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Tamura S, Kamo T, Kobayashi S, Saito H, Igarashi T, Kaizu Y, Miyata K, Kubo H, Ogihara H, Momosaki R. Impact of post-hospitalization dysphagia on dependence in activities of daily living at discharge in older adults with hip fracture: A nationwide inpatient database study. Clin Nutr ESPEN 2025; 67:355-361. [PMID: 40127767 DOI: 10.1016/j.clnesp.2025.03.041] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/17/2025] [Accepted: 03/18/2025] [Indexed: 03/26/2025]
Abstract
BACKGROUND Older adults with hip fractures of the femur have a higher probability of developing dysphagia after surgery. Dysphagia affects older patients with hip fractures in multiple ways, thus clinicians need to understand the impact of dysphagia on the effectiveness of treatment. AIMS The aim of this study is to clarify the impact of dysphagia on dependence in activities of daily living in older adults with hip fractures. METHODS This retrospective observational study utilized a nationwide inpatient database, encompassing acute inpatient care from 2017 to 2022. Older adults (≥60 years) with hip fractures who underwent surgery and survived to discharge were included. Dysphagia was analyzed as a factor affecting dependence in activities of daily living at discharge using binomial logistic regression and the inverse probability of treatment weighting (IPTW) method, which was based on propensity scores. RESULTS The analysis included 88,809 older adults with hip fractures. Binomial logistic regression analysis showed that dysphagia was significantly associated with dependence in activities of daily living, with an odds ratio of 3.24 (95 % confidence interval [CI], 2.72-3.85; p < 0.01). Furthermore, sensitivity analysis confirmed these findings. After adjusting for IPTW, dysphagia remained a significant factor for dependence in activities of daily living at discharge, with an odds ratio of 2.55 (95 % CI, 2.45-2.64; p < 0.01). CONCLUSIONS In older adults with hip fractures, dysphagia negatively affects the activities of daily living at discharge. These results are useful for clinicians for understanding the significance of preventing dysphagia development.
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Affiliation(s)
- Shuntaro Tamura
- Department of Physical Therapy, Ota College of Medical Technology, 1373 Higashi-nagaoka-cho, Ota, Gunma 373-0812, Japan.
| | - Tomohiko Kamo
- Department of Physical Therapy, Faculty of Rehabilitation, Gunma Paz University, 1-7-1 Tonyamachi, Takasaki-shi, Gunma 370-0006, Japan.
| | - Sota Kobayashi
- Department of Physical Therapy, Niigata University of Health and Welfare, 1398 Shimami-cho, Kita-ku, Niigata-shi, Niigata 950-3198, Japan.
| | - Hiroyuki Saito
- Department of Rehabilitation, Geriatrics Research Institute and Hospital, 3-26-8 Ootomo-cho, Maebashi-shi, Gunma 371-0847, Japan.
| | - Tatsuya Igarashi
- Department of Physical Therapy, Bunkyo Gakuin University, 1196 Kamekubo, Fujimino-shi, Saitama 356-8533, Japan.
| | - Yoichi Kaizu
- Rehabilitation Center, Hidaka Rehabilitation Hospital, 2204 Maniwa Yoshii-machi, Takasaki, Gunma 370-2104, Japan.
| | - Kazuhiro Miyata
- Department of Physical Therapy, Ibaraki Prefectural University of Health Sciences, 4669-2 Inashiki-gun, Ami-Machi, Ibaraki 300-0394, Japan.
| | - Hiroki Kubo
- Department of Physical Therapy, Faculty of Nursing and Rehabilitation, Konan Women's University, 6-2-23, Morikita-machi, Higashinada-ku, Kobe City, Hyogo 658-0001, Japan.
| | - Hirofumi Ogihara
- Division of Physical Therapy, Department of Rehabilitation, Faculty of Health Sciences, Nagano University of Health and Medicine, 11-1, Imaihara, Kawanakajima-machi, Nagano-City, Nagano 381-2227, Japan.
| | - Ryo Momosaki
- Department of Rehabilitation Medicine, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu-shi, Mie 514-8507, Japan.
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Perna A, Rovere G, Passiatore M, Franchini A, Macchiarola L, Maruccia F, Vitiello R, Gorgoglione FL. Crystal Ball in a Blood's Drop: Unlocking Hidden Prognostic Power in the Neutrophil-to-Lymphocyte Ratio (NLR) and the Platelet-to-Lymphocyte Ratio (PLR) for Elderly Hip Fracture Patients. J Clin Med 2025; 14:3584. [PMID: 40429579 PMCID: PMC12112460 DOI: 10.3390/jcm14103584] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/29/2025] [Revised: 05/17/2025] [Accepted: 05/19/2025] [Indexed: 05/29/2025] Open
Abstract
Background/Objectives: Hip fractures in elderly patients are associated with high morbidity and mortality, requiring early risk stratification to optimize management. Systemic inflammatory markers such as the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) have emerged as potential prognostic tools. This study aimed to evaluate the predictive value of the NLR and PLR measured at admission for adverse outcomes following hip fracture surgery in elderly patients. Methods: This retrospective, single-center cohort study included patients aged 65 years or older admitted for hip fractures between January 2019 and December 2023. Baseline demographic, clinical, surgical, and laboratory data were collected. Primary outcomes were 30-day, 90-day, and 1-year mortality; secondary outcomes included postoperative ICU admission and prolonged hospitalization (>15 days). Univariable and multivariable Cox regression analyses were performed. Receiver operating characteristic (ROC) curve analysis determined optimal cut-offs for the NLR and PLR. Results: Among 395 included patients (mean age 84 years, 56.4% female), the 30-day, 90-day, and 1-year mortality rates were 4.8%, 10.5%, and 13.9%, respectively. ROC analysis identified cut-offs of 7.2 for the NLR (AUC 0.78, sensitivity 69.7%, specificity 85.4%) and 189.4 for the PLR (AUC 0.73, sensitivity 65.1%, specificity 76.1%). Elevated NLR and PLR were independently associated with increased risk of mortality, ICU admission, and prolonged hospitalization. Conclusions: Elevated NLR and PLR at admission are independent, strong predictors of adverse outcomes in elderly patients with hip fractures. These inexpensive, readily available biomarkers could enhance early risk stratification and inform perioperative management strategies.
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Affiliation(s)
- Andrea Perna
- Department of Orthopedics and Trauma Surgery, Fondazione Casa Sollievo Della Sofferenza IRCCS, 71013 San Giovanni Rotondo, Italy; (A.F.); (L.M.); (F.M.)
| | - Giuseppe Rovere
- Clinical Science and Translational Medicine, Section of Orthopaedics and Traumatology, University of Rome Tor Vergata, 00133 Rome, Italy;
| | - Marco Passiatore
- Bone and Joint Surgery Department, University of Brescia, ASST-Spedali Civili, 25123 Brescia, Italy;
| | - Andrea Franchini
- Department of Orthopedics and Trauma Surgery, Fondazione Casa Sollievo Della Sofferenza IRCCS, 71013 San Giovanni Rotondo, Italy; (A.F.); (L.M.); (F.M.)
| | - Luca Macchiarola
- Department of Orthopedics and Trauma Surgery, Fondazione Casa Sollievo Della Sofferenza IRCCS, 71013 San Giovanni Rotondo, Italy; (A.F.); (L.M.); (F.M.)
| | - Francesco Maruccia
- Department of Orthopedics and Trauma Surgery, Fondazione Casa Sollievo Della Sofferenza IRCCS, 71013 San Giovanni Rotondo, Italy; (A.F.); (L.M.); (F.M.)
| | - Raffaele Vitiello
- Department of Orthopedics and Geriatric Sciences, Catholic University of the Sacred Heart, 00168 Rome, Italy;
| | - Franco Lucio Gorgoglione
- Department of Orthopedics and Trauma Surgery, Fondazione Casa Sollievo Della Sofferenza IRCCS, 71013 San Giovanni Rotondo, Italy; (A.F.); (L.M.); (F.M.)
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Fink A, Falk SSI, Georges D. Comparing mortality in the elderly after proximal femur fractures and coxarthrosis: the effect of individual health characteristics and day of surgery. Eur J Trauma Emerg Surg 2025; 51:213. [PMID: 40392330 DOI: 10.1007/s00068-025-02882-y] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/10/2025] [Accepted: 05/04/2025] [Indexed: 05/22/2025]
Abstract
PURPOSE This study investigates mortality variations between elective and urgent hip surgeries, focusing surgery timing and its impact on post-operative mortality. By comparing cases of femoral neck fractures, pertrochanteric fractures, and coxarthrosis across different follow-up durations, it aims to identify factors contributing to increased mortality. METHODS We used a random sample of German longitudinal health claims data (N = 250,000, 2004-2019) and identified 10,310 patients aged 50 years and older who underwent surgery for femoral neck fracture, pertrochanteric fracture, or coxarthrosis between 2004 and 2014. We tracked mortality at 30 days, 1 year, and 5 years. Cox proportional models were used, adjusted for the following covariates at the time of surgery: sex, age, comorbidities, nursing home dependency, discharge diagnosis, and weekday of surgery. RESULTS Mortality probabilities were 5% at 30 days, 15.6% at 1 year, and 38.9% at 5 years, with significantly higher risks for fractures than coxarthrosis. Key factors influencing mortality included age, comorbidities (e.g., heart failure, stroke, myocardial infarction, dementia), and care dependency levels. Women had lower risks than men across all periods. Short-term mortality was most affected by comorbidities, while long-term mortality correlated with chronic health conditions such as nicotine abuse and diabetes mellitus, and care needs. Surgery timing showed no consistent weekday effects. CONCLUSION Mortality differences reflect the impact of acute trauma from emergency surgery rather than the surgical procedure itself, emphasizing the need for optimized planning, preparation, early treatment and adaptable care structures in an aging population.
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Affiliation(s)
- Anne Fink
- German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
- Department of Child and Adolescent Psychiatry, Rostock University Medical Center, Rostock, Germany
| | - Steffi S I Falk
- Department of Trauma, Hand and Reconstructive Surgery, Rostock University Medical Center, Rostock, Germany
| | - Daniela Georges
- Institute for Occupational, Social and Environmental Medicine, Rostock University Medical Center, Rostock, Germany.
- Faculty of Economic and Social Sciences, Institute of Sociology and Demography, Chair of Empirical Methods in Social Science and Demography, University of Rostock, Rostock, Germany.
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Takahashi A, Naruse H, Hasegawa D, Nakajima H, Matsumine A. Functional Recovery Predictors in Hip Fractures: Insights from a Community Clinical Pathway. J Clin Med 2025; 14:3430. [PMID: 40429427 PMCID: PMC12112208 DOI: 10.3390/jcm14103430] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/18/2025] [Revised: 05/07/2025] [Accepted: 05/12/2025] [Indexed: 05/29/2025] Open
Abstract
Background: Osteoporotic hip fractures in the elderly significantly impact mobility and quality of life. Optimising early management is crucial for improving the functional outcomes. Methods: This single-centre retrospective cohort study included patients with femoral trochanteric (n = 142) or femoral neck fractures (n = 127) treated between January 2016 and March 2023. The patients were divided into ambulatory and non-ambulatory groups based on their walking ability at discharge from the rehabilitation hospital. The explanatory variables included age, sex, fracture type, surgical method, pre-surgical days, hospital days, dementia, and the Nursing Needs Score (NNS). Results: The most common age group was 85-89 years old. Only 23.4% of patients underwent surgery within 2 days of admission. The median hospital stay was 20 days in acute care and 52 days in rehabilitation hospitals. Walking ability declined in 66.9% of the patients. Pre-injury mobility and acute care hospital NNS were identified as independent predictors of ambulatory outcomes. Conclusions: Pre-injury mobility and the Nursing Needs Score (NNS) assessed at the acute care hospital were identified as critical determinants of postoperative ambulatory status. These findings highlight the importance of community collaboration and preventive rehabilitation strategies aimed at improving basic mobility, maintaining cognitive function, and preserving walking ability.
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Affiliation(s)
- Ai Takahashi
- Department of Orthopaedics and Rehabilitation Medicine, University of Fukui, 23-3 Matsuoka Shimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan; (A.T.); (A.M.)
- Division of Rehabilitation Medicine, University of Fukui Hospital, 23-3 Matsuoka Shimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan; (H.N.); (D.H.)
| | - Hiroaki Naruse
- Division of Rehabilitation Medicine, University of Fukui Hospital, 23-3 Matsuoka Shimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan; (H.N.); (D.H.)
| | - Daiki Hasegawa
- Division of Rehabilitation Medicine, University of Fukui Hospital, 23-3 Matsuoka Shimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan; (H.N.); (D.H.)
| | - Hideaki Nakajima
- Department of Orthopaedics and Rehabilitation Medicine, University of Fukui, 23-3 Matsuoka Shimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan; (A.T.); (A.M.)
- Division of Rehabilitation Medicine, University of Fukui Hospital, 23-3 Matsuoka Shimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan; (H.N.); (D.H.)
| | - Akihiko Matsumine
- Department of Orthopaedics and Rehabilitation Medicine, University of Fukui, 23-3 Matsuoka Shimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan; (A.T.); (A.M.)
- Division of Rehabilitation Medicine, University of Fukui Hospital, 23-3 Matsuoka Shimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan; (H.N.); (D.H.)
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Sivro M, Omerović Đ, Lazović F, Papović A. The influence of high doses of vitamin C on functional recovery and postoperative pain in patients with trochanteric fracture after intramedullary nailing during a three-month follow-up: a full-scale study. EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY & TRAUMATOLOGY : ORTHOPEDIE TRAUMATOLOGIE 2025; 35:189. [PMID: 40355782 DOI: 10.1007/s00590-025-04332-2] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 10/11/2024] [Accepted: 05/04/2025] [Indexed: 05/15/2025]
Abstract
PURPOSE To determine the effects of high peri- and postoperative doses of vitamin C administration on severity of pain in postoperative period and functional outcome of the patients with trochanteric fracture treated with intramedullary nailing during a three-month follow-up. METHODS A prospective, randomised, full-scale study included 74 patients who were randomly divided into vitamin C (intervention) and control groups. In the intervention group, patients received vitamin C perioperatively by intravenous route for 2 days, and oral vitamin C for 38 days postoperatively. Baseline characteristics, postoperative metamizole consumption, visual analogue scale (VAS) score, Harris hip score (HHS) value, and the prevalence of complications were evaluated in both groups. RESULTS No significant differences were noted between the groups regarding age, gender, length of hospitalisation, and distribution in fracture type as well as in postoperative HHS values. Postoperative metamizole consumption was notably higher in the control group compared to the vitamin C group (p = 0.003). Postoperative VAS scores were higher in the control group than in the vitamin C group at all time follow-ups (p < 0.05). The group variable significantly contributed to VAS score, and age and gender variables significantly contributed to HHS value. CONCLUSION Significant reduction of subjective pain levels and lower analgesic consumption was found in patients who received vitamin C, suggesting that it should be considered as an adjuvant agent for analgesia in patients with hip fracture.
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Affiliation(s)
- Mirza Sivro
- Kantonalna Bolnica Zenica, Zenica, Bosnia and Herzegovina.
| | - Đemil Omerović
- Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina
| | - Faruk Lazović
- Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina
| | - Adnan Papović
- Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina
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Hilali AEK, Shacham D, Frenkel R, Abu-Ajaj A, Zikrin E, Freud T, Press Y. Successful Rehabilitation After Surgical Repair of Hip Fracture Has Been Associated With Handgrip Strength But Not With Orthostatic Hypotension in Patients 65 Yrs of Age and Above. Am J Phys Med Rehabil 2025; 104:407-414. [PMID: 39235903 DOI: 10.1097/phm.0000000000002618] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 09/07/2024]
Abstract
OBJECTIVE The identification of factors associated with successful rehabilitation after hip fractures enables more successful planning of the rehabilitation process and discharge from the hospital. Orthostatic hypotension and handgrip strength have been evaluated in previous studies as potential predictors of rehabilitation outcomes, with inconsistent results. DESIGN A retrospective study of patients 65 yrs of age and above who underwent rehabilitation after surgical repair of hip fracture in the geriatric department between July 2020 and October 2023. Handgrip strength was measured during the first 3 days of hospitalization using a digital dynamometer. Orthostatic hypotension was measured a week after admission to the ward by the tilt table test. Successful rehabilitation was defined as a Montebello Rehabilitation Factor Score Revised above 50%. RESULTS Data were collected for 253 patients. The mean age was 80.5 ± 7.7 and 32.4% were males. The mean handgrip strength was 17.2 ± 6.6 kg. Orthostatic hypotension was diagnosed in 32.8%. One hundred ninety-three patients (76.3%) reached the goal of Montebello Rehabilitation Factor Score Revised ≥ 50 at the end of the rehabilitation. In a logistic regression analysis, handgrip strength, cognitive state, and sex were associated with successful rehabilitation. CONCLUSIONS Measuring handgrip strength, but not orthostatic hypotension, can predict successful rehabilitation.
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Affiliation(s)
- Abdu El Karim Hilali
- From the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel (AEKH, DS, RF, AAA, EZ, YP); Department of Geriatrics, Soroka Medical Center, Beer-Sheva, Israel (AEKH, DS, RF, AAA, EZ, YP); Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel (TF, YP), Unit for Community Geriatrics, Division of Health in the Community, Ben-Gurion University of the Negev, Beer-Sheva, Israel (YP), and Center for Multidisciplinary Research in Aging, Ben-Gurion University of the Negev, Beer-Sheva, Israel (YP)
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Raagul TS, Kumar KVP, Seetharaman K, Bharath V, Ranganathan T, Murugesan V. Fixation in Intertrochanteric Fractures Using Short Proximal Femoral Nail Anti-Rotation-2: A Functional and Radiological Prospective Study. J Orthop Case Rep 2025; 15:261-268. [PMID: 40351654 PMCID: PMC12064268 DOI: 10.13107/jocr.2025.v15.i05.5628] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/02/2025] [Revised: 03/21/2025] [Indexed: 05/14/2025] Open
Abstract
Introduction Intertrochanteric fractures are among the most common fractures in elderly patients, often associated with osteoporosis and high morbidity. Surgical fixation is the preferred treatment approach to enable early mobilization and reduce complications. The Short Proximal Femoral Nail Anti-Rotation-2 (PFNA-2) has emerged as an effective implant for these fractures, offering improved stability, enhanced biomechanical properties, and reduced risk of implant failure. This study aims to evaluate the functional and radiological outcomes of PFNA-2 in the management of intertrochanteric fractures. Materials and Methods This prospective study was conducted at the Department of Orthopaedics, Chettinad Health Institute, Tamil Nadu, involving 50 patients with Boyd and Griffin Type 1-4 intertrochanteric fractures. Functional outcomes were assessed using the Modified Harris Hip Score (MHHS), while radiological outcomes were evaluated based on fracture union time, neck-shaft angle, and tip-apex distance (TAD). Patients were followed for a minimum of 6 months postoperatively, with serial radiographic assessments conducted at 6, 12, and 24 weeks. Post-operative rehabilitation included early mobilization, pain management, and weight-bearing exercises to optimize recovery. Results The mean age of the study population was 69.04 ± 10.69 years, with a slight female predominance (52%). The mean MHHS was 83.08 ± 8.005, with 44% of patients categorized as having good outcomes and 26% classified as excellent. Younger patients demonstrated significantly better functional outcomes (P = 0.000). The mean neck-shaft angle was 130.6° ± 2.1°, with no significant variation across demographic groups (P = 0.191). The mean TAD was 18.25 ± 4.89 mm, with 12% of patients having a TAD >25 mm. Post-operative complications were minimal, with screw cut-out occurring in 4% of cases and superficial wound healing delays in 2%. Conclusion The findings suggest that PFNA-2 provides effective fixation and favorable functional outcomes in intertrochanteric fractures, particularly in elderly patients. With minimal complications and early mobilization benefits, PFNA-2 proves to be a reliable implant for optimizing recovery. Future studies with larger cohorts and longer follow-ups are recommended to validate these findings.
