Cancer, influenced by genetics and the environment, involves anoikis, a cell death mechanism upon extracellular matrix detachment crucial for metastasis. Understanding this relationship is key for therapy. We analyze cancer and anoikis trends using bibliometrics.

A search was conducted from Web of Science Core, PubMed, Scopus and non-English databases such as the CNKI (inception- 21 December 2024). Data analysis employed Microsoft Excel, VOSviewer, CiteSpace, R software, and the online platform (https://bibliometric.com/).

2510 publications were retrieved, with a significant increase in the last decade. China led, the University of Texas system was productive, and the Oncogene Journal was popular. Breast, and colorectal cancers were frequently studied. Among them, representative tumor-related mechanisms were identified, commonalities such as (EMT, ECM, autophagy) and respective specific mechanisms were summarized.

This bibliometric analysis highlights rapid advances in anoikis research in cancer, emphasizing EMT and FAK pathways' translational potential, guiding targeted therapies, and improving cancer treatment outcomes.

Globally, there are over 3 million severe cases of influenza each year, leading to up to half a million deaths. This study provides a comprehensive analysis of the current status of children's influenza vaccine research over the past 20 years and explores potential future research trends, including improvements in vaccine coverage and strategies to address vaccine hesitancy. We extracted all research data on children's influenza vaccines from 2004 to 2024 using the Web of Science Core Collection (WOSCC). The contributions of various countries/regions, institutions, authors, and journals in this field were assessed, and research hotspots as well as promising future trends were predicted through keyword analysis using CiteSpace and VOSviewer. A total of 2,598 related publications from 2004 to 2024 were identified and collected for analysis. The United States (USA) and England emerged as the leading contributors with the highest number of published papers. AstraZeneca was identified as a key leader among research institutions, and Ambrose Christopher S was recognized as the most productive author in this field. The journals Vaccine and Human Vaccines & Immunotherapeutics stood out as the most prominent publications in this area. The keyword analysis highlighted that international research collaboration maybe a promising strategy for bridging global gaps; Addressing vaccine hesitancy could potentially increase vaccination coverage; Live attenuated vaccines, intranasal administration and universal vaccines are promising directions for future development. These insights highlight potential avenues for improving influenza vaccine coverage and inform strategies to mitigate vaccine hesitancy, crucial for protecting children and enhancing public health.

Vaccination is the most effective measure to prevent Chlamydia infection. However, to date, no vaccine has successfully completed the rigorous clinical trial process and gained regulatory approval for use in clinical practice. Scholars have been working on a safe and effective Chlamydia vaccine. In order to better grasp, the global frontiers and development trends in this field, a comprehensive bibliometric analysis was carried out. A total of 234 publications closely regarding Chlamydia vaccines were culled from the Web of Science Core Collection database, and the bibliometric information was then extracted with CiteSpace and VOSviewer software. After measurement analysis, the most influential papers were identified in this area, including highly cited papers, references with strong citation burst, and high co-citated papers. Vaccine has published the most literature on Chlamydia vaccines. Only scholars from 39 countries/regions have been engaged in studying Chlamydia vaccines. The USA is the most prolific country and has the highest collaborative strength. The current research area has focused on protective immunity and immunopathological response. Major outer membrane protein (MOMP) is the most common target vaccine antigen. This study reveals the status of literature and highlights emerging trends in this field, which helps researchers seek insights into this area and serve as a reference guide for further investigations.

Onconephrology is an expanding subspecialty focused on the management of cancer patients with renal injury. This study used a comprehensive bibliometric analysis to emphasize the need for cooperation between oncologists and nephrologists, exploring current trends and future research areas in onconephrology.

Relevant literature on onconephrology published between 1 January 2000 and 27 April 2024 was retrieved from the Science Citation Index Expanded of the Web of Science Core Collection, followed by manual screening. Bibliometric analyses were performed using CiteSpace, VOSviewer, and Bibliometrix software.

A total of 1,853 publications, including 1,647 articles and 206 reviews, by 11,606 authors from 2,757 institutions in 73 countries, were analyzed. Annual publications generally follow a steadily increasing trend, ranging from 25 to 161 documents. The United States (n = 464), The University of Texas MD Anderson Cancer Center (n = 39), Meletios A. Dimopoulos (n = 21), and Nephrology Dialysis Transplantation (n = 35) were the most productive country, institution, author, and journal, respectively. Immune checkpoint inhibitors, glomerular filtration rate, and cisplatin were clusters of highly cited references after 2015. Oxaliplatin, calcium, open-label, and thrombotic microangiopathy were trending topics after 2020. Outcome, acute kidney injury, immunotherapy, and chronic kidney disease were keyword bursts that persisted through 2024.

Current research of onconephrology is focusing on chemotherapeutic nephrotoxicity, kidney function assessment, dosing of chemotherapeutic agents in chronic kidney disease, glomerular disease in cancer, immunotherapy, and electrolyte disturbances. Future directions in this field include clinical trials and thrombotic microangiopathy.

Sleeping disorders negatively affect cancer patient management, quality of life, and recovery. Immunotherapy, a rising cancer treatment, shows potential to improve sleep quality by reducing inflammation. This study analyzed 255 publications (2000-2024) from the Web of Science Core Collection using bibliometric methods. The US and China dominate research output, with The Mayo Clinic as a key contributor. Core topics are "immunotherapy," "quality of life," and "antibodies." Emerging keywords like "cancer," "encephalitis," and "depression" highlight a shift toward clinical psychology in treating tumors and rare diseases. It is noteworthy that with the rapid expansion of immunotherapy in cancer treatment, clinical trials have shown that it can improve sleep quality in cancer patients by reducing inflammation. As its application in cancer treatment expands, immunotherapy's potential for treating sleep disorders is promising. Future development is expected to improve sleep quality and address clinical issues, offering broad prospects for patient outcomes.

Diabetes Mellitus, characterized by insufficient insulin secretion, pancreatic beta cell damage, or insulin resistance, is the third most prevalent chronic metabolic disease worldwide. Polysaccharides, biocompatible natural macromolecules, have garnered significant attention for their potential in modulating diabetes through various mechanisms. Despite extensive studies, a comprehensive and impartial evaluation of anti-diabetic polysaccharides (ATDPs) research is still lacking. This study employs bibliometric and knowledge mapping techniques to analyze research trends and developments concerning ATDPs. A total of 3435 publications from 2001 to 2024 were examined, revealing a marked increase in publication volume and citation frequency, particularly since 2016. Network analysis indicates China as the leading contributor, with the highest number of publications and prominent institutions. The International Journal of Biological Macromolecules is identified as the most prolific journal in this field. Shaoping Nie stands out as a leading researcher with the highest citation frequency and h-index. Current research trends focus on the role of polysaccharides in regulating oxidative stress and inflammation, modulation of gut microbiota, and their structural characterization. Emerging studies investigate how these polysaccharides impact gut microbiota composition, enhance intestinal barrier functions, and modulate immune responses, representing cutting-edge areas in diabetes research. This research pioneers the use of bibliometric analysis to map ATDPs research trajectories, offering valuable insights into prevailing trends, emerging topics, and opportunities for future research and collaboration.

The aim of this study was to analyze the 100 most cited articles (T100) on Cubital Tunnel Syndrome (CuTS).

