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Zhang Q, Inagaki NF, Ito T. Recent advances in micro-sized oxygen carriers inspired by red blood cells. SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS 2023; 24:2223050. [PMID: 37363800 PMCID: PMC10288928 DOI: 10.1080/14686996.2023.2223050] [Citation(s) in RCA: 5] [Impact Index Per Article: 2.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 03/23/2023] [Revised: 05/22/2023] [Accepted: 05/31/2023] [Indexed: 06/28/2023]
Abstract
Supplementing sufficient oxygen to cells is always challenging in biomedical engineering fields such as tissue engineering. Originating from the concept of a 'blood substitute', nano-sized artificial oxygen carriers (AOCs) have been studied for a long time for the optimization of the oxygen supplementation and improvement of hypoxia environments in vitro and in vivo. When circulating in our bodies, micro-sized human red blood cells (hRBCs) feature a high oxygen capacity, a unique biconcave shape, biomechanical and rheological properties, and low frictional surfaces, making them efficient natural oxygen carriers. Inspired by hRBCs, recent studies have focused on evolving different AOCs into microparticles more feasibly able to achieve desired architectures and morphologies and to obtain the corresponding advantages. Recent micro-sized AOCs have been developed into additional categories based on their principal oxygen-carrying or oxygen-releasing materials. Various biomaterials such as lipids, proteins, and polymers have also been used to prepare oxygen carriers owing to their rapid oxygen transfer, high oxygen capacity, excellent colloidal stability, biocompatibility, suitable biodegradability, and long storage. In this review, we concentrated on the fabrication techniques, applied biomaterials, and design considerations of micro-sized AOCs to illustrate the advances in their performances. We also compared certain recent micro-sized AOCs with hRBCs where applicable and appropriate. Furthermore, we discussed existing and potential applications of different types of micro-sized AOCs.
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Affiliation(s)
- Qiming Zhang
- Department of Chemical System Engineering, The University of Tokyo, Tokyo, Japan
| | - Natsuko F. Inagaki
- Center for Disease Biology and Integrative Medicine, The University of Tokyo, Tokyo, Japan
| | - Taichi Ito
- Department of Chemical System Engineering, The University of Tokyo, Tokyo, Japan
- Center for Disease Biology and Integrative Medicine, The University of Tokyo, Tokyo, Japan
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Lu J, Guo Z, Zheng R, Xie W, Gao X, Gao J, Zhang Y, Xu W, Ye J, Guo X, Tang J, Yu J, Wang L, Xu B, Zhang G, Zhao L. Local Destruction of Tumors for Systemic Immunoresponse: Engineering Antigen-Capturing Nanoparticles as Stimulus-Responsive Immunoadjuvants. ACS APPLIED MATERIALS & INTERFACES 2022; 14:4995-5008. [PMID: 35051331 DOI: 10.1021/acsami.1c21946] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 06/14/2023]
Abstract
Immunotherapy has established a new paradigm for cancer treatment and made many breakthroughs in clinical practice. However, the rarity of immune response suggests that additional intervention is necessary. In recent years, it has been reported that local tumor destruction (LTD) can cause cancer cell death and induce an immunologic response. Thus, the combination of immunotherapy and LTD methods will be a promising approach to improve immune efficiency for cancer treatment. Herein, a nanobiotechnology platform to achieve high-precision LTD for systemic cancer immunotherapy has been successfully constructed. Possessing radio-sensitizing and photothermal properties, the engineered immunoadjuvant-loaded nanoplatform, which could precisely induce radiotherapy (RT)/photothermal therapy (PTT) to eliminate local tumor and meanwhile lead to the release of tumor-derived protein antigens (TDPAs), has been facilely fabricated by commercialized SPG membrane emulsification technology. Further on, the TDPAs could be captured and form personal nanovaccines in situ to serve as both reservoirs of antigen and carriers of immunoadjuvant, which can effectively improve the immune response. The investigations suggest that the combination of RT/PTT and improved immunotherapy using adjuvant-encapsulated antigen-capturing nanoparticles holds tremendous promise in cancer treatments.
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Affiliation(s)
- Jingsong Lu
- State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China
- Research Center of Magnetic and Electronic Materials, College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou 310014, China
| | - Zhenhu Guo
- State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China
- State Key Laboratory of Powder Metallurgy, Powder Metallurgy Research Institute, Central South University, Changsha 410083, China
| | - Rong Zheng
- Department of Radiation Oncology, Fujian Medical University Union Hospital, Fujian 350001, China
| | - Wensheng Xie
- State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China
- Department of Chemistry, Tsinghua University, Beijing 100084, China
| | - Xiaohan Gao
- State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China
- Department of Neurosurgery, Yuquan Hospital, School of Clinical Medicine, Tsinghua University, Beijing 100084, China
| | - Jianping Gao
- State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Science, Beijing 100190, China
| | - Yang Zhang
- State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Science, Beijing 100190, China
| | - Wanling Xu
- State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China
| | - Jielin Ye
- State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China
| | - Xiaoxiao Guo
- State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China
| | - Jingwei Tang
- State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China
| | - Jing Yu
- Research Center of Magnetic and Electronic Materials, College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou 310014, China
| | - Lianyan Wang
- State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Science, Beijing 100190, China
| | - Benhua Xu
- Department of Radiation Oncology, Fujian Medical University Union Hospital, Fujian 350001, China
| | - Guifeng Zhang
- State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Science, Beijing 100190, China
| | - Lingyun Zhao
- State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China