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Affiliation(s)
- Thangaraj Shenbagamoorthy Raagul
- Department of Orthopaedics, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India
| | - K V Prem Kumar
- Department of Orthopaedics, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India
| | - Karthik Seetharaman
- Department of Orthopaedics, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India
| | - V Bharath
- Department of Orthopaedics, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India
| | - Thirumal Ranganathan
- Department of Orthopaedics, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India
| | - Vijayashankar Murugesan
- Department of Orthopaedics, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India
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Younesian H, Singleton D, Vereijken B, Garcia-Aymerich J, Rochester L, Aursand Berge M, Engdal M, Buekers J, Koch S, Helbostad JL, Alvarez P, Jansen CP, Aminian K, Paraschiv-Ionescu A, Becker C, Caulfield B. Association of Cut-Point Free Metrics and Common Clinical Tests Among Older Adults After Proximal Femoral Fracture. SENSORS (BASEL, SWITZERLAND) 2025; 25:2557. [PMID: 40285246 PMCID: PMC12031448 DOI: 10.3390/s25082557] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Received: 02/07/2025] [Revised: 04/07/2025] [Accepted: 04/10/2025] [Indexed: 04/29/2025]
Abstract
Wearable and lightweight devices facilitate real-world physical activity (PA) assessments. MX metrics, as a cut-point-free parameter, evaluate acceleration above which the most active X minutes are accumulated. It provides insights into the intensity of PA over specific durations. This study evaluated the association of MX metrics and clinical tests in older adults recovering from proximal femoral fracture (PFF). Analyses were conducted on the PFF cohort from the baseline assessment of the Mobilise-D project using an accelerometer-based device. Participants (N = 396) were categorized into four recovery groups: acute, post-acute, extended recovery, and long-term recovery. Mobility capacity was assessed through the 6 min walking test (6MinWT), Short Physical Performance Battery (SPPB), 4-m walking test (4MWT), and hand grip (HG) strength. Mobility perception was evaluated using the Late-Life Function and Disability Instrument (LLFDI). Eight MX metrics (M1-M90) were calculated using the GGIR package in R. Results showed a moderate to strong positive correlation between M1 and M30 and lower limb mobility capacity tests and mobility perception (Lower Extremity domains) particularly in the extended and long-term recovery groups. MX metrics can be used for measuring PA intensity among older adults recovering from PFF. Hence, MX metrics have a high potential for clinical use as personalized PA targets in PFF rehabilitation.
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Affiliation(s)
- Hananeh Younesian
- School of Public Health, Physiotherapy & Population Science, University College Dublin, D04 V1W8 Dublin, Ireland;
- Insight Research Ireland Centre For Data Analytics, University College Dublin, D04 P7W1 Dublin, Ireland
| | - David Singleton
- School of Public Health, Physiotherapy & Population Science, University College Dublin, D04 V1W8 Dublin, Ireland;
- Insight Research Ireland Centre For Data Analytics, University College Dublin, D04 P7W1 Dublin, Ireland
| | - Beatrix Vereijken
- Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, 7030 Trondheim, Norway; (B.V.); (M.A.B.); (M.E.); (J.L.H.)
| | - Judith Garcia-Aymerich
- Barcelona Institute for Global Health (ISGlobal), 08003 Barcelona, Spain; (J.G.-A.); (J.B.); (S.K.); (P.A.)
- Departament de Medicina i Ciències de la Salut (MELIS), Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain
- CIBER Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain
| | - Lynn Rochester
- Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE4 5PL, UK;
- National Institute for Health and Care Research (NIHR), Newcastle Biomedical Research Centre (BRC), Newcastle University and the Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE4 5PL, UK
| | - Martin Aursand Berge
- Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, 7030 Trondheim, Norway; (B.V.); (M.A.B.); (M.E.); (J.L.H.)
| | - Monika Engdal
- Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, 7030 Trondheim, Norway; (B.V.); (M.A.B.); (M.E.); (J.L.H.)
| | - Joren Buekers
- Barcelona Institute for Global Health (ISGlobal), 08003 Barcelona, Spain; (J.G.-A.); (J.B.); (S.K.); (P.A.)
- Departament de Medicina i Ciències de la Salut (MELIS), Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain
- CIBER Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain
| | - Sarah Koch
- Barcelona Institute for Global Health (ISGlobal), 08003 Barcelona, Spain; (J.G.-A.); (J.B.); (S.K.); (P.A.)
- Departament de Medicina i Ciències de la Salut (MELIS), Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain
- CIBER Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain
- Department for Sport, Exercise, and Health, University of Basel, 4052 Basel, Switzerland
| | - Jorunn L. Helbostad
- Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, 7030 Trondheim, Norway; (B.V.); (M.A.B.); (M.E.); (J.L.H.)
| | - Paula Alvarez
- Barcelona Institute for Global Health (ISGlobal), 08003 Barcelona, Spain; (J.G.-A.); (J.B.); (S.K.); (P.A.)
- Departament de Medicina i Ciències de la Salut (MELIS), Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain
- CIBER Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain
| | - Carl-Philipp Jansen
- Department of Clinical Gerontology, Robert Bosch Hospital, D 69115 Stuttgart, Germany; (C.-P.J.); (C.B.)
| | - Kamiar Aminian
- Laboratory of Movement Analysis and Measurement, Ecole Polytechnique Federale de Lausanne, 1024 Lausanne, Switzerland; (K.A.); (A.P.-I.)
| | - Anisoara Paraschiv-Ionescu
- Laboratory of Movement Analysis and Measurement, Ecole Polytechnique Federale de Lausanne, 1024 Lausanne, Switzerland; (K.A.); (A.P.-I.)
| | - Clemens Becker
- Department of Clinical Gerontology, Robert Bosch Hospital, D 69115 Stuttgart, Germany; (C.-P.J.); (C.B.)
| | - Brian Caulfield
- School of Public Health, Physiotherapy & Population Science, University College Dublin, D04 V1W8 Dublin, Ireland;
- Insight Research Ireland Centre For Data Analytics, University College Dublin, D04 P7W1 Dublin, Ireland
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Nakamura K, Kurobe Y, Sue K, Sakurai S, Sasaki T, Yamamoto S, Ushiyama N, Taga M, Momose K. Impact of early postoperative ambulation on gait recovery after hip fracture surgery: a multicenter cohort study. Sci Rep 2025; 15:12893. [PMID: 40234556 PMCID: PMC12000283 DOI: 10.1038/s41598-025-97632-w] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/28/2024] [Accepted: 04/07/2025] [Indexed: 04/17/2025] Open
Abstract
The study aimed to investigate the effect of early postoperative ambulation on gait recovery at the initial postoperative week and at discharge after hip fracture surgery in older patients. In this prospective cohort study, 882 patients aged ≥ 65 years from 10 acute hospitals in Japan were divided into early-ambulation (EA) (ambulation initiated on postoperative day 1 or 2) and late-ambulation (LA) (ambulation initiated on postoperative day 3 or later) groups. The Functional Independence Measure (FIM) was assessed 1 day postoperatively, 1 week postoperatively, and at discharge. Independent walking regardless of walking aids was defined as walking FIM ≥ 5. Multivariate logistic regression analysis and a generalized linear mixed model, accounting for inter-hospital variability, determined whether EA affected independent walking at 1 week postoperatively and at discharge. The number of patients walking independently 1 week postoperatively and at discharge was 156 (17.7%) and 292 (33.1%), respectively. On multivariate logistic regression analysis, EA was associated with independent walking at 1 week postoperatively (odds ratio [OR] 3.27; 95% confidence interval [CI] 2.17-4.94; P < 0.0001) and at discharge (OR 3.33; 95% CI 2.38-4.69; P < 0.0001). This study highlights the importance of EA in promoting postoperative independent walking, regardless of hospital setting.
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Affiliation(s)
- Keisuke Nakamura
- Department of Physical Therapy, School of Health Sciences, Shinshu University, Matsumoto, Nagano, 390-8621, Japan.
| | - Yasushi Kurobe
- Department of Rehabilitation, Fujimi-Kogen Hospital, Fujimi-Kogen Medical Center, Fujimi Town, Nagano, 399-0214, Japan
| | - Keita Sue
- Department of Rehabilitation, JA Nagano Kouseiren, Kakeyu-Misayama Rehabilitation Center Kakeyu Hospital, Ueda, Nagano, 386-0322, Japan
| | - Shinichi Sakurai
- Department of Rehabilitation, Saku Central Hospital, Saku, Nagano, 385-0051, Japan
| | - Tomohiro Sasaki
- Department of Rehabilitation, Matsumoto City Hospital, Matsumoto, Nagano, 390-1401, Japan
| | - Shuhei Yamamoto
- Department of Rehabilitation, Shinshu University Hospital, Matsumoto, Nagano, 390-8621, Japan
| | - Naoko Ushiyama
- Department of Rehabilitation, Fujimi-Kogen Hospital, Fujimi-Kogen Medical Center, Fujimi Town, Nagano, 399-0214, Japan
| | - Masahito Taga
- Department of Rehabilitation, Ina Central Hospital, Ina, Nagano, 396-8555, Japan
| | - Kimito Momose
- Department of Physical Therapy, School of Health Sciences, Shinshu University, Matsumoto, Nagano, 390-8621, Japan
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Guo Z, Wu W, Lv B, Mao Y, She C, Xu W, Gu J, Li L, Pan J. Does a high body mass index remain a protective factor in hip fracture patients with hypertension and diabetes? Aging Clin Exp Res 2025; 37:109. [PMID: 40172720 PMCID: PMC11965231 DOI: 10.1007/s40520-025-03010-x] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/06/2024] [Accepted: 03/13/2025] [Indexed: 04/04/2025]
Abstract
BACKGROUND Body mass index (BMI) was used to classify overweight or obesity. The obesity paradox was observed in elderly hip fracture patients. However, obesity has been implicated as one of the major risk factors for hypertension and diabetes. This study aims to determine whether a high body mass index (BMI) remains a protective factor in hip fracture patients with comorbid hypertension or diabetes, and to identify the optimal BMI threshold that best supports motor function recovery. METHODS This study included patients aged 65 years and older who have underwent hip fracture surgery. Harris Hip Score (HHS) was utilized to evaluate the functional recovery, the relationship between BMI and HHS was examined using both linear and generalized additive model (GAM). A threshold model was established with BMI of 24 kg/m2 and the difference between the threshold model and the GAM was compared utilizing the likelihood ratio test (LRT). RESULTS A total of 213 patients were enrolled in the study. A nonlinear relationship was identified between BMI and HHS in patients with either hypertension or diabetes and the HHS demonstrated a significant downward trend with increasing BMI. The LRT revealed no significant difference between the threshold effect model with a BMI value of 24 kg/m2 and the GAM. CONCLUSIONS This study reveals that the protective effect of high BMI on postoperative motor function in hip fracture patients is significantly modulated by comorbidities. We recommend modulating the BMI to approximately 24 kg/m2 for elderly patients with hip fractures and comorbid conditions such as hypertension and diabetes.
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Affiliation(s)
- Zhening Guo
- Department of Pharmacy, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China
| | - Weicheng Wu
- Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China
| | - Bo Lv
- Department of Pharmacy, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China
| | - Yongtao Mao
- Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China
| | - Chang She
- Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China
| | - Wei Xu
- Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China
| | - Jun Gu
- Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China
| | - Liubing Li
- Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
- State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, China.
| | - Jie Pan
- Department of Pharmacy, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
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11
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Karpouzian-Rogers T, Dworak EM, Bucko P, Ho EH, Ece B, Mather MA, Novack MA, Pila S, Hosseinian Z, Hall L, Mkhize T, Bassard AM, Gershon RC, Weintraub S. Measures of decision-making ability and functional outcomes in older adults: results from a scoping review in the ARMCADA study. Front Psychol 2025; 16:1540493. [PMID: 40191575 PMCID: PMC11968701 DOI: 10.3389/fpsyg.2025.1540493] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/09/2024] [Accepted: 02/26/2025] [Indexed: 04/09/2025] Open
Abstract
Background Though often not routinely assessed in older adults, declines in decision-making (DM) abilities are often observed in aging and may lead to adverse outcomes in multiple aspects of daily functioning. The Advancing Reliable Measurement in Cognitive Aging and Decision-making Ability (ARMCADA) research initiative seeks to address these issues. This scoping review investigates the current published literature on existing DM measures in aging samples, with emphasis on the domain of functional outcomes, defined as skills or behaviors related to one's ability to live independently. Methods We identified studies published between 2018-2023 using key words related to DM abilities and functional outcomes in aging populations through multiple databases. Titles and abstracts were first reviewed by two reviewers, full texts were then screened, and data were extracted from included articles. Results The scoping review identified 16,278 articles across domains with adults aged 45 and older. After screening and extraction, 705 total articles were included; 301 were related to functional outcomes and, from these, 231 distinct measures were identified. Mode of administration of most measures were self-administered with supervision, followed by examiner-administered, and most were conducted with clinical samples (e.g., MCI/AD, chronic health conditions, and Parkinson's disease, or clinical samples and a control group). Discussion The goal of the current scoping review is to provide a comprehensive examination of the current DM measures in older adults; this article focuses on the domain of functional outcomes. This scoping review guides a project to create and validate measures that can efficiently assess DM abilities in older adults across the cognitive aging spectrum.
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Affiliation(s)
- Tatiana Karpouzian-Rogers
- Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
| | - Elizabeth M. Dworak
- Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
| | - Patricia Bucko
- Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
| | - Emily H. Ho
- Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
| | - Berivan Ece
- Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
| | - Molly A. Mather
- Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
- Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
| | - Miriam A. Novack
- Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
| | - Sarah Pila
- Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
| | - Zahra Hosseinian
- Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
| | - LaToya Hall
- Department of Gerontology, Wayne State University, Detroit, MI, United States
| | - Tarry Mkhize
- Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
| | - Adrianna M. Bassard
- Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
| | - Richard C. Gershon
- Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
| | - Sandra Weintraub
- Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
- Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, IL, United States
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12
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Yeramosu T, Taitsman LA, Kates SL. Trends and Complications of Hip Fracture Fixation Among Early Career Orthopaedic Surgeons: An Analysis of the American Board of Orthopaedic Surgery Part II Oral Examination Database. Geriatr Orthop Surg Rehabil 2025; 16:21514593241291792. [PMID: 40103706 PMCID: PMC11915309 DOI: 10.1177/21514593241291792] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 06/13/2024] [Revised: 08/19/2024] [Accepted: 09/23/2024] [Indexed: 03/20/2025] Open
Abstract
Background Hip fractures are a major public health concern with a high mortality rate. Numerous risk factors for hip fracture have been identified, and efforts made to reduce complications and improve outcomes. This study aimed to assess recent trends in postoperative complications amongst early-career orthopaedic surgeons. Methods This retrospective study analyzed surgical cases submitted to the American Board of Orthopaedic Surgery (ABOS) for the Part II Oral Examination from 2013 to 2022. The database includes patient demographics and medical and surgical complications. Current Procedural Terminology codes reflecting operative fixation for hip fracture were selected. Data was split into two cohorts: 2013-2016 and 2017-2020. Univariate and multivariable logistic regression analyses were used to identify significant differences between cohorts. Results 49,418 cases were analyzed. Compared to 2013-2016, 2017-2020 had a reduction in the overall medical complication rate (-1.49%, P = 0.0005), saw slight increases in congestive heart failure (+0.18%, P = 0.049), renal failure (+0.37%, P = 0.004), hypotension (+0.41%, P = 0.0007), and hypoxia (+0.41%, P = 0.0016). Minor decreases in myocardial infarction (-0.18%, P = 0.047) and pneumonia (-0.34%, P = 0.021) were noted. No differences occurred in confusion/delirium, deep vein thrombosis/pulmonary embolism, and mortality. There were no significant differences in overall surgical complications. The 90-day readmission rate increased with time (+1.17%, P < 0.0001). Multivariable logistic regression identified a decrease in the likelihood of overall medical complications (Odds Ratio (OR): 0.92 [0.89, 0.96]; P < 0.0001). Decreases were noted for the likelihood of myocardial infarction (OR: 0.81 [0.68, 0.98]; P = 0.031), pneumonia (OR: 0.87 [0.78, 0.97]; P = 0.013), fracture (OR: 0.80 [0.69, 0.92]; P = 0.002), and recurrent/persistent/uncontrolled pain (OR: 0.72 [0.56, 0.92]; P = 0.008). The likelihood of renal failure (OR: 1.18 [1.04, 1.34]; P = 0.009) and readmission increased (OR: 1.14 [1.07, 1.20]; P < 0.0001). Conclusion This study found little change in postoperative complication patterns over the past decade. These findings suggest that more efforts are needed to improve hip fracture care and outcomes.
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Affiliation(s)
- Teja Yeramosu
- Virginia Commonwealth University School of Medicine, Richmond, VA, USA
| | - Lisa A Taitsman
- Department of Orthopaedics and Sports Medicine, University of Washington School of Medicine, Seattle, WA, USA
| | - Stephen L Kates
- Department of Orthopaedic Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA, USA
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13
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González de Villaumbrosia C, Barba R, Ojeda-Thies C, Grifol-Clar E, Álvarez-Diaz N, Álvarez-Espejo T, Cancio-Trujillo JM, Mora-Fernández J, Pareja-Sierra T, Barrera-Crispín R, Calle-Egusquiza A, Capdevila-Reniu A, Carrasco-Paniagua C, Cervera Díaz MC, Condorhuamán-Alvarado P, Cotano-Abad L, Cuadra-Llopart L, García-Cárdenas V, González-Chávez S, Hernández-Sánchez LA, Herrero-Pinilla B, López-Castro J, Montero-Fernández N, Muñoz-Pascual A, Muñoz-Vélez M, Ortés-Gómez R, Sáenz-Tejada A, Sanz-Reig J, Torras-Cortada S, Ramos Cortés M, Sáez-López P. Predictive factors of gait recovery after hip fracture: a scoping review. Age Ageing 2025; 54:afaf057. [PMID: 40100147 DOI: 10.1093/ageing/afaf057] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/26/2024] [Indexed: 03/20/2025] Open
Abstract
OBJECTIVE This scoping review aimed to identify predictive factors influencing gait recovery post-hip fracture surgery among adults aged 65 and older. DESIGN A systematic search of MEDLINE, Embase and CINAHL databases was conducted, focusing on studies assessing predictive factors of gait recovery within one month to one-year post-surgery. Two independent reviewers carried out study selection, quality assessment and data extraction using the Quality in Prognosis Studies Tool to gauge evidence levels. RESULTS About 10,627 articles were initially identified. After duplicates were removed, 7665 were screened based on title and abstract, then 796 based on full text; 138 articles were finally included.The review identified a total of 77 predictive factors. However, just under half (34) of these were supported by studies with a low risk of bias. Higher-level evidence-supported factors were age, pre-fracture independence in daily activities, cognitive impairment, delirium, orthogeriatric multidisciplinary co-management, specific surgical interventions, allowing weight-bearing, comorbidities, nutritional status, rehabilitation treatments and polypharmacy. CONCLUSION The identified factors influencing gait recovery include both non-modifiable factors [such as younger age, pre-fracture independence in activities of daily living, absence of cognitive impairment, fewer comorbidities and lower anaesthetic risk] and modifiable factors, including rehabilitation treatments, organisational factors, absence of delirium, orthogeriatric co-management, surgical factors such as implant type and unrestricted weight-bearing, better nutritional status and strength, and reduced polypharmacy. We believe the latter should be prioritised in managing patients with hip fractures to achieve optimal recovery.
