Deep diving in the PACIFIC: Practical issues in stage III non-small cell lung cancer to avoid shipwreck

Figure 1 Radiotherapy and immune checkpoint inhibitors: Complementary mechanisms of action. The yellow arrows indicate anti-tumor processes and the red lines, mechanisms that block or suppress this anti-tumor immune response. APC: Adenomatous polyposis coli; ICI: Immune checkpoint inhibitors.

Figure 2 Decision making process diagram to evaluate candidate patients for durvalumab consolidation according to PACIFIC trial strategy in clinical practice. ¹In Europe. CRT: Chemoradiotherapy; EBUS: Endobronchial ultrasonography; EUS: Esophageal ultrasonography; HIV: Human immunodeficiency virus; NSCLC: Non-small cell lung cancer; PET-CT: Positron emission tomography-computed tomography; PD-L1: Programmed cell death ligand 1.