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Nicoletti F, Hammer L, Furtado S, Mangano K, Mathiowitz E, Green B, Auci DL. Oral Delivery of Encapsulated All-Trans Retinoic Acid Ameliorates Disease in Rodent Models of Colitis. Inflamm Bowel Dis 2021; 28:455-465. [PMID: 34417826 PMCID: PMC8889276 DOI: 10.1093/ibd/izab204] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/30/2021] [Indexed: 12/09/2022]
Abstract
BACKGROUND All-trans retinoic acid (ATRA) is a biologically active isomer of retinoic acid (RA). Topical ATRA (retin-a, retin-a micro, atralin, renova, and avita) is the active pharmaceutical ingredient for FDA-approved treatments for acne and skin wrinkles. Oral formulations (Vesanoid) treat acute promyelocytic leukemia, but oral dosing can induce severe side effects. Despite benefits in various rodent models of inflammatory bowel disease (IBD), toxicity and controversial clinical observations have diminished enthusiasm for ATRA IBD clinical trials. To circumvent these issues and to use ATRA's key role in maintaining gut tolerance, we developed a poly(lactic-co-glycolic acid) (PLGA) microsphere (MS) encapsulated ATRA formulation aimed at directing ATRA delivery to immune structures of the gut, limiting systemic exposure. Initially, ATRA MS was developed as a component of a combinatorial product (TreXTAM) that also contained encapsulated transforming growth factor (TGF)-β and ATRA in a 1:2 w/w ratio. Although the combination was optimal, benefit was also observed when ATRA MS was given alone in the CD4+ CD25-T-cell adoptive transfer (ACT) colitis model. METHODS We used the ACT and DSS-induced murine models of colitis to expand on the dose-dependent effects of oral ATRA MS when given alone. The DSS model was also used to compare the efficacy of ATRA MS and soluble ATRA, while healthy animals were used to compare the pharmacokinetics of the two drugs. RESULTS In both the ACT and DSS-induced murine models of colitis, ATRA MS was observed to be effective in ameliorating disease. ATRA MS was also observed to be more effective than soluble ATRA in these models and displayed more favorable pharmacokinetics. CONCLUSIONS We suggest ATRA MS, as a standalone product, may attenuate IBD and perhaps limit fibrosis, while limiting systemic side effects.
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Affiliation(s)
| | | | | | | | | | | | - Dominick L Auci
- Therapyx, Inc., Louisville, Kentucky, USA,Address correspondence to: Dominick L. Auci, PhD, Vice President, Research and Development, Therapyx, Inc., 2010 Cherokee Pkwy, Suite 2, Louisville, KY 40204, USA ()
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Lu Q, Gao CY, Choi HJ. Shirasu porous glass membrane processed uniform-sized Fe3O4-embedded polymethylmethacrylate nanoparticles and their tunable rheological response under magnetic field. Colloids Surf A Physicochem Eng Asp 2021. [DOI: 10.1016/j.colsurfa.2020.125756] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/09/2023]
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Hammer L, Furtado S, Mathiowitz E, Auci DL. Oral encapsulated transforming growth factor β1 reduces endogenous levels: Effect on inflammatory bowel disease. World J Gastrointest Pharmacol Ther 2020; 11:79-92. [PMID: 33251033 PMCID: PMC7667406 DOI: 10.4292/wjgpt.v11.i5.79] [Citation(s) in RCA: 6] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/07/2020] [Revised: 06/18/2020] [Accepted: 10/09/2020] [Indexed: 02/06/2023] Open
Abstract
BACKGROUND TreXTAM® is a combination of the key regulatory cytokine transforming growth factor beta (TGFβ) and all trans retinoic acid (ATRA) microencapsulated for oral delivery to immune structures of the gut. It is in development as a novel treatment for inflammatory bowel disease (IBD).
AIM To measure TGFβ levels in blood and tissue after oral administration of encapsulated TGFβ.
METHODS Animals were orally administered encapsulated TGFβ by gavage. Levels of drug substance in blood and in gut tissues at various times after administration were measured by ELISA.
RESULTS We made the surprising discovery that oral administration of TreXTAM dramatically (approximately 50%) and significantly (P = 0.025) reduced TGFβ levels in colon, but not small intestine or mesenteric lymph nodes. Similarly, levels in rat serum after 25 d of thrice weekly dosing with either TreXTAM, or microencapsulated TGFβ alone (denoted as TPX6001) were significantly (P < 0.01) reduced from baseline levels. When tested in the SCID mouse CD4+CD25- adoptive cell transfer (ACT) model of IBD, oral TPX6001 alone provided only a transient benefit in terms of reduced weight loss.
CONCLUSION These observations suggest a negative feedback mechanism in the gut whereby local delivery of TGFβ results in reduced local and systemic levels of the active form of TGFβ. Our findings suggest potential clinical implications for use of encapsulated TGFβ, perhaps in the context of IBD and/or other instances of fibrosis and/or pathological TGFβ signaling.
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Affiliation(s)
- Laura Hammer
- Department of Research and Development, TherapyX, Buffalo, NY 14214, United States
| | - Stacia Furtado
- Department of Research and Development, TherapyX, Buffalo, NY 14214, United States
- Department of Molecular Pharmacology, Brown University, Providence, RI 02912, United States
| | - Edith Mathiowitz
- Department of Molecular Pharmacology, Brown University, Providence, RI 02912, United States
| | - Dominick L Auci
- Department of Research and Development, TherapyX, Buffalo, NY 14214, United States
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Pontrelli G, Carr EJ, Tiribocchi A, Succi S. Modeling drug delivery from multiple emulsions. Phys Rev E 2020; 102:023114. [PMID: 32942448 DOI: 10.1103/physreve.102.023114] [Citation(s) in RCA: 8] [Impact Index Per Article: 1.6] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/09/2020] [Accepted: 07/30/2020] [Indexed: 06/11/2023]
Abstract
We present a mechanistic model of drug release from a multiple emulsion into an external surrounding fluid. We consider a single multilayer droplet where the drug kinetics are described by a pure diffusive process through different liquid shells. The multilayer problem is described by a system of diffusion equations coupled via interlayer conditions imposing continuity of drug concentration and flux. Mass resistance is imposed at the outer boundary through the application of a surfactant at the external surface of the droplet. The two-dimensional problem is solved numerically by finite volume discretization. Concentration profiles and drug release curves are presented for three typical round-shaped (circle, ellipse, and bullet) droplets and the dependency of the solution on the mass transfer coefficient at the surface analyzed. The main result shows a reduced release time for an increased elongation of the droplets.