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Affiliation(s)
- Cristina González de Villaumbrosia
- Geriatrics, Hospital Universitario Rey Juan Carlos, Madrid, Spain
- Escuela Internacional de Doctorado, Universidad Rey Juan Carlos, Madrid, Spain
- Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain
| | - Raquel Barba
- Internal Medicine, Hospital Universitario Rey Juan Carlos, Madrid, Spain
- Faculty of Health Sciences, Universidad Rey Juan Carlos, Madrid, Spain
| | - Cristina Ojeda-Thies
- Traumatology and Orthopaedic Surgery, Hospital Universitario 12 De Octubre, Madrid, Spain
| | | | | | - Teresa Álvarez-Espejo
- Internal Medicine, Hospital Universitario Rey Juan Carlos, Madrid, Spain
- Faculty of Health Sciences, Universidad Rey Juan Carlos, Madrid, Spain
| | | | | | | | | | | | - Aina Capdevila-Reniu
- Geriatrics, Clinic Barcelona Hospital Department of General Internal Medicine, Barcelona, Spain
| | | | | | | | | | | | | | | | | | | | - Jose López-Castro
- Internal Medicine, Hospital Público De Monforte De Lemos, Monforte De Lemos, Spain
| | | | | | | | | | | | - Javier Sanz-Reig
- Orthopedics, Hospital Universitari Sant Joan D'Alacant, Alicante, Spain
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14
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Lim SK, Lim JY. The implications of bioelectrical impedance vector analysis in older adults with hip fractures. Maturitas 2025; 194:108209. [PMID: 39892122 DOI: 10.1016/j.maturitas.2025.108209] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/14/2024] [Revised: 12/20/2024] [Accepted: 01/26/2025] [Indexed: 02/03/2025]
Abstract
OBJECTIVES This study used bioelectrical impedance vector analysis to assess body composition in older adults with hip fractures, comparing results with reference populations. STUDY DESIGN This cross-sectional study included patients aged 65 years or more who had undergone surgery for hip fracture and baseline bioelectrical impedance analysis at 50 kHz. Using raw impedance data, bioelectrical impedance vector analysis was conducted, calculating phase angle and analyzing resistance (R) and reactance (Xc) relative to height (R/H and Xc/H) on RXc graphs. MAIN OUTCOME MEASURES Men and women were compared with reference populations using confidence ellipses. Individual vectors were plotted against 50 %, 75 %, and 95 % tolerance ellipses and compared with international references matched for age and body mass index and a young adult group, further differentiated by sarcopenia status. RESULTS Among 103 patients with hip fracture (24 men, 79 women), confidence ellipses showed significant differences from reference populations (P < 0.001), with reduced Xc and lower phase angle (men: 4.3 ± 1.5°; women: 3.8 ± 1.0°), consistent with higher R/H and lower Xc/H. Most vectors lay outside the 75 % and 95 % tolerance ellipses, primarily in the lower-right and upper-right quadrants, indicating body cell mass loss and water imbalance. Only 8.3 % of men and 12.7 % of women fell within the 75 % tolerance ellipse of community-dwelling older adults. Sarcopenic patients showed greater rightward displacement, indicating more severe muscle wasting and dehydration. CONCLUSIONS Older hip fracture patients showed a distinct pattern on bioelectrical impedance vector analysis indicating frailty and malnutrition. Bioelectrical impedance vector analysis may effectively screen for body composition changes and nutritional status, supporting timely, multidisciplinary interventions.
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Affiliation(s)
- Seung-Kyu Lim
- Department of Rehabilitation Medicine, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, 31 Soonchunhyang 6-gil, Dongnam-gu, Cheonan-si, Chungcheongnam-do 31151, Republic of Korea
| | - Jae-Young Lim
- Department of Rehabilitation Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 82 Gumi-ro 173beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 13620, Republic of Korea; Institute on Aging, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.
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15
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Schwarz F, Klee E, Schenk P, Katscher S, Schnake KJ, Bäumlein M, Zimmermann V, Schmeiser G, Scherer MA, Müller M, Sprengel K, Spiegl U, Osterhoff G, Schramm S, Siekmann H, Franck A, Scheyerer MJ, Ullrich B, The Working Group Osteoporotic Fractures of the Spine Section of the German Society of Orthopaedics and Trauma. Impact of Anxiety During Hospitalization on the Clinical Outcome of Patients With Osteoporotic Thoracolumbar Vertebral Fracture. Global Spine J 2025; 15:417-424. [PMID: 37549640 PMCID: PMC11877610 DOI: 10.1177/21925682231192847] [Citation(s) in RCA: 3] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 08/09/2023] Open
Abstract
STUDY DESIGN Multicenter prospective cohort study. OBJECTIVES Anxiety in combination with osteoporotic vertebral compression fractures (OVCFs) of the spine remains understudied. The purpose of this study was to analyze whether anxiety has an impact on the short-term functional outcome of patients with an OVCF. Furthermore, a direct impact of the fracture on the patient's anxiety during hospitalization should be recognized. METHODS All inpatients with an OVCF of the thoracolumbar spine from 2017 to 2020 were included. Trauma mechanism, analgetic medication, anti-osteoporotic therapy, timed-up-and-go test (TuG), mobility, Barthel index, Oswestry-Disability Index (ODI) and EQ5D-5L were documented.For statistical analysis, the U test, chi-square independence test, Spearman correlation, General Linear Model for repeated measures, Bonferroni analysis and Wilcoxon test were used. The item anxiety/depression of the EQ5D-5L was analyzed to describe the patients' anxiousness. RESULTS Data from 518 patients from 17 different hospitals were evaluated. Fracture severity showed a significant correlation (r = .087, P = .0496) with anxiety. During the hospital stay, pain medication (P < .001), anti-osteoporotic medication (P < .001), and initiation of surgical therapy (P < .001) were associated with less anxiety. The anxiety of a patient at discharge was negatively related to the functional outcomes at the individual follow-up: TuG (P < .001), Barthel index (P < .001), ODI (P < .001) and EQ5D-5L (P < .001). CONCLUSIONS Higher anxiety is associated with lower functional outcome after OVCF. The item anxiety/depression of the EQ5D-5L provides an easily accessible, quick and simple tool that can be used to screen for poor outcomes and may also offer the opportunity for a specific anxiety intervention.
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Affiliation(s)
- F. Schwarz
- Department of Neurosurgery, University Hospital Jena, Jena, Germany
| | - E. Klee
- Department of Neurosurgery, University Hospital Jena, Jena, Germany
| | - P. Schenk
- Department of Science and Research, BG Clinic Bergmannstrost Halle (Saale), Halle, Deutschland
| | - S. Katscher
- Interdisciplinary Center for Spine and Neurotrauma, Sana Clinic Borna, Borna, Germany
| | - K. J. Schnake
- Interdisciplinary Center for Spinal and Scoliosis Surgery, Waldkrankenhaus Erlangen, Erlangen, Germany
- Department of Orthopaedics and Traumatology, Paracelsus Private Medical University Nuremberg, Nuremberg, Germany
| | - M. Bäumlein
- Department of Orthopaedics and Traumatology, University Hospital Marburg, Marburg, Germany
| | - V. Zimmermann
- Department of Trauma and Orthopedic Surgery, Klinikum Traunstein, Traunstein, Germany
| | - G. Schmeiser
- Department of Spinal Surgery, Schön Clinic Hamburg Eilbek, Hamburg, Germany
| | - M. A. Scherer
- Medical Practice Clinic Orthopedics and Surgery Munich West, Munich, Germany
| | - M. Müller
- Department of Orthopaedics and Traumatology, University Hospital Kiel, Kiel, Germany
| | - K. Sprengel
- Department of Traumatology, Hirslanden Clinic St. Anna, University of Lucerne, Lucerne, Switzerland
- Department of Traumatology, University Hospital Zurich (USZ), University of Zurich, Zurich, Switzerland
| | - U. Spiegl
- Department of Orthopaedics, Traumatology and Plastic Surgery, University Hospital Leipzig, Leipzig, Germany
| | - G. Osterhoff
- Department of Orthopaedics, Traumatology and Plastic Surgery, University Hospital Leipzig, Leipzig, Germany
| | - S. Schramm
- Department of Trauma and Orthopaedic Surgery, University Hospital Erlangen, Erlangen, Germany
| | - H. Siekmann
- Department of Traumatology and Reconstructive Surgery, AMEOS Klinikum Halberstadt, Halberstadt, Germany
| | - A. Franck
- Department of Orthopaedics and Traumatology, Regiomed-Clinic of Coburg, Coburg, Germany
| | - M.-J. Scheyerer
- Department of Orthopaedics and Traumatology, University Hospital Duesseldorf, Duesseldorf, Germany
| | - B.W. Ullrich
- Department of Traumatology and Reconstructive Surgery, BG Clinic Bergmannstrost Halle (Saale), Halle, Germany
- Department of Hand, Trauma- and Reconstructive Surgery, University Hospital Jena, Jena, Germany
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16
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Salvesen ES, Taraldsen K, Lønne G, Lydersen S, Lamb SE, Opdal K, Saltvedt I, Johnsen LG. Characteristics and outcomes for hip fracture patients in an integrated orthogeriatric care model: a descriptive study of four discharge pathways with one-year follow-up. BMC Musculoskelet Disord 2025; 26:184. [PMID: 39994680 PMCID: PMC11849285 DOI: 10.1186/s12891-025-08427-z] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/09/2024] [Accepted: 02/13/2025] [Indexed: 02/26/2025] Open
Abstract
BACKGROUND Orthogeriatric hospital care is recommended for hip fra cture patients, but differentiated hospital care has not been evaluated. The aim of this study was to describe physical performance and health-related quality of life for hip fracture patients 1-year after surgery in four treatment pathways. We also report changes in functional outcomes from baseline to 1-year follow-up together with readmission and mortality rates for each pathway. METHODS We included 177 hip fracture patients aged 65 years or older from a single center in Norway. Participants were discharged home, to specialised rehabilitation, regular rehabilitation or nursing home based on orthogeriatric assessment of pre- and postfracture function, mobility level and Ac tivities of Daily Living. Outcome variables included Short Physical Performance Battery, EuroQol-5-dimension-5-level, Barthel-index, Lawton & Brody Instrumental Activities of Daily Living, Lawton & Brody Self-Maintenance Scale, readmission and mortality rates during follow-up. RESULTS Participants discharged home and to specialised rehabilitation were younger and healthier than participants discharged to regular rehabilitation and nursing home. All groups had a clinically important improvement in Short Physical Performance Battery score (mean 4.8 points, 95% confidence interval (CI) 4.2, 5.5) from post-surgery to 1-year follow-up and a clinically important decline in EuroQol-5-dimension-5-level (mean -0.12 points, CI -0.16, -0.07) from baseline to 1-year follow-up. The decline in Barthel-index from baseline to 1-year follow-up was greater in the regular rehabilitation group (mean -2.3 points, CI -4.2, -0.2) than in the home group (mean -0.6 points, CI -1.4, 0.2) and specialised rehabilitation group (mean -0.4 points, CI -2.4, 1.6). Participants in the regular rehabilitation group were more frequently readmitted (standardised Pearson residual 4.1) and mortality rates were higher in the nursing home group (standardised Pearson residual 7.8) during the first year. CONCLUSIONS Orthogeriatric treatment pathways for hip fracture patients entailed differentiation based on factors such as age, mobility, comorbidity and physical function. Participants in all pathways improved in physical performance-scores, yet experienced decline in quality of life-scores during follow-up. Overall readmission and mortality rates were not influenced, but varied between pathways. Further research is needed to investigate the need for differentiated hospital treatment and its potential effects on rehabilitation after discharge.
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Affiliation(s)
- Eirik Solheim Salvesen
- Department of Neuromedicine and Movement Science, NTNU, Trondheim, Norway.
- Department of Orthopaedic Surgery, Sørlandet Hospital HF, Arendal, Norway.
| | - Kristin Taraldsen
- Department of Rehabilitation Science and Health Technology, OsloMet, Oslo, Norway
| | - Greger Lønne
- Department of Orthopaedic Surgery, Innlandet Hospital HF, Lillehammer, Norway
| | - Stian Lydersen
- The Regional Centre for Child and Youth, Department of Mental Health, NTNU, Trondheim, Norway
| | | | - Kjersti Opdal
- Department of Neuromedicine and Movement Science, NTNU, Trondheim, Norway
- Department of Geriatrics, St Olav`s Hospital HF, Trondheim, Norway
| | - Ingvild Saltvedt
- Department of Neuromedicine and Movement Science, NTNU, Trondheim, Norway
- Department of Geriatrics, St Olav`s Hospital HF, Trondheim, Norway
| | - Lars Gunnar Johnsen
- Department of Neuromedicine and Movement Science, NTNU, Trondheim, Norway
- Department of Orthopaedic Surgery, St Olav`s Hospital HF, Trondheim, Norway
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Ferro FC, Campos MAG, Picolli TCS, de Sá Mayoral V, Soares VM, Ferreira JC, Peres LDB, Tibeau TTM, Bernardi VEC, Pereira DN, Gumieiro DN, Curcelli EC, Navarro E Lima LH, do Nascimento Junior P, Lazzarin T, Ballarin RS, Okoshi MP, Minicucci MF, de Paiva SAR, Gordon AL, Sahota O, Pereira FWL, Azevedo PS. Performance of the Nottingham hip fracture score (NHFS) as a predictor of 30-day mortality after proximal femur fracture in an older people Brazilian cohort. Sci Rep 2025; 15:5607. [PMID: 39955409 PMCID: PMC11830071 DOI: 10.1038/s41598-025-89869-2] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/11/2024] [Accepted: 02/10/2025] [Indexed: 02/17/2025] Open
Abstract
Perioperative risk assessment helps inform clinical practice for older people with hip fractures. This is a cohort study, where perioperative risk screening, including NHFS, was performed at admission, followed by an evaluation of 30-day outcomes. 503 patients were included, 73% female, 79.4 ± 9.3 years old; 58% presented extracapsular and 42% intracapsular fractures, with a 30-day mortality of 9%. The NHFS was higher in the patients who died at 5.6 ± 1.1 compared to survivals at 4.3 ± 1.5 (p-value < 0.001). NHFS > 4 was associated with 30-day mortality observed by Cox regression adjusted by fracture type: HR 4.55 (95% CI 2.10-9.82) (p-value < 0.001) and Kaplan-Meyer Curve (HR 3.94; 95% CI 2.19-7.07; p-value < 0.001). ROC curve showed the accuracy of NHFS in explaining 30-day mortality (AUC 0.74; 95% CI 0.67-0.81). Complications were higher among patients with NHFS > 4. The performance of NHFS was better than the traditional perioperative risk ASA score. Therefore, NHFS can be implemented in real-world clinical practice to estimate the 30-day mortality risk for hip fracture in older patients in Brazil. NHFS > 4 is critical for 30-day mortality and complications; this cutoff helps inform clinical practice. The present study might motivate other centers to consider NHFS in their perioperative risk assessment routine.
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Affiliation(s)
- Flávio Cruz Ferro
- Internal Medicine Department, Medical School, São Paulo State University (UNESP), Prof. Mário Rubens Guimarães Montenegro Avenue, Botucatu, SP, 18618-970, Brazil
| | - Marcos Adriano Garcia Campos
- Global Emergency Medicine Innovation and Implementation Research Center, Department of Emergency Medicine, Duke University School of Medicine, Durham, NC, USA
| | - Thais Caroline Silva Picolli
- Internal Medicine Department, Medical School, São Paulo State University (UNESP), Prof. Mário Rubens Guimarães Montenegro Avenue, Botucatu, SP, 18618-970, Brazil
| | - Vania de Sá Mayoral
- Internal Medicine Department, Medical School, São Paulo State University (UNESP), Prof. Mário Rubens Guimarães Montenegro Avenue, Botucatu, SP, 18618-970, Brazil
- Hospital das Clínicas da Faculdade de Medicina de Botucatu, Secretaria de Saúde do Estado de São Paulo, São Paulo, Brazil
| | - Victoria Moralez Soares
- Internal Medicine Department, Medical School, São Paulo State University (UNESP), Prof. Mário Rubens Guimarães Montenegro Avenue, Botucatu, SP, 18618-970, Brazil
| | - Jessica Caroline Ferreira
- Internal Medicine Department, Medical School, São Paulo State University (UNESP), Prof. Mário Rubens Guimarães Montenegro Avenue, Botucatu, SP, 18618-970, Brazil
| | - Lucas Dias Borges Peres
- Internal Medicine Department, Medical School, São Paulo State University (UNESP), Prof. Mário Rubens Guimarães Montenegro Avenue, Botucatu, SP, 18618-970, Brazil
| | - Theodor Terra Mayer Tibeau
- Internal Medicine Department, Medical School, São Paulo State University (UNESP), Prof. Mário Rubens Guimarães Montenegro Avenue, Botucatu, SP, 18618-970, Brazil
| | - Victor El Chihimi Bernardi
- Internal Medicine Department, Medical School, São Paulo State University (UNESP), Prof. Mário Rubens Guimarães Montenegro Avenue, Botucatu, SP, 18618-970, Brazil
| | - David Nascimento Pereira
- Internal Medicine Department, Medical School, São Paulo State University (UNESP), Prof. Mário Rubens Guimarães Montenegro Avenue, Botucatu, SP, 18618-970, Brazil
| | - David Nicoletti Gumieiro
- Hospital das Clínicas da Faculdade de Medicina de Botucatu, Secretaria de Saúde do Estado de São Paulo, São Paulo, Brazil
- Surgery and Orthopedics Department, São Paulo State University (UNESP), Medical School, Botucatu, Brazil
| | - Emilio Carlos Curcelli
- Hospital das Clínicas da Faculdade de Medicina de Botucatu, Secretaria de Saúde do Estado de São Paulo, São Paulo, Brazil
| | - Lais Helena Navarro E Lima
- Department of Anaesthesiology, Perioperative, and Pain Medicine, University of Manitoba, Winnipeg, MB, Canada
- Department of Surgical Specialties and Anaesthesiology, Medical School, São Paulo State University (UNESP), Botucatu, Brazil
| | - Paulo do Nascimento Junior
- Department of Surgical Specialties and Anaesthesiology, Medical School, São Paulo State University (UNESP), Botucatu, Brazil
| | - Taline Lazzarin
- Internal Medicine Department, Medical School, São Paulo State University (UNESP), Prof. Mário Rubens Guimarães Montenegro Avenue, Botucatu, SP, 18618-970, Brazil
- Hospital das Clínicas da Faculdade de Medicina de Botucatu, Secretaria de Saúde do Estado de São Paulo, São Paulo, Brazil
| | - Raquel Simões Ballarin
- Internal Medicine Department, Medical School, São Paulo State University (UNESP), Prof. Mário Rubens Guimarães Montenegro Avenue, Botucatu, SP, 18618-970, Brazil
- Hospital das Clínicas da Faculdade de Medicina de Botucatu, Secretaria de Saúde do Estado de São Paulo, São Paulo, Brazil
| | - Marina Politi Okoshi
- Internal Medicine Department, Medical School, São Paulo State University (UNESP), Prof. Mário Rubens Guimarães Montenegro Avenue, Botucatu, SP, 18618-970, Brazil
| | - Marcos Ferreira Minicucci
- Internal Medicine Department, Medical School, São Paulo State University (UNESP), Prof. Mário Rubens Guimarães Montenegro Avenue, Botucatu, SP, 18618-970, Brazil
| | - Sergio Alberto Rupp de Paiva
- Internal Medicine Department, Medical School, São Paulo State University (UNESP), Prof. Mário Rubens Guimarães Montenegro Avenue, Botucatu, SP, 18618-970, Brazil
| | - Adam Lee Gordon
- Wolfson Institute of Population Health, Queen Mary University of London, London, UK
- Academic Centre for Healthy Ageing, Whipps Cross Hospital, Barts Health NHS Trust, London, UK
| | - Opinder Sahota
- Nottingham University Hospitals NHS Trust, Nottingham, UK
| | - Filipe Welson Leal Pereira
- Internal Medicine Department, Medical School, São Paulo State University (UNESP), Prof. Mário Rubens Guimarães Montenegro Avenue, Botucatu, SP, 18618-970, Brazil
- Hospital das Clínicas da Faculdade de Medicina de Botucatu, Secretaria de Saúde do Estado de São Paulo, São Paulo, Brazil
| | - Paula Schmidt Azevedo
- Internal Medicine Department, Medical School, São Paulo State University (UNESP), Prof. Mário Rubens Guimarães Montenegro Avenue, Botucatu, SP, 18618-970, Brazil.
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Hernández-Pascual C, Santos-Sánchez JÁ, Hernández-Rodríguez J, Silva-Viamonte CF, Pablos-Hernández C, Alonso-Rodríguez P, Mirón-Canelo JA. Partial weight bearing and long-term survival outcomes in extracapsular hip fractures treated with trochanteric Gamma3 nails. BMC Musculoskelet Disord 2025; 26:129. [PMID: 39920603 PMCID: PMC11804022 DOI: 10.1186/s12891-024-08043-3] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/21/2024] [Accepted: 11/08/2024] [Indexed: 02/09/2025] Open
Abstract
BACKGROUND Benefits of partial weight bearing (PWB) in operated extracapsular hip fractures (ECF) have not been proved. We have assessed influence of PWB on long-term survival and the final mobility achieved, dependence and mortality-related factors. METHODS Retrospective cohort study of osteoporotic ECF in ≥ 65-year-old patients who underwent surgery with trochanteric Gamma3 nails in 2014 (n = 218), followed in the long-term (consolidation or stabilisation). According to Baumgaertner-Fogagnolo classification (138 good, 71 acceptable and 9 poor) a postoperative protocol was applied. 116 cases bore weight before discharge (Immediate Partial Weight Bearing, IPWB = 116; Not-IPWB = 102), and 118 did it after a month (Early PWB, EPWB = 118; Not-EPWB = 100). Variables were collected from medical records and complementary studies. We used FMS (Fracture Mobility Score) and the National Mortality Database from the Spanish Ministry of Health at > 5 years. EPWB and Not-EPWB were comparable, except for hospital stay and dependence. We used the Cox method for mortality. < 0.05 p-values were significant. RESULTS Survival improved in IPWB earlier than in EPWB, although there was no statistical significance. The final FMS was significantly favourable only in EPWB. Not-EPWB showed greater dependence. Age (per year of increment), moderate Charlson comorbidity index (not age-modified) and greater immediate post-operative estimated blood loss were independent factors for mortality, but we did not find radiological factors implied. CONCLUSIONS Postoperative PWB in ECF may increase mid-term and long-term survival rates, but considerably delayed in EPWB. Only EPWB improved final mobility. Not-EPWB presented with greater dependence. Only clinical factors were independently related to mortality, but no radiological factors were.
