Endometrial polypoid adenomyoma outcomes and fertility-sparing treatments efficacy for atypical type: A systematic review and network meta-analysis

Table 1 Rankings of interventions based on surface under the cumulative ranking curve analysis

Treatment	SUCRA (%)	PrBest (%)	Mean rank
TCRP	40.9	16.8	8.3
TCRP + HDP	49.9	15.8	7
TCRP + MPA (10 mg/day)	78.3	5.7	3.6
TCRP + COC	56.1	10	6.3
TCRP + LNG-IUS	66	14.7	5.1
TCRP + PT	42.3	10.3	7.9
TCRE	54.3	1.1	6.5
TCRE + PT	51.3	4.1	6.9
PWH	38.2	2.6	8.4
PWH + HDP	50.2	1	7
PWH + HDP + MT	49	3.8	7.1
LNG-IUS	40.3	10.1	8.2
PT	43.1	4	7.8

SUCRA: Surface under the cumulative ranking curve; PrBest: Probability of being the best; TCRP: Transcervical resection of polyps; LNG-IUS: Levonorgestrel-releasing intrauterine system; COC: Combined oral contraceptive; PT: Progesterone therapy; MPA: Medroxyprogesterone acetate; TCRE: Transcervical resection of endometrium; PWH: Polyp resection without hysteroscopy; HDP: High-dose progestin; MT: Hormone maintenance therapy.

Table 2 Rankings of interventions based on their ability to inhibit recurrence as indicated by surface under the cumulative ranking curve analysis

Treatment	SUCRA (%)	PrBest (%)	Mean rank
TCRP	45.3	2	7
TCRP + HDP	60.3	0	5.4
TCRP + MPA (10 mg/day)	65.3	0.2	4.8
TCRP + COC	47.4	4.8	6.8
TCRP + LNG-IUS	47.6	4.6	6.8
TCRP + GnRH-a	55.3	2.1	5.9
TCRP + PT	50.1	0.6	6.5
TCRE	53.9	22.8	6.1
TCRE + PT	58.2	17.1	5.6
PWH + HDP	43.2	17	7.3
PWH + HDP + MT	59.3	16.2	5.5
PWH	30.4	12.6	8.7

SUCRA: Surface under the cumulative ranking curve; PrBest: Probability of being the best; TCRP: Transcervical resection of polyps; LNG-IUS: Levonorgestrel-releasing intrauterine system; COC: Combined oral contraceptive; PT: Progesterone therapy; MPA: Medroxyprogesterone acetate; TCRE: Transcervical resection of endometrium; PWH: Polyp resection without hysteroscopy; HDP: High-dose progestin; MT: Hormone maintenance therapy; GnRH-a: Gonadotrophin-releasing hormone agonist.

Table 3 Rankings of interventions based on their ability to suppress endometrial cancer as indicated by surface under the cumulative ranking curve analysis

Treatment	SUCRA (%)	PrBest (%)	Mean rank
TCRP	47.1	15.8	7.7
TCRP + HDP	73.1	11.9	4.2
TCRP + COC	46.8	8	7.4
TCRP + LNG-IUS	47.5	10.9	7.3
TCRP + PT	55.6	8	6.3
TCRP + GnRH-a	38.4	8.7	8.4
TCRE	51	6.2	6.9
TCRE + PT	53.6	5.6	6.6
PWH + HDP	45.9	4.6	7.5
PWH + HDP + MT	57.8	5.9	6.1
PWH	54	10.2	6.5
LNG-IUS	39.8	3.6	8.2
PT	46.9	0.6	7.4

SUCRA: Surface under the cumulative ranking curve; PrBest: Probability of being the best; TCRP: Transcervical resection of polyps; LNG-IUS: Levonorgestrel-releasing intrauterine system; COC: Combined oral contraceptive; PT: Progesterone therapy; TCRE: Transcervical resection of endometrium; HDP: High-dose progestin; MT: Hormone maintenance therapy; PWH: Polyp resection without hysteroscopy; GnRH-a: Gonadotrophin-releasing hormone agonist.