T100 articles were identified using the Web of Science database with the keyword cubital tunnel syndrome on January 10, 2024. Bibliometric analysis included information such as article title, total number of citations, number of authors, author names, country of publication, year of publication, type of publication, subject covered, journal publishing, h-index of publishing journals, Q classification, and impact factor.

The number of citations for T100 articles ranged between 28 and 183. Journal of Hand Surgery - American Volume (n = 28) was the journal with the highest number of T100 articles. In the comparison between countries, the United States of America (n = 55) was represented by the highest number of articles. The evaluation of the main topics covered in the articles showed that surgical treatment (n = 64) was the main topic in the majority of T100 articles.

The results of this study provide insight into the scientific community's interest in CuTS. This study can be a guide for further research and potential solutions for CuTS.

Ovarian cancer (OC) is a common malignant tumor in women, with poor prognosis and high mortality rates. Early diagnosis, screening, and prognostic prediction of OC have long been focal points and challenges in this field. In recent years, machine learning (ML) has gradually demonstrated its unique advantages in the early diagnosis, screening, and prognostic prediction of tumors, including OC.This study aims to analyze global development trends and research hotspots in the application of ML for OC, thereby providing a reference for future research directions.

We searched the Web of Science Core Collection (WoSCC) for all publications related to OC and ML from 2004 to 2024, conducting a quantitative analysis using VOSviewer, R software, and CiteSpace.

A total of 777 articles were retrieved.The number of publications related to ML and OC has grown continuously over the past 20 years.China led with 254 articles.The most prominent journals include Gynecologic Oncology, Nature, Clinical Cancer Research, Cancer Research, and Journal of Clinical Oncology.Research hotspots are: (a) ML-driven OC biomarker discovery and personalized treatment; (b) ML in tumor microenvironment analysis and resistance prediction; (c) ML in imaging-based diagnosis and risk stratification; (d) ML in multicenter OC studies.

ML in OC is currently in a developmental phase and shows promising potential for the future. This study provides researchers and clinicians with a more systematic understanding of research priorities and forthcoming developments in this area.

Microneedles can physically penetrate the stratum corneum, creating micropores on the skin, and allowing for drug delivery through direct diffusion, injection, or other methods. As a novel drug delivery method, it possesses significant application potential. This study uses bibliometric analysis to explore the research hotspots and development trends of microneedle-mediated drug delivery.

Relevant research articles on microneedle-mediated drug delivery published between 1998 and 2024 in the Web of Science Core Collection (WoSCC) database were retrieved. Data analysis and visualization were performed using VOSviewer, CiteSpace, Scimago Graphica, and Pajek, enabling the prediction of research trends in microneedle-mediated drug delivery.

In general, research on microneedle-mediated drug delivery has shown a continuous increase. China and the United States are the leading countries in this field of study. Notably, Ryan F. Donnelly (n=224) is the most prominent contributor to this field. The current core research directions include: disease treatment, enhancement of transdermal absorption performance of microneedles, vaccine delivery, and new materials and technologies for microneedle manufacturing.

Microneedle-mediated drug delivery, as a novel technology and method, holds significant research value and application potential. However, further strengthening of international collaboration and the clinical translation of research findings are needed.

Nucleic acid probes, which are short sequences of nucleic acids designed to complement specific DNA or RNA targets, have broad applications in biosensing, genetic studies, and various other fields. In tumor diagnosis and treatment, nucleic acid probes offer a precise and accessible approach that is essential for improving patient care and quality of life. Despite substantial research on nucleic acid probes over the past three decades, few comprehensive reviews have retrospectively examined the field.

This study extracted 30 years of nucleic acid probe-related research articles from the Web of Science Core Collection database. We used CiteSpace, VOSviewer, and R tools to systematically analyze the field's current status and developmental trends, with an emphasis on applications in oncology.

Our findings indicate a continuous growth trend in nucleic acid probe research, with the United States and China, along with their leading institutions and authors, making the most significant contributions. In oncology specifically, nucleic acid probe research has focused primarily on signal amplification, liquid biopsy, and drug delivery. The emergence of novel biomarkers and assay techniques has been a pivotal factor driving advancements in this field.

Nucleic acid probes show strong potential for applications in tumor precise diagnosis and treatment. Continued innovation and closer interdisciplinary collaboration will be vital for further advancements, while large-scale clinical studies are needed to validate their clinical utility.

Clonal hematopoiesis (CH) refers to the clonal expansion of hematopoietic stem cells caused by somatic mutations. CH is commonly observed in elderly individuals and is closely associated with myeloid malignancies as well as various non-malignant diseases. This study aims to explore the research trends and hotspots of CH using bibliometric analysis.

Relevant studies were retrieved from the Web of Science Core Collection database based on predefined inclusion criteria. Bibliometric analysis and visualization were conducted using VOSviewer, CiteSpace, and R software.

A total of 851 studies were included. From 2014 to 2024, the annual number of publications showed a consistent upward trend. The United States was identified as the leading country in this field, contributing 53.7% of the total publications. Harvard Medical School and Benjamin L Ebert were recognized as the most influential institution and author, respectively. Blood was the most prolific journal, with the highest citation and H-index. Research on CH-related gene mutations and their association with the risk of acute myeloid leukemia is currently the most extensively studied area, while cardiovascular diseases and inflammation have emerged as recent research hotspots.

This study is the first to systematically analyze research related to CH using bibliometric methods. Our analysis reveals the overall landscape of CH research and identifies the most influential contributors in the field, including countries, institutions, authors, and journals. Moreover, we identify emerging research hotspots and key areas, highlighting potential avenues for exploration and innovation within the field of CH.

BackgroundAlzheimer's disease (AD) is characterized by amyloid-β plaques and tau aggregates, with autophagy dysfunction playing a key pathogenic role. While autophagy modulation shows therapeutic promise, comprehensive bibliometric analyses are lacking.ObjectiveThis study aims to map the research landscape of autophagy in AD through bibliometric analysis, identifying key trends, contributors, and emerging focus areas.MethodsWe analyzed 4018 publications (2003-2023) from Web of Science using VOSviewer and CiteSpace. Publication trends, influential authors, countries, institutions, and research hotspots were examined through co-occurrence, burst detection, and clustering analyses.ResultsAnnual publications have steadily increased, peaking in 2022. The US led in output and citations, with major contributions from the University of California and New York University. Ralph A. Nixon emerged as the most influential author. Early research (2003-2013) primarily focused on protein degradation mechanisms, whereas recent studies (2014-2023) emphasize mitochondrial dysfunction, apoptosis, and related pathways. Key evolving topics include endoplasmic reticulum stress and chaperone-mediated autophagy, with significant implications for therapeutic innovation.ConclusionsAutophagy plays a critical role in AD pathogenesis and represents a promising therapeutic target. Despite mechanistic advances, clinical translation remains challenging. Future research should prioritize multi-omics integration, drug delivery optimization, and managing risks associated with excessive autophagy activation. These findings provide valuable insights for developing novel AD therapies targeting autophagy.

Pediatric bronchial asthma, a prevalent chronic inflammatory respiratory disease, significantly affects children globally. However, bibliometric analyses focused on its inflammatory and immunological aspects are limited. This study aims to provide an overview of the field, identify key focus areas, and predict emerging trends.

