Whole-body magnetic resonance imaging for cutaneous melanoma staging: A scientific review

Table 1 Risk of bias and applicability concerns assessment according to QUADAS-2 for included studies

Study	Risk of bias				Applicability concerns
	Patient selection	Index test	Reference standard	Flow and timing	Patient selection	Index test	Reference standard
Study 1	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk
Study 2	High risk	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk
Study 3	Low risk	Unclear risk	Low risk	Low risk	High risk	Low risk	Low risk
Study 4	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk
Study 5	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk
Study 6	Low risk	Low risk	Low risk	Low risk	Low risk	Unclear risk	Low risk
Study 7	Low Risk	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk
Study 8	Low risk	Low risk	Low risk	Low risk	Low risk	Unclear risk	Low risk
Study 9	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk
Study 10	Low risk	Low risk	Low risk	High risk	Low risk	Low risk	Low risk
Study 11	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk
Study 12	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk
Study 13	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk
Study 14	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk
Study 15	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk
Study 16	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk	Low risk

Table 2 Studies included in QUADAS-2 analysis

Study	Patient selection (risk of bias)	Patient selection (applicability)	Index test (risk of bias)	Index test (applicability)	Reference standard (risk of bias)	Reference standard (applicability)	Flow and timing (risk of bias)
Study 1	Low	Low	Low	Low	Low	Low	Low
Study 2	High	Low	Low	High	Low	Low	Low
Study 3	Low	High	Unclear	Low	Low	High	Low
Study 4	Low	Unclear	High	Low	Low	Low	High
Study 5	Low	Low	Low	Unclear	Low	Low	Low
Study 6	Low	High	Low	Unclear	High	High	Low
Study 7	Low	Low	High	Low	Low	Low	Low
Study 8	Low	High	Unclear	Low	High	Low	Low
Study 9	Low	Low	Low	High	Unclear	Unclear	Low
Study 10	Low	Unclear	Low	Unclear	Low	Low	Low
Study 11	Low	Low	High	Low	Low	Low	Low
Study 12	Low	Low	Low	High	Low	Low	Low
Study 13	Low	High	High	Low	Low	Low	Low
Study 14	Low	Low	Low	High	Low	Low	Low
Study 15	Low	High	Low	Low	High	High	Low
Study 16	Low	Unclear	Unclear	Low	Low	Unclear	Low

Table 3 Site-specific diagnostic performance of whole-body magnetic resonance imaging in detecting melanoma metastases

Metastatic site	Sensitivity (%)	Specificity (%)
Bone	85-95	90-98
Liver	80-90	92-97
Brain	90-95	> 95
Lung	60-70	85-90