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Affiliation(s)
- Carlos Hernández-Pascual
- Department of Trauma and Orthopaedic Surgery, Hospital Universitario de Salamanca, Paseo de la Transición Española, 37007, Salamanca, Spain.
| | - José Ángel Santos-Sánchez
- Department of Radiology, Hospital Universitario de Salamanca, Paseo de la Transición Española, 37007, Salamanca, Spain
| | - Jorge Hernández-Rodríguez
- Department of Medical Physics and Radiation Protection, Hospital Universitario de Salamanca, Paseo de la Transición Española, 37007, Salamanca, Spain
| | - Carlos Fernando Silva-Viamonte
- Department of Statistics, Faculty of Medicine, Universidad de Salamanca. Campus Miguel de Unamuno, Avda. Alfonso X El Sabio S/N, 37007, Salamanca, Spain
| | - Carmen Pablos-Hernández
- Department of Geriatrics, Hospital Universitario de Salamanca, Paseo de la Transición Española, 37007, Salamanca, Spain
| | - Pablo Alonso-Rodríguez
- Department of Rehabilitation, Hospital Universitario de Salamanca, Paseo de la Transición Española, 37007, Salamanca, Spain
| | - José Antonio Mirón-Canelo
- Department of Biomedical and Diagnostic Sciences. Preventive Medicine and Public Health, Faculty of Medicine, Universidad de Salamanca. Campus Miguel de Unamuno, Avda. Alfonso X El Sabio S/N, 37007, Salamanca, Spain
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Cacciatore S, Ferrara MC, Iuorio MS, Dall'Olio L, Bellelli F, Elmi D, Bencivenga L, Trevisan C, Marzetti E, Okoye C. Urinary Catheterization Management in Older Adults with Hip Fracture: A Systematic Review. J Am Med Dir Assoc 2025; 26:105410. [PMID: 39675731 DOI: 10.1016/j.jamda.2024.105410] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/14/2024] [Revised: 10/30/2024] [Accepted: 11/04/2024] [Indexed: 12/17/2024]
Abstract
OBJECTIVES Urinary catheterization is a common procedure in the perioperative management of patients with hip fracture. However, decisions on its insertion or removal are often variable. This systematic review aimed to synthesize current evidence on urinary catheterization management in older patients with hip fracture by thoroughly reviewing the implementation of structured programs. DESIGN Systematic review. SETTING AND PARTICIPANTS Older adults hospitalized for hip fracture. METHODS Studies published until April 1, 2023, were retrieved from MEDLINE (PubMed interface), SCOPUS (Elsevier interface), and Cochrane Central Register of Controlled Trials (EBSCO interface). Observational and interventional studies investigating the use of urinary catheterization in older adults with hip fracture were included and corresponding data on structured programs and associated results were extracted. The quality assessment of the studies was performed using the Critical Appraisal Skills Programme tool. RESULTS Of the 674 articles identified through the literature search, 16 studies were included. The mean ages in the 16 studies ranged from 67 to 86 years. Studies on the implementation of structured programs were few and heterogeneous. These studies identified 24 to 48 hours as the appropriate duration of postoperative catheterization; intermittent catheterization was associated with a lower incidence of complications. CONCLUSIONS AND IMPLICATIONS Our review revealed a lack of standardized perioperative urinary catheterization management in older patients with hip fracture and uncovered the need for a tailored approach, which is crucial to improving the quality of care and outcomes in these patients.
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Affiliation(s)
- Stefano Cacciatore
- Department of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, Rome, Italy; Young Epidemiologists of the Italian Society of Gerontology and Geriatrics (SIGG) (YES) working group, Italian Society of Gerontology and Geriatrics, Florence, Italy; Department of Geriatrics, Orthopedics and Rheumatology, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy
| | - Maria Cristina Ferrara
- Young Epidemiologists of the Italian Society of Gerontology and Geriatrics (SIGG) (YES) working group, Italian Society of Gerontology and Geriatrics, Florence, Italy; School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
| | - Maria Serena Iuorio
- Young Epidemiologists of the Italian Society of Gerontology and Geriatrics (SIGG) (YES) working group, Italian Society of Gerontology and Geriatrics, Florence, Italy; Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy
| | - Linda Dall'Olio
- Department of Medical Sciences, University of Ferrara, Ferrara, Italy
| | - Federico Bellelli
- Young Epidemiologists of the Italian Society of Gerontology and Geriatrics (SIGG) (YES) working group, Italian Society of Gerontology and Geriatrics, Florence, Italy; Specialty Training School in Geriatric and Gerontology, University of Milan, Milan, Italy
| | - Daniele Elmi
- Department of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, Rome, Italy
| | - Leonardo Bencivenga
- Young Epidemiologists of the Italian Society of Gerontology and Geriatrics (SIGG) (YES) working group, Italian Society of Gerontology and Geriatrics, Florence, Italy; Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy
| | - Caterina Trevisan
- Young Epidemiologists of the Italian Society of Gerontology and Geriatrics (SIGG) (YES) working group, Italian Society of Gerontology and Geriatrics, Florence, Italy; Department of Medical Sciences, University of Ferrara, Ferrara, Italy
| | - Emanuele Marzetti
- Department of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, Rome, Italy; Department of Geriatrics, Orthopedics and Rheumatology, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy
| | - Chukwuma Okoye
- Young Epidemiologists of the Italian Society of Gerontology and Geriatrics (SIGG) (YES) working group, Italian Society of Gerontology and Geriatrics, Florence, Italy; School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy
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20
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Sivro M, Omerović Đ, Lazović F, Papović A. The effect of intravenous vitamin C administration on postoperative pain and intraoperative blood loss in older patients after intramedullary nailing of trochanteric fractures. Eur Geriatr Med 2025; 16:237-243. [PMID: 39674960 DOI: 10.1007/s41999-024-01131-6] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/19/2024] [Accepted: 12/03/2024] [Indexed: 12/17/2024]
Abstract
PURPOSE The purpose of this study was to determine the effects of peri and postoperative intravenous vitamin C administration on severity of postoperative pain and intraoperative blood loss in patients with trochanteric fracture treated with intramedullary nailing. METHODS A prospective, single-blinded, controlled, randomised clinical study was conducted. It included 60 patients who were randomly divided into the Vitamin C and Control groups. Baseline characteristics, haemoglobin levels, number of Red Blood Cell (RBC) units transfusion, and metamizole consumption were noted in each group. Visual Analogue Scale (VAS) score was evaluated at 24 and 48 h postoperatively. RESULTS There were no differences between the groups concerning age, gender, length of hospitalisation, fracture type distribution, preoperative and postoperative haemoglobin levels. Postoperative metamizole consumption was higher in the Control group than in the Vitamin C group, with statistically significant difference (p = 0.003). The median VAS scores were higher in the Control group compared to the Vitamin C group at 24 and 48 h postoperatively with significant differences (p = 0.001 and p < 0.0005, respectively). Multivariate logistic regression analysis revealed two independent predictors of postoperative blood transfusion: unstable fracture pattern (OR = 0.065, 95% CI 0.007-0.571, p = 0.014), and preoperative haemoglobin level (OR = 903, 95% CI 0.846-0.965, p = 0.003). CONCLUSION The results showed significant reduction of subjective pain levels and lower analgesic consumption in patients who received intravenous vitamin C, suggesting that it could be considered as an adjuvant agent for analgesia in older patients with hip fracture. Unstable fracture pattern and preoperative haemoglobin levels significantly contributed to postoperative blood transfusion requirement.
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Affiliation(s)
- Mirza Sivro
- Department of Orthopaedics and Traumatology, Cantonal Hospital Zenica, Crkvice 67, 72000, Zenica, Bosnia and Herzegovina.
| | - Đemil Omerović
- Clinic of Orthopaedics and Traumatology, Clinical Center of Sarajevo University, Sarajevo, Bosnia and Herzegovina
| | - Faruk Lazović
- Clinic of Orthopaedics and Traumatology, Clinical Center of Sarajevo University, Sarajevo, Bosnia and Herzegovina
| | - Adnan Papović
- Clinic of Orthopaedics and Traumatology, Clinical Center of Sarajevo University, Sarajevo, Bosnia and Herzegovina
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21
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Hansen MS, Kristensen MT, Zilmer CK, Berger AL, Kirk JW, Marie Skibdal K, Kallemose T, Bandholm T, Pedersen MM. Very low levels of physical activity among patients hospitalized following hip fracture surgery: a prospective cohort study. Disabil Rehabil 2025:1-10. [PMID: 39835691 DOI: 10.1080/09638288.2025.2451769] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/26/2024] [Revised: 01/07/2025] [Accepted: 01/07/2025] [Indexed: 01/22/2025]
Abstract
PURPOSE The evidence supports early and intensive mobilization and physical activity for patients who are hospitalized following hip fracture. The objectives were to determine levels of physical activity among patients hospitalized following hip fracture surgery, and to explore the association between levels of physical activity and 30-day post-discharge readmission, and mortality. MATERIALS AND METHODS We collected data at two university hospitals in Denmark from March-June 2023. Patients were included on postoperative day (POD) 1 to 3. 24-h upright time was measured from inclusion to discharge using a thigh-worn accelerometer. 30-day readmission and mortality were verified by patient records. RESULTS 101 patients with a mean (SD) age of 79.9(8.4) years were included. The median (IQR) 24-h upright time on POD2-6 ranged from 15(7:31) to a maximum of 34(16:67) mins. Within 30 days after discharge, 25 patients(25%) were readmitted or referred to an emergency ward and 3(3%) patients died (no clear association with upright time). CONCLUSIONS For patients hospitalized following hip-fracture surgery, the level of physical activity seems extremely low the first week, but it does not seem to influence the rate of readmissions. Considering evidence supporting physical activity during acute hospitalization, the low activity level in these patients calls for action. CLINICALTRIALS.GOV-IDENTIFIER NCT05756517.
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Affiliation(s)
- Maria Swennergren Hansen
- Physical Medicine & Rehabilitation Research - Copenhagen (PMR-C), Department of Physical and Occupational Therapy, Department of Orthopedic Surgery, Department of Clinical Research, Copenhagen University Hospital, Amager and Hvidovre, Hvidovre, Denmark
| | - Morten Tange Kristensen
- Department of Physical and Occupational Therapy, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark
- Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
| | - Camilla Kampp Zilmer
- Department of Physical and Occupational Therapy, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark
| | - Anja Løve Berger
- Department of Physical and Occupational Therapy, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark
| | - Jeanette Wassar Kirk
- Department of Clinical Research, Copenhagen University Hospital, Amager and Hvidovre, Hvidovre, Denmark
- Department of Health and Social Context, National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark
| | - Kira Marie Skibdal
- Physical Medicine & Rehabilitation Research - Copenhagen (PMR-C), Department of Physical and Occupational Therapy, Department of Orthopedic Surgery, Department of Clinical Research, Copenhagen University Hospital, Amager and Hvidovre, Hvidovre, Denmark
| | - Thomas Kallemose
- Department of Clinical Research, Copenhagen University Hospital, Amager and Hvidovre, Hvidovre, Denmark
| | - Thomas Bandholm
- Physical Medicine & Rehabilitation Research - Copenhagen (PMR-C), Department of Physical and Occupational Therapy, Department of Orthopedic Surgery, Department of Clinical Research, Copenhagen University Hospital, Amager and Hvidovre, Hvidovre, Denmark
- Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
- Department of Clinical Research, Copenhagen University Hospital, Amager and Hvidovre, Hvidovre, Denmark
| | - Mette Merete Pedersen
- Physical Medicine & Rehabilitation Research - Copenhagen (PMR-C), Department of Physical and Occupational Therapy, Department of Orthopedic Surgery, Department of Clinical Research, Copenhagen University Hospital, Amager and Hvidovre, Hvidovre, Denmark
- Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
- Department of Clinical Research, Copenhagen University Hospital, Amager and Hvidovre, Hvidovre, Denmark
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22
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Ohana N, Marom O, Segal D, Behrbalk R, Ben-Sira Y, Tavdi A, Palmanovich E, Yaacobi E. Femoral Head Pathology in Subcapital Hip Fractures: Clinical Value and Cost-Effectiveness in a 230-Patient Case Series. Diagnostics (Basel) 2025; 15:234. [PMID: 39857118 PMCID: PMC11764477 DOI: 10.3390/diagnostics15020234] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/08/2024] [Revised: 01/17/2025] [Accepted: 01/18/2025] [Indexed: 01/27/2025] Open
Abstract
Background/Objectives: Osteoporotic fractures, particularly subcapital hip fractures (SCF), pose a significant healthcare and economic burden. The routine pathological examination of resected femoral heads in such cases is common practice, aimed at identifying malignancies that may have contributed to bone fragility. This study evaluated the cost-effectiveness and clinical utility of routine femoral head pathology in patients undergoing surgical treatment for SCF. Methods: A retrospective cohort study was conducted at a university-affiliated, tertiary care hospital. Patients undergoing surgical treatment for SCF between 2015 and 2018, with available femoral head pathology reports, were included. Data on demographics, prior or active malignancies, surgical procedures, and pathology results were analyzed. Results: The study included 230 patients with a mean age of 82.4 ± 14.1 years, of whom 57% were female. A total of 72 (31%) patients had a history of malignancy at the time of surgery. Pathological examination identified malignancies in eight patients (3.4%), all of whom had active malignancies at the time of admission. The most common malignancies detected were breast cancer and multiple myeloma (three cases each). None of the findings led to changes in patient management. Conclusions: The routine pathological examination of femoral heads following SCF provided a limited diagnostic yield and did not alter clinical management in this cohort. These findings suggest that routine pathology may not be cost-effective and support the adoption of selective screening approaches based on clinical risk factors such as a history of malignancy or atypical fracture presentations.
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Affiliation(s)
- Nissim Ohana
- Orthopedic Department, Meir Medical Center, Kfar Saba, Faculty of Medical and Health Sciences, Tel-Aviv University, Tel Aviv 6997801, Israel; (O.M.); (D.S.); (R.B.); (E.P.); (E.Y.)
- Department of Orthopaedic Surgery, Meir Medical Center, 59 Tchernichovsky St., Kfar Saba 4428164, Israel
| | - Omer Marom
- Orthopedic Department, Meir Medical Center, Kfar Saba, Faculty of Medical and Health Sciences, Tel-Aviv University, Tel Aviv 6997801, Israel; (O.M.); (D.S.); (R.B.); (E.P.); (E.Y.)
| | - David Segal
- Orthopedic Department, Meir Medical Center, Kfar Saba, Faculty of Medical and Health Sciences, Tel-Aviv University, Tel Aviv 6997801, Israel; (O.M.); (D.S.); (R.B.); (E.P.); (E.Y.)
| | - Refael Behrbalk
- Orthopedic Department, Meir Medical Center, Kfar Saba, Faculty of Medical and Health Sciences, Tel-Aviv University, Tel Aviv 6997801, Israel; (O.M.); (D.S.); (R.B.); (E.P.); (E.Y.)
| | - Yuval Ben-Sira
- Orthopedic Department, Shamir Medical Center (Assaf Harofeh), Faculty of Medical and Health Sciences, Tel-Aviv University, Tel Aviv 6997801, Israel;
| | - Alex Tavdi
- Orthopedic Department, Meir Medical Center, Kfar Saba, Faculty of Medical and Health Sciences, Tel-Aviv University, Tel Aviv 6997801, Israel; (O.M.); (D.S.); (R.B.); (E.P.); (E.Y.)
| | - Ezequiel Palmanovich
- Orthopedic Department, Meir Medical Center, Kfar Saba, Faculty of Medical and Health Sciences, Tel-Aviv University, Tel Aviv 6997801, Israel; (O.M.); (D.S.); (R.B.); (E.P.); (E.Y.)
| | - Eyal Yaacobi
- Orthopedic Department, Meir Medical Center, Kfar Saba, Faculty of Medical and Health Sciences, Tel-Aviv University, Tel Aviv 6997801, Israel; (O.M.); (D.S.); (R.B.); (E.P.); (E.Y.)
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23
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Urquiza M, Fernández N, Arrinda I, Espin A, García-García J, Rodriguez-Larrad A, Irazusta J. Predictors of Hospital Readmission, Institutionalization, and Mortality in Geriatric Rehabilitation Following Hospitalization According to Admission Reason. J Geriatr Phys Ther 2025; 48:5-13. [PMID: 38875011 DOI: 10.1519/jpt.0000000000000414] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 06/16/2024]
Abstract
BACKGROUND AND PURPOSE Older adults following an inpatient geriatric rehabilitation (GR) program commonly experience adverse health outcomes such as hospital readmission, institutionalization, and mortality. Although several studies have explored factors related to these outcomes, the influence of admission reason on the predictive factors of adverse health outcomes in the rehabilitation process remains unclear. Therefore, this study aimed to identify predictive factors for adverse health outcomes in inpatients attending GR according to their admission reason. METHODS This retrospective study included patients with orthogeriatric (OG) conditions and patients with hospital-associated deconditioning (HAD) admitted to GR after an acute hospitalization between 2016 and 2020. Patients were evaluated by a comprehensive geriatric assessment at admission, including sociodemographic data, social resources, clinical data, cognitive, functional and nutritional status, and physical performance measurements. Adverse health outcomes were collected (hospital readmission, institutionalization, and mortality). Univariate analyses and multivariate backward binary logistic regressions were used to determine predictive factors. RESULTS AND DISCUSSION In this study, 290 patients were admitted for OG conditions, and 122 patients were admitted due to HAD. In patients with OG conditions, lower Mini-Mental State Examination (MMSE) predicted institutionalization and mortality. Lower Mini Nutritional Assessment-Short Form predicted institutionalization, whereas lower Barthel Index and lower Tinetti-Performance-Oriented Mobility Assessment scores were associated with higher mortality. In patients with HAD, higher age-adjusted comorbidity index predicted hospital readmission and mortality, and lower Short Physical Performance Battery scores predicted institutionalization and mortality. Finally, lower MMSE scores, worse values in Older Americans Resources and Services Scale and male gender were associated with a higher risk of institutionalization. CONCLUSIONS Predictive factors for hospital readmission, institutionalization, and mortality in patients with OG conditions and HAD during GR were different. Some of those predictors, such as nutritional status and physical performance, are modifiable. Understanding predictive factors for adverse outcomes, and how these factors differ by admission diagnosis, improves our ability to identify patients most at risk. Early identification of these patients could assist with prevention efforts and lead to a reduction of negative outcomes.
