Copyright ©The Author(s) 2017.
World J Gastrointest Pathophysiol. May 15, 2017; 8(2): 39-50
Published online May 15, 2017. doi: 10.4291/wjgp.v8.i2.39
Table 1 Similarities between the inflammatory changes developed after triple partial portal vein ligation in the rat and the extra-embryonic functions in mammals
Inflammatory phenotypeExtra-embryonic and embryonic functions
NeurogenicPortal ischemia Hepatic arterial reperfusion Neuroendocrine response Hyperdynamic circulation Mild edema of space of DisseCoelomic-amniotic functions Neurogenic potential Interstitial edema Bacteriostasis Anti-inflammation
ImmuneKupffer cell and hepatic stellate cell activation Leukocyte infiltration Acute phase response Angiogenesis Hepatic steatosisTrophoblastic-yolk sac functions Digestive (phagocytic) functions Acute phase proteins Angiogenic switch Lipid and protein nutrients (vitellum)
EndocrineSinusoidal remodeling Capillarization of hepatic sinusoids Perisinusoidal fibrosis SteatohepatitisGastrulation-like functions Epithelial-mesenchymal transition Intra-embryonic mesenchyma