dalian University of Technology, School of Chemistry, Dalian University of Technology, Dalian, Liaoning 116024, China
| | - Jiancheng Zhang
- Central Hospital of Dalian University of Technology, School of Chemistry, Dalian University of Technology, Dalian, Liaoning 116024, China
| | - Hao Mo
- Central Hospital of Dalian University of Technology, School of Chemistry, Dalian University of Technology, Dalian, Liaoning 116024, China
| | - Wencheng Li
- Central Hospital of Dalian University of Technology, School of Chemistry, Dalian University of Technology, Dalian, Liaoning 116024, China
| | - Bingzhang Lu
- School of Chemical Engineering and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China
| | - Xuhan Liu
- Central Hospital of Dalian University of Technology, School of Chemistry, Dalian University of Technology, Dalian, Liaoning 116024, China
| | - Nan Zhu
- Central Hospital of Dalian University of Technology, School of Chemistry, Dalian University of Technology, Dalian, Liaoning 116024, China
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Yang Y, Sheng C, Dong F, Liu S. An integrated wearable differential microneedle array for continuous glucose monitoring in interstitial fluids. Biosens Bioelectron 2024; 256:116280. [PMID: 38603840 DOI: 10.1016/j.bios.2024.116280] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/22/2024] [Revised: 04/02/2024] [Accepted: 04/08/2024] [Indexed: 04/13/2024]
Abstract
Monitoring biomarkers in human interstitial fluids (ISF) using microneedle sensors has been extensively studied. However, most of the previous studies were limited to simple in vitro demonstrations and lacked system integration and analytical performance. Here we report a miniaturized, high-precision, fully integrated wearable electrochemical microneedle sensing device that works with a customized smartphone application to wirelessly and in real-time monitor glucose in human ISF. A microneedle array fabrication method is proposed which enables multiple individually addressable, regionally separated sensing electrodes on a single microneedle system. As a demonstration, a glucose sensor and a differential sensor are integrated in a single sensing patch. The differential sensing electrodes can eliminate common-mode interference signals, thus significantly improving the detection accuracy. The basic mechanism of microneedle penetration into the skin was analyzed using the finite element method (FEM). By optimizing the structure of the microneedle, the puncture efficiency was improved while the puncture force was reduced. The electrochemical properties, biocompatibility, and system stability of the microneedle sensing device were characterized before human application. The test results were closely correlated with the gold standard (blood). The platform can be used not only for glucose detection, but also for various ISF biomarkers, and it expands the potential of microneedle technology in wearable sensing.
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Affiliation(s)
- Yong Yang
- School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China
| | - Can Sheng
- School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China
| | - Fang Dong
- The Institute of Technological Sciences, Wuhan University, Wuhan, 430072, China.
| | - Sheng Liu
- School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China; The Institute of Technological Sciences, Wuhan University, Wuhan, 430072, China; School of Power and Mechanical Engineering, Wuhan University, Wuhan, 430072, China; School of Microelectronics, Wuhan University, Wuhan, 430072, China.
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11
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Kammarchedu V, Asgharian H, Zhou K, Soltan Khamsi P, Ebrahimi A. Recent advances in graphene-based electroanalytical devices for healthcare applications. NANOSCALE 2024; 16:12857-12882. [PMID: 38888429 PMCID: PMC11238565 DOI: 10.1039/d3nr06137j] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 06/20/2024]
Abstract
Graphene, with its outstanding mechanical, electrical, and biocompatible properties, stands out as an emerging nanomaterial for healthcare applications, especially in building electroanalytical biodevices. With the rising prevalence of chronic diseases and infectious diseases, such as the COVID-19 pandemic, the demand for point-of-care testing and remote patient monitoring has never been greater. Owing to their portability, ease of manufacturing, scalability, and rapid and sensitive response, electroanalytical devices excel in these settings for improved healthcare accessibility, especially in resource-limited settings. The development of different synthesis methods yielding large-scale graphene and its derivatives with controllable properties, compatible with device manufacturing - from lithography to various printing methods - and tunable electrical, chemical, and electrochemical properties make it an attractive candidate for electroanalytical devices. This review article sheds light on how graphene-based devices can be transformative in addressing pressing healthcare needs, ranging from the fundamental understanding of biology in in vivo and ex vivo studies to early disease detection and management using in vitro assays and wearable devices. In particular, the article provides a special focus on (i) synthesis and functionalization techniques, emphasizing their suitability for scalable integration into devices, (ii) various transduction methods to design diverse electroanalytical device architectures, (iii) a myriad of applications using devices based on graphene, its derivatives, and hybrids with other nanomaterials, and (iv) emerging technologies at the intersection of device engineering and advanced data analytics. Finally, some of the major hurdles that graphene biodevices face for translation into clinical applications are discussed.
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Affiliation(s)
- Vinay Kammarchedu
- Department of Electrical Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
- Center for Atomically Thin Multifunctional Coatings, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
- Materials Research Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
| | - Heshmat Asgharian
- Department of Electrical Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
- Materials Research Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
| | - Keren Zhou
- Department of Electrical Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
- Materials Research Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
| | - Pouya Soltan Khamsi
- Department of Electrical Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
- Materials Research Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
| | - Aida Ebrahimi
- Department of Electrical Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
- Center for Atomically Thin Multifunctional Coatings, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
- Materials Research Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
- Department of Biomedical Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
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12
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Lee S, Liang X, Kim JS, Yokota T, Fukuda K, Someya T. Permeable Bioelectronics toward Biointegrated Systems. Chem Rev 2024; 124:6543-6591. [PMID: 38728658 DOI: 10.1021/acs.chemrev.3c00823] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 05/12/2024]
Abstract
Bioelectronics integrates electronics with biological organs, sustaining the natural functions of the organs. Organs dynamically interact with the external environment, managing internal equilibrium and responding to external stimuli. These interactions are crucial for maintaining homeostasis. Additionally, biological organs possess a soft and stretchable nature; encountering objects with differing properties can disrupt their function. Therefore, when electronic devices come into contact with biological objects, the permeability of these devices, enabling interactions and substance exchanges with the external environment, and the mechanical compliance are crucial for maintaining the inherent functionality of biological organs. This review discusses recent advancements in soft and permeable bioelectronics, emphasizing materials, structures, and a wide range of applications. The review also addresses current challenges and potential solutions, providing insights into the integration of electronics with biological organs.