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Affiliation(s)
- Miriam Urquiza
- Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Bizkaia, Spain
- Clinical Nursing and Community Health Research Group, BioCruces Health Research Institute, Barakaldo, Bizkaia, Spain
| | - Naiara Fernández
- Geriatric Department, Igurco Servicios Socio Sanitarios, Grupo IMQ, Bilbao, Spain
| | - Ismene Arrinda
- Geriatric Department, Igurco Servicios Socio Sanitarios, Grupo IMQ, Bilbao, Spain
| | - Ander Espin
- Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Bizkaia, Spain
- Clinical Nursing and Community Health Research Group, BioCruces Health Research Institute, Barakaldo, Bizkaia, Spain
| | - Julia García-García
- Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Bizkaia, Spain
- Clinical Nursing and Community Health Research Group, BioCruces Health Research Institute, Barakaldo, Bizkaia, Spain
| | - Ana Rodriguez-Larrad
- Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Bizkaia, Spain
- Clinical Nursing and Community Health Research Group, BioCruces Health Research Institute, Barakaldo, Bizkaia, Spain
| | - Jon Irazusta
- Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Bizkaia, Spain
- Clinical Nursing and Community Health Research Group, BioCruces Health Research Institute, Barakaldo, Bizkaia, Spain
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24
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Toro LÁ, González FI, Botero S, García HD, Duque G, Gómez F. Handgrip strength as a predictor of 1‑year mortality after hip fracture surgery in the Colombian Andes Mountains. Osteoporos Int 2025; 36:61-69. [PMID: 39419826 PMCID: PMC11706921 DOI: 10.1007/s00198-024-07258-3] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/05/2024] [Accepted: 09/12/2024] [Indexed: 10/19/2024]
Abstract
Hip fracture is a public health problem recognized worldwide and a potentially catastrophic threat for older persons, even carrying a demonstrated excess of mortality. Handgrip strength (HGS) has been identified as a predictor of different outcomes (mainly mortality and disability) in several groups with hip fracture. PURPOSE The aim of this study was to determine the association between low HGS and 1-year mortality in a cohort of older patients over 60 years old with fragility hip fractures who underwent surgery in the Colombian Andes Mountains. METHODS A total of 126 patients (median age 81 years, women 77%) with a fragility hip fracture during 2019-2020 were admitted to a tertiary care hospital. HGS was measured using dynamometry upon admission, and data about sociodemographic, clinical and functional, laboratory, and surgical intervention variables were collected. They were followed up until discharge. Those who survived were contacted by telephone at one, three, and 12 months. Bivariate, multivariate, and Kaplan-Meier analyses with survival curves were performed. RESULTS The prevalence of low HGS in the cohort was 71.4%, and these patients were older, had poorer functional and cognitive status, higher comorbidity, higher surgical risk, time from admission to surgery > 72 h, lower hemoglobin and albumin values, and greater intra-hospital mortality at one and three months (all p < 0.01). Mortality at one year in in patients with low HGS was 42.2% and 8.3% in those with normal HGS, with a statistically significant difference (p = 0.000). In the multivariate analysis, low HGS and dependent gait measured by Functional Ambulation Classification (FAC) were the factors affecting postoperative 1-year mortality in older adults with hip fractures. CONCLUSION In this study of older people with fragility hip fractures, low HGS and dependent gait were independent predictive markers of 1-year mortality.
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Affiliation(s)
- Luis-Ángel Toro
- Geriatrics Section, Internal Medicine and Medical Specialties Department, Hospital Pablo Tobón Uribe, Medellín, Colombia
| | - Fernando-Iván González
- Research Group on Geriatrics and Gerontology, Faculty of Health Sciences, Universidad de Caldas, Manizales, Colombia
| | - Sandra Botero
- Internal Medicine Section, Faculty of Health Sciences, Universidad de Caldas, Manizales, Colombia
| | - Hernán-David García
- Geriatrics Section, Internal Medicine and Medical Specialties Department, Hospital Pablo Tobón Uribe, Medellín, Colombia
| | - Gustavo Duque
- Department of Medicine, Dr. Joseph Kaufmann Chair in Geriatric Medicine, McGill University, Montreal, Canada
- Bone, Muscle, and Geroscience Group - Research Institute of the McGill University Health Centre, Montreal, Canada
| | - Fernando Gómez
- Research Group on Geriatrics and Gerontology, Faculty of Health Sciences, Universidad de Caldas, Manizales, Colombia.
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25
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Hovsepian SE, Zwemer CH, Halpern AI, Wu SH, Farag CM, Herur-Raman A, Ismail A, Srivastava AP, Melnyk O, Baginsky M, Kartiko S. Psoas Muscle Volume as an Indicator of Sarcopenia and Disposition in Traumatic Hip Fracture Patients. J Surg Res 2024; 304:67-73. [PMID: 39522405 DOI: 10.1016/j.jss.2024.10.005] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/29/2024] [Revised: 09/09/2024] [Accepted: 10/11/2024] [Indexed: 11/16/2024]
Abstract
INTRODUCTION Sarcopenia, or the loss of lean muscle mass, is associated with increased morbidity and mortality as well as poor surgical outcomes. The aim of our study was to utilize computed tomography imaging to obtain the total psoas volume (TPV) as a potential marker of sarcopenia. We then investigated the relationship between TPV and outcomes in surgically managed hip fracture patients, particularly their discharge disposition. METHODS A retrospective review of surgically managed hip fracture patients at a single institution level one American College of Surgeons verified trauma center between 2017 and 2022 was performed. The primary endpoint was patient disposition after hospitalization. TPV was collected via three dimension reconstruction of computed tomography images. Student's t-test was used to assess for association between TPV and demographic variables. Binary logistic regressions were performed to examine variables that could predict patient disposition among the patients. RESULTS We identified 64 surgically managed hip fracture patients, 57.8% of whom were males, with a median age of 74 (IQR: 62, 88). Black race (244.4 vs. 190.3, P = 0.032) and younger age (252.2 vs. 181.8, P = 0.004) were associated with higher TPV. Male patients with higher TPV had a higher likelihood of being discharged home as opposed to a skilled nursing or rehabilitation facility (251.3 vs. 191.1, P = 0.02). In multivariable analysis adjusting for sex, race, body mass index, and age, males with a higher TPV were more likely to be discharged home (odds ratio: 1.012; 95% confidence interval: 1.004 1.020; P = 0.028). CONCLUSIONS Psoas muscle volume can be used to predict which male patients are likely to be discharged home postoperatively after surgically managed traumatic hip fracture.
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Affiliation(s)
- Sahak E Hovsepian
- Department of Surgery, The George Washington University School of Medicine Health Sciences, Washington, District of Columbia
| | - Catherine H Zwemer
- Department of Surgery, The George Washington University School of Medicine Health Sciences, Washington, District of Columbia
| | - Alex I Halpern
- Department of Surgery, The George Washington University School of Medicine Health Sciences, Washington, District of Columbia
| | - Sophia H Wu
- Department of Surgery, The George Washington University School of Medicine Health Sciences, Washington, District of Columbia
| | - Christian M Farag
- Department of Surgery, The George Washington University School of Medicine Health Sciences, Washington, District of Columbia
| | - Aalap Herur-Raman
- Department of Surgery, The George Washington University School of Medicine Health Sciences, Washington, District of Columbia
| | - Ahmed Ismail
- Department of Surgery, The George Washington University School of Medicine Health Sciences, Washington, District of Columbia
| | - Aneil P Srivastava
- Department of Surgery, The George Washington University School of Medicine Health Sciences, Washington, District of Columbia
| | - Oleksiy Melnyk
- Department of Surgery, The George Washington University School of Medicine Health Sciences, Washington, District of Columbia
| | - Mary Baginsky
- George Washington University Hospital, Washington, District of Columbia
| | - Susan Kartiko
- Department of Surgery, The George Washington University School of Medicine Health Sciences, Washington, District of Columbia.
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26
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MacRae C, Meyer A, Mercer SW, Lone N, Dibben C, Duckworth AD, Modig K, Guthrie B. Impact of household characteristics on patient outcomes post hip fracture: a Welsh nationwide observational cohort study. BMC Public Health 2024; 24:3344. [PMID: 39616325 PMCID: PMC11607986 DOI: 10.1186/s12889-024-20766-5] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/01/2023] [Accepted: 11/15/2024] [Indexed: 12/06/2024] Open
Abstract
BACKGROUND Hip fracture is common in older people and has significant health and care implications. This study aimed to examine the impact of household characteristics (living alone or living with someone who is themselves ill) on adverse outcomes following hip fracture. METHODS A cohort study of hip fracture patients aged ≥ 50 years living alone or with one co-resident using Welsh nationwide data between January 2013 and December 2018. Outcomes were emergency hospital admission within 30 days and care-home admission and mortality within one year of hospital discharge. Analysis used cause-specific Cox proportional hazards models to examine associations with living alone and with co-resident chronic disease status. RESULTS Of the 12,089 hip fracture patients discharged, 56.0% lived alone. Compared to hip fracture patients living with a co-resident, those living alone were more commonly women (78.4% versus 65.2%), older (mean 83.1 versus 78.5 years), and had more long-term conditions (mean 5.7 versus 5.3). In unadjusted analyses, compared to living with a co-resident with 0-1 long-term condition and no dementia, living alone (hazard ratio [HR] 1.44, 95%CI 1.23-1.68), living with someone with dementia (HR 1.57, 95%CI 1.07-2.30), and living with someone with 4 + physical long-term conditions (HR 1.24, 95%CI 1.03-1.49) were associated with an increase in mortality, but no significant association was found in adjusted analysis. Adjusted for age, sex, socioeconomic position, and long-term condition count of the hip fracture patient, living alone (adjusted HR [aHR] 2.26, 95%CI 1.81-2.81) and living with a co-resident with dementia (aHR 2.38, 95%CI 1.59-3.57) were both associated with more than double the risk of care home admission. There were no significant associations with 30-day hospital admission. CONCLUSIONS Hip fracture patients who live alone have higher one-year mortality, but associations are explained by the demographic and clinical characteristics of those living alone. However, living alone or living with a co-resident with dementia was independently associated with an additional doubling of the risk of care home admission. Household-based approaches to research and health policy may help target risk groups following hip fracture community discharge and further research is needed to understand the mechanisms by which these associations act.
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Affiliation(s)
- Clare MacRae
- Advanced Care Research Centre, University of Edinburgh, Bio Cube 1, Edinburgh BioQuarter, 13 Little France Road, Edinburgh, EH16 4UX, UK.
- Usher Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK.
- Unit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
| | - Anna Meyer
- Unit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
| | - Stewart W Mercer
- Advanced Care Research Centre, University of Edinburgh, Bio Cube 1, Edinburgh BioQuarter, 13 Little France Road, Edinburgh, EH16 4UX, UK
- Usher Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK
| | - Nazir Lone
- Usher Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK
| | - Chris Dibben
- Institute of Geography Edinburgh, University of Edinburgh Institute of Geography, Edinburgh, UK
| | - Andrew D Duckworth
- Usher Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK
- Edinburgh Orthopaedics, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, Midlothian, EH16 4SA, UK
| | - Karin Modig
- Unit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
| | - Bruce Guthrie
- Advanced Care Research Centre, University of Edinburgh, Bio Cube 1, Edinburgh BioQuarter, 13 Little France Road, Edinburgh, EH16 4UX, UK
- Usher Institute, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK
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27
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Wu CY, Tsai CF, Hsu YH, Yang HY. Exploring mortality risk factors and specific causes of death within 30 days after hip fracture hospitalization. Sci Rep 2024; 14:27544. [PMID: 39528781 PMCID: PMC11555071 DOI: 10.1038/s41598-024-79297-z] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/21/2024] [Accepted: 11/07/2024] [Indexed: 11/16/2024] Open
Abstract
This study examined the sex-specific mortality risk and causes of death soon after hip fracture in Taiwan. The objective of this study was to evaluate the 30-day mortality risk and cause of death in patients with hip fracture and identify its associated risk factors. We conducted a retrospective cohort study using data from the National Health Insurance Research Database in Taiwan from 2000 to 2015. This study included patients aged 50 years or older who were admitted to a hospital with a hip fracture diagnosis for the first time. Of 285,891 patients hospitalized for their first hip fracture, 8,505 (2.98%) died within 30 days. The mortality risk of hip fracture declined from 3.76% in 2000 to 2.92% in 2015. Circulatory system diseases like ischemic heart disease and cerebrovascular disease were the most common cause of death and accounted for 22% of deaths within 30 days after fracture. Accidents and unintentional injuries caused 18% of deaths, followed by malignant neoplasms in 10% of deaths. Multivariate Cox regression identified older age, male sex, higher Charlson Comorbidity Index (CCI), suburban or rural residence, and lower income as risk factors for hip fracture mortality. The 30-day mortality risk of hip fractures has decreased but remains correlated with male sex, older age, and comorbidities. Circulatory diseases were the main cause of death. Early identification and treatment by experienced clinicians may optimize outcomes, minimize complications, and reduce mortality risk in the 30 days following hip fracture.
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Affiliation(s)
- Cheng-Yi Wu
- Department of Orthopedics, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City, 600, Taiwan
- Osteoporosis Center, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City, 600, Taiwan
| | - Ching-Fang Tsai
- Clinical Data Center, Ditmanson Medical Foundation Chia-Yi Christian Hospital, No. 539, Zhongxiao Rd., East District, Chiayi City, 600, Taiwan
| | - Yueh-Han Hsu
- Department of Medical Research, China Medical University Hospital and China Medical University, Taichung, 404, Taiwan
- Division of Nephrology, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi City, 600, Taiwan
- Department of Nursing, Min-Hwei College of Health Care Management, Tainan, 736, Taiwan
| | - Hsin-Yi Yang
- Clinical Data Center, Ditmanson Medical Foundation Chia-Yi Christian Hospital, No. 539, Zhongxiao Rd., East District, Chiayi City, 600, Taiwan.
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Chen Y, Liu G, Zhang J, Ge Y, Tan Z, Peng W, Gao F, Tu C, Tian M, Yang M, Wu X. Prognostic Nutritional Index (PNI) as an Independent Predictor of 3-Year Postoperative Mortality in Elderly Patients with Hip Fracture: A Post hoc Analysis of a Prospective Cohort Study. Orthop Surg 2024; 16:2761-2770. [PMID: 39142664 PMCID: PMC11541133 DOI: 10.1111/os.14200] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/03/2024] [Revised: 07/26/2024] [Accepted: 07/29/2024] [Indexed: 08/16/2024] Open
Abstract
OBJECTIVE The prognostic nutritional index (PNI) has been reported as a significant predictor in various diseases. However, the prognostic value of the PNI in geriatric hip fracture patients has not been thoroughly evaluated. This study aimed to investigate the association between admission PNI and 3-year mortality in those patients. METHODS In this post hoc analysis, we included patients aged ≥65 years who underwent surgery for hip fracture between 2018 and 2019. The admission PNI was calculated as serum albumin (g/L) +5 × total lymphocyte count (×109/L). Patients were categorized into four groups based on PNI quartiles (≤ 43.55, 43.55-46.55, 46.55-49.20, and >49.20, respectively). The median follow-up duration was 3.1 years. Cox proportional hazards models were used to calculate the hazard ratio (HR). Receiver operating characteristic curve (ROC) was conducted for using PNI to predict mortality. RESULTS Of the 942 eligible patients, 190 (20.2%) patients died during the follow-up. Compared to patients in the first quartile (Q1), those in the second (Q2), third (Q3), and fourth (Q4) quartiles had significantly lower mortality risks (HRs 0.50, 95% CI 0.35-0.74; 0.41, 95% CI 0.26-0.64; and 0.26, 95% CI 0.15-0.45, respectively). The optimal cutoff of PNI for predicting mortality was set as 45.275 (sensitivity, 0.674; specificity, 0.692; area under the curve (AUC), 0.727). Patients with higher PNI (>45.275) had a significant lower mortality risk (HR 0.39, 95% CI 0.28-0.55) compared to those with lower PNI (≤ 45.275). CONCLUSION PNI is a reliable and independent predictor of 3-year mortality after hip fracture surgery in the elderly.
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Affiliation(s)
- Yimin Chen
- Peking University Fourth School of Clinical MedicineBeijingChina
- Department of Orthopedics and TraumatologyBeijing Jishuitan Hospital, Capital Medical UniversityBeijingChina
- National Center for OrthopaedicsBeijingChina
| | - Gang Liu
- Peking University Fourth School of Clinical MedicineBeijingChina
- Department of Orthopedics and TraumatologyBeijing Jishuitan Hospital, Capital Medical UniversityBeijingChina
- National Center for OrthopaedicsBeijingChina
| | - Jing Zhang
- School of Public Health, Harbin Medical UniversityHarbinChina
| | - Yufeng Ge
- Peking University Fourth School of Clinical MedicineBeijingChina
- Department of Orthopedics and TraumatologyBeijing Jishuitan Hospital, Capital Medical UniversityBeijingChina
- National Center for OrthopaedicsBeijingChina
| | - Zhelun Tan
- Peking University Fourth School of Clinical MedicineBeijingChina
- Department of Orthopedics and TraumatologyBeijing Jishuitan Hospital, Capital Medical UniversityBeijingChina
- National Center for OrthopaedicsBeijingChina
| | - Weidong Peng
- Peking University Fourth School of Clinical MedicineBeijingChina
- Department of Orthopedics and TraumatologyBeijing Jishuitan Hospital, Capital Medical UniversityBeijingChina
- National Center for OrthopaedicsBeijingChina
| | - Feng Gao
- Peking University Fourth School of Clinical MedicineBeijingChina
- Department of Orthopedics and TraumatologyBeijing Jishuitan Hospital, Capital Medical UniversityBeijingChina
- National Center for OrthopaedicsBeijingChina
| | - Chao Tu
- Peking University Fourth School of Clinical MedicineBeijingChina
- Department of Orthopedics and TraumatologyBeijing Jishuitan Hospital, Capital Medical UniversityBeijingChina
- National Center for OrthopaedicsBeijingChina
| | - Maoyi Tian
- School of Public Health, Harbin Medical UniversityHarbinChina
- The George Institute for Global Health, University of New South WalesSydneyNSWAustralia
| | - Minghui Yang
- Peking University Fourth School of Clinical MedicineBeijingChina
- Department of Orthopedics and TraumatologyBeijing Jishuitan Hospital, Capital Medical UniversityBeijingChina
- National Center for OrthopaedicsBeijingChina
| | - Xinbao Wu
- Peking University Fourth School of Clinical MedicineBeijingChina
- Department of Orthopedics and TraumatologyBeijing Jishuitan Hospital, Capital Medical UniversityBeijingChina
- National Center for OrthopaedicsBeijingChina
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29
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Goodman M, Pillai A. A Comparative Analysis of Age, BMI, Age/BMI Ratio, Nottingham Hip Fracture Score, and American Society of Anesthesiologists (ASA) Grade as Predictors of 30-Day Mortality After Neck of Femur Fractures: A Retrospective Cohort Study. Cureus 2024; 16:e73021. [PMID: 39640110 PMCID: PMC11617786 DOI: 10.7759/cureus.73021] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 11/04/2024] [Indexed: 12/07/2024] Open
Abstract
Background and objective Hip fracture is a condition associated with high mortality rates, necessitating the use of risk assessment tools to optimise patient care. This study aimed to introduce and describe a novel score using Age/BMI as an improved predictor of 30-day mortality Methods A retrospective cohort study was conducted at a high-volume neck of the femur centre. Data from 574 patients treated over one year were collected and analysed. Multivariate logistic regression analysis was used to determine variables that significantly increased the risk of 30-day mortality. Results A total of 574 patients were identified: 388 females and 186 males. The overall mortality of the patient cohort at the time of data collection was 21.78% (n=125). The 30-day mortality was found to be 5.75% (n=33) while the one-year mortality rate was 21.08% (n=121). The key risk factors for mortality in neck of femur fractures, highlighted in the literature review, were compared against the binomial outcome variable of 30-day mortality. Categorical data analysis was first completed to highlight key trends. A regression analysis then demonstrated the significance of each factor. Age (p=0.75207), BMI (p=0.97674), and Age/BMI (p=0.92205) showed no statistical significance. The Nottingham Hip Fracture Score (NHFS) was marginally significant (p=0.05749). The American Society of Anesthesiologists (ASA) grade was shown to be statistically significant, emerging as the strongest predictor of 30-day mortality (p=0.00953). Conclusions Our findings show that current guidelines utilising ASA and NHFS are excellent predictors of 30-day mortality in hip fracture patients. The proposed Age/BMI score did not demonstrate efficacy in this cohort. Further research is warranted to explore alternative predictors and enhance risk assessment in this population.
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Affiliation(s)
- Matthew Goodman
- Trauma and Orthopaedics, University of Manchester, Manchester, GBR
| | - Anand Pillai
- Trauma and Orthopaedics, Wythenshawe Hospital, Manchester, GBR
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30
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Song SK, Hwang JH, Bae JW, Oh HK, Cho MR. Relationship between histological findings of vastus lateralis muscle and function after total hip arthroplasty in patients with hip fracture: a prospective cohort study. Acta Orthop 2024; 95:612-618. [PMID: 39466193 PMCID: PMC11519523 DOI: 10.2340/17453674.2024.42099] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/09/2024] [Accepted: 09/20/2024] [Indexed: 10/29/2024] Open
Abstract
BACKGROUND AND PURPOSE We aimed to examine the histological characteristics of vastus lateralis muscles in patients undergoing total hip arthroplasty (THA) following femoral neck fractures and to explore the correlation between muscle fiber types and postoperative functional recovery. METHODS 34 patients undergoing THA for femoral neck fractures were included. A biopsy of the vastus lateralis muscle was performed during surgery, followed by immunohistochemical staining. Subsequently, image analysis was conducted to measure the average area of muscle fiber types and the number of type I and II muscle fibers, and the ratio of the area and the number of type II muscle fibers. Functional recovery was assessed 2 weeks post-surgery using the Short Physical Performance Battery (SPPB). RESULTS A significant positive correlation was observed between type II muscle fibers and SPPB scores. The ratio of type II muscle fiber area and number strongly correlated with the SPPB scores, indicating a robust static association. The average area of type II fibers showed a strong correlation (r = 0.63, P < 0.001), as did the number of type II fibers (r = 0.53, P = 0.001). Moreover, the ratio of type II muscle fiber area and number significantly correlated with SPPB scores (area: r = 0.77, P < 0.001; number: r = 0.51, P = 0.002), indicating that larger and more numerous type II fibers are associated with better physical performance. CONCLUSION The reduction of type II muscle fibers was strongly correlated with a low SPPB postoperative functional recovery in patients who underwent THA following femoral neck fractures.
