Copyright ©2010 Baishideng Publishing Group Co.
World J Clin Oncol. Nov 10, 2010; 1(1): 35-40
Published online Nov 10, 2010. doi: 10.5306/wjco.v1.i1.35
Figure 3
Figure 3 Proposed mechanism of procathepsin D/cathepsin D function in cancer progression. The over-expressed procathepsin D (pCD) escapes the physiological intracellular targeting pathways and is secreted by the cancer cells. Small part of secreted pCD is bound and internalized via M6PR pathway, the rest by a yet unidentified receptor. The receptor-pCD interaction activates mitogen-activated protein kinases (MAPK) pathway with subsequent changes in expression of numerous cancer-promoting genes including NFKB2 and some cytokines. Interaction of pCD with endothelial and stromal cells is also involved.