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Affiliation(s)
- Sunghoon Lee
- Thin-Film Device Laboratory & Center for Emergent Matter Science (CEMS), RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan
| | - Xiaoping Liang
- Electrical and Electronic Engineering and Information Systems, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
| | - Joo Sung Kim
- Thin-Film Device Laboratory & Center for Emergent Matter Science (CEMS), RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan
| | - Tomoyuki Yokota
- Electrical and Electronic Engineering and Information Systems, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
| | - Kenjiro Fukuda
- Thin-Film Device Laboratory & Center for Emergent Matter Science (CEMS), RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan
| | - Takao Someya
- Thin-Film Device Laboratory & Center for Emergent Matter Science (CEMS), RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan
- Electrical and Electronic Engineering and Information Systems, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
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13
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Huang X, Yao C, Huang S, Zheng S, Liu Z, Liu J, Wang J, Chen HJ, Xie X. Technological Advances of Wearable Device for Continuous Monitoring of In Vivo Glucose. ACS Sens 2024; 9:1065-1088. [PMID: 38427378 DOI: 10.1021/acssensors.3c01947] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 03/02/2024]
Abstract
Managing diabetes is a chronic challenge today, requiring monitoring and timely insulin injections to maintain stable blood glucose levels. Traditional clinical testing relies on fingertip or venous blood collection, which has facilitated the emergence of continuous glucose monitoring (CGM) technology to address data limitations. Continuous glucose monitoring technology is recognized for tracking long-term blood glucose fluctuations, and its development, particularly in wearable devices, has given rise to compact and portable continuous glucose monitoring devices, which facilitates the measurement of blood glucose and adjustment of medication. This review introduces the development of wearable CGM-based technologies, including noninvasive methods using body fluids and invasive methods using implantable electrodes. The advantages and disadvantages of these approaches are discussed as well as the use of microneedle arrays in minimally invasive CGM. Microneedle arrays allow for painless transdermal puncture and are expected to facilitate the development of wearable CGM devices. Finally, we discuss the challenges and opportunities and look forward to the biomedical applications and future directions of wearable CGM-based technologies in biological research.
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Affiliation(s)
- Xinshuo Huang
- State Key Laboratory of Optoelectronic Materials and Technologies, Guangdong Province Key Laboratory of Display Material and Technology, School of Electronics and Information Technology, Sun Yat-Sen University, Guangzhou, 510006, China
| | - Chuanjie Yao
- State Key Laboratory of Optoelectronic Materials and Technologies, Guangdong Province Key Laboratory of Display Material and Technology, School of Electronics and Information Technology, Sun Yat-Sen University, Guangzhou, 510006, China
| | - Shuang Huang
- State Key Laboratory of Optoelectronic Materials and Technologies, Guangdong Province Key Laboratory of Display Material and Technology, School of Electronics and Information Technology, Sun Yat-Sen University, Guangzhou, 510006, China
| | - Shantao Zheng
- State Key Laboratory of Optoelectronic Materials and Technologies, Guangdong Province Key Laboratory of Display Material and Technology, School of Electronics and Information Technology, Sun Yat-Sen University, Guangzhou, 510006, China
| | - Zhengjie Liu
- State Key Laboratory of Optoelectronic Materials and Technologies, Guangdong Province Key Laboratory of Display Material and Technology, School of Electronics and Information Technology, Sun Yat-Sen University, Guangzhou, 510006, China
| | - Jing Liu
- The First Affiliated Hospital of Sun Yat-Sen University, Sun Yat-Sen University, Guangzhou, 510006, China
| | - Ji Wang
- The First Affiliated Hospital of Sun Yat-Sen University, Sun Yat-Sen University, Guangzhou, 510006, China
| | - Hui-Jiuan Chen
- State Key Laboratory of Optoelectronic Materials and Technologies, Guangdong Province Key Laboratory of Display Material and Technology, School of Electronics and Information Technology, Sun Yat-Sen University, Guangzhou, 510006, China
| | - Xi Xie
- State Key Laboratory of Optoelectronic Materials and Technologies, Guangdong Province Key Laboratory of Display Material and Technology, School of Electronics and Information Technology, Sun Yat-Sen University, Guangzhou, 510006, China
- The First Affiliated Hospital of Sun Yat-Sen University, Sun Yat-Sen University, Guangzhou, 510006, China
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14
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Darvishmehr Z, Naderi L, Shahrokhian S, Ezzati M. Electrodeposition of CoFeS nanoflakes on Cu 2O nanospheres as an ultrasensitive sensing platform for measurement of the hydrazine and hydrogen peroxide in seawater sample. CHEMOSPHERE 2024; 352:141340. [PMID: 38301836 DOI: 10.1016/j.chemosphere.2024.141340] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 11/18/2023] [Revised: 01/16/2024] [Accepted: 01/29/2024] [Indexed: 02/03/2024]
Abstract
Nanoarchitectured design of the metal sulfides with highly available surface and abundant electroactive centers and using them as electrocatalyst for fabricate the electrochemical sensors for the detection of hydrazine (N2H4) and hydrogen peroxide (H2O2) is challenging and desirable. Herein, Cu2O nanospheres powder is firstly prepared using chemical reduction of copper chloride and then drop-casted on the glassy carbon electrode (GCE) surface. In the next step, CoFeS nanoflakes are electrodeposited on Cu2O nanospheres by cyclic voltammetry method to form CoFeS/Cu2O nanocomposite as a detection platform for measuring N2H4 and H2O2. Accordingly, Cu2O nanospheres are not only used as substrate, but also guided the CoFeS nanoflakes to adhere to the electrode surface without need to any binder or conductive additive, which enhances the electrical conductivity of the sensing active materials. As the hydrazine sensor, the CoFeS/Cu2O/GCE displayed wide linear ranges (0.0001-0.021 mM and 0.021-1.771 mM), low detection limit (0.12 μM), very high sensitivities (103.33 and 21.23 mA mM-1 cm-2), and excellent selectivity. The as-made nanocomposite also exhibited low detection limit of 1.26 μM for H2O2 sensing with very high sensitivities (12.31 and 3.96 mA mM-1 cm-2) for linear ranges of 0.001-0.03 mM and 0.03-2.03 mM, respectively, and negligible response against interfering substances. The superior analytical performance of the CoFeS/Cu2O for N2H4 electro-oxidation and H2O2 electro-reduction can be attributed to structure stability, high electroactive surface area, and good availability to analyte species and electrolyte diffusion. Moreover, to examine the potency of the prepared nanocomposite in real applications, the seawater sample was analyzed and results display that the CoFeS/Cu2O/GCE can be utilized as a reliable and applicable platform for measuring N2H4 and H2O2.
