Knowledge structure analysis and network visualization of tumor-associated macrophages in hepatocellular carcinoma research: A bibliometric mapping

Table 1 Top 10 countries/institutions related to tumor-associated macrophages in hepatocellular carcinoma research

Country	Output	Citations	Organization	Location	Output	Citations
China	513	20006	Fudan University	China	67	3667
United States	118	9336	Sun Yat Sen University	China	35	1158
Japan	54	2992	Zhejiang University	China	31	983
Italy	42	2861	Shanghai Jiao Tong University	China	27	2210
Germany	37	2298	Nanjing Medical University	China	24	905
United Kingdom	22	717	Shandong University	China	23	1064
Korea	19	473	Central South University	China	23	473
France	15	848	Huazhong University of Science and Technology	China	21	810
Spain	14	878	Chinese Academy of Sciences	China	20	1421
Singapore	14	846	Peking Central South University	China	16	846

Table 2 Top 10 journals of impact related to tumor-associated macrophages in hepatocellular carcinoma research

Journal	H-index	Output	Citations	IF (2022)	JCR quartile
Hepatology	16	20	1754	13.5	Q1
Frontiers in Immunology	15	37	730	7.3	Q1
Cancer Letters	11	17	688	9.7	Q1
International Journal of Molecular Sciences	11	22	412	5.6	Q1
Journal of Hepatology	11	13	1043	25.7	Q1
Oncology Letters	10	14	166	2.9	Q3
Cancer Immunology Immunotherapy	9	10	338	5.8	Q1
Cancer Research	9	10	2285	11.2	Q1
Cancers	9	17	367	5.2	Q2
Frontiers in Oncology	8	13	316	4.7	Q2

IF: Impact factor; JCR: Journal Citation Reports.

Table 3 Top 10 authors with highest outputs, citations, and co-citations related to tumor-associated macrophages in hepatocellular carcinoma research

Author	Output	Author	Citations	Co-author	Co-citations
Fan Jia	16	Sun Hui-Chuan	1178	Alberto Mantovani	429
Zhou Jian	15	Zhu Xiao-Dong	1160	Josep M Llovet	232
Zhang Jian	12	Zhang Wei	987	Antonio Sica	179
Sun Hui-Chuan	9	Tang Zhao-You	984	Qian Bin-Zhi	143
Zheng Li-Min	9	Fan Jia	949	Kuang Dong-Ming	132
Zhu Xiao-Dong	8	Wang Lu	874	Subhra K Biswas	111
Gao Qiang	7	Wu Wei-Zhong	874	Wan Shanshan	111
Wang Xue-Hao	7	Shirabe Ken	813	Richard S Finn	107
Yang Yang	7	Zhuang Peng-Yuan	800	Zhou Shao-Lai	105
Li Yan	6	Maehara Yoshihiko	783	Roy Noy	99

Table 4 Top 10 most co-cited references related to tumor-associated macrophages in hepatocellular carcinoma research

Ref.	Type	Citations	IF (2022)
Qian and Pollard[30], 2010	Review	630	64.5
NOY and Pollard[13], 2014	Review	493	32.4
Mantovani et al[34], 2002	Review	348	168.9
Wan et al[56], 2014	Basic research	347	29.4
Mantovani et al[20], 2017	Review	335	78.8
Llovet et al[57], 2008	Clinical research	311	158.5
Pollard[58], 2004	Review	309	78.5
El-khoueiry et al[35], 2017	Clinical research	301	168.9
Kuang et al[59], 2009	Basic research	294	15.3
Zhu et al[60], 2008	Clinical research	292	45.4

IF: Impact factor.

Table 5 Top 20 author keywords related to tumor-associated macrophages in hepatocellular carcinoma research

Rank	Keyword	Occurrences	Total link strength	Rank	Keyword	Occurrences	Total link strength
1	HCC	338	1210	11	NF-kappa B	20	76
2	TAMs	223	855	12	Tamoxifen	19	51
3	TME	152	624	13	Angiogenesis	18	106
4	Immunotherapy	89	379	14	M2 macrophages	18	60
5	Prognostic	55	194	15	Biomarkers	17	75
6	Inflammation	33	124	16	PD-L1	17	78
7	Polarization	33	115	17	Immune infiltration	16	54
8	EMT	30	118	18	Immunosuppression	15	76
9	CSCs	26	107	19	MicroRNA	14	67
10	Metastasis	21	102	20	Exosomes	14	59

HCC: Hepatocellular carcinoma; TAMs: Tumor-associated macrophages; TME: Tumor microenvironment; EMT: Epithelial-mesenchymal transition; CSCs: Cancer stem cells; NF: Nuclear factor; PD-L1: Programmed death ligand 1.