Case Report
Copyright ©The Author(s) 2016.
World J Clin Oncol. Oct 10, 2016; 7(5): 420-424
Published online Oct 10, 2016. doi: 10.5306/wjco.v7.i5.420
Table 1 The comparison of male and female breast cancer with respect to diagnostics and therapy
Female breast cancerMale breast cancer
EpidemiologyVery common (125 new cases per 100000 women per year)Very rare (1.2 new cases per 100000 men per year)
Average age at diagnosis62 yr67 yr
DiagnosticsMammography, sonography; in selected cases MRISonography; mammography if possible; in selected cases MRI
Association with BRCA mutation5%-10% of all cases are BRCA-positive10%-20% of all cases are BRCA-positive
SurgeryBreast-conserving surgery (70%-80% patients) or mastectomy; sentinel node biopsy in cN0Mastectomy; sentinel node biopsy in cN0
Reconstruction techniquesImplant or flap-based reconstruction after mastectomyFlap-based reconstruction of thoracic wall in case of a large tumor
ChemotherapyRecommendation depends on tumor biology and tumor load; adjuvant or neoadjuvant use; usually anthracycline- and taxane-based
Endocrine therapyRecommended in hormone receptor positive tumors; tamoxifen or aromatase inhibitorRecommended in hormone receptor positive tumors; tamoxifen
HER2-targeted treatmentTrastuzumab recommended in HER2-positive tumors
Radiation therapyThoracic wall or lymph node radiation in case of higher tumor load
Recommended after breast-conserving surgery; thoracic wall or lymph node radiation in case of higher tumor load