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Affiliation(s)
- Zahra Darvishmehr
- Department of Chemistry, Sharif University of Technology, Tehran, Iran
| | - Leila Naderi
- Department of Chemistry, Sharif University of Technology, Tehran, Iran
| | - Saeed Shahrokhian
- Department of Chemistry, Sharif University of Technology, Tehran, Iran.
| | - Milad Ezzati
- Department of Chemistry, Sharif University of Technology, Tehran, Iran
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15
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Antonova IV, Ivanov AI, Shavelkina MB, Poteryayev DA, Buzmakova AA, Soots RA. Engineering of graphene-based composites with hexagonal boron nitride and PEDOT:PSS for sensing applications. Phys Chem Chem Phys 2024; 26:7844-7854. [PMID: 38376373 DOI: 10.1039/d3cp05953g] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 02/21/2024]
Abstract
A unique nanomaterial has been developed for sweat analysis, including glucose level monitoring. Simple resusable low-cost sensors from composite materials based on graphene, hexagonal boron nitride, and conductive PEDOT:PSS (poly(3,4-ethylenedioxythiophene)polystyrene sulfonate) polymer have been developed and fabricated via 2D printing on flexible substrates. The sensors were tested as biosensors using different water-based solutions. A strong increase in the current response (several orders of magnitude) was observed for aqua vapors or glucose solution vapors. This property is associated with the sorption capacity of graphene synthesized in a volume of plasma jets and thus having many active centers on the surface. The structure and properties of graphene synthesized in a plasma are different from those of graphene created by other methods. As a result, the current response for a wearable sensor is 3-5 orders of magnitude higher for the reference blood glucose concentration range of 4-14 mM. It has been found that the most promising sensor with the highest response was fabricated based on the graphene:PEDOT:PSS composite. The graphene:h-BN:PEDOT:PSS (h-BN is hexagonal boron nitride) sensors demonstrated a longer response and the highest response after the functionalization of the sensors with a glucose oxidase enzyme. The reusable wearable graphene:PEDOT:PSS glucose sensors on a paper substrate demonstrated a current response of 10-10 to 10-5 A for an operating voltage of 0.5 V and glucose range of 4-10 mM.
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Affiliation(s)
- Irina V Antonova
- Rzhanov Institute of Semiconductor Physics SB RAS, 13 Lavrentiev Av., Novosibirsk 630090, Russia.
- Department of Semiconductor Devices and Microelectronics, Novosibirsk State Technical University, 20 K. Marx Str., Novosibirsk 630073, Russia
| | - Artem I Ivanov
- Rzhanov Institute of Semiconductor Physics SB RAS, 13 Lavrentiev Av., Novosibirsk 630090, Russia.
| | - Marina B Shavelkina
- Joint Institute for High Temperatures RAS, Izhorskaya Str. 13 Bd.2, Moscow 125412, Russia
| | - Dmitriy A Poteryayev
- Rzhanov Institute of Semiconductor Physics SB RAS, 13 Lavrentiev Av., Novosibirsk 630090, Russia.
- Department of Semiconductor Devices and Microelectronics, Novosibirsk State Technical University, 20 K. Marx Str., Novosibirsk 630073, Russia
| | - Anna A Buzmakova
- Department of Semiconductor Devices and Microelectronics, Novosibirsk State Technical University, 20 K. Marx Str., Novosibirsk 630073, Russia
| | - Regina A Soots
- Rzhanov Institute of Semiconductor Physics SB RAS, 13 Lavrentiev Av., Novosibirsk 630090, Russia.
