Implication of miRNAs for inflammatory bowel disease treatment: Systematic review

Table 1 List a core set of altered microRNAs involved in inflammatory bowel disease and their mRNA targets

miRNA	Target mRNA	Net effect	Ref.
Increased expression
miR-146a	NUMB	SHH signaling upregulation	[23]
miR-146b	Siah2	NFκB signaling upregulation	[40]
miR-126	IκBα	NFκB signaling upregulation	[24]
	Vascular cell adhesion molecule-1	Suppresses proinflammatory cytokines	[25]
miR-122	Nucleotide-binding oligomerization domain 2	Decreases intestinal epithelial cell injury	[31]
	Occluding	Intestinal permeability upregulation	[32]
miR-132	AChE	Decreases circulation AChE activity	[37]
miR-21	RhoB	Impairment of tight junctions	[52,53]
miR-150	c-Myb	Promotes apoptosis	[54]
miR-141	CXCL12β	Regulates leukocyte migration	[62]
miR-106b	ATG16L1	deregulation of autophagy	[67,68]
miR-196	IRGM	deregulation of autophagy	[70]
miR-30c	ATG5	inhibition of autophagic activity	[69]
miR-130a	ATG16L1	inhibition of autophagic activity	[69]
Decreased expression
miR-10a	IL-12/IL-23p40	Regulates intestinal homeostasis	[43]
miR-124	STAT3	Promotes inflammation	[48]
miR-200b	ZEB1, SMAD2	Regulates epithelial-mesenchymal transition	[59,60]
miR-192,miR-495, miR-512,miR-671	NOD2	NFκB signaling upregulation	[34]

NF-κB: Nuclear transcription factor kappa B; NOD2: Nucleotide-binding oligomerization domain 2; AChE: Acetylcholinesterase; IRGM: Immunity-related GTPase family; IL: Interleukin; ZEB1: Zinc finger E-box binding homeobox 1; SMAD2: SMAD family member 2.