Copyright ©The Author(s) 2016.
World J Clin Oncol. Apr 10, 2016; 7(2): 131-134
Published online Apr 10, 2016. doi: 10.5306/wjco.v7.i2.131
Table 1 Indirect comparison between studies investigating in the role of dual positron emission tomography/computed tomography
Ref.Type of studyPatients enrolledSensitivity in detection of liver metastasisSensitivity in detection of lympho-node metastasisSensitivity in detection of bone metastasisRelationship between grading and PET/CT positivityImpact of dual PET/CT on therapeutic decision
Naswa et al[9]Retrospective study51 GEP-NETsNo statistical differences between 68Ga and 18F-FDG68Ga was superior to 18F-FDG (P < 0.003)No statistical differences between 68Ga and 18F-FDGNo dataDual PET/CT helped in selecting therapies
Has Simsek et al[10]Prospective study27 GEP-NETs: 10 G1 17 G268Ga: 95% 18F-FDG: 40%68Ga: 95% 18F-FDG: 28%68Ga: 90% 18F-FDG: 28%In 74% of patients, 68Ga predominated in patients with lower Ki-67 index, while 18F-FDG in higer ki-67 index GEP-NETsDual PET/CT influenced treatment decision in 59% of cases
Partelli et al[11]Retrospective, bi-institutional study49 P-NETs18F-FDG: Described 1 false negativeNo data18F-FDG: described 1 false negativeMedian Ki-67 for 68Ga positive tumors: 7%. Median Ki-67 for both 68Ga and 18F- FDG positive tumors: 10% (P = 0.130)No significant differences
Table 2 Comparison between 68Ga-DOTATATE and 18F-fluorodeoxyglucose positron emission tomography/computed tomography sensitivity in neuroendocrine neoplasms
Kayani et al[13]Sensitivity 82%Sensitivity 66%
Kayani et al[14]Sensitivity 100%Sensitivity 54%
Conry et al[15]Sensitivity 72%Sensitivity 78%