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16
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Tian H, Ma J, Li Y, Xiao X, Zhang M, Wang H, Zhu N, Hou C, Ulstrup J. Electrochemical sensing fibers for wearable health monitoring devices. Biosens Bioelectron 2024; 246:115890. [PMID: 38048721 DOI: 10.1016/j.bios.2023.115890] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/07/2023] [Revised: 11/17/2023] [Accepted: 11/25/2023] [Indexed: 12/06/2023]
Abstract
Real-time monitoring of health conditions is an emerging strong issue in health care, internet information, and other strongly evolving areas. Wearable electronics are versatile platforms for non-invasive sensing. Among a variety of wearable device principles, fiber electronics represent cutting-edge development of flexible electronics. Enabled by electrochemical sensing, fiber electronics have found a wide range of applications, providing new opportunities for real-time monitoring of health conditions by daily wearing, and electrochemical fiber sensors as explored in the present report are a promising emerging field. In consideration of the key challenges and corresponding solutions for electrochemical sensing fibers, we offer here a timely and comprehensive review. We discuss the principles and advantages of electrochemical sensing fibers and fabrics. Our review also highlights the importance of electrochemical sensing fibers in the fabrication of "smart" fabric designs, focusing on strategies to address key issues in fiber-based electrochemical sensors, and we provide an overview of smart clothing systems and their cutting-edge applications in therapeutic care. Our report offers a comprehensive overview of current developments in electrochemical sensing fibers to researchers in the fields of wearables, flexible electronics, and electrochemical sensing, stimulating forthcoming development of next-generation "smart" fabrics-based electrochemical sensing.
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Affiliation(s)
- Hang Tian
- State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, 201620, PR China
| | - Junlin Ma
- School of Chemistry, Dalian University of Technology, Dalian, Liaoning, 116024, PR China
| | - Yaogang Li
- State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, 201620, PR China.
| | - Xinxin Xiao
- Department of Chemistry and Bioscience, Aalborg University, 9220, Aalborg, Denmark.
| | - Minwei Zhang
- Xinjiang Key Laboratory of Biological Resources and Gentic Engineering, College of Life Science & Technology, Xinjiang University, Urumqi, 830046, PR China
| | - Hongzhi Wang
- State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, 201620, PR China
| | - Nan Zhu
- School of Chemistry, Dalian University of Technology, Dalian, Liaoning, 116024, PR China.
| | - Chengyi Hou
- State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, 201620, PR China.
| | - Jens Ulstrup
- Department of Chemistry, Technical University of Denmark, Kongens Lyngby, 2800, Denmark.
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17
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Zhang Y, Fu J, Ding Y, Babar AA, Song X, Chen F, Yu X, Zheng Z. Thermal and Moisture Managing E-Textiles Enabled by Janus Hierarchical Gradient Honeycombs. ADVANCED MATERIALS (DEERFIELD BEACH, FLA.) 2023:e2311633. [PMID: 38112378 DOI: 10.1002/adma.202311633] [Citation(s) in RCA: 4] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 11/03/2023] [Revised: 11/30/2023] [Indexed: 12/21/2023]
Abstract
Moisture and thermal comfort are critical for long-term wear. In recent years, there has been rapidly growing attention on the importance of the comfortability in wearable electronic textiles (e-textiles), particularly in fields such as health monitoring, sports training, medical diagnosis and treatment, where long-term comfort is crucial. Nonetheless, simultaneously regulating thermal and moisture comfort for the human body without compromising electronic performance remains a significant challenge to date. Herein, a thermal and moisture managing e-textile (TMME-textile) that integrates unidirectional water transport and daytime radiative cooling properties with highly sensitive sensing performance is developed. The TMME-textile is made by patterning sensing electrodes on rationally designed Janus hierarchical gradient honeycombs that offer wetting gradient and optical management. The TMME-textile can unidirectionally pump excessive sweat, providing a dry and comfortable microenvironment for users. Moreover, it possesses high solar reflectivity (98.3%) and mid-infrared emissivity (89.2%), which reduce skin temperature by ≈7.0 °C under a solar intensity of 1 kW m-2 . The TMME-textile-based strain sensor displays high sensitivity (0.1749 kPa-1 ) and rapid response rate (170 ms), effectively enabling smooth long-term monitoring, especially during high-intensity outdoor sports where thermal and moisture stresses are prominent challenges to conventional e-textiles.
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Affiliation(s)
- Yufei Zhang
- Laboratory for Advanced Interfacial Materials and Devices, School of Fashion and Textiles, The Hong Kong Polytechnic University, Hong Kong SAR, 999077, China
| | - Jingjing Fu
- Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong SAR, 999077, China
| | - Yichun Ding
- Laboratory for Advanced Interfacial Materials and Devices, School of Fashion and Textiles, The Hong Kong Polytechnic University, Hong Kong SAR, 999077, China
| | - Aijaz Ahmed Babar
- Textile Engineering Department, Mehran University of Engineering and Technology, Jamshoro, 76060, Pakistan
| | - Xian Song
- Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong SAR, 999077, China
| | - Fan Chen
- Laboratory for Advanced Interfacial Materials and Devices, School of Fashion and Textiles, The Hong Kong Polytechnic University, Hong Kong SAR, 999077, China
| | - Xinge Yu
- Department of Biomedical Engineering, City University of Hong Kong, Hong Kong SAR, 999077, China
- Hong Kong Centre for Cerebro-Cardiovascular Health Engineering (COCHE), Hong Kong Science Park, Hong Kong SAR, 999077, China
| | - Zijian Zheng
- Laboratory for Advanced Interfacial Materials and Devices, School of Fashion and Textiles, The Hong Kong Polytechnic University, Hong Kong SAR, 999077, China
- Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong SAR, 999077, China
- Research Institute for Intelligent Wearable Systems (RI-IWEAR), The Hong Kong Polytechnic University, Hong Kong SAR, 999077, China
- Research Institute for Smart Energy (RISE), The Hong Kong Polytechnic University, Hong Kong SAR, 999077, China
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18
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Lin R, Lei M, Ding S, Cheng Q, Ma Z, Wang L, Tang Z, Zhou B, Zhou Y. Applications of flexible electronics related to cardiocerebral vascular system. Mater Today Bio 2023; 23:100787. [PMID: 37766895 PMCID: PMC10519834 DOI: 10.1016/j.mtbio.2023.100787] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/06/2023] [Revised: 08/14/2023] [Accepted: 08/28/2023] [Indexed: 09/29/2023] Open
Abstract
Ensuring accessible and high-quality healthcare worldwide requires field-deployable and affordable clinical diagnostic tools with high performance. In recent years, flexible electronics with wearable and implantable capabilities have garnered significant attention from researchers, which functioned as vital clinical diagnostic-assisted tools by real-time signal transmission from interested targets in vivo. As the most crucial and complex system of human body, cardiocerebral vascular system together with heart-brain network attracts researchers inputting profuse and indefatigable efforts on proper flexible electronics design and materials selection, trying to overcome the impassable gulf between vivid organisms and rigid inorganic units. This article reviews recent breakthroughs in flexible electronics specifically applied to cardiocerebral vascular system and heart-brain network. Relevant sensor types and working principles, electronics materials selection and treatment methods are expounded. Applications of flexible electronics related to these interested organs and systems are specially highlighted. Through precedent great working studies, we conclude their merits and point out some limitations in this emerging field, thus will help to pave the way for revolutionary flexible electronics and diagnosis assisted tools development.