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Affiliation(s)
- Suk-Kyoon Song
- Department of Orthopaedic Surgery, Daegu Catholic University Medical Center, South Korea
| | - Ji-Hyun Hwang
- College of Medicine, Daegu Catholic University, South Korea
| | - Jin-Woo Bae
- Department of Orthopaedic Surgery, Daegu Catholic University Medical Center, South Korea
| | - Hoon-Kyu Oh
- Department of Pathology, Daegu Catholic University Medical Center, South Korea.
| | - Myung-Rae Cho
- Department of Orthopaedic Surgery, Daegu Catholic University Medical Center, South Korea
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Martín-Nieto A, Chana-Valero P, Ruiz-Tovar J, Escobar-Aguilar G, Simarro-González M, Rodríguez-Bernal P, García-García E. Nutritional Status Impact on Hip Fracture Patients in a Rural Environment. Nutrients 2024; 16:3622. [PMID: 39519455 PMCID: PMC11547679 DOI: 10.3390/nu16213622] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/02/2024] [Revised: 10/15/2024] [Accepted: 10/23/2024] [Indexed: 11/16/2024] Open
Abstract
(1) Background: Hip fractures are highly prevalent traumatic events with significant functional consequences, particularly among the older population. These fractures are associated with increased mortality, postoperative complications, and functional dependence. Medical and nutritional factors such as malnutrition and sarcopenia are crucial for predicting functional outcomes and mortality in these patients. This study aimed to assess the nutritional status, vitamin D levels, and sarcopenia, as well as their relationship with mortality, mean hospital stay, and 30-day-readmission rate, in patients with hip fracture who underwent surgery in a rural hospital setting. (2) Methods: A longitudinal retrospective study involving 124 patients who underwent hip fracture surgery in 2021 was conducted. Sociodemographic, surgical, and nutritional data, including vitamin D, albumin, and blood urea nitrogen (BUN) levels, were collected. (3) Results: The average age of the sample was 89.1 years, with a postoperative 30-day-mortality rate of 8.1% and an average hospital stay of 10.4 days. Vitamin D deficiency was present in 79.7% of patients, and a high prevalence of malnutrition was indicated by low albumin and elevated BUN levels. Elevated BUN levels and low vitamin D levels were associated with higher mortality. (4) Conclusions: Adequate nutritional assessment in patients with hip fracture is vital for identifying the risks of complications and mortality. Understanding the current nutritional status and its associated complications will aid in developing strategies to improve health and reduce complications in the future.
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Affiliation(s)
- Ana Martín-Nieto
- San Juan de Dios Foundation, 28036 Madrid, Spain; (A.M.-N.); (P.C.-V.); (G.E.-A.); (M.S.-G.); (E.G.-G.)
- Health Sciences Department, San Juan de Dios School of Nursing and Physical Therapy, Comillas Pontifical University, 28036 Madrid, Spain
| | - Pedro Chana-Valero
- San Juan de Dios Foundation, 28036 Madrid, Spain; (A.M.-N.); (P.C.-V.); (G.E.-A.); (M.S.-G.); (E.G.-G.)
- Health Sciences Department, San Juan de Dios School of Nursing and Physical Therapy, Comillas Pontifical University, 28036 Madrid, Spain
| | - Jaime Ruiz-Tovar
- San Juan de Dios Foundation, 28036 Madrid, Spain; (A.M.-N.); (P.C.-V.); (G.E.-A.); (M.S.-G.); (E.G.-G.)
- Health Sciences Department, San Juan de Dios School of Nursing and Physical Therapy, Comillas Pontifical University, 28036 Madrid, Spain
| | - Gema Escobar-Aguilar
- San Juan de Dios Foundation, 28036 Madrid, Spain; (A.M.-N.); (P.C.-V.); (G.E.-A.); (M.S.-G.); (E.G.-G.)
- Health Sciences Department, San Juan de Dios School of Nursing and Physical Therapy, Comillas Pontifical University, 28036 Madrid, Spain
| | - María Simarro-González
- San Juan de Dios Foundation, 28036 Madrid, Spain; (A.M.-N.); (P.C.-V.); (G.E.-A.); (M.S.-G.); (E.G.-G.)
- Health Sciences Department, San Juan de Dios School of Nursing and Physical Therapy, Comillas Pontifical University, 28036 Madrid, Spain
| | | | - Elena García-García
- San Juan de Dios Foundation, 28036 Madrid, Spain; (A.M.-N.); (P.C.-V.); (G.E.-A.); (M.S.-G.); (E.G.-G.)
- Health Sciences Department, San Juan de Dios School of Nursing and Physical Therapy, Comillas Pontifical University, 28036 Madrid, Spain
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Nguyen BTT, Huang SW, Kuo YJ, Nguyen TT, Chen YP. The Second Hip Fracture is not an Independent Predictor of Poor Outcomes in Elderly Patients - A Case-Control Study. Geriatr Orthop Surg Rehabil 2024; 15:21514593241293645. [PMID: 39444567 PMCID: PMC11497524 DOI: 10.1177/21514593241293645] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/11/2023] [Revised: 08/19/2024] [Accepted: 10/05/2024] [Indexed: 10/25/2024] Open
Abstract
Introduction Hip fracture is particularly seen in elderly patients with frailty and osteoporosis and leads to diminished functional independence and quality of life. Despite the susceptibility of these patients to a second hip fracture (SHF), the literature insufficiently discussed its impact leading to poor outcomes. This study aims to directly assess the outcomes of elderly patients with initial hip fractures (IHF) vs those experiencing an SHF within a well-matched group with similar characteristics. Materials and Methods This case-control study gathered data from the clinical hip fracture registry at a medical center from 2019 to 2022. Patients with SHF were matched with those with IHF in a 1:2 ratio according to the similarity of age, sex, and Charlson Comorbidity Index classification. Demographics at admission, baseline characteristics, and 1-year postoperative outcome were compared between the SHF and IHF groups. Results Thirty-two SHF patients were matched with 64 IHF patients (81.25% of women, median age of 86 years). Anthropometric measurements and socioeconomic factors were not significantly different between the two groups. No differences in baseline characteristics were observed, except IHF patients had a significantly lower T-score than SHF patients (-3.98 vs. -3.31, P = 0.016). At one-year follow-up, despite a notable decrease in Barthel Index scores and an uptick in EQ-5D measures among the patients, the IHF and SHF groups demonstrated similar quality of life and a high level of activities of daily living. Discussions In this case-control study, after matching for age, sex, and comorbidities, an SHF did not indicate poorer outcomes than an IHF, providing a more optimistic outlook for the patients and healthcare providers. Conclusion Despite the significant challenges presented by hip fracture, the one-year postoperative outcomes did not differ between IHF and SHF patients, suggesting that SHF is not an independent predictor of poor outcomes following hip fracture in the elderly population.
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Affiliation(s)
- Bao Tu Thai Nguyen
- The International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
- Department of Orthopedics, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam
| | - Shu-Wei Huang
- Graduate Institute of Health and Biotechnology Law, Taipei Medical University, Taipei, Taiwan
| | - Yi-Jie Kuo
- Department of Orthopedics, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
- Deparment of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
| | - Tan Thanh Nguyen
- Department of Orthopedics, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam
| | - Yu-Pin Chen
- Department of Orthopedics, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
- Deparment of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
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Eiter A, Kellerer JD. Long-term Outcomes in Orthogeriatric Co-management: a Literature Review. ZEITSCHRIFT FUR ORTHOPADIE UND UNFALLCHIRURGIE 2024; 162:504-509. [PMID: 37699512 DOI: 10.1055/a-2134-5803] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 09/14/2023]
Abstract
Fragility fractures of the hip are one of the most important triggers of poor health outcomes in older adults. They often result in limitations in the ability of patients to care for themselves and mortality remains high. Orthogeriatric co-management may improve outcomes for this high-risk population. However, the impact on long-term results has not yet been definitively clarified. The purpose of this study was to present the influence of orthogeriatric co-management on mortality and self-care ability, as measured by the Barthel score, one year after hip fracture in people ≥ 60 years.A systematic literature search was performed in accordance with the process steps of identification, selection, and evaluation, with a systematic search of the MEDLINE, CINAHL Complete and Cochrane Library databases in the period from February to March 2022. Articles in English and German published between 2012 and 2022 were included. Twelve studies were finally used.Six studies demonstrated a statistically significant reduction in the one-year mortality rate. Only one of four studies evaluating self-care ability showed a significant improvement when the patient was treated on a specialised ward.Orthogeriatric co-management seems to be beneficial in positively influencing one-year mortality and self-care ability. In view of the heterogeneous results, the implementation of this care model can only be recommended to a limited extent.
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Affiliation(s)
- Andrea Eiter
- Institut für Pflegewissenschaft und Gerontologie, UMIT Tirol - Privatuniversität für Gesundheitswissenschaften und -technologie GmbH, Hall in Tirol, Österreich
| | - Jan Daniel Kellerer
- Institut für Pflegewissenschaft und Gerontologie, UMIT Tirol - Privatuniversität für Gesundheitswissenschaften und -technologie GmbH, Hall in Tirol, Österreich
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Sasaki K, Takahashi Y, Toyama M, Ueshima H, Ohura T, Okabayashi S, Shimamoto T, Tateyama Y, Ikeuchi H, Murakami J, Furuita N, Kato G, Iwami T, Nakayama T. Implementation status of postoperative rehabilitation for older patients with hip fracture in Kyoto City, Japan: A population-based study using medical and long-term care insurance claims data. PLoS One 2024; 19:e0307889. [PMID: 39264933 PMCID: PMC11392384 DOI: 10.1371/journal.pone.0307889] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/22/2024] [Accepted: 09/02/2024] [Indexed: 09/14/2024] Open
Abstract
Continuing rehabilitation after hip fractures is recommended to improve physical function and quality of life. However, the long-term implementation status of postoperative rehabilitation is unclear. This study aims to investigate the implementation status of postoperative rehabilitation for older patients with hip fractures and the factors associated with continuing rehabilitation. A retrospective cohort study evaluated medical and long-term care insurance claims data of patients aged 75 years or older in Kyoto City, Japan, who underwent hip fracture surgeries from April 2013 to October 2018. We used logistic regression analysis to examine factors associated with six-month rehabilitation continuation. Of the 8,108 participants, 8,037 (99%) underwent rehabilitation the first month after surgery, but only 1,755 (22%) continued for six months. The following variables were positively associated with continuing rehabilitation for six months: males (adjusted odds ratio: 1.41 [95% confidence interval: 1.23-1.62]), an intermediate frailty risk (1.50 [1.24-1.82]), high frailty risk (2.09 [1.69-2.58]) estimated using the hospital frailty risk scores, and preoperative care dependency levels: support level 1 (1.69 [1.28-2.23]), support level 2 (2.34 [1.88-2.90]), care-need level 1 (2.04 [1.68-2.49]), care-need level 2 (2.42 [2.04-2.89]), care-need level 3 (1.45 [1.19-1.76]), care-need level 4 (1.40 [1.12-1.75]), and care-need level 5 (1.31 [0.93-1.85]). In contrast, dementia was cited as a disincentive (0.53 [0.45-0.59]). Less than 30% of older patients continued rehabilitation for six months after surgery. Factors associated with continuing rehabilitation were male sex, higher frailty risk, care dependency before hip fracture surgeries, and non-dementia.
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Affiliation(s)
- Kosuke Sasaki
- Department of Health Informatics, School of Public Health, Graduate School of Medicine, Kyoto University, Kyoto, Japan
| | - Yoshimitsu Takahashi
- Department of Health Informatics, School of Public Health, Graduate School of Medicine, Kyoto University, Kyoto, Japan
| | - Mayumi Toyama
- Department of Health Informatics, School of Public Health, Graduate School of Medicine, Kyoto University, Kyoto, Japan
| | - Hiroaki Ueshima
- Center for Innovative Research and Education in Data Science, Institute for Liberal Arts and Sciences, Kyoto University, Kyoto, Japan
| | - Tomoko Ohura
- Department of Health Informatics, School of Public Health, Graduate School of Medicine, Kyoto University, Kyoto, Japan
- Evidence-based Long-term Care Team, Center for Gerontology and Social Science, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan
| | - Satoe Okabayashi
- Agency for Health, Safety and Environment, Kyoto University, Kyoto, Japan
| | - Tomonari Shimamoto
- Department of Preventive Services, School of Public Health, Graduate School of Medicine, Kyoto University, Kyoto, Japan
| | - Yukiko Tateyama
- Department of Preventive Services, School of Public Health, Graduate School of Medicine, Kyoto University, Kyoto, Japan
| | - Hiroko Ikeuchi
- Department of Preventive Services, School of Public Health, Graduate School of Medicine, Kyoto University, Kyoto, Japan
| | - Junichi Murakami
- Department of Orthopaedic Surgery, Kyoto Min-iren Chuo Hospital, Kyoto, Japan
| | - Noriko Furuita
- Department of Obstetrics and Gynecology, Kyoto Min-iren Chuo Hospital, Kyoto, Japan
| | - Genta Kato
- Department of Hospital Ward Management, Kyoto University Hospital, Kyoto, Japan
| | - Taku Iwami
- Department of Preventive Services, School of Public Health, Graduate School of Medicine, Kyoto University, Kyoto, Japan
| | - Takeo Nakayama
- Department of Health Informatics, School of Public Health, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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Phruetthiphat OA, Lawanprasert A, Satravaha Y, Pinijprapa P, Songpatanasilp T, Pongchaiyakul C. Nine-year survival after intertrochanteric fracture in elderly with chronic kidney disease. Sci Rep 2024; 14:20912. [PMID: 39245762 PMCID: PMC11381514 DOI: 10.1038/s41598-024-72140-5] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/16/2024] [Accepted: 09/04/2024] [Indexed: 09/10/2024] Open
Abstract
The outcome of this study was to identify 9-year survivors of intertrochanteric fracture at each stage of chronic kidney disease (CKD) and to investigate the risk factors associated with mortality following surgery with proximal femoral nail anti-rotation (PFNA). 443 elderly intertrochanteric fractures underwent PFNA fixation were recruited. Mortality rate was identified until 9 years. We compared the survival time of hip fracture in each stage of CKD. A regression analysis was used to determine the association between risk factors and one-year mortality. The overall median survival time was 7.1 years. The Kaplan-Meier curve was significantly different in each CKD stage especially in CKD5. In addition, the incidence rate of mortality was highest in CKD 5 (17.4%) and the median survival time in CKD 5 was 3.3 years. The multivariate analysis demonstrated that heart disease, operative time > 60 min, presence of pulmonary embolism, and poor to fair Harris hip score were significantly increased mortality. CKD stage 5 is associated with the highest mortality rate and the shortest median time of survival during the 9-year follow up. Patients who have high risk should focus on long-term care planning, including the counseling for their healthcare providers and families.
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Affiliation(s)
- Ong-Art Phruetthiphat
- Department of Orthopaedics, Phramongkutklao Hospital and College of Medicine, 315 Ratchawidhi Rd, Thung Phaya Thai, Ratchathewi, Bangkok, 10400, Thailand.
| | | | - Yodhathai Satravaha
- Department of Orthodontics, Faculty of Dentistry, Mahidol University, Bangkok, Thailand
| | - Panukorn Pinijprapa
- Department of Orthopaedics, Phramongkutklao Hospital and College of Medicine, 315 Ratchawidhi Rd, Thung Phaya Thai, Ratchathewi, Bangkok, 10400, Thailand
| | - Thawee Songpatanasilp
- Department of Orthopaedics, Phramongkutklao Hospital and College of Medicine, 315 Ratchawidhi Rd, Thung Phaya Thai, Ratchathewi, Bangkok, 10400, Thailand
| | - Chatlert Pongchaiyakul
- Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
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Azevedo SF, Mazeda C, Silva SP, Barcelos A. Two-Year Mortality Predictors in Fragility Fractures-A Medical Records Review Study. J Clin Rheumatol 2024; 30:239-242. [PMID: 38956644 DOI: 10.1097/rhu.0000000000002087] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 07/04/2024]
Abstract
PURPOSE To evaluate two-year mortality predictors in all subtypes of fragility fractures. METHODS Medical records review, single-center study with Portuguese patients with fragility fractures; A univariate analysis, with chi-square for categorical variables and parametric t-student and non-parametric Wilcoxon tests for continuous variables, was performed. Posteriorly, a survival analysis, with subsequent Cox regression was conducted to establish independent risk factors/ predictors of two-year mortality in fragility fractures. RESULTS 758 patients were enrolled in the study. We found a total of 151 deaths within the first two years post-fracture. On Cox regression, older age [OR1.10 CI (1.05-1.11)], male sex [OR1.85 CI(1.24-2.75)], anemia at baseline [OR2.44 CI(1.67-3.57)], malignancy [OR4.68 CI (2.13-10.27)], and multimorbidity [OR1.78 CI(1.11-2.87)] were found as independent predictors for two-year post-fracture mortality. CONCLUSION Our study suggests that male sex, older age, anemia, malignancy, and multimorbidity are mortality predictors in the first two years after fragility fractures, reinforcing the importance of comorbidity management in preventing or, at least, minimizing adverse outcomes following fragility fractures.