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Affiliation(s)
- G Pontrelli
- Istituto per le Applicazioni del Calcolo, CNR, Via dei Taurini 19, 00185 Rome, Italy
| | - E J Carr
- School of Mathematical Sciences, Queensland University of Technology (QUT), Brisbane, Australia
| | - A Tiribocchi
- Istituto per le Applicazioni del Calcolo, CNR, Via dei Taurini 19, 00185 Rome, Italy
- Italian Institute of Technology, CNLS@Sapienza, Rome, Italy
| | - S Succi
- Istituto per le Applicazioni del Calcolo, CNR, Via dei Taurini 19, 00185 Rome, Italy
- Italian Institute of Technology, CNLS@Sapienza, Rome, Italy
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Teo N, Jin C, Kulkarni A, Jana SC. Continuous fabrication of core-shell aerogel microparticles using microfluidic flows. J Colloid Interface Sci 2020; 561:772-781. [DOI: 10.1016/j.jcis.2019.11.053] [Citation(s) in RCA: 11] [Impact Index Per Article: 2.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/22/2019] [Revised: 11/12/2019] [Accepted: 11/14/2019] [Indexed: 11/25/2022]
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Yang L, Fan X, Zhang J, Ju J. Preparation and Characterization of Thermoresponsive Poly( N-Isopropylacrylamide) for Cell Culture Applications. Polymers (Basel) 2020; 12:E389. [PMID: 32050412 PMCID: PMC7077488 DOI: 10.3390/polym12020389] [Citation(s) in RCA: 43] [Impact Index Per Article: 8.6] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/07/2019] [Revised: 01/07/2020] [Accepted: 01/17/2020] [Indexed: 12/20/2022] Open
Abstract
Poly(N-isopropylacrylamide) (PNIPAAm) is a typical thermoresponsive polymer used widely and studied deeply in smart materials, which is attractive and valuable owing to its reversible and remote "on-off" behavior adjusted by temperature variation. PNIPAAm usually exhibits opposite solubility or wettability across lower critical solution temperature (LCST), and it is readily functionalized making it available in extensive applications. Cell culture is one of the most prospective and representative applications. Active attachment and spontaneous detachment of targeted cells are easily tunable by surface wettability changes and volume phase transitions of PNIPAAm modified substrates with respect to ambient temperature. The thermoresponsive culture platforms and matching thermal-liftoff method can effectively substitute for the traditional cell harvesting ways like enzymatic hydrolysis and mechanical scraping, and will improve the stable and high quality of recovered cells. Therefore, the establishment and detection on PNIPAAm based culture systems are of particular importance. This review covers the important developments and recommendations for future work of the preparation and characterization of temperature-responsive substrates based on PNIPAAm and analogues for cell culture applications.
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Affiliation(s)
- Lei Yang
- College of Chemistry, Chemical Engineering and Environmental Engineering, Liaoning Shihua University, Fushun 113001, China; (J.Z.); (J.J.)
| | - Xiaoguang Fan
- College of Engineering, Shenyang Agricultural University, Shenyang 110866, China
| | - Jing Zhang
- College of Chemistry, Chemical Engineering and Environmental Engineering, Liaoning Shihua University, Fushun 113001, China; (J.Z.); (J.J.)
| | - Jia Ju
- College of Chemistry, Chemical Engineering and Environmental Engineering, Liaoning Shihua University, Fushun 113001, China; (J.Z.); (J.J.)
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9
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Huang L, Wu K, Zhang R, Ji H. Fabrication of Multicore Milli- and Microcapsules for Controlling Hydrophobic Drugs Release Using a Facile Approach. Ind Eng Chem Res 2019. [DOI: 10.1021/acs.iecr.9b02351] [Citation(s) in RCA: 12] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/26/2022]
Affiliation(s)
- Liyun Huang
- Fine Chemical Industry Research Institute, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China
| | - Kui Wu
- Fine Chemical Industry Research Institute, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China
| | - Rui Zhang
- Fine Chemical Industry Research Institute, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China
- Guangdong Provincial Key Lab of Green Chemical Product Technology, Guangzhou 510640, China
| | - Hongbing Ji
- Fine Chemical Industry Research Institute, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China
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10
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Recent and prominent examples of nano- and microarchitectures as hemoglobin-based oxygen carriers. Adv Colloid Interface Sci 2018; 260:65-84. [PMID: 30177214 DOI: 10.1016/j.cis.2018.08.006] [Citation(s) in RCA: 44] [Impact Index Per Article: 6.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/24/2018] [Revised: 08/21/2018] [Accepted: 08/22/2018] [Indexed: 12/16/2022]
Abstract
Blood transfusions, which usually consist in the administration of isolated red blood cells (RBCs), are crucial in traumatic injuries, pre-surgical conditions and anemias. Although RBCs transfusion from donors is a safe procedure, donor RBCs can only be stored for a maximum of 42 days under refrigerated conditions and, therefore, stockpiles of RBCs for use in acute disasters do not exist. With a worldwide shortage of donor blood that is expected to increase over time, the creation of oxygen-carriers with long storage life and compatibility without typing and cross-matching, persists as one of the foremost important challenges in biomedicine. However, research has so far failed to produce FDA approved RBCs substitutes (RBCSs) for human usage. As such, due to unacceptable toxicities, the first generation of oxygen-carriers has been withdrawn from the market. Being hemoglobin (Hb) the main component of RBCs, a lot of effort is being devoted in assembling semi-synthetic RBCS utilizing Hb as the oxygen-carrier component, the so-called Hb-based oxygen carriers (HBOCs). However, a native RBC also contains a multi-enzyme system to prevent the conversion of Hb into non-functional methemoglobin (metHb). Thus, the challenge for the fabrication of next-generation HBOCs relies in creating a system that takes advantage of the excellent oxygen-carrying capabilities of Hb, while preserving the redox environment of native RBCs that prevents or reverts the conversion of Hb into metHb. In this review, we feature the most recent advances in the assembly of the new generation of HBOCs with emphasis in two main approaches: the chemical modification of Hb either by cross-linking strategies or by conjugation to other polymers, and the Hb encapsulation strategies, usually in the form of lipidic or polymeric capsules. The applications of the aforementioned HBOCs as blood substitutes or for oxygen-delivery in tissue engineering are highlighted, followed by a discussion of successes, challenges and future trends in this field.