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Affiliation(s)
- Runxing Lin
- Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Avenida da Universidade, Taipa, Macau, 999078, China
- Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China
| | - Ming Lei
- Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Avenida da Universidade, Taipa, Macau, 999078, China
| | - Sen Ding
- Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Avenida da Universidade, Taipa, Macau, 999078, China
| | - Quansheng Cheng
- Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Avenida da Universidade, Taipa, Macau, 999078, China
| | - Zhichao Ma
- Institute of Medical Robotics, School of Biomedical Engineering, Shanghai Jiao Tong University, No.800 Dongchuan Road, Shanghai, 200240, China
| | - Liping Wang
- Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China
| | - Zikang Tang
- Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Avenida da Universidade, Taipa, Macau, 999078, China
| | - Bingpu Zhou
- Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Avenida da Universidade, Taipa, Macau, 999078, China
| | - Yinning Zhou
- Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Avenida da Universidade, Taipa, Macau, 999078, China
- Department of Physics and Chemistry, Faculty of Science and Technology, University of Macau, Avenida da Universidade, Taipa, Macau, 999078, China
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Leung HMC, Forlenza GP, Prioleau TO, Zhou X. Noninvasive Glucose Sensing In Vivo. SENSORS (BASEL, SWITZERLAND) 2023; 23:7057. [PMID: 37631595 PMCID: PMC10458980 DOI: 10.3390/s23167057] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 07/11/2023] [Revised: 08/02/2023] [Accepted: 08/07/2023] [Indexed: 08/27/2023]
Abstract
Blood glucose monitoring is an essential aspect of disease management for individuals with diabetes. Unfortunately, traditional methods require collecting a blood sample and thus are invasive and inconvenient. Recent developments in minimally invasive continuous glucose monitors have provided a more convenient alternative for people with diabetes to track their glucose levels 24/7. Despite this progress, many challenges remain to establish a noninvasive monitoring technique that works accurately and reliably in the wild. This review encompasses the current advancements in noninvasive glucose sensing technology in vivo, delves into the common challenges faced by these systems, and offers an insightful outlook on existing and future solutions.
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Affiliation(s)
- Ho Man Colman Leung
- Department of Computer Science, Columbia University, New York, NY 10027, USA;
| | - Gregory P. Forlenza
- Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA;
| | | | - Xia Zhou
- Department of Computer Science, Columbia University, New York, NY 10027, USA;
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20
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Zhang H, Wang H, Zhang Z, Pan Y, Luo X. A negative-work knee energy harvester based on homo-phase transfer for wearable monitoring devices. iScience 2023; 26:107011. [PMID: 37389177 PMCID: PMC10300368 DOI: 10.1016/j.isci.2023.107011] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/03/2023] [Revised: 05/09/2023] [Accepted: 05/27/2023] [Indexed: 07/01/2023] Open
Abstract
Wearable health monitoring devices can effectively capture human body information and are widely used in health monitoring, but battery life is an important bottleneck in its development. A full negative-work energy harvester based on the homo-phase transfer mechanism by analyzing human motion characteristics was proposed in this paper. The system was designed based on the homo-phase transfer mechanism, including a motion input module, gear acceleration module, energy conversion module, and electric energy storage module. The output performance in three human-level, downhill, and running states was tested, respectively. Finally, we have evaluated the feasibility of an energy harvester powering wearable health monitoring devices, and the harvester can generate 17.40 J/day power, which can satisfy the normal operation of a typical health monitoring device. This study has certain promoting significance for the development of a new generation of human health monitoring.