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Janghala A, Niknam K, Freshman R, Cogan CJ, Zhang AL, Lansdown D. Effect of Obesity on Short- and Long-Term Complications After Ankle Fracture Fixation. J Orthop Trauma 2024; 38:e312-e317. [PMID: 39150303 DOI: 10.1097/bot.0000000000002849] [Citation(s) in RCA: 2] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/13/2024] [Indexed: 08/17/2024]
Abstract
OBJECTIVES This study evaluated the relationship between obesity and postoperative complications in patients undergoing ankle open reduction internal fixation (ORIF). METHODS DESIGN Retrospective cohort study. SETTING PearlDiver-Mariner All-Payor Database. PATIENT SELECTION CRITERIA Patients who underwent ankle ORIF from 2010 to 2021 and had a minimum of 2 years of follow-up were identified using Current Procedural Terminology, ICD-9, and ICD-10 codes. OUTCOME MEASURES AND OUTCOMES Patients were stratified by body mass index into nonobese, obese, morbidly obese, and super-obese groups. Complication rates, including 90-day readmissions, infection, and post-traumatic osteoarthritis, were compared between obesity groups. Patients were additionally compared with a 1:1 matched analysis that controlled for demographics and comorbidities. RESULTS A total of 160,415 patients undergoing ankle ORIF from 2010 to 2021 were identified. The cohort consisted mostly of females (64.8%) and the average age was 52.5 (SD 18.4) years. There were higher rates of 90-day readmissions, UTIs, DVT/PE, pneumonia, superficial infections, and acute kidney injuries in patients with increasing levels of obesity (P < 0.001). There were increased odds of nonunion and post-traumatic arthritis in the matched analysis at 2 years in the obesity group [OR: 2.36, 95% confidence interval (CI): 1.68-3.31, P < 0.001; OR: 2.18, 95% CI: 1.77-2.68, P < 0.001, respectively]. CONCLUSIONS Postoperative medical complication rates in patients undergoing ankle ORIF, including infection, are higher in obese patients, even in the 1:1 matched analysis that controlled for demographic and comorbidity factors. Rates of nonunion and post-traumatic arthritis were higher in obese patients, as well. As such, it is important for surgeons to provide appropriate education regarding the risks after ankle ORIF in patients with obesity. LEVEL OF EVIDENCE Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
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Affiliation(s)
- Abhinav Janghala
- Department of Orthopaedic Surgery, University of California-San Francisco, San Francisco, CA
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Pehkonen M, Luukkaala TH, Hongisto MT, Nuotio MS. Elevated Albumin-Corrected Calcium Predicts Mortality in Older Hip Fracture Patients. J Am Med Dir Assoc 2024; 25:105127. [PMID: 38972333 DOI: 10.1016/j.jamda.2024.105127] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/15/2024] [Revised: 05/30/2024] [Accepted: 05/31/2024] [Indexed: 07/09/2024]
Affiliation(s)
- Matias Pehkonen
- Department of Geriatric Medicine, Turku University Hospital and University of Turku, Turku, Finland.
| | - Tiina H Luukkaala
- Research, Development and Innovation Center, Tampere University Hospital, Tampere, Finland; Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland
| | - Markus T Hongisto
- Division of Orthopaedics and Traumatology, Seinäjoki Central Hospital, Wellbeing Services County of South Ostrobothnia, Seinäjoki, Finland; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
| | - Maria S Nuotio
- Department of Geriatric Medicine, Turku University Hospital and University of Turku, Turku, Finland
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Chen Y, Tu C, Liu G, Peng W, Zhang J, Ge Y, Tan Z, Bei M, Gao F, Tian M, Yang M, Wu X. Association between admission inflammatory indicators and 3-year mortality risk in geriatric patients after hip fracture surgery: a retrospective cohort study. Front Surg 2024; 11:1440990. [PMID: 39229251 PMCID: PMC11368716 DOI: 10.3389/fsurg.2024.1440990] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/30/2024] [Accepted: 08/06/2024] [Indexed: 09/05/2024] Open
Abstract
Background Recent research indicates that the monocyte lymphocyte ratio (MLR), neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), C-reactive protein (CRP), and systemic immune-inflammation index (SII) may serve as valuable predictors of early postoperative mortality in elderly individuals with hip fractures. The primary objective of the study was to examine the association between preoperative MLR, NLR, PLR, CRP, and SII levels and 3-year mortality risk in geriatric patients after hip fracture surgery. Patients and methods The study included patients aged 65 years or older who underwent hip fracture surgery between November 2018 and November 2019. Admission levels of MLR, NLR, PLR, CRP, and SII were measured. The median follow-up period was 3.1 years. Cox proportional hazards models were used to calculate the hazard ratio (HR) for mortality with adjusting for potential covariates. Time-dependent receiver operating characteristic (ROC) curves were employed to assess the predictive capability of inflammatory indicators for mortality. Results A total of 760 patients completed the follow-up (79.4 ± 7.8 years, 71.1% female). A higher preoperative MLR was found to be significantly associated with an increased 3-year postoperative mortality risk (HR 1.811, 95% CI 1.047-3.132, P = 0.034). However, no significant correlations were observed between preoperative NLR, PLR, CRP, SII and 3-year mortality. The areas under the ROC curve (AUCs) of MLR for predicting 30-day, 120-day, 1-year, and 3-year mortality were 0.74 (95% CI 0.53-0.95), 0.70 (95% CI 0.57-0.83), 0.67 (95% CI 0.60-0.74), and 0.61 (95% CI 0.56-0.66), respectively. Conclusion Preoperative MLR is a useful inflammatory marker for predicting 3-year mortality in elderly hip fracture patients, but its predictive ability diminishes over time.
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Affiliation(s)
- Yimin Chen
- Peking University Fourth School of Clinical Medicine, Beijing, China
- Department of Orthopaedics and Traumatology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China
- National Center for Orthopaedics, Beijing, China
| | - Chao Tu
- Peking University Fourth School of Clinical Medicine, Beijing, China
- Department of Orthopaedics and Traumatology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China
- National Center for Orthopaedics, Beijing, China
| | - Gang Liu
- Peking University Fourth School of Clinical Medicine, Beijing, China
- Department of Orthopaedics and Traumatology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China
- National Center for Orthopaedics, Beijing, China
| | - Weidong Peng
- Peking University Fourth School of Clinical Medicine, Beijing, China
- Department of Orthopaedics and Traumatology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China
- National Center for Orthopaedics, Beijing, China
| | - Jing Zhang
- Peking University Fourth School of Clinical Medicine, Beijing, China
- School of Population Health, University of New South Wales, Sydney, NSW, Australia
| | - Yufeng Ge
- Peking University Fourth School of Clinical Medicine, Beijing, China
- Department of Orthopaedics and Traumatology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China
- National Center for Orthopaedics, Beijing, China
| | - Zhelun Tan
- Peking University Fourth School of Clinical Medicine, Beijing, China
- Department of Orthopaedics and Traumatology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China
- National Center for Orthopaedics, Beijing, China
| | - Mingjian Bei
- Peking University Fourth School of Clinical Medicine, Beijing, China
- Department of Orthopaedics and Traumatology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China
- National Center for Orthopaedics, Beijing, China
| | - Feng Gao
- Peking University Fourth School of Clinical Medicine, Beijing, China
- Department of Orthopaedics and Traumatology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China
- National Center for Orthopaedics, Beijing, China
| | - Maoyi Tian
- School of Public Health, Harbin Medical University, Harbin, Heilongjiang, China
- The George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia
| | - Minghui Yang
- Peking University Fourth School of Clinical Medicine, Beijing, China
- Department of Orthopaedics and Traumatology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China
- National Center for Orthopaedics, Beijing, China
| | - Xinbao Wu
- Peking University Fourth School of Clinical Medicine, Beijing, China
- Department of Orthopaedics and Traumatology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China
- National Center for Orthopaedics, Beijing, China
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Kim HS, Kim S, Kim H, Song SY, Cha Y, Kim JT, Kim JW, Ha YC, Yoo JI. A retrospective evaluation of individual thigh muscle volume disparities based on hip fracture types in followed-up patients: an AI-based segmentation approach using UNETR. PeerJ 2024; 12:e17509. [PMID: 39161969 PMCID: PMC11332390 DOI: 10.7717/peerj.17509] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/04/2023] [Accepted: 05/13/2024] [Indexed: 08/21/2024] Open
Abstract
Background Hip fractures are a common and debilitating condition, particularly among older adults. Loss of muscle mass and strength is a common consequence of hip fractures, which further contribute to functional decline and increased disability. Assessing changes in individual thigh muscles volume in follow-up patients can provide valuable insights into the quantitative recovery process and guide rehabilitation interventions. However, accurately measuring anatomical individual thigh muscle volume can be challenging due to various, labor intensive and time-consuming. Materials and Methods This study aimed to evaluate differences in thigh muscle volume in followed-up hip fracture patients computed tomography (CT) scans using an AI based automatic muscle segmentation model. The study included a total of 18 patients at Gyeongsang National University, who had undergone surgical treatment for a hip fracture. We utilized the automatic segmentation algorithm which we have already developed using UNETR (U-net Transformer) architecture, performance dice score = 0.84, relative absolute volume difference 0.019 ± 0.017%. Results The results revealed intertrochanteric fractures result in more significant muscle volume loss (females: -97.4 cm3, males: -178.2 cm3) compared to femoral neck fractures (females: -83 cm3, males: -147.2 cm3). Additionally, the study uncovered substantial disparities in the susceptibility to volume loss among specific thigh muscles, including the Vastus lateralis, Adductor longus and brevis, and Gluteus maximus, particularly in cases of intertrochanteric fractures. Conclusions The use of an automatic muscle segmentation model based on deep learning algorithms enables efficient and accurate analysis of thigh muscle volume differences in followed up hip fracture patients. Our findings emphasize the significant muscle loss tied to sarcopenia, a critical condition among the elderly. Intertrochanteric fractures resulted in greater muscle volume deformities, especially in key muscle groups, across both genders. Notably, while most muscles exhibited volume reduction following hip fractures, the sartorius, vastus and gluteus groups demonstrated more significant disparities in individuals who sustained intertrochanteric fractures. This non-invasive approach provides valuable insights into the extent of muscle atrophy following hip fracture and can inform targeted rehabilitation interventions.
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Affiliation(s)
- Hyeon Su Kim
- Department of Biomedical Research Institute, Inha University Hospital, Incheon, South Korea
| | - Shinjune Kim
- Department of Biomedical Research Institute, Inha University Hospital, Incheon, South Korea
| | - Hyunbin Kim
- Department of Biomedical Research Institute, Inha University Hospital, Incheon, South Korea
| | - Sang-Youn Song
- Department of Orthopaedic Surgery, Gyeongsang National University Hospital, Jinju, South Korea
| | - Yonghan Cha
- Department of Orthopaedic Surgery, Daejeon Eulji Medical Center, Daejeon, South Korea
| | - Jung-Taek Kim
- Department of Orthopaedic Surgery, Ajou University School of Medicine, Ajou Medical Center, Suwon, Republic of South Korea
| | - Jin-Woo Kim
- Department of Orthopaedic Surgery, Nowon Eulji Medical Center, Seoul, South Korea
| | - Yong-Chan Ha
- Department of Orthopaedic Surgery, Seoul Bumin Hospital, Seoul, Republic of South Korea
| | - Jun-Il Yoo
- Department of Orthopaedic Surgery, Inha University Hospital, Inha University College of Medicine, Incheon, Republic of South Korea
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Park C, Kim C, Park RW, Jeon JY. Comparative effectiveness and safety outcomes between denosumab and bisphosphonate in South Korea. J Bone Miner Res 2024; 39:835-843. [PMID: 38722817 DOI: 10.1093/jbmr/zjae070] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/12/2023] [Revised: 03/01/2024] [Accepted: 05/08/2024] [Indexed: 08/07/2024]
Abstract
Both bisphosphonates and denosumab are the mainstays of treatment for osteoporosis to prevent fractures. However, there are still few trials directly comparing the prevention of fractures and the safety of 2 drugs in the treatment of osteoporosis. We aimed to compare the efficacy and safety between denosumab and bisphosphonates using a nationwide claims database. The database was covered with 10 million, 20% of the whole Korean population sampled by age and sex stratification of the Health Insurance Review and Assessment Service in South Korea. Among 228 367 subjects who were over 50 yr of age and taking denosumab or bisphosphonate from January 2018 to April 2022, the analysis was performed on 91 460 subjects after 1:1 propensity score matching. The primary outcome was treatment effectiveness; total fracture, major osteoporotic fracture, femur fracture, pelvic fracture, vertebral fracture, adverse drug reactions; acute kidney injury, chronic kidney disease, and atypical femoral fracture. Total fracture and osteoporotic major fracture, as the main outcomes of efficacy, were comparable in the denosumab and bisphosphonate group (HR 1.06, 95% CI, 0.98-1.15, P = .14; HR 1.13, 95% CI, 0.97-1.32, P = .12, respectively). Safety for acute kidney injury, chronic kidney disease, and atypical femoral fracture also did not show any differences between the 2 groups. In subgroup analysis according to ages, the denosumab group under 70 yr of age had a significantly lower risk for occurrences of acute kidney injury compared to the bisphosphonate group under 70 yr of age (HR 0.53, 95% CI, 0.29-0.93, P = .03). In real-world data reflecting clinical practice, denosumab and bisphosphonate showed comparable effectiveness for total fractures and major osteoporosis fractures, as well as safety regarding acute kidney injury, chronic kidney disease, and atypical femoral fracture.
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Affiliation(s)
- ChulHyoung Park
- Department of Biomedical Informatics, Ajou University School of Medicine, Suwon 16499, Republic of Korea
| | - Chungsoo Kim
- Department of Internal Medicine, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06510, United States
- Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, CT 06510, United States
| | - Rae Woong Park
- Department of Biomedical Informatics, Ajou University School of Medicine, Suwon 16499, Republic of Korea
- Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon 16499, Republic of Korea
| | - Ja Young Jeon
- Department of Endocrinology and Metabolism, Ajou University School of Medicine, 206, World cup-ro, Yeongtong-gu, Suwon 16499, Gyeonggi-do, Republic of Korea
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Chen Y, Tu C, Liu G, Bei M, Zhang J, Tan Z, Ge Y, Peng W, Gao F, Tian M, Yang M, Wu X. Preoperative Thyroid-Stimulating Hormone Levels and Three-Year Mortality in Elderly Hip Fracture Patients: Insights from a Prospective Cohort Study. Med Sci Monit 2024; 30:e944465. [PMID: 39099160 PMCID: PMC11312405 DOI: 10.12659/msm.944465] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/12/2024] [Accepted: 07/01/2024] [Indexed: 08/06/2024] Open
Abstract
BACKGROUND It is unclear whether preoperative thyroid-stimulating hormone (TSH) level is correlated with long-term mortality in the elderly after hip fracture surgery. We aimed to assess the association between TSH levels and 3-year mortality in these patients. MATERIAL AND METHODS We enrolled patients aged 65 and above who had hip fracture surgery and thyroid function tests upon admission from 2018 to 2019. Patients were categorized based on TSH median value, quartiles, or thyroid function status. The median follow-up time was 3.1 years. Cox proportional hazards models were used to examine the correlation between TSH levels and mortality, adjusting for covariates. RESULTS Out of 799 eligible patients, 92.7% (741/799) completed the follow-up, with 20.6% (153/741) of those having died by the end of the follow-up. No statistically significant differences in mortality risks were found when stratified by TSH median value (HR 0.88, 95% CI 0.64-1.22, P=0.448) or quartiles (HR ranging from 0.90 to 1.13, P>0.05). Similarly, when categorized based on admission thyroid function status, patients who presented with hypothyroidism, subclinical hypothyroidism, hyperthyroidism, and subclinical hyperthyroidism upon admission did not demonstrate a statistically significant difference in mortality risk compared to those who were considered euthyroid (HR 1.34, 95% CI 0.72-2.49, P=0.359; HR 0.77, 95% CI 0.38-1.60, P=0.489; HR 1.15, 95% CI 0.16-8.30, P=0.890; HR 1.07, 95% CI 0.34-3.38, P=0.913, respectively). CONCLUSIONS Admission TSH is not significantly associated with 3-year mortality in geriatric patients after hip fracture surgery.
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Affiliation(s)
- Yimin Chen
- Department of Orthopaedics and Traumatology, Peking University Fourth School of Clinical Medicine, Beijing, PR China
- Department of Orthopaedics and Traumatology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, PR China
- Department of Orthopaedics and Traumatology, National Center for Orthopaedics, Beijing, PR China
| | - Chao Tu
- Department of Orthopaedics and Traumatology, Peking University Fourth School of Clinical Medicine, Beijing, PR China
- Department of Orthopaedics and Traumatology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, PR China
- Department of Orthopaedics and Traumatology, National Center for Orthopaedics, Beijing, PR China
| | - Gang Liu
- Department of Orthopaedics and Traumatology, Peking University Fourth School of Clinical Medicine, Beijing, PR China
- Department of Orthopaedics and Traumatology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, PR China
- Department of Orthopaedics and Traumatology, National Center for Orthopaedics, Beijing, PR China
| | - Mingjian Bei
- Department of Orthopaedics and Traumatology, Peking University Fourth School of Clinical Medicine, Beijing, PR China
- Department of Orthopaedics and Traumatology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, PR China
- Department of Orthopaedics and Traumatology, National Center for Orthopaedics, Beijing, PR China
| | - Jing Zhang
- Department of Orthopaedics and Traumatology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, PR China
- School of Population Health, University of New South Wales, Sydney, New South Wales, Australia
| | - Zhelun Tan
- Department of Orthopaedics and Traumatology, Peking University Fourth School of Clinical Medicine, Beijing, PR China
- Department of Orthopaedics and Traumatology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, PR China
- Department of Orthopaedics and Traumatology, National Center for Orthopaedics, Beijing, PR China
| | - Yufeng Ge
- Department of Orthopaedics and Traumatology, Peking University Fourth School of Clinical Medicine, Beijing, PR China
- Department of Orthopaedics and Traumatology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, PR China
- Department of Orthopaedics and Traumatology, National Center for Orthopaedics, Beijing, PR China
| | - Weidong Peng
- Department of Orthopaedics and Traumatology, Peking University Fourth School of Clinical Medicine, Beijing, PR China
- Department of Orthopaedics and Traumatology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, PR China
- Department of Orthopaedics and Traumatology, National Center for Orthopaedics, Beijing, PR China
| | - Feng Gao
- Department of Orthopaedics and Traumatology, Peking University Fourth School of Clinical Medicine, Beijing, PR China
- Department of Orthopaedics and Traumatology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, PR China
- Department of Orthopaedics and Traumatology, National Center for Orthopaedics, Beijing, PR China
| | - Maoyi Tian
- School of Public Health, Harbin Medical University, Harbin, Heilongjiang, PR China
- The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia
| | - Minghui Yang
- Department of Orthopaedics and Traumatology, Peking University Fourth School of Clinical Medicine, Beijing, PR China
- Department of Orthopaedics and Traumatology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, PR China
- Department of Orthopaedics and Traumatology, National Center for Orthopaedics, Beijing, PR China
| | - Xinbao Wu
- Department of Orthopaedics and Traumatology, Peking University Fourth School of Clinical Medicine, Beijing, PR China
- Department of Orthopaedics and Traumatology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, PR China
- Department of Orthopaedics and Traumatology, National Center for Orthopaedics, Beijing, PR China
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Kamimura T, Kobayashi Y, Tamaki S, Koinuma M. Impact of Prefracture Cognitive Impairment and Postoperative Delirium on Recovery after Hip Fracture Surgery. J Am Med Dir Assoc 2024; 25:104961. [PMID: 38428834 DOI: 10.1016/j.jamda.2024.01.030] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/21/2023] [Revised: 01/29/2024] [Accepted: 01/30/2024] [Indexed: 03/03/2024]
Abstract
OBJECTIVES This study aimed to examine the impact of prefracture cognitive impairment (CI) severity and postoperative delirium on recovery after hip fracture surgery in older patients. DESIGN Prospective study with a 1-year follow-up. SETTING AND PARTICIPANTS We included 355 patients aged ≥80 years from 2 acute hospitals in Japan. METHODS Barthel Index (BI) ambulation scores were assessed prefracture and at 1, 3, 6, and 12 months postoperatively. The score at each time point minus the prefracture score was used as the ambulation recovery variable. The 21-item Dementia Assessment Sheet for the Community-based Care System (DASC-21) and Confusion Assessment Method were used to assess CI severity and delirium, respectively. The impacts of CI severity and delirium on recovery at 1 month and by 12 months postoperatively were examined. Linear multiple regression and linear mixed effects models were used. RESULTS BI ambulation scores remained the same or improved from prefracture levels in 26.8%, 34.4%, 33.0%, and 30.4% of patients at 1, 3, 6, and 12 months, respectively. Ten patients (2.8%) had fall-related hip fractures, 20 (5.6%) were rehospitalized, and 43 (12.1%) died during this period. Although DASC-21 CI severity significantly affected the recovery both at 1 month and by 12 months postoperatively [standardized β (Stdβ) = -0.39, P < .0001, and Stdβ = -0.37, P < .0001, respectively], delirium did not. Other variables affecting recovery by 12 months postoperatively included prefracture BI ambulation scores, Mini Mental State Examination scores, age, fracture type, place of residence, and time. CONCLUSIONS AND IMPLICATIONS Postoperative ambulation recovery, excluding the effect of death and other poor outcomes, is influenced by prefracture CI severity, and the presence of delirium itself may not be the moderating variable. These results emphasize the importance of treatment planning based on prefracture CI severity and indicate that assessments such as the DASC-21 may be useful in implementing such a plan.
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Affiliation(s)
- Tomoko Kamimura
- Department of Medical Sciences, Shinshu University, Matsumoto, Nagano, Japan.
| | - Yuya Kobayashi
- Department of Rehabilitation, Aizawa Hospital, Matsumoto, Nagano, Japan
| | - Satoshi Tamaki
- Department of Rehabilitation, Kamiiida-Daiichi General Hospital, Nagoya, Aichi, Japan
| | - Masayoshi Koinuma
- Faculty of Pharmaceutical Sciences, Teikyo Heisei University, Tokyo, Japan
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Zhang YN, Xiao P, Zhang BF. The association between preoperative serum cholinesterase and all-cause mortality in geriatric patients with hip fractures: a cohort study of 2387 patients. Perioper Med (Lond) 2024; 13:82. [PMID: 39049017 PMCID: PMC11267686 DOI: 10.1186/s13741-024-00443-2] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/29/2024] [Accepted: 07/17/2024] [Indexed: 07/27/2024] Open
Abstract
OBJECTIVE This study is to evaluate the association between preoperative cholinesterase levels and all-cause mortality in geriatric hip fractures. METHODS Elderly patients with hip fractures were screened between Jan 2015 and Sep 2019. Demographic and clinical characteristics of patients were collected. Linear and nonlinear multivariate Cox regression models were used to identify the association between preoperative cholinesterase levels and mortality in these patients. Analyses were performed using EmpowerStats and the R software. RESULTS Two thousand three hundred eighty-seven patients were included in this study. The mean follow-up period was 37.64 months. Seven hundred eighty-seven (33.0%) patients died due to all-cause mortality. Preoperative cholinesterase levels were 5910 ± 1700 U/L. Linear multivariate Cox regression models showed that preoperative cholinesterase level was associated with mortality (HR = 0.83, 95% CI: 0.78-0.88), P < 0.0001) for every 1000 U/L. However, the linear association was unstable, and nonlinearity was identified. A cholinesterase concentration of 5940 U/L was an inflection point. When preoperative cholinesterase level < 5940 U/L, the mortality decreased by 28% for every 1000 U/L increase in cholinesterase (HR = 0.72, 95%CI: 0.66-0.79, P < 0.0001). When cholinesterase was > 5940 U/L, the mortality was no longer decreased with the rise of cholinesterase (HR = 1.01, 95%CI: 0.91-1.11, P = 0.9157). We found the nonlinear association was very stable in the propensity score-matching sensitive analysis. CONCLUSIONS Preoperative cholinesterase levels were nonlinearly associated with mortality in elderly hip fractures, and cholinesterase was a risk indicator of all-cause mortality. TRIAL REGISTRATION This study is registered on the website of the Chinese Clinical Trial Registry (ChiCTR: ChiCTR2200057323) (08/03/2022).