We collected and analyzed relevant literature published from January 1, 2000, to May 31, 2024, from the Web of Science Core Collection. Collaborative network analysis was conducted using CiteSpace 5.8.R3, VOSviewer 1.6.20, and Bibliometrix.

A total of 911 papers were retrieved, showing growth in research output since 2006, with the United States leading in publications. The University of Western Australia ranks first in publication count, while the University of Wisconsin-Madison has the highest average citations per paper. Among 5,059 authors, 146 core authors contributed to 592 articles, accounting for 64.98% of total publications, with Anne M. Fitzpatrick as the leading author. The journal "Allergy, Asthma & Immunology Reviews" is the most influential, and "asthma" is the most cited keyword. Co-citation analysis reveals 20 keyword clusters, with hotspots including "efficacy" and "allergic rhinitis." The most cited paper is by D. P. Strachan in the "British Medical Journal."

This study reveals a significant increase in pediatric asthma research from 2000 to 2024, with the U.S. leading in scholarly contributions. Key findings highlight allergic airway inflammation and type 2 inflammation as primary mechanisms underlying the disease. Inhaled corticosteroids and biologics are identified as effective treatments. These insights emphasize the importance of global collaboration and ongoing research efforts to advance understanding of pathogenic mechanisms and clinical management in pediatric asthma patients.

Type 2 diabetes mellitus (T2DM) is estimated to impact 693 million individuals globally by 2045. Diabetes remission has the potential to slow disease progression, alleviate psychological burdens, minimize complications, and improve quality of life. We aimed to perform a bibliometric analysis of research on T2DM remission. We searched the Web of Science (WoS) database to identify relevant publications on T2DM remission during 2002 to 2022. Research trends and hotspots in T2DM remission were analyzed using Bibliometrix R and CiteSpace. The analysis considered various factors such as publication year, authors, journal, institution, country/region, themes, thematic evolution, keywords, and keyword bursts. The WoS search yielded 2254 articles. The annual scientific output has consistently increased. Lee was the most prolific author (48 papers). Obesity surgery was the leading journal (296 publications), while diabetes care had the highest h_index (43). The University of Copenhagen was the most active institution (116 papers). The most productive countries were the US (476), China (347), the UK (180), Italy (121), and Japan (90). The top 3 keywords were "bariatric surgery," "weight loss," and "remission." From 2013 to 2015, the usage of the term "medical therapy" significantly surged, lasting for 3 years. The term "GLP-I receptor agonists" also had a lasting burst. In the past 5 years, "weight loss" and "low-calorie diets" have emerged as prominent areas of research. This study analyzed the research trends and key factors in the field of type 2 diabetes mitigation through bibliometrics, providing important data support and a basis for decision-making for future research and public health policies.

Osteoarthritis (OA) is one of the common chronic arthritis in middle-aged and elderly people, but the effect of lipid metabolism on OA is still unclear. The aim of this study was to explore the value of lipid metabolism markers as emerging biomarkers for assessing OA disease activity. The literature on OA and lipid metabolism indicators was extensively analyzed by bibliometric. Correlation analysis was used to analyze the correlation between lipid profile indicators (total cholesterol; triglycerides [TG]; high density lipoprotein cholesterol [HDL-C]; and low density lipoprotein cholesterol) and immunoinflammatory indicators (high sensitivity C-reactive protein; erythrocyte sedimentation rate [ESR]) in patients with OA as well as the disease activity level (visual analog scale (VAS). Logistic regression modeling was used to calculate univariate and multivariate factors of disease activity. A total of 843 papers were retrieved. China and the United States are the 2 most productive countries in this field, and the United States has the highest H-index. In addition, Osteoarthritis and Cartilage is the most published journal. OA lipid metabolism research has long focused on inflammation, lipid metabolism, and pain. The levels of inflammation (ESR, high sensitivity C-reactive protein) and lipid metabolism indicators (total cholesterol; TG, HDL-C) were significantly increased in OA patients. Inflammation indicators were significantly correlated with lipid metabolism indicators. In addition, HDL-C, ESR, and TG were identified as independent influencing factors for OA-VAS. In summary, the role of lipid metabolism in OA has been a hot topic. Markers of inflammation and lipid metabolism were independent influencing factors of OA-VAS.

Pulmonary metastasis frequently complicates osteosarcoma, making the investigation of its mechanisms and therapeutic strategies a focal point in both clinical medicine and biosciences. The explosive growth of the relevant literature has still not been systematically sorted out and summarized.

Bibliometric methods were used in this study, Literature was retrieved from the Web of Science Core Collection, SCOPUS, and PubMed up until July 1, 2024. Bibliometric indicators were analyzed and research trends and hotspots in the field visualized using the Bibliometrix package, VOSviewer 1.6.19 and Citespace 6.3.R1 software.

A total of 1148 publications were reviewed, revealing that over the past five decades, the cumulative number of publications on pulmonary metastasis of osteosarcoma has gradually increased. China leads in the number of published papers, while the United States exhibits the most collaborative relationships with other countries. Italy is noted for the highest quality of research. Sun Yat-sen University is the most prolific institution, and the most productive author is Eugenie S. Kleinerman from the University of Texas MD Anderson Cancer Center. "Cancer" is the journal with the most publications, and Zhou Yan's 2020 paper received the highest local citations. Keywords such as "angiogenesis," "tumor microenvironment," and "surgery" appeared frequently, suggesting these topics are current research hotspots.

"Immunotherapy", "survival", "chemotherapy", "prognosis", "biomarkers", "metastasectomy", "microRNA", "angiogenesis", "tumor microenvironment", and "surgery" define key research areas. Current hot topics include tumor-associated macrophages and the tumor microenvironment, which may hold the key to future therapeutic breakthroughs.

Venous thromboembolism (VTE) is a leading cause of cardiovascular-related deaths. Non-vitamin K antagonist oral anticoagulants (NOACs) offer effective therapy without injections or blood monitoring. This bibliometric analysis explores the research on NOACs for preventing VTE and pulmonary embolism.

Literature up to July 20, 2024, was searched in Web of Science Core Collection. Citespace software was used for screening and analysis.

In this study, we analyzed 2124 articles and 767 reviews from 11,282 institutions across 528 countries and regions, encompassing 830 publications and 60 research directions. The USA led in publication count, followed by Germany and Canada. Cardiovascular System Cardiology, Hematology, and General Internal Medicine were the top research areas, while THROMBOSIS AND HAEMOSTASIS was the leading journal. From 2004 to 2024, we observed accelerated publication growth, particularly from 2008, highlighting the emergence of NOACs as a major research focus. Key contributors, including Bengt I. Eriksson, and major institutions like Harvard Medical School and University of Amsterdam, played pivotal roles in advancing anticoagulant research. Co-citation and keyword clustering analyses revealed research hotspots in NOACs, cancer-associated venous thromboembolism, stroke prevention, and COVID-19-related thrombotic events, reflecting a shift towards individualized anticoagulation therapy and the growing importance of NOACs in various clinical contexts.

The development of NOACs has progressed rapidly, with an increasing number of publications, indicating the lead research in the United States and other Western nations. Comparative studies on the safety and efficacy of NOACs have become a significant focus, shifting from traditional anticoagulants. Pharmacogenetics-guided use of NOACS shows new hope of precision medicine.