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11
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Guo P, Huang J, Zhao Y, Martin CR, Zare RN, Moses MA. Nanomaterial Preparation by Extrusion through Nanoporous Membranes. SMALL (WEINHEIM AN DER BERGSTRASSE, GERMANY) 2018; 14:e1703493. [PMID: 29468837 DOI: 10.1002/smll.201703493] [Citation(s) in RCA: 58] [Impact Index Per Article: 8.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Received: 10/06/2017] [Revised: 01/09/2018] [Indexed: 05/20/2023]
Abstract
Template synthesis represents an important class of nanofabrication methods. Herein, recent advances in nanomaterial preparation by extrusion through nanoporous membranes that preserve the template membrane without sacrificing it, which is termed as "non-sacrificing template synthesis," are reviewed. First, the types of nanoporous membranes used in nanoporous membrane extrusion applications are introduced. Next, four common nanoporous membrane extrusion strategies: vesicle extrusion, membrane emulsification, precipitation extrusion, and biological membrane extrusion, are examined. These methods have been utilized to prepare a wide range of nanomaterials, including liposomes, emulsions, nanoparticles, nanofibers, and nanotubes. The principle and historical context of each specific technology are discussed, presenting prominent examples and evaluating their positive and negative features. Finally, the current challenges and future opportunities of nanoporous membrane extrusion methods are discussed.
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Affiliation(s)
- Peng Guo
- Vascular Biology Program, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA
- Department of Surgery, Harvard Medical School and Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA
| | - Jing Huang
- Vascular Biology Program, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA
- Department of Surgery, Harvard Medical School and Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA
| | - Yaping Zhao
- School of Chemistry and Chemical Engineering, Shanghai Jiaotong University, 800 Dongchuan road, Shanghai, 200240, China
| | - Charles R Martin
- Department of Chemistry, University of Florida, 214 Leigh Hall, Gainesville, FL, 32611, USA
| | - Richard N Zare
- Department of Chemistry, Stanford University, 333 Campus Drive, Stanford, CA, 94305, USA
| | - Marsha A Moses
- Vascular Biology Program, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA
- Department of Surgery, Harvard Medical School and Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA
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12
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Ishizuka F, Stenzel MH, Zetterlund PB. Microcapsule synthesis via RAFT photopolymerization in vegetable Oil as a green solvent. ACTA ACUST UNITED AC 2018. [DOI: 10.1002/pola.28958] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/18/2022]
Affiliation(s)
- Fumi Ishizuka
- School of Chemical Engineering, Centre for Advanced Macromolecular Design, The University of New South Wales; Sydney New South Wales 2052 Australia
| | - Martina H. Stenzel
- School of Chemistry, Centre for Advanced Macromolecular Design; The University of New South Wales; Sydney New South Wales 2052 Australia
| | - Per B. Zetterlund
- School of Chemical Engineering, Centre for Advanced Macromolecular Design, The University of New South Wales; Sydney New South Wales 2052 Australia
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Zhu C, Xu J, Hou Z, Liu S, Li T. Scale Effect on the Interface Reaction between PDMS-E Emulsion Droplets and Gelatin. LANGMUIR : THE ACS JOURNAL OF SURFACES AND COLLOIDS 2017; 33:9926-9933. [PMID: 28872325 DOI: 10.1021/acs.langmuir.7b02532] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 06/07/2023]
Abstract
In this study, the scale effect on the interface reaction between PDMS-E emulsion droplets and gelatin was studied systematically. The monodisperse α-[3-(2,3-epoxy-propoxy)propyl]-ω-butyl-polydimethylsiloxane (PDMS-E) emulsion droplets on different scales were prepared using a Shirasu porous glass (SPG) membrane with a 0.5 μm pore size. The zeta potential results showed that the surface charge density of PDMS-E droplets decreased with the droplet scale, and the variation went through three stages, which corresponded to the diameter ranges of 100-450, 450-680, and 670-800 nm, respectively. The results of Raman spectra indicated that the distribution concentration of head groups in surfactants decreased but the polar epoxy groups tend to be exposed on the interface with the increase in the droplet scale. This was conducive to the nucleophilic attack of amino groups in gelatin on the epoxy group. Thus, the conversion of amino groups was related to the scale of the PDMS-E droplet. This study might provide a proper way to control the rate of interfacial reaction between immiscible macromolecule monomers.