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Affiliation(s)
- Yan-Ning Zhang
- Department of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, No. 555 Youyi East Road, Beilin District, Xi'an, Shaanxi Province, 710054, China
| | - Peng Xiao
- Department of Orthopedics (International Ward), Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
| | - Bin-Fei Zhang
- Department of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, No. 555 Youyi East Road, Beilin District, Xi'an, Shaanxi Province, 710054, China.
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45
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Long X, Li W, Hou D, Li X, Cheng D. Enhanced recovery after surgery speeds up healing for hip fracture patients. Am J Transl Res 2024; 16:3231-3239. [PMID: 39114676 PMCID: PMC11301509 DOI: 10.62347/aevl7890] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/25/2024] [Accepted: 05/14/2024] [Indexed: 08/10/2024]
Abstract
OBJECTIVE To investigate the effects of enhanced recovery after surgery (ERAS) on the perioperative healing and stress response in patients with hip fractures. METHODS A retrospective analysis was conducted on the medical records of 86 patients with hip fractures admitted to the Affiliated Hospital of Southwest Medical University between January 2022 and August 2023. Among them, 48 patients in the research group received ERAS, while 38 patients in the control group received conventional nursing. Hip joint function, pain levels, stress response, fracture healing time, incidence of complications, and nursing satisfaction were compared between the two groups. RESULTS After nursing, the Harris scores notably increased in both groups, with the research group showing notably higher scores compared to the control group (P<0.05). The levels of cortisol and epinephrine, as well as the visual analog scale scores significantly decreased in both groups, with the research group showing significantly lower levels (P<0.05). In addition, the research group experienced significantly shorter fracture healing time (P<0.05), higher nursing satisfaction (P=0.014), and lower incidence of complications (P=0.028). Logistic regression analysis revealed that age, underlying diseases, nursing method, emotional disorders, and timing of surgery were independent factors influencing the post-nursing outcomes. CONCLUSION The ERAS mode can effectively alleviate pain, improve hip joint function, reduce fracture healing time and complications, mitigate stress response, and accelerate postoperative recovery in patients with hip fractures. It is worthy of application and promotion in clinical practice.
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Affiliation(s)
- Xia Long
- Department of Orthopaedics, The Affiliated Hospital of Southwest Medical University Luzhou 646000, Sichuan, China
| | - Wen Li
- Department of Orthopaedics, The Affiliated Hospital of Southwest Medical University Luzhou 646000, Sichuan, China
| | - Dan Hou
- Department of Orthopaedics, The Affiliated Hospital of Southwest Medical University Luzhou 646000, Sichuan, China
| | - Xiaoyue Li
- Department of Orthopaedics, The Affiliated Hospital of Southwest Medical University Luzhou 646000, Sichuan, China
| | - Dongyue Cheng
- Department of Orthopaedics, The Affiliated Hospital of Southwest Medical University Luzhou 646000, Sichuan, China
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Fan TD, Bei DK, Wang Q. Relationship between admission blood urea nitrogen levels and postoperative length of stay in patients with hip fracture: A retrospective study. Medicine (Baltimore) 2024; 103:e38918. [PMID: 38996118 PMCID: PMC11245248 DOI: 10.1097/md.0000000000038918] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/16/2024] [Accepted: 06/21/2024] [Indexed: 07/14/2024] Open
Abstract
To investigate the relationship between admission blood urea nitrogen (BUN) levels and postoperative length of stay (LOS) in hip fracture (HF) patients. This retrospective study retrieved related data from the MIMIC-IV database, of which the laboratory variables were taken preoperatively. The patients were divided into 4 groups according to the BUN quartile levels. After exploring the nonlinear relationship between BUN and LOS by generalized additive model, their connection was further analyzed using the generalized linear models, quantile regression models, and interaction analysis. Receiver operating characteristic curve analysis and decision curve analysis were performed to evaluate its value in predicting first intensive care unit admission and in-hospital mortality. Totally 1274 patients with HF were enrolled in the study. There was a nonlinear relationship between BUN and LOS (P < .05). Besides, BUN was an independent predictor for LOS after adjusting different covariates in 3 models (P < .05). Age served as a significant interactor in this relationship (P < .05). Moreover, receiver operating characteristic curve and decision curve analysis revealed the predictive value of BUN for intensive care unit admission and in-hospital mortality in HF. Admission BUN level as a cost-effective and easy-to-collect biomarker is significantly related to LOS in patients with HF. It helps clinicians to identify potential high-risk populations and take effective preventions before surgery to reduce postoperative LOS.
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Affiliation(s)
- Teng-di Fan
- Department of Orthopedics, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang, China
| | - Di-kai Bei
- Department of Orthopedics, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang, China
| | - Qi Wang
- Department of Medical Record Office, Ningbo Medical Center Lihuili Hospital, Ningbo, Zhejiang, China
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Shirai N, Usui N, Abe Y, Tamiya H, Amari T, Kojima S, Mikami K, Nagashima M, Shinozaki N, Shimano Y, Saitoh M. Relationship Among Falls, Fear of Falling, and Physical Activity Level in Patients on Hemodialysis. Phys Ther 2024; 104:pzae064. [PMID: 38696344 DOI: 10.1093/ptj/pzae064] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/05/2023] [Revised: 11/20/2023] [Accepted: 02/26/2024] [Indexed: 05/04/2024]
Abstract
OBJECTIVE Patients on hemodialysis are highly susceptible to falls and fractures. Amplified apprehension regarding the fear of falling (FOF) constitutes a risk factor that restricts physical activity and escalates the probability of falls among the elderly population. This study aimed to elucidate the association between falls and FOF and physical activity in patients on hemodialysis. METHODS A prospective cohort study was conducted across 9 centers. FOF was assessed using the Falls Efficacy Scale-International (FES-I). Physical activity was assessed using the Japanese version of the International Physical Activity Questionnaire short form. Subsequently, falls were monitored over a duration of 1 year. Logistic regression analysis was performed to evaluate the relationship between falls and FOF and physical activity. In addition, in the receiver operating characteristic analysis, the cutoff value of FES-I that predicts falls was determined using the Youden Index. A restricted cubic spline curve was utilized to analyze the nonlinear association between falls and the FES-I. RESULTS A total of 253 patients on hemodialysis (70.0 [59.0-77.0] years old; 105 female [41.5%]) were included in the analysis. During the 1-year observation period, 90 (35.6%) patients experienced accidental falls. The median FES-I score was 36.0 (24.0-47.0) points, and patients with higher FES-I scores had more falls. Following adjusted logistic regression analysis, FES-I exhibited an independent association with falls (OR = 1.04; 95% CI = 1.01-1.06), but physical activity was not. The area under the receiver operating characteristic curve was 0.70 (95% CI = 0.64-0.77), and the FES-I threshold value for distinguishing fallers from non-fallers was determined as 37.5 points (sensitivity 65.6%, specificity 35.0%). A nonlinear relationship between falls and FES-I was observed. CONCLUSION FOF was associated with the incidence of falls in patients on hemodialysis. IMPACT The evaluation and implementation of interventions targeting the FOF may mitigate the risk of falls.
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Affiliation(s)
- Nobuyuki Shirai
- Department of Rehabilitation, Niigata Rinko Hospital, Higashi-ku, Niigata City, Niigata, Japan
- Renal Exercise and Physical Activity Network - Virtual Laboratory, Japan
| | - Naoto Usui
- Renal Exercise and Physical Activity Network - Virtual Laboratory, Japan
- Department of Physical Therapy, Kisen Hospital, Toganemachi, katsushika-ku, Tokyo, Japan
| | - Yoshifumi Abe
- Renal Exercise and Physical Activity Network - Virtual Laboratory, Japan
- Department of Rehabilitation, Faculty of Health Sciences, Tokyo Kasei University, Inariyama, Sayama City, Saitama, Japan
| | - Hajime Tamiya
- Renal Exercise and Physical Activity Network - Virtual Laboratory, Japan
- Department of Physical Therapy, Niigata University of Health and Welfare, Shimami-cho, Kita-ku, Niigata City, Niigata, Japan
| | - Takashi Amari
- Renal Exercise and Physical Activity Network - Virtual Laboratory, Japan
- Department of Physical Therapy, Health Science University, Kodachi, Fujikawaguchiko-machi, Minamitsuru-gun, Yamanashi, Japan
| | - Sho Kojima
- Renal Exercise and Physical Activity Network - Virtual Laboratory, Japan
- Department of Physical Therapy, Kisen Hospital, Toganemachi, katsushika-ku, Tokyo, Japan
| | - Kenta Mikami
- Renal Exercise and Physical Activity Network - Virtual Laboratory, Japan
- Department of Cardiac Rehabilitation, Iwatsuki Minami Hospital, Kuroya, Iwatsuki-ku, Saitama City, Saitama, Japan
| | - Mizuki Nagashima
- Renal Exercise and Physical Activity Network - Virtual Laboratory, Japan
- Department of Cardiac Rehabilitation, Iwatsuki Minami Hospital, Kuroya, Iwatsuki-ku, Saitama City, Saitama, Japan
| | - Nobuhito Shinozaki
- Renal Exercise and Physical Activity Network - Virtual Laboratory, Japan
- Department of Rehabilitation, Tokatsu Clinic Hospital, Hinoguchi, Matsudo City, Chiba, Japan
| | - Yu Shimano
- Renal Exercise and Physical Activity Network - Virtual Laboratory, Japan
- Department of Rehabilitation, Saiyu Clinic, Sagamicyo, Koshigaya City, Saitama, Japan
| | - Masakazu Saitoh
- Renal Exercise and Physical Activity Network - Virtual Laboratory, Japan
- Department of Physical Therapy, Faculty of Health Science, Juntendo University, Hongo, Bunkyo-ku, Tokyo, Japan
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Rana P, Brennan JC, Johnson AH, King PJ, Turcotte JJ. Trends in Patient-Reported Physical Function After Hip Fracture Surgery. Cureus 2024; 16:e64572. [PMID: 39144900 PMCID: PMC11323809 DOI: 10.7759/cureus.64572] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 07/14/2024] [Indexed: 08/16/2024] Open
Abstract
Background Hip fractures carry significant morbidity and mortality, yet studies assessing post-surgical functional recovery from the patient's perspective are scarce, lacking benchmarks against age-matched populations. This study aimed to identify factors influencing postoperative functional outcomes, compared to the lower 25th percentile of normal age-matched populations, and to compare postoperative physical function with one-year mortality following hip fracture surgery. Methodology A retrospective review of 214 hip fracture patients reporting to the emergency department (ED) from July 2020 to June 2023 was conducted, with all completing a three-month postoperative Patient-Reported Outcomes Measurement Information System-Physical Function (PROMIS-PF) survey. Primary outcomes included three-month PROMIS-PF scores, with secondary outcomes focusing on one-year mortality. Factors such as demographics, comorbidities, procedures, time to surgery, length of stay, and postoperative outcomes were analyzed for correlation. Multivariate logistic regression assessed predictors of achieving a PROMIS-PF T-score of at least 32.5, representing the bottom 25th percentile for age-matched populations, and the relationship between three-month PROMIS PF T-scores and one-year mortality. Results Surgery was performed within 24 hours of ED arrival in 118 (55.1%) patients, the average length of stay was 5.2 days, and 64 (29.9%) were discharged home. Total hip arthroplasty and home discharge correlated with higher physical function scores. In contrast, older age, higher American Society of Anesthesiologists scores, certain comorbidities, specific surgical procedures, and longer hospital stays were associated with lower scores. Fewer than half (102 [47.7%]) achieved functional levels comparable to the 25th percentile of age-matched populations. Multivariate analysis indicated chronic obstructive pulmonary disease and home discharge as predictors of achieving this threshold, while higher PROMIS-PF T-scores were associated with reduced one-year mortality. Conclusions Patients undergoing hip fracture surgery are unlikely to achieve high levels of physical function within the three-month postoperative period. Fewer than half of these patients will reach functional levels, and decreased early function is associated with an increased risk of one-year mortality.
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Affiliation(s)
- Parimal Rana
- Orthopedic Research, Anne Arundel Medical Center, Annapolis, USA
| | - Jane C Brennan
- Orthopedic Research, Anne Arundel Medical Center, Annapolis, USA
| | | | - Paul J King
- Orthopedic Surgery, Anne Arundel Medical Center, Annapolis, USA
| | - Justin J Turcotte
- Orthopedic and Surgical Research, Anne Arundel Medical Center, Annapolis, USA
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Ansari H, Fung K, Cheung AM, Jaglal S, Bogoch ER, Kurdyak PA. Outcomes following hip fracture surgery in adults with schizophrenia in Ontario, Canada: A 10-year population-based retrospective cohort study. Gen Hosp Psychiatry 2024; 89:60-68. [PMID: 38797059 DOI: 10.1016/j.genhosppsych.2024.05.010] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/03/2024] [Revised: 04/02/2024] [Accepted: 05/17/2024] [Indexed: 05/29/2024]
Abstract
OBJECTIVE To understand immediate and long-term outcomes following hip fracture surgery in adults with schizophrenia. METHODS Retrospective population-based cohort study leveraging health administrative databases from Ontario, Canada. Individuals aged 40-105 years with hip fracture surgery between April 1, 2009 and March 31, 2019 were included. Schizophrenia was ascertained using a validated algorithm. Outcomes were: 30-day mortality; 30-day readmission; 1-year survival; and subsequent hip fracture within 2 years. Analyses incorporated Generalized Estimating Equation models, Kaplan-Meier curves, and Fine-Gray competing risk models. RESULTS In this cohort study of 98,126 surgically managed hip fracture patients, the median [IQR] age was 83[75-89] years, 69.2% were women, and 3700(3.8%) had schizophrenia. In Fine-Gray models, schizophrenia was associated with subsequent hip fracture (sdRH, 1.29; 95% CI, 1.09-1.53), with male patients with schizophrenia sustaining a refracture 50 days earlier. In age- and sex-adjusted GEE models, schizophrenia was associated with 30-day mortality (OR, 1.31; 95% CI, 1.12-1.54) and readmissions (OR, 1.40; 95% CI, 1.25-1.56). Kaplan-Meier survival curves suggested that patients with schizophrenia were less likely to be alive at 1-year. CONCLUSIONS Study highlights the susceptibility of hip fracture patients with schizophrenia to worse outcomes, including refracture, with implications for understanding modifiable processes of care to optimize their recovery.
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Affiliation(s)
- Hina Ansari
- Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
| | | | - Angela M Cheung
- Department of Medicine and Joint Department of Medical Imaging, University Health Network and Sinai Health System, University of Toronto, Toronto, Ontario, Canada
| | - Susan Jaglal
- ICES, Toronto, Ontario, Canada; Toronto Rehabilitation Institute, University Health Network, Toronto, Ontario, Canada; Department of Physical Therapy, University of Toronto, Toronto, Ontario, Canada
| | - Earl R Bogoch
- Brookfield Chair in Fracture Prevention, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada; Department of Surgery, University of Toronto, Toronto, Ontario, Canada; Li Ka Shing Knowledge Institute of St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada
| | - Paul A Kurdyak
- Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; ICES, Toronto, Ontario, Canada; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Centre for Addiction and Mental Health, Toronto, Ontario, Canada
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50
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Khan AA, Slart RHJA, Ali DS, Bock O, Carey JJ, Camacho P, Engelke K, Erba PA, Harvey NC, Lems WF, Morgan S, Moseley KF, O'Brien C, Probyn L, Punda M, Richmond B, Schousboe JT, Shuhart C, Ward KA, Lewiecki EM. Osteoporotic Fractures: Diagnosis, Evaluation, and Significance From the International Working Group on DXA Best Practices. Mayo Clin Proc 2024; 99:1127-1141. [PMID: 38960497 DOI: 10.1016/j.mayocp.2024.01.011] [Citation(s) in RCA: 11] [Impact Index Per Article: 11.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/23/2023] [Revised: 01/17/2024] [Accepted: 01/24/2024] [Indexed: 07/05/2024]
Abstract
Osteoporotic fractures, also known as fragility fractures, are reflective of compromised bone strength and are associated with significant morbidity and mortality. Such fractures may be clinically silent, and others may present clinically with pain and deformity at the time of the injury. Unfortunately, and even at the time of detection, most individuals sustaining fragility fractures are not identified as having underlying metabolic bone disease and are not evaluated or treated to reduce the incidence of future fractures. A multidisciplinary international working group with representation from international societies dedicated to advancing the care of patients with metabolic bone disease has developed best practice recommendations for the diagnosis and evaluation of individuals with fragility fractures. A comprehensive narrative review was conducted to identify key articles on fragility fractures and their impact on the incidence of further fractures, morbidity, and mortality. This document represents consensus among the supporting societies and harmonizes best practice recommendations consistent with advances in research. A fragility fracture in an adult is an important predictor of future fractures and requires further evaluation and treatment of the underlying osteoporosis. It is important to recognize that most fragility fractures occur in patients with bone mineral density T scores higher than -2.5, and these fractures confirm the presence of skeletal fragility even in the presence of a well-maintained bone mineral density. Fragility fractures require further evaluation with exclusion of contributing factors for osteoporosis and assessment of clinical risk factors for fracture followed by appropriate pharmacological intervention designed to reduce the risk of future fracture. Because most low-trauma vertebral fractures do not present with pain, dedicated vertebral imaging and review of past imaging is useful in identifying fractures in patients at high risk for vertebral fractures. Given the importance of fractures in confirming skeletal fragility and predicting future events, it is recommended that an established classification system be used for fracture identification and reporting.
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Affiliation(s)
- Aliya A Khan
- Division of Endocrinology and Metabolism, McMaster University, Hamilton, Ontario, Canada.
| | - Riemer H J A Slart
- University Medical Center Groningen, Medical Imaging Centre, Department of Nuclear Medicine and Molecular Imaging, Groningen, The Netherlands
| | - Dalal S Ali
- Division of Endocrinology and Metabolism, McMaster University, Hamilton, Ontario, Canada
| | - Oliver Bock
- Department of Osteoporosis, Inselspital, Bern University Hospital, Switzerland, IG Osteoporose, Bern, Switzerland
| | - John J Carey
- Department of Rheumatology, University of Galway, Galway, Ireland
| | | | - Klaus Engelke
- Department of Medicine 3 and Institute of Medical Physics, FAU University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Germany
| | - Paola A Erba
- Department of Medicine and Surgery, Nuclear Medicine UnitASST, Ospedale Papa Giovanni, University of Milan-Bicocca, Piazza, Bergamo, Italy
| | - Nicholas C Harvey
- MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton General Hospital and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital NHS Foundation Trust, Southampton, UK
| | - Willem F Lems
- Department of Rheumatology, Amsterdam University Medical Center, The Netherlands
| | - Sarah Morgan
- Osteoporosis Prevention and Treatment Center and DXA Facility, University of Alabama at Birmingham, Birmingham, AL
| | | | | | - Linda Probyn
- Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
| | - Marija Punda
- Department of Oncology and Nuclear Medicine, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia
| | | | - John T Schousboe
- Division of Health Policy and Management, University of Minnesota, Minneapolis, MN
| | | | - Kate A Ward
- MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton General Hospital and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital NHS Foundation Trust, Southampton, UK
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