Scinderin promotes glioma cell migration and invasion via remodeling actin cytoskeleton

Figure 4 Scinderin silencing promotes F-actin depolymerization and inhibits RhoA/focal adhesion kinase signaling of glioma cells. A: F-actin cytoskeleton in glioma cells was visualized using Phalloidin staining (green). Scinderin (SCIN) led to a diminution of ruffles and pseudopods on the cell surface; B: Knockdown of SCIN reduced the expression of p-cofilin, RhoA, p-focal adhesion kinase, and Talin, as demonstrated by western blotting. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001.