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Affiliation(s)
- Hexiang Zhang
- School of Mechanical Engineering, Southwest Jiaotong University, Chengdu 610031, P.R. China
- Yibin Research Institute, Southwest Jiaotong University, Yibin 644000, P.R. China
| | - Hao Wang
- School of Mechanical Engineering, Southwest Jiaotong University, Chengdu 610031, P.R. China
- Yibin Research Institute, Southwest Jiaotong University, Yibin 644000, P.R. China
| | - Zutao Zhang
- School of Mechanical Engineering, Southwest Jiaotong University, Chengdu 610031, P.R. China
- Yibin Research Institute, Southwest Jiaotong University, Yibin 644000, P.R. China
| | - Yajia Pan
- School of Mechanical Engineering, Southwest Jiaotong University, Chengdu 610031, P.R. China
| | - Xiao Luo
- Yibin Research Institute, Southwest Jiaotong University, Yibin 644000, P.R. China
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21
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Xu J, Sun X, Sun B, Zhu H, Fan X, Guo Q, Li Y, Zhu Z, Qian K. Stretchable, Adhesive, and Bioinspired Visual Electronic Skin with Strain/Temperature/Pressure Multimodal Non-Interference Sensing. ACS APPLIED MATERIALS & INTERFACES 2023. [PMID: 37424086 DOI: 10.1021/acsami.3c07857] [Citation(s) in RCA: 7] [Impact Index Per Article: 3.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 07/11/2023]
Abstract
It is highly desirable to construct a single-multimodal sensor that could synchronously perceive multiple stimuli without interference. Here, we propose an adhesive multifunctional chromotropic electronic skin (MCES) that can respond to and distinguish three different stimuli of stain, temperature, and pressure within the two-terminal sensing unit. The mutually discriminating "three-in-one" device converts strain into capacitance and pressure into voltage signals for a tactile stimulus response and produces visual color changes against temperature. In this MCES system, the interdigital capacitor sensor shows high linearity (R2 = 0.998), and temperature sensing is realized via reversible multicolor switching bioinspired by the chameleon, showing attractive potential in visualization interaction. Notably, the energy-harvesting triboelectric nanogenerator in MCES can not only detect pressure incentive but also identify objective material species. Looking forward, these findings promise for multimodal sensor technology with reduced complexity and production costs that are highly anticipated in soft robotics, prosthetics, and human-machine interaction applications.
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Affiliation(s)
- Jing Xu
- School of Microelectronics, Shandong University, Jinan 250100, China
- Shenzhen Research Institute of Shandong University, Shenzhen 518057, China
- Suzhou Research Institute of Shandong University, Suzhou 215123, China
- Lu'an Branch, Anhui Institute of Innovation for Industrial Technology, Lu'an 237100, China
| | - Xin Sun
- School of Microelectronics, Shandong University, Jinan 250100, China
| | - Bowen Sun
- School of Microelectronics, Shandong University, Jinan 250100, China
| | - He Zhu
- School of Microelectronics, Shandong University, Jinan 250100, China
| | - Xiaoli Fan
- School of Microelectronics, Shandong University, Jinan 250100, China
| | - Qikai Guo
- School of Microelectronics, Shandong University, Jinan 250100, China
| | - Yang Li
- School of Microelectronics, Shandong University, Jinan 250100, China
| | - Zede Zhu
- Lu'an Branch, Anhui Institute of Innovation for Industrial Technology, Lu'an 237100, China
| | - Kai Qian
- School of Microelectronics, Shandong University, Jinan 250100, China
- Shenzhen Research Institute of Shandong University, Shenzhen 518057, China
- Suzhou Research Institute of Shandong University, Suzhou 215123, China
- Lu'an Branch, Anhui Institute of Innovation for Industrial Technology, Lu'an 237100, China
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Xiao G, Ju J, Li M, Wu H, Jian Y, Sun W, Wang W, Li CM, Qiao Y, Lu Z. Weavable yarn-shaped supercapacitor in sweat-activated self-charging power textile for wireless sweat biosensing. Biosens Bioelectron 2023; 235:115389. [PMID: 37216843 DOI: 10.1016/j.bios.2023.115389] [Citation(s) in RCA: 2] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/17/2023] [Revised: 04/29/2023] [Accepted: 05/12/2023] [Indexed: 05/24/2023]
Abstract
The yarn-based sweat-activated battery (SAB) is a promising energy source for textile electronics due to its excellent skin compatibility, great weavability, and stable electric output. However, its power density is too low to support real-time monitoring and wireless data transmission. Here, we developed a scalable, high-performance sweat-based yarn biosupercapacitor (SYBSC) with two symmetrically aligned electrodes made by wrapping hydrophilic cotton fibers on polypyrrole/poly (3,4-ethylenedioxythiophene):poly (styrenesulfonate)-modified stainless steel yarns. Once activated with artificial sweat, the SYBSC could offer a high areal capacitance of 343.1 mF cm-2 at 0.5 mA cm-2. After 10,000 times of bending under continuous charge-discharge cycles and 25 cycles of machine washing, the device could retain the capacitance at rates of 68% and 73%, respectively. The SYBSCs were integrated with yarn-shaped SABs to produce hybrid self-charging power units. The hybrid units, pH sensing fibers, and a mini-analyzer were woven into a sweat-activated all-in-one sensing textile, in which the hybrid, self-charging units could power the analyzer for real-time data collection and wireless transmission. The all-in-one electronic textile could be successfully employed to real-time monitor the pH values of the volunteers' sweat during exercise. This work can promote the development of self-charging electronic textiles for monitoring human healthcare and exercise intensity.
