Prognostic and immunological roles of heat shock protein A4 in lung adenocarcinoma

Table 1 Demographic and clinicopathological parameters of high and low HSPA4 expression group patients in The Cancer Genome Atlas - lung adenocarcinoma, n (%)

Characteristics	Low expression of HSPA4	High expression of HSPA4	P value
n	269	270
Pathologic T stage			0.141
T1	99 (18.5)	77 (14.4)
T2	137 (25.6)	155 (28.9)
T3 & T4	33 (6.2)	35 (6.5)
Pathologic N stage			0.028
N0	189 (36.1)	161 (30.8)
N1	41 (7.8)	56 (10.7)
N2 & N3	31 (5.9)	45 (8.6)
Pathologic stage			0.012
Stage I	163 (30.7)	133 (25)
Stage II	58 (10.9)	67 (12.6)
Stage III & Stage IV	43 (8.1)	67 (12.6)
Gender			0.410
Female	149 (27.6)	140 (26)
Male	120 (22.3)	130 (24.1)
Primary therapy outcome			< 0.001
PD	22 (4.9)	49 (10.9)
SD & PR	22 (4.9)	22 (4.9)
CR	186 (41.4)	148 (33)
OS event			0.002
Alive	190 (35.3)	157 (29.1)
Dead	79 (14.7)	113 (21)

CR: Complete response; PD: Progressive disease; SD: Stable disease; PR: Partial response; OS: Overall survival.

Table 2 The COX regression analysis about clinicopathological characteristics associated with the survival of lung adenocarcinoma patients

Characteristics	Total (N)	Univariate analysis		Multivariate analysis
		Hazard ratio (95%CI)	P value	Hazard ratio (95%CI)	P value
Pathologic T stage	527
T1	176	Reference		Reference
T2	285	1.507 (1.059-2.146)	0.023	1.086 (0.726-1.624)	0.687
T3 & T4	66	3.095 (1.967-4.868)	< 0.001	1.571 (0.827-2.984)	0.168
Pathologic N stage	514
N0	345	Reference		Reference
N1	96	2.293 (1.632-3.221)	< 0.001	1.293 (0.653-2.560)	0.461
N2 & N3	73	2.993 (2.057-4.354)	< 0.001	1.774 (0.906-3.471)	0.094
Pathologic stage	522
Stage I	292	Reference		Reference
Stage II & stage III & stage IV	230	2.889 (2.141-3.897)	< 0.001	1.587 (0.789-3.193)	0.195
Age	520
≤ 65	257	Reference
> 65	263	1.216 (0.910-1.625)	0.186
Gender	530
Female	283	Reference
Male	247	1.087 (0.816-1.448)	0.569
Number pack years smoked	363
< 40	183	Reference
≥ 40	180	1.073 (0.753-1.528)	0.697
HSPA4	530
Low	266	Reference		Reference
High	264	1.476 (1.104-1.972)	0.009	1.356 (0.967-1.901)	0.078