Hairy root is a special form of root tissue, which is induced by Rhizobium rhizogenes and could mediate genetic transformation after the infection of explants. They have attracted attentions because of their advantages of fast growth rate, convenient culture, stable genetic properties and strong synthesis ability of secondary metabolites. With bibliometrics, this study employed CiteSpace and VOSvivewer softwares to analyze the publications on hairy roots researches from 2009 to 2024 based on WOS database. The subject distribution, countries, institutions and personnel, research hotspots and research trends of hairy roots were discussed and analyzed. The results revealed a consistent increase in publications on hairy root with America, China and India as the main countries. The institutions were mainly universities and the Chinese Academy of Sciences was a major contributor to this topic and had close cooperation with other institutions. The researches of hairy roots mainly focused on plant genetic transformation, secondary metabolism and gene molecular function analysis, and in environmental remediation. The application of hairy roots could be an important research hotspot in the future.

This study analyzes research trends in anesthesiology over the past decade (2013-2023) by conducting a systematic keyword analysis of articles published in leading anesthesia journals, including Anesthesia, British Journal of Anesthesia, Anesthesiology, Journal of Clinical Anesthesia, and Anesthesia & Analgesia. Using the Bibliometrix software package (R version 3.5.6), we identified temporal patterns and journal-specific preferences in research themes. Early trends emphasized pain management, neuromuscular blockade, and perioperative physiology, while the COVID-19 pandemic shifted focus toward respiratory management and pandemic-related concerns. In recent years, research priorities have increasingly highlighted perioperative brain health, including postoperative cognitive dysfunction and delirium, alongside the integration of artificial intelligence to optimize perioperative care. These findings reflect the evolving landscape of anesthesiology, with a growing emphasis on mitigating postoperative complications and addressing the cognitive outcomes of surgical patients-issues of relevance to aging populations. By bridging gaps between research innovations and clinical application, this study underscores the importance of multidisciplinary collaboration to enhance patient outcomes and inform public health strategies in the perioperative setting.

Alzheimer's disease (AD) is a neurodegenerative disease that imposes a heavy burden on patients and their families. Hypertension is an important risk factor for AD, but the specific mechanism of its impact is still unclear. This study thus aimed to analyze the relationship and trend changes between AD and hypertension through bibliometric methods.

Literature on AD and hypertension was retrieved from the Web of Science Core Collection (WoSCC) database between 2004 and 2023. Data regarding countries, institutions, authors and journals were sourced from WoSCC. CiteSpace and VOSviewer were used for data visualization, including author collaboration, timelines view of references, reference bursts and overlay visualization maps of keywords. Excel 2018 software was used for the statistical analysis.

A total of 1,833 publications were ultimately included. From 2004 to 2023, the number of publications per year basically showed an increasing trend. The United States (United States) not only had the largest output of publications and the highest H-index but also had the seven highest frequencies of publication institutions. Kehoe, Patrick ranked first with the most articles among 9,330 authors. The journal with the most published articles was the Journal of Alzheimer's Disease. Reference analysis revealed a hotspot in the exploration of the pathophysiological association between AD and hypertension. Second, the treatment effects and potential risks of antihypertensive drugs (AHDs) on AD are also the focus of research. Researchers have carried out a series of studies ranging from basic research to clinical research on AHDs for the treatment of AD. Finally, personalized treatment strategies will also become one of the hotspots of future research. Controlling hypertension through lifestyle changes and medication interventions in AD patients is a promising strategy. The analysis of keywords revealed that "amyloid deposition," "preeclampsia," "Corona Virus Disease 2019 (COVID-19)" and "biomarkers" have been research hotspots in recent years.

By analyzing the references and keywords, we summarized the hot topics and research trends in this field. These findings provide useful information for researchers to explore the relationship between hypertension and AD further, with the hope of providing more effective treatments for AD patients to delay disease progression and improve quality of life.

This study analyzes trends and hotspots in the research on exercise for insomnia using bibliometric methods and visually presents key information in the field.

Using Web of Science Core Collection as a source of literature, Microsoft Excel 2019, CiteSpace, VOSviewer, and the Bibliometrix package based on R language software were used to create visualization graphs and analyze the publications by country and region, institution, journal, author, reference, and keyword.

This study included 1,419 papers. The overall number of publications showed an increasing trend, and the highest number of papers in this field were published by the United States and China by country, the University of California System in the United States by institution, and Markus Gerber from Switzerland by author. The trends and hotspots in this field identified through keyword analysis include "insomnia," exercise," "depression," "older adults," and "quality of life."

The research field of exercise therapy for insomnia is receiving increasing attention, and this study provides a clear and intuitive reference for researchers.

Along with discussing bibliometric analyses' limitations and potential biases, this paper addresses the growing need for comprehensive guidelines in evaluating bibliometric research by providing systematic frameworks for both peer reviewers and readers. While numerous publications provide guidance on implementing bibliometric methods, there is a notable lack of frameworks for assessing such research, particularly regarding performance analysis and science mapping. Drawing from an extensive review of bibliometric practices and methodological literature, this paper develops structured evaluation frameworks that address the complexity of modern bibliometric analysis, introducing the VALOR framework (Verification, Alignment, Logging, Overview, Reproducibility) for assessing multi-source bibliometric studies. The paper's key contributions include comprehensive guidelines for evaluating data selection, cleaning, and analysis processes; specific criteria for assessing conceptual, intellectual, and social structure analyses; and practical guidance for integrating performance analysis with science mapping results. By providing structured frameworks for reviewers and practical guidelines for readers to interpret and apply bibliometric insights, this work enhances the rigor of bibliometric research evaluation while supporting more effective peer review processes and research planning. The paper also discusses potential areas for further development, including the integration of qualitative analysis with bibliometric data and the advancement of field-normalized metrics, ultimately aiming to support authors, reviewers, and readers in navigating the complexities of bibliometrics and enhancing the meaningfulness of bibliometric research.

Hemophilic arthropathy (HA), a common complication of hemophilia caused by recurrent hemarthrosis, significantly impacts patients' quality of life. Despite ongoing research, a comprehensive overview of research trends for HA is lacking. Therefore, this study utilizes bibliometrics and knowledge mapping techniques to visually analyze the current status and developmental trends of HA-related research, and analyzed and predicted future research hotspots.

A bibliometric analysis was conducted using the Web of Science Core Collection database. Data on publications, author names, countries, research institutions, journals, and keywords were extracted and visualized using Bibliometrix, VOSviewer, and CiteSpaces.

The number of HA-related publications has increased steadily over time. United States was found to be the leading country in terms of publications and international collaborations. HEMOPHILIA was found to be the most influential journal and Hospital Universitario La Paz to be the leading institution conducting HA-related research. Rodriguez-Merchan EC was identified as the most prominent researcher in the field. Keyword analysis identified five main research clusters, namely, quality of life and management, pathogenesis, classification and functional assessment, replacement surgery, and ankle arthritis treatment.

This bibliometric analysis provides a comprehensive overview of the research trends for HA. Future studies must focus on elucidating the underlying mechanisms of HA, developing early diagnostic biomarkers, and exploring personalized treatment strategies to improve patient outcomes. Our study offers valuable insights to researchers to facilitate the identification of emerging trends and prioritization of future research directions.

Recently, numerous studies have reported the application of nanomedicines in colorectal cancer treatment. However, no systematic bibliometric analysis has been conducted to examine the potential and mechanisms of action of nanomedicine in this context. Such an analysis may provide a comprehensive overview of the current research landscape, identify emerging trends, and highlight key areas for future investigation.

