Combination curcumin and vitamin E treatment attenuates diet-induced steatosis in Hfe-/- mice

Table 1 Percent steatosis, lobular and non-alcoholic fatty liver disease activity score were reduced due to combination therapy

	HCD (n = 9)	HCD + Cu (n = 9)	HCD + VE (n = 7)	HCD + Cu + VE (n = 9)
Histology diagnosis	NASH (9)	Steatosis (2)/NASH (7)	Steatosis (2)/NASH (5)	Steatosis (4)/NASH (5)
Steatosis grade	3 (3-3)	3 (2-3)	3 (2-3)	3 (2-3)
% steatosis	95 (80-100)	80 (40-100)	95 (70-100)	75 (40-95)a
Lobular score	2 (1-2)	2 (1-3)	1 (0-2)	1 (0-3)
Ballooning	2 (1-2)	2 (1-2)	1 (1-2)	1 (0-2)
NAS score	6 (5-7)	6 (4-8)	6 (4-6)	5 (3-8)
Fibrosis stage	1a (0-1a)	0 (0-1a)	0 (0-1a)	0 (0-1a)

Values are expressed as the median (range).

^aP < 0.05 vs HCD alone, Kruskal-Wallis ANOVA. HCD: High calorie diet; Cu: Curcumin; VE: Vitamin E; NAS: Non-alcoholic fatty liver disease activity score.