First-line pazopanib in patients with advanced non-clear cell renal carcinoma: An Italian case series

doi:10.5306/wjco.v12.i11.1037

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Nov 24, 2021 (publication date) through Jul 27, 2024

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Nov 24, 2021; 12(11): 1037-1046
Published online Nov 24, 2021. doi: 10.5306/wjco.v12.i11.1037

Table 1 Characteristics of patients, n (%)

Baseline characteristic	n = 48
Age, median (range)	70 (27-86)
Sex
Males	36 (75)
Females	12 (25)
Histology
Papillary	24 (50)
Chromophobe	9 (10.8)
Xp11 translocation	1 (2.1)
Unclassified	6 (12.5)
Mixed¹	8 (16.7)
Grade (Fuhrman/ISUP)
1-2	6 (12.5)
3	15 (31.3)
4	4 (8.3)
NA	23 (47.9)
Stage at diagnosis
I-III	33 (68.8)
IV	15 (31.3)
Previous nephrectomy
Yes	41 (85.4)
No	7 (14.6)
Metastasectomy
Yes	7 (14.6)
No	41 (85.4)
ECOG PS
0	37 (77.1)
1	11 (22.9)
IMDC score risk group
Good	19 (39.6)
Intermediate	25 (52.1)
Poor	2 (4.2)
NA	2 (4.2)
Starting dose of pazopanib
800 mg	31(64.6)
600 mg	10 (20.8)
400 mg	7 (14.6)

¹Four tumors had mixed histology (clear-cell/papillary) with papillary histology prevalence and four tumors had mixed histology (clear-cell/chromophobe) with chromophobe histology prevalence.

NA: Not assessed/available; IMDC: International Metastatic Renal Cell Carcinoma Database Consortium; ECOG PS: Eastern Cooperative Oncology Group Performance Status; ISUP: International Society of Urological Pathology.

Citation: Buti S, Bersanelli M, Massari F, De Giorgi U, Caffo O, Aurilio G, Basso U, Carteni G, Caserta C, Galli L, Boccardo F, Procopio G, Facchini G, Fornarini G, Berruti A, Fea E, Naglieri E, Petrelli F, Iacovelli R, Porta C, Mosca A. First-line pazopanib in patients with advanced non-clear cell renal carcinoma: An Italian case series. World J Clin Oncol 2021; 12(11): 1037-1046
URL: https://www.wjgnet.com/2218-4333/full/v12/i11/1037.htm
DOI: https://dx.doi.org/10.5306/wjco.v12.i11.1037