To describe the current global research landscape on the application of nanomedicine in colorectal cancer treatment.

The Web of Science Core Collection database was searched for literature published from January 1, 2010, to August 7, 2024, focusing on the application of nanomedicine in colorectal cancer treatment. Bibliometric analysis and visualization mapping of countries, institutions, authors, keywords, references of the relevant research literature were conducted using CiteSpace (6.2R6), VOSviewer (1.6.20), and bibliometrix (based on R 4.3.2).

A total of 3598 articles were included, with a rapid increase in publication volume starting from 2010. China published the most papers on this topic, followed by the United States and India. The United States emerged as the central country in this field, and the Egyptian Knowledge Bank and Chinese Academy of Sciences were the institutions with the highest number of publications. The Chinese Academy of Sciences exhibited the highest centrality. The most prolific author was Zhang Y, whereas Siegel RL was the most cited author, and Li Y had the highest H-index. The International Journal of Nanomedicine had the most publications and Biomaterials received the most citations. Keyword co-occurrence analysis identified 11837 keywords grouped into 13 clusters with 15 high-frequency highlighted keywords. The top three keyword clusters were "0 colorectal cancer", "1 drug delivery", and "2 delivery", with the top three keywords being "nanoparticles", "colorectal cancer", and "drug delivery".

Research on nanomedicine for colorectal cancer has surged since 2010, focusing on "nanoparticles" and "drug delivery". Future studies should investigate nanomaterial stability and target-specific drug release.

Renal fibrosis (RF) represents a significant public health challenge, necessitating the urgent identification of effective and safe therapeutic agents. Mitochondrial-targeted strategies have demonstrated considerable promise in restoring renal function and mitigating fibrosis. This study aims to examine the evolution of research and therapeutic interventions for RF from a mitochondrial perspective through bibliometric analysis. Literature retrieval was primarily conducted using the Web of Science Core Collection. Visual analysis was performed utilizing the Bibliometrix package (R- 4.4.2), CiteSpace 6.3.R1, and VOSviewer 1.6.19. A total of 819 documents were included for analysis. Significant contributions were made by researchers from China and the USA, with Nanjing Medical University leading in publication volume. Zhang Aihua and Huang Songming emerge as key scholars in the field, while the International Journal of Molecular Sciences is the journal with the highest publication output. Key research themes include oxidative stress, expression, injury, activation, mechanisms, and mitochondrial dysfunction. Mitochondrial-targeted approaches for treating RF can be categorized into six main strategies: mitochondrial biogenesis regulators, mitochondrial dynamics modulators, mitophagy inducers, oxidative stress regulators, NLRP3 inhibitors, and other mitochondrial-targeted therapeutic approaches. This study comprehensively examines the current state of RF research from a mitochondrial standpoint, summarizing key drugs and potential mechanisms of mitochondrial regulation. The findings aim to enhance scholarly understanding of the ongoing research trends and provide valuable insights for the development of targeted therapeutic agents.

The incidence of nerve entrapment-related diseases, caused by a variety of factors, has been increasing annually, significantly impairing patients' quality of life. Nerve decompression serves as one of the critical approaches for treating such conditions. However, there remains a scarcity of bibliometric analyses within the field of nerve decompression.

The publications related to nerve decompression in the Web of Science database from 2005 to 2024 were collected. Bibliometric methods were used to analyze the basic components of publications, synthesize research trends, and predict future research hotspots.

A total of 606 publications were included in our study, with the number of publications ranging from 16 in 2005 to 52 in 2024. In terms of countries, the United States occupies a central position in both the number of publications (213 publications) and the quality (H-index = 34) and works closely with other countries. In terms of publishing institutions, Shanghai Jiao Tong University has the largest number of 18 publications. Acta Neurochirurgica is the journal with the highest number of 27 publications. The focus of research in this field can be divided into 3 main categories: cranial nerves, upper limb nerves, and lower limb nerves. The topic of research has gradually transferred to the lower limb nerve, and the keyword sacral nerve will be a hot topic in this field.

This is the first bibliometric study to comprehensively summarize trends and hotspots in nerve decompression research. Our findings shed light on future research directions, international collaborations, and interdisciplinary relationships. The sacral nerve has emerged as a current and potential future research hotspot, warranting further exploration.

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive degeneration of motor neurons, marked by complex pathological mechanisms and a lack of effective treatments. Despite substantial global research efforts, no comprehensive bibliometric analysis has systematically mapped the evolution of ALS biomarkers, therapeutic targets, and pharmacological advancements.

This study, based on 4,250 publications retrieved from the Web of Science Core Collection (2005-2025), employs bibliometric tools such as CiteSpace and VOSviewer to conduct the first multidimensional analysis of global trends in ALS biomarkers, therapeutic targets, and drug research.

The results revealed contributions from 20,168 authors across 92 countries, with annual publications growing at an average rate of 16.5%. The United States dominated research output, accounting for 34.07% (n=1,448, TLCS=7,100), while the United Kingdom achieved the highest research impact with an average of 68 citations per article. Leading institutions, including the University of Oxford and the University of Milan, consistently produced high-impact studies. Pioneering scholars such as Turner MR and Kiernan MC made significant contributions to advancing therapeutic targets and drug discovery. The interdisciplinary integration of molecular biology and genetics emerged as a core driver of progress in ALS research. Neurofilament light chain (NfL), antisense oligonucleotide (ASO) drugs, transcranial magnetic stimulation (TMS), oxygen free radicals (oxidative stress), and gene therapy have consistently remained central research focuses in the ALS therapeutic field. Looking ahead, stem cell therapy, blood-brain barrier (BBB) penetration technologies, and skeletal muscle targeting are poised to emerge as prominent research directions.

The United States dominates ALS research productivity, whereas the United Kingdom demonstrates superior citation influence. Despite China's substantial publication volume, its limited citation impact underscores the necessity for enhanced methodological rigor and strategic international collaboration. Current research priorities encompass NfL, TMS, and ASO therapies, with emerging innovations in stem cell therapy, BBB penetration technologies and skeletal muscle targeting showing therapeutic promise. Future directions should prioritize biomarker standardization, optimization of drug delivery systems, and Clinical Translation.

The synergistic epidemic of diabetes mellitus and tuberculosis (DM-TB) has created a dual disease burden, challenging global health systems with complex pathophysiological interactions and suboptimal treatment outcomes. To decode the evolving research landscape, this study presents the latest comprehensive bibliometric analysis mapping the intellectual architecture of DM-TB research over three decades.

We systematically analyzed 791 peer-reviewed articles from the Web of Science Core Collection (1995-2023) using CiteSpace, VOSviewer, and Bibliometrix. Advanced metrics including co-citation networks, keyword burst detection, and institutional collaboration patterns were employed to identify paradigm-shifting trends.

Three distinct growth phases were observed: initial stagnation (1995-2007, <10 annual publications), exponential growth (2008-2019), and research diversification (2020-2023). The United States dominated scientific output (27.3% of total publications), while the London School of Hygiene & Tropical Medicine emerged as the central hub for international collaborations (TLS=176). Keyword evolution revealed three transformative phases: (1) Pathomechanistic exploration (1995-2016): Focused on hyperglycemia-immunity interplay and epidemiological surveillance; (2) Translational innovation (2017-2020): Shifted to preclinical models, pharmacokinetic optimization, and multidrug resistance; (3) Precision medicine era (2021-2023): Emerging hotspots in latent TB screening (burst strength=6.82), metformin-mediated immunomodulation, and AI-driven diagnostic biomarkers.