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Affiliation(s)
- Gang Xiao
- Institute for Clean Energy & Advanced Materials, School of Materials & Energy, Southwest University, Chongqing, 400715, PR China; Sino-Singapore Joint Laboratory of Materials and Technologies for Proactive Health Monitoring, School of Materials & Energy, Southwest University, Chongqing, 400715, PR China; Experimental Center for Virtual Simulation of Sports and Health, Southwest University, Chongqing, 400715, PR China
| | - Jun Ju
- Institute for Clean Energy & Advanced Materials, School of Materials & Energy, Southwest University, Chongqing, 400715, PR China; Sino-Singapore Joint Laboratory of Materials and Technologies for Proactive Health Monitoring, School of Materials & Energy, Southwest University, Chongqing, 400715, PR China; Experimental Center for Virtual Simulation of Sports and Health, Southwest University, Chongqing, 400715, PR China
| | - Min Li
- Institute for Clean Energy & Advanced Materials, School of Materials & Energy, Southwest University, Chongqing, 400715, PR China; Sino-Singapore Joint Laboratory of Materials and Technologies for Proactive Health Monitoring, School of Materials & Energy, Southwest University, Chongqing, 400715, PR China; Experimental Center for Virtual Simulation of Sports and Health, Southwest University, Chongqing, 400715, PR China
| | - Huajun Wu
- Institute for Clean Energy & Advanced Materials, School of Materials & Energy, Southwest University, Chongqing, 400715, PR China; Sino-Singapore Joint Laboratory of Materials and Technologies for Proactive Health Monitoring, School of Materials & Energy, Southwest University, Chongqing, 400715, PR China; Experimental Center for Virtual Simulation of Sports and Health, Southwest University, Chongqing, 400715, PR China
| | - Yihao Jian
- Institute for Clean Energy & Advanced Materials, School of Materials & Energy, Southwest University, Chongqing, 400715, PR China; Sino-Singapore Joint Laboratory of Materials and Technologies for Proactive Health Monitoring, School of Materials & Energy, Southwest University, Chongqing, 400715, PR China; Experimental Center for Virtual Simulation of Sports and Health, Southwest University, Chongqing, 400715, PR China
| | - Wei Sun
- Key Laboratory of Laser Technology and Optoelectronic Functional Materials of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, 571158, PR China
| | - Wei Wang
- Singapore Institute of Manufacturing Technology, 138669, Singapore
| | - Chang Ming Li
- School of Materials Science and Engineering, Suzhou University of Science and Technology, Suzhou, 215011, PR China
| | - Yan Qiao
- Institute for Clean Energy & Advanced Materials, School of Materials & Energy, Southwest University, Chongqing, 400715, PR China; Sino-Singapore Joint Laboratory of Materials and Technologies for Proactive Health Monitoring, School of Materials & Energy, Southwest University, Chongqing, 400715, PR China; Experimental Center for Virtual Simulation of Sports and Health, Southwest University, Chongqing, 400715, PR China.
| | - Zhisong Lu
- Institute for Clean Energy & Advanced Materials, School of Materials & Energy, Southwest University, Chongqing, 400715, PR China; Sino-Singapore Joint Laboratory of Materials and Technologies for Proactive Health Monitoring, School of Materials & Energy, Southwest University, Chongqing, 400715, PR China; Experimental Center for Virtual Simulation of Sports and Health, Southwest University, Chongqing, 400715, PR China.
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23
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Zhi C, Shi S, Zhang S, Si Y, Yang J, Meng S, Fei B, Hu J. Bioinspired All-Fibrous Directional Moisture-Wicking Electronic Skins for Biomechanical Energy Harvesting and All-Range Health Sensing. NANO-MICRO LETTERS 2023; 15:60. [PMID: 36864316 PMCID: PMC9981859 DOI: 10.1007/s40820-023-01028-2] [Citation(s) in RCA: 42] [Impact Index Per Article: 21.0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Received: 11/21/2022] [Accepted: 01/20/2023] [Indexed: 06/18/2023]
Abstract
Highlights Bioinspired directional moisture-wicking electronic skin (DMWES) was successfully realized by surface energy gradient and push–pull effect via the design of distinct hydrophobic-hydrophilic difference. The DMWES membrane showed excellent comprehensive pressure sensing performance with high sensitivity and good single-electrode triboelectric nanogenerator performance The superior pressure sensing and triboelectric performance enabled the DMWES for all-range healthcare sensing, including accurate pulse monitoring, voice recognition, and gait recognition. Abstract Electronic skins can monitor minute physiological signal variations in the human skins and represent the body’s state, showing an emerging trend for alternative medical diagnostics and human–machine interfaces. In this study, we designed a bioinspired directional moisture-wicking electronic skin (DMWES) based on the construction of heterogeneous fibrous membranes and the conductive MXene/CNTs electrospraying layer. Unidirectional moisture transfer was successfully realized by surface energy gradient and push–pull effect via the design of distinct hydrophobic-hydrophilic difference, which can spontaneously absorb sweat from the skin. The DMWES membrane showed excellent comprehensive pressure sensing performance, high sensitivity (maximum sensitivity of 548.09 kPa−1), wide linear range, rapid response and recovery time. In addition, the single-electrode triboelectric nanogenerator based on the DMWES can deliver a high areal power density of 21.6 µW m−2 and good cycling stability in high pressure energy harvesting. Moreover, the superior pressure sensing and triboelectric performance enabled the DMWES for all-range healthcare sensing, including accurate pulse monitoring, voice recognition, and gait recognition. This work will help to boost the development of the next-generation breathable electronic skins in the applications of AI, human–machine interaction, and soft robots. Supplementary Information The online version contains supplementary material available at 10.1007/s40820-023-01028-2.
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Affiliation(s)
- Chuanwei Zhi
- Department of Biomedical Engineering, City University of Hong Kong, Hong Kong S.A.R, 999077, China
| | - Shuo Shi
- Department of Biomedical Engineering, City University of Hong Kong, Hong Kong S.A.R, 999077, China
| | - Shuai Zhang
- Department of Biomedical Engineering, City University of Hong Kong, Hong Kong S.A.R, 999077, China
| | - Yifan Si
- Department of Biomedical Engineering, City University of Hong Kong, Hong Kong S.A.R, 999077, China
| | - Jieqiong Yang
- Department of Biomedical Engineering, City University of Hong Kong, Hong Kong S.A.R, 999077, China
| | - Shuo Meng
- Department of Biomedical Engineering, City University of Hong Kong, Hong Kong S.A.R, 999077, China
| | - Bin Fei
- Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hong Kong S.A.R, 999077, China
| | - Jinlian Hu
- Department of Biomedical Engineering, City University of Hong Kong, Hong Kong S.A.R, 999077, China.
