Use of thiopurines in inflammatory bowel disease: Safety issues

doi:10.4292/wjgpt.v5.i2.63

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May 6, 2014 (publication date) through May 3, 2024

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World Journal of Gastrointestinal Pharmacology and Therapeutics

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2150-5349

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pharmacol Ther. May 6, 2014; 5(2): 63-76
Published online May 6, 2014. doi: 10.4292/wjgpt.v5.i2.63

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Figure 1 Metabolism of azathioprine and mercaptopurine. AZA: Azathioprine; MP: Mercaptopurine; XO: Xanthine oxidase; 6-TU: 6-thiouric acid; TPMT: Thiopurine methyltransferase; 6-MMP: 6-methylmercaptopurine; HPRT: Hypoxanthine phosphoribosyltransferase; 6-TImP: 6-thioinosino-5’ monophosphate; IMPDH: Inosine monophosphate dehydrogenase; 6-MMPR: 6-methylmercaptopurine ribonucleotides; 6-TGN: 6-thioguanine nucleotides.

Citation: Konidari A, Matary WE. Use of thiopurines in inflammatory bowel disease: Safety issues. World J Gastrointest Pharmacol Ther 2014; 5(2): 63-76
URL: https://www.wjgnet.com/2150-5349/full/v5/i2/63.htm
DOI: https://dx.doi.org/10.4292/wjgpt.v5.i2.63