Beyond delineating historical trajectories, this study identifies critical knowledge gaps in inflammation-resolution mechanisms and insulin resistance pathways, proposing a roadmap for targeted biomarker discovery and global health policy formulation. The constructed knowledge framework empowers strategic resource allocation for combating the DM-TB syndemic.

Neuropathic pain represents a significant public health concern due to its complex pathophysiology and the disability it can cause. Despite advancements in understanding its underlying mechanisms and potential treatments, challenges persist in achieving effective management. This bibliometric analysis aims to offer a comprehensive overview of research trends, key contributors, and existing gaps in the literature on neuropathic pain, providing valuable insights to guide future studies and enhance clinical approaches.

A bibliometric analysis was conducted using the Web of Science Core Collection (WoSCC) database. Key metrics, including publication trends, citation patterns, co-authorship networks, and keyword co-occurrence, were evaluated. Statistical analyses included average annual percentage change (APC) assessments and trend forecasting with an Auto Regressive Integrated Moving Average (ARIMA) model.

A total of 9,974 studies published between 2005 and 2024 were included. Publications peaked between 2021 and 2022 but showed a slight decline thereafter, with forecasts predicting a steady increase from 2025 to 2030. Most papers were published in high-impact Q1 journals, reflecting the quality of research. Co-authorship analysis revealed central hubs of collaboration in the USA and China, with limited integration of smaller countries into the global research network. Keyword analysis identified multiple thematic clusters, including "chronic pain," "molecular mechanisms," and "clinical management." Specific gaps were noted in understanding personalized therapeutic approaches, and non-pharmacological interventions.

This analysis underscores the critical need for continued research to address gaps in diagnosis, treatment, and management of neuropathic pain. Strengthening international collaborations and fostering multidisciplinary efforts will be pivotal in advancing this field.

In recent years, an increasing body of evidence has revealed a complex interplay between obesity and asthma, prompting academic and medical communities to intensify their focus on this area of research. The objective of this study is to undertake a comprehensive bibliometric analysis of the research literature pertaining to obesity-related asthma from 2004 to 2023. This analysis aims to provide precise and valuable insights, as well as to systematically reflect upon the current status and emerging trends within the field.

Literature data on obesity and asthma research was sourced from the Web of Science Core Collection database. CiteSpace and VOSviewer were utilized to visually analyze bibliometric indicators such as co-authorship, citation networks, and publication frequency of the data to facilitate the identification of patterns and trends.

A total of 3,118 papers were included in the analysis, encompassing 2,539 articles and 579 reviews. Throughout the last 20 years, the volume of publications has shown a consistent upward trend. The United States and Harvard University are at the forefront of this research field. Professor Dixon Anne E. is recognized as a pioneer and leading figure in the cultivation of obesity-related asthma research. Keyword analysis identified topics such as "childhood asthma," "bariatric surgery," "physical activity," "gut microbiota," "COVID-19," "food allergy," "asthma control," "nutrition examination," and "severe asthma."

The research domain of obesity-related asthma has experienced a substantial growth, with the United States, the United Kingdom, and China leading the global landscape. The focus on asthma in obese adolescents and children, the role of bariatric surgery, and lifestyle interventions remains a consistent area of interest, with considerable potential for further study. These findings provide a scientific basis for the development of personalized treatment programs for obese asthma patients. In addition, this study highlights the importance of further research in the fields of gut microbiota, COVID-19, and food allergy, providing directions for future policymaking.

Although research on the association between pulmonary fibrosis and lung cancer is of great significance, to date, no bibliometric analysis has been conducted on the comorbidity of these two diseases. This study aims to explore the current status and cutting - edge trends in this field through bibliometric analysis, and to establish new directions for future research.

Using the Web of Science Core Collection database, statistical calculations, graphic, and data visualization tools such as CiteSpace, VOSviewer, and Biblimatrix - biblioshiny were adopted.

A total of 2,234 original Articles and Reviews on pulmonary fibrosis complicated by lung cancer published between 2004 and 2024 were identified. A slow growth trend in publications related to pulmonary fibrosis complicated by lung cancer was observed. The United States, Japan, and China were the countries with the greatest contributions. Professor Michael Kreuter from Marienhaus Clinic, Mainz, Germany, and the University of Michigan published the most articles. Through cluster analysis of co - cited literature, five main clusters were identified. Keyword analysis predicted that "nintedanib", "pirfenidone", "immunotherapy", etc. might become hot topics in the field of the comorbidity of pulmonary fibrosis and lung cancer.

This bibliometric analysis shows that the literature related to the comorbidity of pulmonary fibrosis and lung cancer is on a continuous upward trend. The research hotspots and trends identified in this study provide a reference for in - depth research in this field, aiming to promote the development of research on the comorbidity of pulmonary fibrosis and lung cancer.

Nitrogen-containing compounds, particularly those with chiral amine structures, play a crucial role in the development of organic active pharmaceutical ingredients. Imine reductases (IREDs), NAD(P)H-dependent enzymes that catalyze the reduction of cyclic imines and the reductive amination of prochiral ketones, offer significant industrial potential for the synthesis of chiral amines. However, despite the growing body of research, a comprehensive and unbiased assessment of IRED research remains lacking. This study aims to explore the research landscape and evolution of IREDs using bibliometric and knowledge mapping methods. A total of 239 research articles and reviews on IREDs, published between 2010 and 2024, were retrieved from the Web of Science Core Collection and analyzed using tools such as CiteSpace, VOSviewer, Pajek, and Scimago Graphica. Results showed a consistent increase in both publications and citations, with a sharp rise since 2014. Collaboration network analysis revealed that the United Kingdom leads the field in terms of publications and influential institutions, while ChemCatChem was identified as the journal with the highest number of articles. Nicholas J. Turner emerged as a key researcher, having published the most papers and achieving the second-highest citation frequency. Research trends and keyword analysis highlighted areas of focus such as IRED crystal structure resolution, protein engineering modifications, and expanded industrial applications, including multi-enzyme cascade reactions. Ongoing advancements in synthetic biology, protein modifications, and enzyme engineering are expected to drive further studies on highly active IREDs for asymmetric synthesis of pharmaceutical compounds, positioning this research at the forefront of the field. By employing bibliometric analysis, this study provides the first visual representation of IRED research, offering valuable insights into current trends and emerging topics that will aid scholars in identifying key research areas and potential collaborators.

Despite the widespread interest in overweight/obese children and adolescents, there is a lack of bibliometric research on the factors influencing eating behaviors.

Collated and screened research papers published between 2003 and 2023 on eating behaviors in children and adolescents affected by overweight or obesity, searched on January 1, 2024. The primary data, comprising complete records and referenced citations of publications, was extracted from the Web of Science Core Collection. Analysis of data using Bibliometrix of R package, CiteSpace, and VOSviewer.

