Clinical pharmacology of intravenous paracetamol in perinatal medicine

Figure 1 Individual clearance paracetamol estimates in young women at delivery compared to similar individual paracetamol clearance estimates in non-pregnant women.

Figure 2 Concentration-time profile estimated based on the pooled pharmacokinetic study in neonates. The profile estimates are based on an initial loading dose (20 mg/kg) of iv paracetamol, followed by 10 mg/kg q6h in a newborn of 36 wk postmenstrual age[40].

Figure 3 Individual pain scores (Leuven Neonatal Pain Score, range 0-14) as collected following iv paracetamol (20 mg/kg) administration. Only observations in 19/60 treated with iv paracetamol (monotherapy) while included in the PARANEO study were reported[10].

Figure 4 Paracetamol metabolism in the human, hereby indicating the changes in paracetamol drug metabolism at delivery and in early infancy.