- City University of Hong Kong Shenzhen Research Institute, Shenzhen, 518057, People's Republic of China.
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24
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Zhang J, Chen G, Zhang K, Zhao D, Li Z, Zhong J. Washable and Breathable Electret Sensors Based on a Hydro-Charging Technique for Smart Textiles. ACS APPLIED MATERIALS & INTERFACES 2023; 15:2449-2458. [PMID: 36583700 DOI: 10.1021/acsami.2c19224] [Citation(s) in RCA: 5] [Impact Index Per Article: 2.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 06/17/2023]
Abstract
Flexible electromechanical sensors based on electret materials have shown great application potential in wearable electronics. However, achieving great breathability yet maintaining good washability is still a challenge for traditional electret sensors. Herein, we report a washable and breathable electret sensor based on a hydro-charging technique, namely, hydro-charged electret sensor (HCES). The melt-blown polypropylene (MBPP) electret fabric can be charged while washing with water. The surface potential of MBPP electret fabric can be improved by optimizing the type of water, water pressure, water temperature, drying temperature, drying time, ambient air pressure, and ambient relative humidity. It is proposed that the single fiber has charges of different polarities on the upper and lower surfaces due to contact electrification with water, thereby forming electric dipoles between fibers, which can lead to better surface potential stability than the traditional corona-charging method. The HCES can achieve a high air permeability of ∼215 mm/s and sensitivity up to ∼0.21 V/Pa, with output voltage remaining stable after over 36,000 working cycles and multiple times of water washing. As a demonstration example, the HCES is integrated into a chest strap to monitor human respiration conditions.
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Affiliation(s)
- Jianfeng Zhang
- Laboratory of Electret & Its Application, Hangzhou Dianzi University, Hangzhou 310018, China
| | - Gangjin Chen
- Laboratory of Electret & Its Application, Hangzhou Dianzi University, Hangzhou 310018, China
- Hangzhou Dianzi University Information Engineering College, Hangzhou 311305, China
| | - Kaijun Zhang
- Department of Electromechanical Engineering and Centre for Artificial Intelligence and Robotics, University of Macau, Macau SAR 999078, China
| | - Dazhe Zhao
- Department of Electromechanical Engineering and Centre for Artificial Intelligence and Robotics, University of Macau, Macau SAR 999078, China
| | - Zhaoyang Li
- Department of Electromechanical Engineering and Centre for Artificial Intelligence and Robotics, University of Macau, Macau SAR 999078, China
| | - Junwen Zhong
- Department of Electromechanical Engineering and Centre for Artificial Intelligence and Robotics, University of Macau, Macau SAR 999078, China
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25
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Affiliation(s)
- Baoying Dai
- State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM) Jiangsu Key Laboratory for Biosensors Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing University of Posts and Telecommunications Nanjing China
| | - Chenchen Gao
- State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM) Jiangsu Key Laboratory for Biosensors Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing University of Posts and Telecommunications Nanjing China
| | - Yannan Xie
- State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM) Jiangsu Key Laboratory for Biosensors Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing University of Posts and Telecommunications Nanjing China
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26
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Zha X, Yang W, Shi L, Li Y, Zeng Q, Xu J, Yang Y. Morphology Control Strategy of Bimetallic MOF Nanosheets for Upgrading the Sensitivity of Noninvasive Glucose Detection. ACS APPLIED MATERIALS & INTERFACES 2022; 14:37843-37852. [PMID: 35947783 DOI: 10.1021/acsami.2c10760] [Citation(s) in RCA: 17] [Impact Index Per Article: 5.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 06/15/2023]
Abstract
The precise measurement of glucose level is significant for the health management of the human body. However, the existing sensitive materials and detection methods for glucose are less satisfying for practical applications. Herein, an ultrathin reticular two-dimensional nanosheets array composed of trimesic acid (H3BTC)-based bimetal metal-organic frameworks (MOFs) and carbon cloth (CC), which is constructed through a morphology control strategy, is reported for glucose sensing. Meanwhile, this nonmoving sweat glucose sensor based on a NiCo-BTC/CC electrode has been successfully prepared by a screen printing method. Benefiting from the regular and ultrathin nanosheets array, the NiCo-BTC/CC electrode has an excellent sensitivity of 2701.29 μA mM-1 cm-2, which is about 2.4 times that of its unregulated counterpart (1127.85 μA mM-1 cm-2) in the linear range 5-205 μM. In addition, an ultralow detection limit (0.09 μM, S/N = 3) and good selectivity of NiCo-BTC/CC were also obtained. The high sensitivity of the glucose sensor based on NiCo-BTC/CC electrode is 0.174 μA μM-1 (50-1000 μM). Remarkably, the preciously designed sensor is used to detect glucose concentration in sweat with a noninvasive mode, and the results are basically consistent with those of a commercial glucose device with an invasive mode. This research exhibits potential methodology for the morphology design of bimetallic MOFs nanosheets to achieve a high accuracy rate and noninvasive and timeless measurement of a glucose sensor.
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Affiliation(s)
- Xiaoting Zha
- School of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China
| | - Wenyao Yang
- Chongqing Engineering Research Center of New Energy Storage Devices and Applications, Chongqing University of Arts and Sciences, Chongqing 402160, China
| | - Liuwei Shi
- School of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China
| | - Yi Li
- School of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China
| | - Qi Zeng
- School of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China
| | - Jianhua Xu
- School of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China
| | - Yajie Yang
- School of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China
- Yangtze Delta Region Institute (Huzhou), University of Electronic Science and Technology of China, Huzhou 313001, China
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