A total of 2,142 articles were included. The United States had the most publications in the field and was also the center point for world collaborations. Harvard University had the most affiliated publications, while Luis Moreno was the most prolific author. NUTRIENTS was the most published journal. High-frequency keywords included Children, overweight, physical activity, body mass index, and childhood obesity. Research trends include Epidemiology and Environment factors of obesity; Health risks associated with childhood obesity; Key eating habits and interventions for childhood obesity; Prevention and treatment of childhood and adolescent obesity.

This research provides a comprehensive overview of global trends and key areas in studying dietary behaviors among overweight/obese children and adolescents. It offers a detailed summary of recent advancements, emphasizing this field's critical principles and practices. By exploring these developments, the study highlights the growing importance of this research within global healthcare and suggests pathways for future research and applications.

The pathological features of Parkinson's disease (PD) include the formation of Lewy bodies composed mainly of aggregated alpha-synuclein (α-Syn) and extensive neurodegeneration. Synaptic dysfunction is a key factor contributing to disease progression among the various cellular and molecular mechanisms of PD. This study aims to analyze the research hotspots, frontier trends, and future directions of PD and synapses.

Relevant publications were obtained using the Web of Science database. Software CiteSpace, VOSviewer, and bibliometrix were used for visualization and quantitative analysis.

A total of 3,823 publications were included for analysis, and the number of publications related to the research topic showed an increasing trend from 2001 to 2024. North America, Asia, and Europe were the main research forces with high activity. The United States was the main leader in this field, followed by China and Italy. Emory University was the institution with the largest number of publications. Journal of Neuroscience was the core journal with a large number of publications. Dr. Calabresi, Paolo was a leader in the field of research. High-frequency keywords included PD, α-Syn, synaptic plasticity, basal ganglia, dopamine, substantia-nigra. In recent years, neuroinflammation has been the subject of active research.

Communication and collaboration between different countries, institutions, and authors have promoted the development of this field. The research content mainly focused on α-Syn, synaptic plasticity, and mouse model. Neuroinflammation may be the direction of future research.

As a common type of refractive error, astigmatism has always been one of the important factors affecting visual quality in clinical practice and it is quite an important public health burden. This study aims to evaluate astigmatism research and the clinical application of the vector method of the past half-century through a broad scientometric analysis, and to explore its reference value for guiding clinical treatment.

The literature search was conducted on the Web of Science for astigmatic vector studies published from 1965 to August 2024. Retrieved publications were analyzed by the number of annual publications, prolific countries, and researchers, core publications and journals, and the number of citations through descriptive statistics. Collaboration networks and keyword analysis were visualized by VOSviewer and CiteSpace.

One thousand and fifty-nine publications were included for a visualized analysis. Vector methods help researchers to describe astigmatism specialized, and clinicians are mainly focused on the correction of astigmatism in both corneal and cataract surgery. Journal of Cataract and Refractive Surgery was the core journal for this field. The United States accounts for the largest proportion of publications and Australia had the highest citation ratio. Through the keyword analysis, the network identified 4 major research trends of corneal refractive surgery, penetrating keratoplasty, cataract surgery, and epidemiological surveys of astigmatism. "Photorefractive keratectomy," "postoperative astigmatism" and "surgery" had significant burst strength and continuous attention to the astigmatism vector analysis.

Vector analysis is the most commonly used method to evaluate astigmatism and could significantly improve the accuracy of astigmatism correction, particularly in areas of refractive and cataract surgery. The application of vector analysis is beneficial in guiding the design of surgical incisions, determining the nomogram, optimizing the surgical protocol, and improving the accuracy of astigmatism correction. Meanwhile, the popularization of vector method will help to improve the accuracy of astigmatism analysis and promote the benign development of public health.

Prostate cancer (PC) contributes to male mortality worldwide. The objective of this study is to comprehensively depict the scientific accomplishments and research trends in nanotechnology for PC applications.

Utilizing the Web of Science Core Collection database, publications were gathered on the basis of inclusion and selection criteria. The publications were analyzed and visualized using VOSviewer, R-studio and CiteSpace software tools.

A total of 1949 studies were incorporated. Farokhzad was the most productive author. The United States and China released 58.13% of the total publications. The Chinese Academy of Sciences was the most influential institution, and the International Journal of Nanomedicine stood out as a prominent journal in this field. The most frequently referenced publication and research subject category were identified. The most extensively investigated area was nanoparticle-based drug delivery, while recent research has focused on anticancer with novel nanocarriers.

A bibliometric analysis in the PC and nanotechnology was conducted between 2004 and 2023. The overview and characteristics of the publications were identified. We discussed the application and restrictions faced by nanotechnology in PC management. The study of nanotechnology in PC treatment needs to be further studied.

Postoperative delirium (POD) is one of the most frequent complications after surgery which is closely associated with many adverse outcomes, including high mortality and low quality of life. This study aims to carry out a bibliometric analysis of POD and its risk factors from 2012 to 2022 to reveal the research status and hot spots.

This study is a bibliometric and visualized analysis.

Relevant publications between 2012 and 2022 were extracted from the Web of Science Core Collection database. CiteSpace software (v6.1. R2, Drexel University), VOSviewer software (v1.6.18, Leiden University), and the Online Analysis Platform of Literature Metrology were used to analyze research attributes. These publications were used to analyze research attributes, including countries, journals, institutions, authors, keywords, and burst detection, to predict trends and hot spots.

We included a total of 1,324 related documents from 2012 to 2022. The literature on POD has increased significantly since 2016. The United States and Harvard University were the leading literature publishing country (436/1324, 32.9%) and institution (112/1324, 8.5%). Anesthesia and Analgesia was the most frequently published journal. Keywords analysis with VOSviewer revealed that the keywords could be divided into five clusters, including anesthesia techniques, cardiac surgery, risk factors, intraoperative anesthesia monitoring, and postoperative cognitive dysfunction. We included a total of 198 POD risk factors documents, and the literature on POD risk factors increased. The People's Republic of China and Harvard University were the leading literature publishing country (53/198, 26.8%) and institution (12/198, 6.1%). Elderly, hip surgery, frailty, postoperative pain, cardiac surgery, dementia, and depression are keywords that are risk factors for POD.

The number of literature on POD in the field of anesthesia has increased significantly. Risk factors and anesthesia techniques are still key areas of research. Encephalogram, the use of sedatives, and perioperative nursing may be the new research focus. Older adults, hip fractures, cardiac surgery, liver transplants, dementia, and depression are hot words in the field of POD risk factors.

Ischemic stroke is a complex disease with high mortality and disability rates. Ischemia-reperfusion injury is a common aftermath. There have been significant advancements in understanding ischemia-reperfusion injury in ischemic stroke over the past two decades. This study aims to evaluate the current state of ischemia-reperfusion injury in ischemic stroke through bibliometric analysis, identifying key research areas and emerging trends.

Relevant documents in the Web of Science Core Collection, SCI-Expanded from January 1, 2003, to December 31, 2023, were downloaded on July 10, 2024. Bibliometric analysis was performed using HistCite, VOSviewer, CiteSpace, and Bibliometrics online analysis platform.

A total of 2179 research papers from 611 journals in 66 countries were included in this study. Among these papers, China emerged as the leading contributor of ischemia-reperfusion injury in ischemic stroke publications, with Capital Medical University standing out as the institution with the highest number of publications in this area. Y. Zhang was identified as the author with the most publications during the study period. Brain Research was found to be the most prolific journal for this research. The keywords "ferroptosis", "circular RNA", "polarization", and "fatty acid binding protein" represent the current hot spots of ischemia-reperfusion injury in ischemic stroke research.