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Affiliation(s)
- Cong Zhu
- Key Laboratory of Fine Chemicals of Shandong Province, Qilu University of Technology , Jinan 250353, P. R. China
| | - Jing Xu
- Key Laboratory of Fine Chemicals of Shandong Province, Qilu University of Technology , Jinan 250353, P. R. China
| | - Zhaosheng Hou
- College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University , Jinan 250100, P. R. China
| | - Suqing Liu
- Shandong Province Leather Industrial Research Institute, Jinan 250353, P. R. China
| | - Tianduo Li
- Key Laboratory of Fine Chemicals of Shandong Province, Qilu University of Technology , Jinan 250353, P. R. China
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14
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Huang GQ, Xiao JX, Hao LQ, Yang J. Microencapsulation of an Angiotensin I-Converting Enzyme Inhibitory Peptide VLPVP by Membrane Emulsification. FOOD BIOPROCESS TECH 2017. [DOI: 10.1007/s11947-017-1953-9] [Citation(s) in RCA: 6] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/31/2023]
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15
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Equilibrium adsorption of polyvinylpyrrolidone and its role on thermoregulating microcapsules synthesis process. Colloid Polym Sci 2017; 295:783-792. [PMID: 28479656 PMCID: PMC5395600 DOI: 10.1007/s00396-017-4061-5] [Citation(s) in RCA: 12] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/25/2016] [Revised: 02/20/2017] [Accepted: 02/24/2017] [Indexed: 11/25/2022]
Abstract
The adsorption of polyvinylpyrrolidone (PVP) by the thermoregulating microcapsules has been studied. The mass ratio of PVP has been changed from 1 to 20, with respect to the lowest amount of PVP value (4.08 g). The results confirmed that a large amount of PVP was adsorbed by the polymeric shell. Experimental data were perfectly fitted by Langmuir model, obtaining at a confidence level of 95% values of 192.9 ± 0.4 g/kg and 0.18 ± 0.11 m3/kg for the maximum adsorption capacity and the equilibrium constant, respectively. It was found that utilizing PVP, at a concentration of 5.03 wt% of the total mass provided optimum conditions for synthesizing thermoregulating microcapsules containing Rubitherm®RT27 from poly(styrene-divinylbenzene) (P(St-DVB)), with the best thermal and physical properties. Finally, the robustness of the process was checked at a large scale by using a reactor that maintains geometrical similarities with that used at laboratory scale. The thermal properties, the encapsulation efficiency, and the microcapsule yield were similar, but at pilot plant scale, narrower particle size distributions were obtained.
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Zhang J, Cui Z, Field R, Moloney MG, Rimmer S, Ye H. Thermo-responsive microcarriers based on poly(N-isopropylacrylamide). Eur Polym J 2015. [DOI: 10.1016/j.eurpolymj.2015.04.013] [Citation(s) in RCA: 42] [Impact Index Per Article: 4.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/25/2023]
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17
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Bu JH, Kim Y, Ha JU, Shim SE. Suspension Polymerization of Thermally Expandable Microcapsules with Core-Shell Structure Using the SPG Emulsification Technique: Influence of Crosslinking Agents and Stabilizers. POLYMER KOREA 2015. [DOI: 10.7317/pk.2015.39.1.78] [Citation(s) in RCA: 7] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 11/13/2022]
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18
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Use of electrohydrodynamic processing to develop nanostructured materials for the preservation of the cold chain. INNOV FOOD SCI EMERG 2014. [DOI: 10.1016/j.ifset.2014.10.010] [Citation(s) in RCA: 21] [Impact Index Per Article: 1.9] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/23/2022]
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19
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Teixeira RFA, van den Berg O, Nguyen LTT, Fehér K, Du Prez FE. Microencapsulation of Active Ingredients Using PDMS as Shell Material. Macromolecules 2014. [DOI: 10.1021/ma501897j] [Citation(s) in RCA: 24] [Impact Index Per Article: 2.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/15/2023]
Affiliation(s)
| | | | - Le-Thu T. Nguyen
- SIM vzw, Technologiepark 935, B-9052 Zwijnaarde, Belgium
- Department
of Polymer Materials, Faculty of Materials Technology, Ho Chi Minh
City University of Technology, Vietnam National University, Ly Thuong Kiet 268, District
10, Ho Chi Minh City, Vietnam
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20
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Windbergs M, Zhao Y, Heyman J, Weitz DA. Biodegradable core-shell carriers for simultaneous encapsulation of synergistic actives. J Am Chem Soc 2013; 135:7933-7. [PMID: 23631388 DOI: 10.1021/ja401422r] [Citation(s) in RCA: 126] [Impact Index Per Article: 10.5] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/29/2022]
Abstract
Simultaneous encapsulation of multiple active substances in a single carrier is essential for therapeutic applications of synergistic combinations of drugs. However, traditional carrier systems often lack efficient encapsulation and release of incorporated substances, particularly when combinations of drugs must be released in concentrations of a prescribed ratio. We present a novel biodegradable core-shell carrier system fabricated in a one-step, solvent-free process on a microfluidic chip; a hydrophilic active (doxorubicin hydrochloride) is encapsulated in the aqueous core, while a hydrophobic active (paclitaxel) is encapsulated in the solid shell. Particle size and composition can be precisely controlled, and core and shell can be individually loaded with very high efficiency. Drug-loaded particles can be dried and stored as a powder. We demonstrate the efficacy of this system through the simultaneous encapsulation and controlled release of two synergistic anticancer drugs using two cancer-derived cell lines. This solvent-free platform technology is also of high potential value for encapsulation of other active ingredients and chemical reagents.
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Affiliation(s)
- Maike Windbergs
- School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA.
