Copyright ©2014 Baishideng Publishing Group Inc.
World J Clin Oncol. Dec 10, 2014; 5(5): 1036-1047
Published online Dec 10, 2014. doi: 10.5306/wjco.v5.i5.1036
Table 1 Evolving genomic tools for management of colon cancer
Clinically availableFecal occult blood testSingle gene sequencing (APC) Multigene panel next generation sequencingTargeted gene analysis for therapeutic contraindications (KRAS, UGT1A1)
Research basisFecal genomic DNA analysisTumor genome sequencing for prognosis
Future applicationCell free genomic DNA sequencingDevelopment of gene pathway directed therapeutics (e.g., small molecule inhibitors)