Advances in drug resistance of triple negative breast cancer caused by pregnane X receptor

Table 1 Role of pregnane X receptor in the mechanism of drug resistance in breast cancer (including triple-negative breast cancer)

Phase	Resistance-associated proteins associated with PXR	Resistance-associated proteins associated with breast cancer	Resistance associated proteins associated with TNBC	Resistance related proteins known to be regulated by PXR in TNBC	Possible regulatory targets of PXR in TNBC (unconfirmed)
Phase Ⅰ	CYP3A4, CYP3A23	CYP3A4, CYP3A5	CYP3A4	CYP3A4	CYP2C8
Enzymes metabolism	CYP3A11, CYP2B6	CYP2C8, CYP2C9	CYP4A11
CYPs	CYP2C8, CYP2C9	CYP2J2, CYP1A1	CYP4A22
	CYP2C19, CYP1A	CYP1B1, CYP17A1	CYP2C8
	CYP2B9, CYP2C55	CYP2B6, CYP2D6	CYP1B1
		CYP2C19, CYP2S1
		CYP4V2, CYP26A1
		CYP4A11, CYP4A22
Phase Ⅱ	GSTA1, GSTA2	GSTM1, GSTP1	GSTP1
Enzymes conjugation	GSTA3, GSTM1	GSTA1, GSTA2
GSTs	GSTM2, GSTM3
	GSTM4
UGTs	UGT1A1, UGT1A6	UGT1A, UGT2B7	UGT1A1		UGT1A1
	UGT1A3, UGT1A4
Phase Ⅲ	ABCB1, ABCB2	ABCC1, ABCC3	ABCC1	ABCC1
Ttansporters	ABCC1, ABCC2	ABCB1, ABCG2	ABCG2	ABCG2
ABCs	ABCC3, ABCC4	ABCC11	ABCC11
	ABCC5, ABCG2

PXR: Pregnane X receptor; TNBC: Triple-negative breast cancer; ABC: Adenosine triphosphate binding cassette; CYPs: Cytochrome P450s; UGTs: Uridine diphosphate glucuronosyltransferase; GSTs: Glutathione transferase.