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21
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Nano-structure construction of porous membranes by depositing nanoparticles for enhanced surface wettability. J Memb Sci 2013. [DOI: 10.1016/j.memsci.2012.09.051] [Citation(s) in RCA: 29] [Impact Index Per Article: 2.4] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/21/2022]
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22
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Wagdare NA, Marcelis AT, Boom RM, van Rijn CJ. Porous microcapsule formation with microsieve emulsification. J Colloid Interface Sci 2011; 355:453-7. [DOI: 10.1016/j.jcis.2010.12.053] [Citation(s) in RCA: 25] [Impact Index Per Article: 1.8] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/05/2010] [Revised: 12/15/2010] [Accepted: 12/16/2010] [Indexed: 11/17/2022]
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23
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Controlling morphology of polymer microspheres by Shirasu porous glass (SPG) membrane emulsification and subsequent polymerization: from solid to hollow. Macromol Res 2010. [DOI: 10.1007/s13233-010-1202-9] [Citation(s) in RCA: 10] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/18/2022]
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24
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Sun BJ, Shum HC, Holtze C, Weitz DA. Microfluidic melt emulsification for encapsulation and release of actives. ACS APPLIED MATERIALS & INTERFACES 2010; 2:3411-3416. [PMID: 21082834 DOI: 10.1021/am100860b] [Citation(s) in RCA: 84] [Impact Index Per Article: 5.6] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 05/28/2023]
Abstract
A microfluidic melt emulsification method for encapsulation and release of actives is presented. Using a water-in-oil-in-water (W-O-W) double emulsion template, solid capsules can be formed by freezing the middle shell phase. Actives encapsulated inside the solid shell can be controllably and rapidly released by applying a temperature trigger to melt the shell. The choice of the shell materials can be chosen to accommodate the storage and release temperatures specific to the applications. In addition, we have also demonstrated the same concept to encapsulate multiple actives in multicompartment capsules, which are promising as multifunctional capsules and microreactors.
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25
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Sánchez-Silva L, Carmona M, de Lucas A, Sánchez P, Rodríguez JF. Scale-up of a suspension-like polymerization process for the microencapsulation of phase change materials. J Microencapsul 2010; 27:583-93. [DOI: 10.3109/02652048.2010.501394] [Citation(s) in RCA: 19] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/13/2022]
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26
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Liu W, Yang XL, Ho WSW. Preparation of uniform-sized multiple emulsions and micro/nano particulates for drug delivery by membrane emulsification. J Pharm Sci 2010; 100:75-93. [PMID: 20589949 DOI: 10.1002/jps.22272] [Citation(s) in RCA: 48] [Impact Index Per Article: 3.2] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/24/2010] [Revised: 05/20/2010] [Accepted: 05/21/2010] [Indexed: 12/17/2022]
Abstract
Much attention has in recent years been paid to fine applications of drug delivery systems, such as multiple emulsions, micro/nano solid lipid and polymer particles (spheres or capsules). Precise control of particle size and size distribution is especially important in such fine applications. Membrane emulsification can be used to prepare uniform-sized multiple emulsions and micro/nano particulates for drug delivery. It is a promising technique because of the better control of size and size distribution, the mildness of the process, the low energy consumption, easy operation and simple equipment, and amendable for large scale production. This review describes the state of the art of membrane emulsification in the preparation of monodisperse multiple emulsions and micro/nano particulates for drug delivery in recent years. The principles, influence of process parameters, advantages and disadvantages, and applications in preparing different types of drug delivery systems are reviewed. It can be concluded that the membrane emulsification technique in preparing emulsion/particulate products for drug delivery will further expand in the near future in conjunction with more basic investigations on this technique.
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Affiliation(s)
- Wei Liu
- College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
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27
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Core-shell poly(d,l-lactide-co-glycolide)/poly(ethyl 2-cyanoacrylate) microparticles with doxorubicin to reduce initial burst release. Macromol Res 2009. [DOI: 10.1007/bf03218649] [Citation(s) in RCA: 12] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/27/2022]
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28
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Janus-like polymer particles prepared via internal phase separation from emulsified polymer/oil droplets. POLYMER 2009. [DOI: 10.1016/j.polymer.2009.03.061] [Citation(s) in RCA: 67] [Impact Index Per Article: 4.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/19/2022]
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29
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Ito F, Fujimori H, Honnami H, Kawakami H, Kanamura K, Makino K. Study of types and mixture ratio of organic solvent used to dissolve polymers for preparation of drug-containing PLGA microspheres. Eur Polym J 2009. [DOI: 10.1016/j.eurpolymj.2008.12.037] [Citation(s) in RCA: 44] [Impact Index Per Article: 2.8] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/25/2022]
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30
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Aryanti N, Hou R, Williams RA. Performance of a rotating membrane emulsifier for production of coarse droplets. J Memb Sci 2009. [DOI: 10.1016/j.memsci.2008.08.052] [Citation(s) in RCA: 28] [Impact Index Per Article: 1.8] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/24/2022]
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31
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Budhlall BM, Marquez M, Velev OD. Microwave, photo- and thermally responsive PNIPAm-gold nanoparticle microgels. LANGMUIR : THE ACS JOURNAL OF SURFACES AND COLLOIDS 2008; 24:11959-11966. [PMID: 18817426 DOI: 10.1021/la8019556] [Citation(s) in RCA: 47] [Impact Index Per Article: 2.8] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 05/26/2023]
Abstract
Microwave-, photo- and thermo-responsive polymer microgels that range in size from 500 to 800 microm and are swollen with water were prepared by a novel microarray technique. We used a liquid-liquid dispersion technique in a system of three immiscible liquids to prepare hybrid PNIPAm- co-AM core-shell capsules loaded with AuNPs. The spontaneous encapsulation is a result of the formation of double oil-in-water-in-oil (o/w/o) emulsion. It is facilitated by adjusting the balance of the interfacial tensions between the aqueous phase (in which a water-soluble drug may be dissolved), the monomer phase and the continuous phase. The water-in-oil (w/o) droplets containing 26 wt% NIPAm and Am monomers, 0.1 wt% Tween-80 surfactant, FITC fluorescent dye and colloidal gold nanoparticles spontaneously developed a core-shell morphology that was fixed by in situ photopolymerization. The results demonstrate new reversibly swelling and deswelling AuNP/PNIPAm hybrid core-shell microcapsules and microgels that can be actuated by visible light and/or microwave radiation (<or=1,250 nm) and/or temperature. This is the first study to demonstrate that incorporating AuNPs speeds up the response kinetics of PNIPAm, and hence enhances the sensitivity to external stimuli of PNIPAm. These microgels can have potential applications for microfluidic switches or microactuators, photosensors, and various nanomedicine applications in controlled delivery and release.