This bibliometric analysis offers the first thorough overview of hot spots and research trends in ischemia-reperfusion injury in ischemic stroke over the previous 21 years, providing researchers with new ideas in the field. "ferroptosis", "circular RNA", "polarization", and "fatty acid binding protein" may be the focus of future studies.

Acute High Altitude Illness (AHAI) includes conditions such as Acute Mountain Sickness (AMS), High Altitude Cerebral Edema (HACE), and High Altitude Pulmonary Edema (HAPE), which result from rapid ascent to altitudes exceeding 2,500 m. Although interest in AHAI research has been growing, a systematic and comprehensive analysis of global research trends remains lacking.

A total of 3,214 articles and reviews published from 1937 to 2024 were retrieved from the Web of Science Core Collection. Bibliometric tools, including CiteSpace and VOSviewer, were applied to thoroughly assess publication trends, collaborative networks among authors, institutional contributions, and keyword co-occurrence patterns. The dataset represents the contributions of over 11,758 authors across 86 countries and 3,378 institutions, reflecting the significant growth of this research domain.

Our findings highlight the increasing scholarly attention to AHAI research, with the United States leading in publication numbers. Emerging research themes include cellular activation, oxidative stress, risk factors, and hypobaric hypoxia. This is the first systematic bibliometric review of AHAI literature, offering a detailed roadmap of research hotspots, potential collaborations, and key future directions. These findings provide a valuable reference for researchers aiming to explore gaps and build on the existing knowledge in high-altitude medicine.

Prostate cancer is a major global health issue. Radical prostatectomy is an effective treatment for prostate cancer. The integration of three-dimensional (3D) technology in prostatectomy offers numerous benefits. We intended to perform a bibliometric analysis of the role of 3D technology in prostatectomy.

Articles and review articles related to "3D" and "prostatectomy" were retrieved from Web of Science Core Collection. Microsoft Office Excel, CiteSpace, and VOSviewer were utilized for analysis and visualization.

A total of 441 articles were collected. The annual publication volume and journal distribution were illustrated. Visualizations of collaborations among countries/regions, institutions, and authors were provided. Networks of reference co-citations and keyword co-occurrences, along with their respective clusters were plotted.

The number of published papers significantly increased over the last 25 years. The most productive and influential country was the USA, and The University of California System was the most influential institution. The journal with the highest number of publications was BJU International. Among all authors in this field, Wijkstra H has published the most papers. Porpiglia F was the most cited author. Previous hot topics included advanced imaging and clinical trials, whereas augmented reality (AR) and robotics are likely to be hot topics in the future.

Ubiquitination is a type of post-translational modification, referring to the process in which the small molecular protein ubiquitin covalently binds to target proteins under the catalysis of a series of enzymes. The process of ubiquitination is vital in the onset and progression of breast cancer. The use of the ubiquitin-protease system is expected to be a new way to treat human breast cancer. This research aimed to investigate the evolution patterns, key areas of interest, and future directions of ubiquitination in breast cancer via bibliometric analysis.

Research articles on ubiquitination modifications in breast cancer were sourced from the Web of Science Core Collection database and analyzed via Microsoft Excel 2021, Bibliometrix, VOSviewer, and Citespace software for thorough bibliometrics.

From 2005-2024, 1850 English articles published in 405 journals by 1842 institutions/universities from 61 countries were included in the study. Keywords, research fields, co-cited literature and other information were included. Research on ubiquitination modifications has focused on breast cancer, expression, protein, activation, degradation, ubiquitination, phosphorylation, etc. Notably, the keywords that broke out in the past five years have focused on "triple-negative breast cancer", "promotion", and "metabolism". These findings suggest that key areas of current research are metabolism, immunity, survival, and prognosis in triple-negative breast cancer.

Our findings indicate that research on triple-negative breast cancer, as well as its immunological and metabolic aspects, is a burgeoning and promising area. Our work offers valuable guidance and fresh perspectives on the relationship between breast cancer and ubiquitin modification.

Myocardial fibrosis is a critical link in preventing the progression of heart disease. This study conducted a bibliometric analysis of its mechanism to identify trends and hotspots, aiming to provide valuable references for heart disease prevention and treatment.

This research relies on the Web of Science Core Collection, capturing all related publications on the mechanism of myocardial fibrosis up to November 11, 2023. For the bibliometric analysis, CiteSpace 6.2.R5 (64-bit) and VOSviewer 1.6.19 software tools were utilized.

The mechanism of myocardial fibrosis research involves 14,931 authors from 2,370 institutions in 71 countries/regions, resulting in 2,431 published studies. Nattel Stanley is the most prolific author, while Francogianis Ng is noted for the highest co-publication frequency. The United States leads in countries/regions, with the University of California System being the top institution. Cardiovascular Research is a primary outlet for new studies, and Circulation is a key reference in this research community. Current research primarily examines how myocardial fibrosis contributes to heart failure, myocardial infarction, and myocardial hypertrophy. This emerging field also explores the role of fibroblasts in myocardial injury and investigates innovative treatments to reduce myocardial fibrosis.

Preventing myocardial fibrosis is a crucial strategy in the fight against heart disease. This study utilises bibliometric analysis to explore the vast array of literature on the mechanism of myocardial fibrosis, mapping the research landscape and provide literature references for potential breakthroughs in heart disease prevention and treatment strategies.

MicroRNAs (miRNAs) add a new dimension to HD forecast, diagnosis, and therapy based on the potential applications. The miRNA-related research in the heart disease (HD) field has received close attention in the past two decades. However, there is a lack of studies that comprehensively and objectively analyze the current situation of miRNA application in the HD field using the bibliometrics method.

To comprehensively analyze the global scientific outputs of miRNAs in HD research from 2004 to 2023.

All the articles and reviews of miRNA-related research in the HD field were retrieved using the Web of Science core collection (WOSCC) title search, and bibliometric analysis was performed in Microsoft Excel 2019, CiteSpace, VOSviewer, and Bibliometrics (R-Tool of R-Studio).

3,874 publications were included in the bibliometric analysis. Collaborative network analysis indicates that China with the maximum number of publications (2,063) and the USA with the highest total citations (59,331) are influential countries in this field. Peking Union Medical College is the most prolific university with the maximum publications (134), and the University of California System is the most authoritative institution regarding betweenness centrality (0.27). PLOS ONE tops the journal list of publications, closely followed by the International Journal of Molecular Sciences and Scientific Reports with more than 100 articles. Considering the number of publications, citations, and total link strength overall, Olson. Eric N, Van Rooij Eva, Thum Thomas, Yang Baofeng, Wang Kun; and Lu Yanjie are authoritative authors in this field. The expression changes and regulatory mechanisms of specific miRNAs in various heart biological and pathophysiological processes have been the continuous research hotspots. "exosomes", "extracellular vesicles", "autophagy", and "management" have been novel hot research topics since 2018, which focused on the diagnosis and treatment of HD. The current research development trend is how to translate the achievement of miRNA-related diagnosis and therapeutic drugs for HD into the clinic.

Our study revealed the intellectual structure of miRNA in HD research, which may help scholars understand this field comprehensively and find partners.