Thromboembolic events in metastatic testicular cancer treated with cisplatin-based chemotherapy

Table 2 Thromboembolic events in patients with testicular germ cell tumors who underwent cisplatin-based chemotherapy at our Institution (n = 19)

Type/pathologic stage of testicular tumor	RPLN ≥ 3.0 cm before chemotherapy	Type/number of cycles of chemotherapy	PE/DVT	Timing of PE/DVT in relation to chemotherapy	Anticoagulant	Hospitalization
Seminoma IIB	Yes	BEP (2 cycles), EP (1 cycles)	DVT	Same day immediately prior to Cycle 1	Fondaparinux sodium	Yes
Seminoma IIA	No	EP (3 cycles)	DVT1	During (Cycle 1)	Heparin → apixaban	Yes
Seminoma IIIB	No	EP (4 cycles)	PE + DVT2	3 yr after initial chemotherapy, recurrent disease	Enoxaparin sodium	Yes
Non-seminoma IIB	Yes	BEP (2 cycles)	DVT2	During (Cycle 2)	Warfarin →enoxaparin sodium	Yes
Non-seminoma IIB	No	BEP (3 cycles)	PE	During (Cycle 2)	Heparin → enoxaparin sodium → rivaroxaban → apixaban	Yes
Non-seminoma IIC	Yes	EP (4 cycles)	PE + DVT	1 wk before Cycle 1	Heparin (lovenox) → warfarin	Yes
Non-seminoma IIA	No	BEP (3 cycles)	DVT2	During (Cycle 2)	Fondaparinux sodium	No
Non-seminoma IIB	Yes	BEP (3 cycles)	PE1	During (Cycle 3)	Fondaparinux sodium → warfarin	No
Seminoma IIA	No	BEP (3 cycles)	DVT2	During (Cycle 3)	None	No
Seminoma III	No	BEP (3 cycles)	PE	During (Cycle 3)	Enoxaparin sodium	No
Non-seminoma IIIC	Yes	BEP (4 cycles)	PE	During (Cycle 4)	Enoxaparin sodium	No
Non-seminoma IIIC	Yes	BEP (4 cycles)	DVT	During (Cycle 3)	Enoxaparin sodium	No
Non-seminoma IIA	No	BEP (3 cycles)	PE	During (Cycle 3)	Heparin → rivaroxaban	Yes
Non-seminoma IIA	No	BEP (2 cycles)	PE	During (Cycle 2)	Enoxaparin sodium	No
Seminoma IIC	Yes	BEP (3 cycles)	PE	1 mo after chemotherapy ended	Heparin → enoxaparin sodium	Yes
Seminoma IIA	No	BEP (3 cycles)	PE + DVT	During (Cycle 2)	Heparin → enoxaparin sodium	Yes
Non-seminoma IIB	No	BEP (3 cycles)	DVT	1 d prior to Cycle 1	Heparin → fondaparinux sodium	Yes
Non-seminoma IIIA	No	BEP (3 cycles)	PE	2 wk after chemotherapy ended	Warfarin + enoxaparin sodium	No
Seminoma IIC	Yes	EP (4 cycles)	DVT2	During (Cycle 2)	Enoxaparin sodium → fondaparinux	Yes

¹Infusaport.

²Peripherally inserted central catheter line. PE: Pulmonary embolism; BEP: Bleomycin, etoposide, and cisplatin; DVT: Deep vein thrombosis; EP: Etoposide and cisplatin.