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Affiliation(s)
- Bridgette M Budhlall
- NSF funded Center for High-Rate Nanomanufacturing and Nanomanufacturing Center of Excellence, Department of Plastics Engineering, University of Massachusetts, Lowell, Massachusetts 01854, USA.
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32
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Microencapsulation Based on Emulsification for Producing Pharmaceutical Products: A Literature Review. ACTA ACUST UNITED AC 2008. [DOI: 10.1002/apj.5500140318] [Citation(s) in RCA: 30] [Impact Index Per Article: 1.8] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/07/2022]
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33
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Cheng CJ, Chu LY, Xie R, Wang XW. Hydrophobic Modification and Regeneration of Shirasu Porous Glass Membranes on Membrane Emulsification Performance. Chem Eng Technol 2008. [DOI: 10.1002/ceat.200700353] [Citation(s) in RCA: 16] [Impact Index Per Article: 0.9] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/09/2022]
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34
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Sheibat-Othman N, Burne T, Charcosset C, Fessi H. Preparation of pH-sensitive particles by membrane contactor. Colloids Surf A Physicochem Eng Asp 2008. [DOI: 10.1016/j.colsurfa.2007.07.003] [Citation(s) in RCA: 12] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/23/2022]
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35
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Sánchez L, Sánchez P, de Lucas A, Carmona M, Rodríguez JF. Microencapsulation of PCMs with a polystyrene shell. Colloid Polym Sci 2007. [DOI: 10.1007/s00396-007-1696-7] [Citation(s) in RCA: 174] [Impact Index Per Article: 9.7] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/30/2022]
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36
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Cheng CJ, Chu LY, Ren PW, Zhang J, Hu L. Preparation of monodisperse thermo-sensitive poly(N-isopropylacrylamide) hollow microcapsules. J Colloid Interface Sci 2007; 313:383-8. [PMID: 17553513 DOI: 10.1016/j.jcis.2007.05.004] [Citation(s) in RCA: 60] [Impact Index Per Article: 3.3] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/13/2007] [Revised: 04/23/2007] [Accepted: 05/02/2007] [Indexed: 11/19/2022]
Abstract
We successfully developed a novel and simple method for preparation of monodisperse thermo-sensitive poly(N-isopropylacrylamide) (PNIPAM) hollow microcapsules at the interface of water-in-oil (W/O) single emulsions at a temperature below the lower critical solution temperature (LCST) of PNIPAM. The prepared PNIPAM microcapsules are featured with hollow structures and thin membranes, high monodispersity, excellent reversible thermo-sensitivity and fast response to environmental temperature. This approach exhibits great interests in preparing monodisperse thermo-sensitive microcapsules for encapsulating bioactive materials or drugs requiring mild encapsulation conditions, because of the flexibility in choosing substances being dissolved in the aqueous phase. The preparation methodology demonstrated in this study provides a unique approach for preparing monodisperse hollow polymeric microcapsules with W/O single emulsions.
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Affiliation(s)
- Chang-Jing Cheng
- School of Chemical Engineering, Sichuan University, Chengdu, Sichuan 610065, China
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37
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Bao D, Zhang H, Liu X, Zhao Y, Ma X, Yuan Q. Preparation of Monodispersed Polymer Microspheres by SPG Membrane Emulsification‐Solvent Evaporation Technology. J DISPER SCI TECHNOL 2007. [DOI: 10.1080/01932690601108052] [Citation(s) in RCA: 10] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/23/2022]
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38
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Böhmer MR, Schroeders R, Steenbakkers JA, de Winter SH, Duineveld PA, Lub J, Nijssen WP, Pikkemaat JA, Stapert HR. Preparation of monodisperse polymer particles and capsules by ink-jet printing. Colloids Surf A Physicochem Eng Asp 2006. [DOI: 10.1016/j.colsurfa.2006.04.011] [Citation(s) in RCA: 69] [Impact Index Per Article: 3.6] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/24/2022]
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39
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Cheng CJ, Chu LY, Xie R. Preparation of highly monodisperse W/O emulsions with hydrophobically modified SPG membranes. J Colloid Interface Sci 2006; 300:375-82. [PMID: 16631780 DOI: 10.1016/j.jcis.2006.03.056] [Citation(s) in RCA: 54] [Impact Index Per Article: 2.8] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/04/2006] [Revised: 03/17/2006] [Accepted: 03/18/2006] [Indexed: 12/01/2022]
Abstract
Experimental investigations on the hydrophobic modification of SPG membranes and the preparation of monodisperse W/O (water-in-oil) emulsions using the modified membranes were carried out. Effects of the osmotic pressure of disperse phase, the average pore size of membranes, emulsifier concentrations in continuous phase and the transmembrane pressure on the average size, size distribution and size dispersion coefficient of emulsions were systematically studied. The stability of W/O emulsions was also investigated. The results showed that SPG membranes took on excellent hydrophobicity through the modification by silane coupler reagent (octyltriethoxysilane) or by silicone resin (polymethylsilsesquioxane). Monodisperse W/O emulsions with size dispersion coefficient of about 0.25, which meant high monodispersity, were successfully prepared by using the hydrophobically modified SPG membranes with average pore sizes of 1.8, 2.0, 2.5, 4.8 and 11.1 microm. When the osmotic pressure was lower than 0.855 MPa, the average size of emulsions was gradually increased while the size dispersion coefficient delta gradually decreased with the osmotic pressure; when the osmotic pressure was higher than 0.855 MPa, both the coefficients kept unvarying. When kerosene was saturated with disperse phase in advance, the average size of emulsions became larger and the monodispersity of emulsions was slightly better than that prepared using unsaturated kerosene. The smaller the pore size of SPG membranes was, the better the monodispersity of the W/O emulsions. The average size and size dispersion coefficient delta were nearly independent on the emulsifier concentrations when the PGPR concentration was in the range from 0.5 to 5.0 wt%, whereas both of them slightly increased as the PGPR concentration was below 0.5 wt%. The effect of the transmembrane pressure on size distributions was slight. Both the average size and size dispersion coefficient delta slightly increased to some extent with the increase of the transmembrane pressure in the experimental range. The stability of the W/O emulsions was dependent on the storage time. The mean size of W/O emulsions decreased gradually with the increase of storage time at the first 35 days, and then kept constant; while the size dispersion coefficient of W/O emulsions was nearly not changed.
