Long-term outcomes of interventions for radiation-induced xerostomia: A review

Table 5 Submandibular gland transfer: Salivary function, quality of life, toxicity

Author	Salivary function	Quality of life	Toxicity
Zhang et al[31], 2004	Transfer 1.39 g and 1.6 g saliva vs 0.66 and 0.68 g control at 1 yr and 5 yr, respectively. Significantly higher submandibular gland secretion in transfer group at 5 yr (radionuclide scintigraphy).	Significantly improved speech, chewing, swallowing, changes in eating habits, nighttime xero, need to wake up to drink frequently, sleep quality in transfer group	No surgical death or complications occurred in transfer group
Rieger et al[51], 2012	NA	NA	Not reported
Liu et al[50], 2011	Significantly better trapping and excretion (scintigraphy) in transfer group at 5 yr; Significantly higher mean weight of unstimulated saliva in transfer group at 5 yr	Transfer group improved significantly vs control in dry mouth, night rest, drink to speech, drink to eat, water intake, change in feeding pattern, tooth decay, and visual analogue scale	No major complications of surgery (one pt taken back 2 yr later for removal of wire used to mark borders of transferred gland due to pain)
Seikaly et al[49], 2004	Significantly higher stimulated and unstimulated saliva in transfer group at 16 mo	NA	No surgical complications from submandibular transfer
Jha et al[48], 2003	stimulated and unstimulated saliva decrease gradually, then increase at 16 mo (graphical)	NA	No surgical complications

xero: Xerostomia; NA: Not available.