Prospective Study
Copyright ©The Author(s) 2022.
World J Clin Oncol. Aug 24, 2022; 13(8): 712-724
Published online Aug 24, 2022. doi: 10.5306/wjco.v13.i8.712
Table 3 Univariate correlation analyses of clinicopathological parameters with cytochrome P450 2D6 phenotype classification

IM phenotype, n = 52
EM/UM phenotype, n = 18
P value
Median age in yr62.5 (51-86)61 (50-84)0.574
Disease stage0.595
I246
II178
III114
Ethnicity0.148
Chinese4713
Malay33
Indian12
Others10
Comorbidities0.728
Yes4314
No94
Tumor histology0.518
IDC4014
ILC71
Others53
Tumor grade0.247
1163
22510
3115
Median tumor size in mm16.5 (1.2 to 70.0)20.0 (3.0 to 45.0)0.334
Lymphovascular invasion0.527
Present167
Absent3611
ER intensity0.528
Low20
Moderate112
High3815
Negative11
Proportion of tumor cells staining ER-positive0.267
1% to 10%40
11% to 49%61
50% to 89%143
More than 90%2714
PR intensity0.631
Low51
Moderate95
High3111
Negative71
Proportion of tumor cells staining PR-positive0.785
1% to 10%113
11% to 49%82
50% to 89%187
More than 90%116
HER2 status0.495
Positive112
Negative4116
Clinical subtypes0.692
ER+/HER2-4114
ER+/HER2+102
ER-/HER2+10