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Affiliation(s)
- Chang-Jing Cheng
- School of Chemical Engineering, Sichuan University, Chengdu, Sichuan 610065, China
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40
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Xiao X, Zhuo R, Xu J, Chen L. Effects of reaction temperature and reaction time on positive thermosensitivity of microspheres with poly(acrylamide)/poly(acrylic acid) IPN shells. Eur Polym J 2006. [DOI: 10.1016/j.eurpolymj.2005.07.011] [Citation(s) in RCA: 10] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/25/2022]
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41
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Abstract
With advances in biotechnology, genomics, and combinatorial chemistry, a wide variety of new, more potent and specific therapeutics are being created. Because of common problems such as low solubility, high potency, and/or poor stability of many of these new drugs, the means of drug delivery can impact efficacy and potential for commercialization as much as the nature of the drug itself. Thus, there is a corresponding need for safer and more effective methods and devices for drug delivery. Indeed, drug delivery systems—designed to provide a therapeutic agent in the needed amount, at the right time, to the proper location in the body, in a manner that optimizes efficacy, increases compliance and minimizes side effects—were responsible for $47 billion in sales in 2002, and the drug delivery market is expected to grow to $67 billion by 2006.
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Affiliation(s)
- Mauro Ferrari
- Department of Biomedical Engineering, University of Texas Health Science Center, Houston, TX ,University of Texas M.D. Anderson Cancer Center, Houston, TX ,Rice University, Houston, TX ,University of Texas Medical Branch, Galveston, TX ,Texas Alliance for NanoHealth, Houston, TX
| | - Abraham P. Lee
- Biomedical Engineering, University of California, Irvine
| | - L. James Lee
- Chemical and Biomolecular Engineering, The Ohio State University, USA
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42
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Utada AS, Lorenceau E, Link DR, Kaplan PD, Stone HA, Weitz DA. Monodisperse Double Emulsions Generated from a Microcapillary Device. Science 2005; 308:537-41. [PMID: 15845850 DOI: 10.1126/science.1109164] [Citation(s) in RCA: 1246] [Impact Index Per Article: 62.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/02/2022]
Abstract
Double emulsions are highly structured fluids consisting of emulsion drops that contain smaller droplets inside. Although double emulsions are potentially of commercial value, traditional fabrication by means of two emulsification steps leads to very ill-controlled structuring. Using a microcapillary device, we fabricated double emulsions that contained a single internal droplet in a core-shell geometry. We show that the droplet size can be quantitatively predicted from the flow profiles of the fluids. The double emulsions were used to generate encapsulation structures by manipulating the properties of the fluid that makes up the shell. The high degree of control afforded by this method and the completely separate fluid streams make this a flexible and promising technique.
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Affiliation(s)
- A S Utada
- Division of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA
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Xiao XC, Chu LY, Chen WM, Zhu JH. Monodispersed thermoresponsive hydrogel microspheres with a volume phase transition driven by hydrogen bonding. POLYMER 2005. [DOI: 10.1016/j.polymer.2005.01.075] [Citation(s) in RCA: 42] [Impact Index Per Article: 2.1] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/26/2022]
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44
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Vladisavljević GT, Williams RA. Recent developments in manufacturing emulsions and particulate products using membranes. Adv Colloid Interface Sci 2005; 113:1-20. [PMID: 15763236 DOI: 10.1016/j.cis.2004.10.002] [Citation(s) in RCA: 205] [Impact Index Per Article: 10.3] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/15/2004] [Accepted: 10/15/2004] [Indexed: 10/26/2022]
Abstract
Membrane emulsification (ME) is a relatively new technique for the highly controlled production of particulates. This review focuses on the recent developments in this area, ranging from the production of simple oil-in-water (O/W) or water-in-oil (W/O) emulsions to multiple emulsions of different types, solid-in-oil-in-water (S/O/W) dispersions, coherent solids (silica particles, solid lipid microspheres, solder metal powder) and structured solids (solid lipid microcarriers, gel microbeads, polymeric microspheres, core-shell microcapsules and hollow polymeric microparticles). Other emerging technologies that extend the capabilities into different membrane materials and operation methods (such as rotating membranes, repeated membrane extrusion of coarsely pre-emulsified feeds) are introduced. The results of experimental work carried out by cited researchers in the field together with those of the current authors are presented in a tabular form in a rigorous and systematic manner. These demonstrate a wide range of products that can be manufactured using different membrane approaches. Opportunities for creation of new and novel entities are highlighted for low throughput applications (medical diagnostics, healthcare) and for large-scale productions (consumer and personal products).
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Affiliation(s)
- Goran T Vladisavljević
- Institute of Food Technology and Biochemistry, Faculty of Agriculture, University of Belgrade, P.O. Box 127, YU-11081 Belgrade-Zemun, Serbia & Montenegro.
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